JP6893878B2 - クチナシ色素製剤 - Google Patents
クチナシ色素製剤 Download PDFInfo
- Publication number
- JP6893878B2 JP6893878B2 JP2017543211A JP2017543211A JP6893878B2 JP 6893878 B2 JP6893878 B2 JP 6893878B2 JP 2017543211 A JP2017543211 A JP 2017543211A JP 2017543211 A JP2017543211 A JP 2017543211A JP 6893878 B2 JP6893878 B2 JP 6893878B2
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- Prior art keywords
- lecithin
- pigment
- gardenia
- blue pigment
- kuchinashi
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
- C09B67/0083—Solutions of dyes
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0001—Post-treatment of organic pigments or dyes
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Description
(1)クチナシ青色素及びレシチンを含有することを特徴とするクチナシ色素製剤(組成物)、
(2)レシチンが酵素分解レシチンであることを特徴とする(1)に記載のクチナシ色素製剤、
(3)クチナシ青色素とレシチンとの割合が、クチナシ青色素(色価500換算)/レシチン(質量比)=0.5/1〜30/1である(1)又は(2)に記載のクチナシ色素製剤、
(4)(1)〜(3)のいずれかに記載のクチナシ色素製剤を含む飲食品、
(5)酸性飲食品である(4)記載の飲食品、
から成っている。
本発明のクチナシ色素製剤は、酸性の飲食品等に好ましく使用できる。
[ゲニポシド濃縮液の調製]
粉砕したクチナシの乾燥果実7200gに40vol%エタノール水溶液28800mLを加え、室温で3時間撹拌した後吸引ろ過した。抽出残に40vol%エタノール水溶液を13200mL加え、室温で30分間撹拌した後吸引ろ過する工程を2回繰り返し、ろ液として42000mLの抽出液を得た。この抽出液を、ロータリーエバポレーターを用いて60℃、4kPaの条件で濃縮し、ゲニポシドを含む濃縮液約2000mLを得た。
得られた濃縮液に水を加えて4000mLとし、アンバーライトXAD−7(製品名;オルガノ社製)12000mLを充填したカラムに流速SV=0.5で通液した。その後、カラムに流速SV=0.5で96000mLの水を通液し、排出液を回収した。回収した液をロータリーエバポレーターを用いて、60℃、4kPaの条件で濃縮し、ゲニポシドを43.9%含む濃縮液360gを得た。
[クチナシ青色素の調製]
タンパク質分解物(商品名:プロエキスG2;トウモロコシ由来;アミノ酸残基数約1;播州調味料社製)15.7g、製造例1で得たゲニポシド濃縮液108.4g及び水311.6gを混合して得た水溶液を、クエン酸でpH4.5に調整した。得られた水溶液にβ−グルコシダーゼ(商品名:スミチームC6000;新日本化学工業社製)2.9gを添加した後、水を加えて総液量を500.0gに調整した。得られた水溶液を50℃で72時間β−グルコシダーゼ処理した後、90℃で15分間加熱して酵素を失活させ、更に、ろ過により不溶物を除去し、クチナシ青色素〔試作品1;色価(E10% 1cm)=102.4〕411.2gを得た。
[クチナシ青色素の調製]
タンパク質酵素加水分解物(商品名:ハイニュートR;大豆由来;アミノ酸残基数3〜4;不二製油社製)76.1g、製造例1で得たゲニポシド濃縮液108.4g及び水270.4gを混合して得た水溶液を、水酸化ナトリウムでpH7.0に調整した。得られた水溶液にβ−グルコシダーゼ(商品名:スミチームC6000;新日本化学工業社製)2.9gを添加した後、水を加えて総液量を500.0gに調整した。得られた水溶液を50℃で72時間β−グルコシダーゼ処理した後、90℃で15分間加熱して酵素を失活、ろ過により不溶物を除去し、クチナシ青色素〔試作品2;色価(E10% 1cm)=158.6〕402.6gを得た。
(1)原材料
1)クチナシ青色素(試作品1及び2)
2)酵素分解レシチン(市販品1;商品名:SLP−ホワイトリゾ;高純度粉末リゾレシチン;辻製油社製)
3)酵素分解レシチン(市販品2;商品名:SLP−LPC70;LPC濃縮リゾレシチン;辻製油社製)
4)イオン交換水
上記原材料を用いて調製したクチナシ色素製剤1〜4の配合組成を表1に示した。この内、クチナシ色素製剤1及び2は本発明に係る実施例であり、クチナシ色素製剤3及び4はそれらに対する比較例である。
表1に示した原材料の配合割合に基づいて、クチナシ青色素及び酵素分解レシチンをイオン交換水に溶解し、全量1kgのクチナシ色素製剤1〜4を調製した。クチナシ色素製剤1〜4は、色価(E10% 1cm)=50となるように配合を調整した。
[耐酸性評価試験]
クチナシ色素製剤(製剤1〜4のいずれか)を色価(E10% 1cm)=0.1になるようにpH2.8のMcIlvaine緩衝液に各々溶解し、各50mLの試験液を調製した。該試験液を90℃で15分間加熱殺菌し、30℃で15時間静置した。静置後、メンブレンフィルター(商品名:DISMIC−25CS;孔径:0.8μm;ADVANTEC社製)を用いて該試験液の一部をろ過し、不溶化したクチナシ青色素を除去した。次いで、未ろ過液及びろ過液の極大吸収波長における吸光度を測定し、未ろ過液の極大吸収波長での吸光度をA、ろ過液の極大吸収波長での吸光度をBとして次式により吸光度低下率(%)を求めた。結果を表2に示す。
吸光度低下率(%)=100−(B/A×100)
Claims (6)
- クチナシ青色素及びレシチンを含有することを特徴とするクチナシ色素製剤であって、レシチンが酵素分解レシチンであり、クチナシ青色素とレシチンとの割合が、クチナシ青色素(色価500換算)/レシチン(質量比)=1/1〜10/1である、クチナシ色素製剤。
- クチナシ青色素及びレシチンを含有することを特徴とするクチナシ色素製剤(ただし、下記(1)〜(3)の場合を除く。
(1)プロピレングリコール及びグリセリンを含む可食性インクジェットインク組成物
(2)セルロースエーテル誘導体及び糖アルコールを含有する組成物
(3)羊毛脂、ペクチン、グリセロール及びソルビトールを含む組成物) - レシチンが酵素分解レシチンであることを特徴とする請求項2に記載のクチナシ色素製剤。
- クチナシ青色素とレシチンとの割合が、クチナシ青色素(色価500換算)/レシチン(質量比)=0.5/1〜30/1である請求項2又は3に記載のクチナシ色素製剤。
- 請求項1に記載のクチナシ色素製剤を含む飲食品。
- 酸性飲食品である請求項5記載の飲食品。
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WO2022044291A1 (ja) * | 2020-08-28 | 2022-03-03 | グリコ栄養食品株式会社 | 青色色素及びその製造方法 |
WO2024090582A1 (ja) * | 2022-10-28 | 2024-05-02 | 三栄源エフ・エフ・アイ株式会社 | クチナシ青耐酸性製剤 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5692792A (en) | 1979-07-24 | 1981-07-27 | T Hasegawa Co Ltd | Preparation of natural blue pigment in brightened color |
JPS5813367A (ja) | 1981-07-16 | 1983-01-25 | Toyo Ink Mfg Co Ltd | カロチノイド色素の水性分散体 |
JPS5941364A (ja) | 1982-09-01 | 1984-03-07 | Sumitomo Chem Co Ltd | カロチノイド類を含有する着色剤 |
JPS6075256A (ja) | 1983-06-02 | 1985-04-27 | San Ei Chem Ind Ltd | 油溶性色素の製造法 |
JPH01141571A (ja) | 1987-11-27 | 1989-06-02 | Nakano Vinegar Co Ltd | 分離型液体調味料 |
JP2904968B2 (ja) * | 1991-07-25 | 1999-06-14 | 長谷川香料株式会社 | 色素の褪色防止剤 |
DE4200349C2 (de) | 1992-01-09 | 1997-08-28 | Georg Dr Buech | Verfahren zur Herstellung eines natürlichen, stabilen grünen Farbstoffes auf Basis von Chlorophyll für die Lebensmittel-, Kosmetik- und Pharmaindustrie |
JPH07310023A (ja) | 1994-05-19 | 1995-11-28 | Kuraray Co Ltd | 青色系色素組成物 |
JP2001064531A (ja) * | 1999-08-26 | 2001-03-13 | Taisho Technos Co Ltd | アントシアニン色素の界面活性剤による安定化 |
JP4374494B2 (ja) | 2001-09-28 | 2009-12-02 | 三栄源エフ・エフ・アイ株式会社 | 色調が改善されたクチナシ青色素の色素製剤 |
US20080032011A1 (en) * | 2005-07-01 | 2008-02-07 | Sensient Colors Inc. | Flavored and Edible Colored Fluids for Printing on Edible Substrates and Precision Deposition Thereof |
CN1325040C (zh) | 2005-08-30 | 2007-07-11 | 浙江理工大学 | 复合天然色素迷彩伪装油膏及其制备方法 |
JP2008127505A (ja) | 2006-11-22 | 2008-06-05 | Q P Corp | 粉末状組成物およびその製造方法、ならびにこれを含有する食品組成物 |
JP2010047625A (ja) * | 2008-08-19 | 2010-03-04 | Union Chemicar Co Ltd | 可食性インクジェットインク組成物 |
JP2012051114A (ja) * | 2010-08-31 | 2012-03-15 | Union Chemicar Co Ltd | 口腔内崩壊性錠剤用インクジェットインク組成物 |
JP2012067241A (ja) | 2010-09-27 | 2012-04-05 | Riken Vitamin Co Ltd | クチナシ青色素の製造方法 |
KR20130103645A (ko) | 2012-03-08 | 2013-09-24 | 주식회사 제이스에프아이 | 고 혼탁 천연색소 에멀젼 제조방법 |
JP2014057531A (ja) | 2012-09-14 | 2014-04-03 | Riken Vitamin Co Ltd | クチナシ青色素の製造方法 |
JP6521600B2 (ja) | 2013-10-02 | 2019-05-29 | 三栄源エフ・エフ・アイ株式会社 | 耐酸性を有するクチナシ色素製剤 |
CN103583932B (zh) | 2013-11-19 | 2015-09-09 | 天津博科林药品包装技术有限公司 | 一种应用于食品、保健品的天然薄膜包衣剂 |
CN105623304A (zh) * | 2014-10-31 | 2016-06-01 | 陕西启源科技发展有限责任公司 | 用于栀子蓝色素纯化的方法 |
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