JP6745809B2 - 薬剤送達装置向けの針ユニット - Google Patents
薬剤送達装置向けの針ユニット Download PDFInfo
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- JP6745809B2 JP6745809B2 JP2017542376A JP2017542376A JP6745809B2 JP 6745809 B2 JP6745809 B2 JP 6745809B2 JP 2017542376 A JP2017542376 A JP 2017542376A JP 2017542376 A JP2017542376 A JP 2017542376A JP 6745809 B2 JP6745809 B2 JP 6745809B2
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- needle
- outer cover
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- block structure
- injection
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- Expired - Fee Related
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- 238000012377 drug delivery Methods 0.000 title claims description 39
- 238000002347 injection Methods 0.000 claims description 61
- 239000007924 injection Substances 0.000 claims description 61
- 238000006073 displacement reaction Methods 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 5
- 101000579646 Penaeus vannamei Penaeidin-1 Proteins 0.000 description 9
- 239000003814 drug Substances 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
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- 238000000034 method Methods 0.000 description 3
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- 238000004891 communication Methods 0.000 description 2
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- 230000014509 gene expression Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 229940090048 pen injector Drugs 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 241001631457 Cannula Species 0.000 description 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 description 1
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 description 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3271—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position
- A61M5/3272—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position having projections following labyrinth paths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3286—Needle tip design, e.g. for improved penetration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3245—Constructional features thereof, e.g. to improve manipulation or functioning
- A61M2005/3254—Shielding of proximal needles, e.g. for pen needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
- A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/27—General characteristics of the apparatus preventing use
- A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3245—Constructional features thereof, e.g. to improve manipulation or functioning
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
Claims (6)
- 長手方向軸に沿って延在し、かつ、対象物内に挿入されるように構成された遠位針端部と、リザーバ隔壁を貫通するように構成された近位針端部とを有する、注射針(25)、及び、
前記近位針端部を取り囲み、かつ、薬剤送達装置の針マウントを受容する受容空間(28)を画定する、スカート部(22)であって、スロット(24)を備えるスカート部(22)を備える、針アセンブリ(20)と、
前記スカート部(22)の外側に支持されているブロック構造体(32)とを備える、注射針ユニット(10)であって、
前記ブロック構造体(32)は、前記長手方向軸に向けて付勢されており、かつ、前記受容空間(28)の外のラッチ留め位置から前記受容空間(28)の中の解放位置へと、前記スロット(24)を通じての径方向変位が可能であり、
前記スカート部(22)を少なくとも部分的に取り囲む外部カバー(30)であって、第1相対位置から第2相対位置へと、前記針アセンブリ(20)に対して相対運動を行うことが可能な、外部カバー(30)を更に備え、
前記ブロック構造体(32)は、
(a)前記外部カバー(30)によって支持されており、
(b)前記ラッチ留め位置において、前記スカート部(22)の外表面上にあり、かつ、
(c)前記外部カバー(30)及び前記針アセンブリ(20)が前記第1相対位置から前記第2相対位置に移動することに応じて、前記ラッチ留め位置から前記解放位置に向かって移動するよう適合している、注射針ユニット(10)。 - 前記ブロック構造体(32)が、周縁部に沿って延在する可撓性アーム(31)であって、前記外部カバー(30)の部分を形成している可撓性アーム(31)から、径方向に突き出す、請求項1に記載の注射針ユニット。
- 前記スカート部(22)が、前記スロット(24)と当接面(27)との間に、周縁部に沿って延在している外側凹部(23)を更に備え、
前記ブロック構造体(32)は、前記ラッチ留め位置において、前記凹部(23)内にあり、
前記第1相対位置では、前記ブロック構造体(32)が、前記当接面(27)に接触し、前記外部カバー(30)と前記針アセンブリ(20)との一方向への相対回転運動を防止する、請求項1又は2に記載の注射針ユニット。 - 前記第2相対位置では、前記ブロック構造体(32)が、前記スロット(24)内へと延在することにより、前記外部カバー(30)と前記針アセンブリ(20)とを回転可能に連動させる、請求項1から3のいずれか一項に記載の注射針ユニット。
- 前記スカート部(22)が、前記スロット(24)の遠位に配置された内部ネジ山(29)を備える、請求項1から4のいずれか一項に記載の注射針ユニット。
- 接続用ネジ(5)を有する針マウント(4)を備える薬剤送達装置(1)と、
請求項5に記載の注射針ユニット(10)とを備える、システムであって、
前記接続用ネジ(5)が、前記内部ネジ山(29)に取り外し可能に接続される、システム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15155941 | 2015-02-20 | ||
EP15155941.6 | 2015-02-20 | ||
PCT/EP2016/053552 WO2016131954A1 (en) | 2015-02-20 | 2016-02-19 | Needle unit for drug delivery device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018504991A JP2018504991A (ja) | 2018-02-22 |
JP6745809B2 true JP6745809B2 (ja) | 2020-08-26 |
Family
ID=52477736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017542376A Expired - Fee Related JP6745809B2 (ja) | 2015-02-20 | 2016-02-19 | 薬剤送達装置向けの針ユニット |
Country Status (5)
Country | Link |
---|---|
US (1) | US10406298B2 (ja) |
EP (1) | EP3258997B1 (ja) |
JP (1) | JP6745809B2 (ja) |
CN (1) | CN107405456B (ja) |
WO (1) | WO2016131954A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7219757B2 (ja) | 2017-08-30 | 2023-02-08 | ノボ・ノルデイスク・エー/エス | 保存剤を有する流れ連通ユニット |
US11944791B2 (en) | 2017-08-30 | 2024-04-02 | Novo Nordisk A/S | Multi-use drug delivery device for drugs with less preservatives |
CN108079405A (zh) * | 2017-12-22 | 2018-05-29 | 天津哈娜好医材有限公司 | 自毁式螺旋注射器及其使用方法 |
US11684727B2 (en) * | 2018-02-12 | 2023-06-27 | Embecta Corp. | Pen needle apparatus |
JP7471682B2 (ja) * | 2019-09-24 | 2024-04-22 | クリーデンス メドシステムズ,インコーポレイテッド | 安全シリンジのためのシステムおよび方法 |
CN117100949B (zh) * | 2023-09-26 | 2024-02-23 | 安徽宏宇五洲医疗器械股份有限公司 | 一种带安全防护式自主注射通用注射针头 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101568359B (zh) * | 2006-12-22 | 2012-04-18 | 诺沃-诺迪斯克有限公司 | 带有被偏压的安全护罩的可防护针组件 |
US7871397B2 (en) * | 2006-12-26 | 2011-01-18 | Stat Medical Devices, Inc. | Pen needle tip |
US7462168B2 (en) * | 2007-01-23 | 2008-12-09 | Becton, Dickinson And Company | Safety pen needle with passive safety shield system |
US7462169B2 (en) | 2007-01-23 | 2008-12-09 | Becton, Dickinson And Company | Safety shield system for an injection pen needle |
JP5361744B2 (ja) * | 2007-03-07 | 2013-12-04 | ノボ・ノルデイスク・エー/エス | 後方針 |
EP2262558B1 (en) | 2008-03-13 | 2016-11-16 | Becton, Dickinson and Company | Safety pen needle assembly having shielding for patient and non-patient ends |
EP2376152A1 (en) | 2008-12-15 | 2011-10-19 | Novo Nordisk A/S | Tiltable safety needle |
US8864740B2 (en) | 2010-10-01 | 2014-10-21 | Sanofi-Aventis Deutschland Gmbh | Needle assembly with release mechanism |
EP2701784B1 (en) | 2011-04-28 | 2015-07-22 | Sanofi-Aventis Deutschland GmbH | Dispense interface with lockout element |
JP6124870B2 (ja) | 2011-05-06 | 2017-05-10 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 使い捨て部材のための再使用保護 |
EP2601992A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
JP6647043B2 (ja) | 2012-10-25 | 2020-02-14 | ノボ・ノルデイスク・エー/エス | 充填済みの使い捨て注射装置 |
-
2016
- 2016-02-19 CN CN201680011085.0A patent/CN107405456B/zh not_active Expired - Fee Related
- 2016-02-19 EP EP16705199.4A patent/EP3258997B1/en active Active
- 2016-02-19 JP JP2017542376A patent/JP6745809B2/ja not_active Expired - Fee Related
- 2016-02-19 WO PCT/EP2016/053552 patent/WO2016131954A1/en active Application Filing
- 2016-02-19 US US15/544,045 patent/US10406298B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2018504991A (ja) | 2018-02-22 |
WO2016131954A1 (en) | 2016-08-25 |
EP3258997A1 (en) | 2017-12-27 |
US10406298B2 (en) | 2019-09-10 |
EP3258997B1 (en) | 2020-04-22 |
US20180264203A1 (en) | 2018-09-20 |
CN107405456B (zh) | 2020-02-21 |
CN107405456A (zh) | 2017-11-28 |
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