JP5837598B2 - 光学的血液モニタリングシステム用の血液チャンバ - Google Patents
光学的血液モニタリングシステム用の血液チャンバ Download PDFInfo
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Description
本発明の第一の目的は、レシオメトリックモデルを介して酸素飽和度を算出するために使用される検出シグナルの予測されるダイナミックレンジ全体にわたって酸素飽和度の正確な測定を促進し、かつ、高いヘマトクリットレベルおよび低いヘマトクリットレベルの両方でそれを行うことである。
Io= 関心のある波長におけるLED光エミッタから印加された強度;
ip= 光検出器での直接的なパイピング経路から受信した強度;
ρ = いくつかの変数v1、v2、v3,・・・・・vnのパイピング関数)
である。
i = 足し合わされ、光検出器でのカレントに統合された総強度シグナル
is= シグナル経路dbに沿ってLED88から到達した光の成分
ip= 光パイピング経路を通ってLED88から到達した光の成分)
である。
ダクティングが存在する場合、式(8)は、ipを各レシオメトリック項isに足すことにより修正されなければならない。ipおよびレシオメトリック項isは比例的に変化しないため、ipの値がレシオメトリック項isと比較して有意である場合、多項式gは解を持たず決定できない。
Claims (17)
- 体外のチューブを流れる血液を光学的にモニタリングするための、該体外のチューブに接続された血液チャンバであって、当該血液チャンバは、
チャンバ本体を有し、該チャンバ本体は、内部血流キャビティを形成しており、該内部血流キャビティは、流れる血液のための流れの経路を提供し、かつ、該内部血流キャビティは、光エミッタと光検出器とを用いた血液の光学的モニタリングのための平坦な観察エリアを含んでおり、
前記の平坦な観察エリアの外側にある前記チャンバ本体の部分を有し、該部分は、青色が付いており、かつ、赤色光に対して不透明でありかつそれ以外の可視光に対しては透明であり、該チャンバ本体の青色の付いた部分は、該チャンバ本体を通過して前記内部血流キャビティに入る周辺光のうちの赤色光を減衰させるように構成されており、
透明な材料製の向かい合ったレンズを有し、これらレンズは、前記内部血流キャビティを通過する、前記光エミッタからの光を伝播するために、前記チャンバ本体の前記平坦な観察エリア内に、取り付けられているかまたは一体的に形成されており、かつ、
周壁を有し、該周壁は、前記光エミッタと光検出器とを含んだクリップに噛み合うために、前記の向かい合ったレンズのそれぞれの周りに延びている、
前記血液チャンバ。 - 前記の向かい合ったレンズが、透明なポリカーボネート材料から成形されており、かつ、前記チャンバ本体の青色の付いた部分が、青色の付いたポリカーボネート材料から成形されている、請求項1に記載の血液チャンバ。
- 前記チャンバ本体の青色の付いた領域が、該チャンバ本体の向かい合ったレンズに対して溶接されている、請求項1に記載の血液チャンバ。
- 前記チャンバ本体の青色の付いた部分が、赤色光の全スペクトルに対して不透明な材料から作られている、請求項1に記載の血液チャンバ。
- 前記の向かい合ったレンズのそれぞれの全体が透明なポリカーボネート材料から成形されている、請求項1に記載の血液チャンバ。
- 前記内部血流キャビティが、前記の向かい合ったレンズの間の観察エリアの周囲に堀を有する、請求項1に記載の血液チャンバ。
- 前記チャンバ本体が、入力ポートと出力ポートを含んでおり、これら入力ポートと出力ポートは、当該血液チャンバを横断する軸に沿って位置合わせされている、請求項1に記載の血液チャンバ。
- 光学的血液モニタリングシステムであって、当該光学的血液モニタリングシステムは、
体外チューブを有し、該体外チューブは、患者から採取された血液を通すためのものであり、
血液チャンバを有し、該血液チャンバは、該体外チューブを流れる血液を受け取るものであり、該血液チャンバは、内部血流キャビティを通る流れの経路を定めており、かつ、血液の光学的モニタリングのための観察エリアを提供し、
該血液チャンバは、チャンバ本体を有し、該チャンバ本体は、平坦な内壁、および、該平坦な内壁の周囲に延びる周壁を有し、該平坦な内壁および該周壁は、該内部血流キャビティの一部分を形成し、
該血液チャンバは、観察レンズを有し、該観察レンズは、該チャンバ本体の該平坦な内壁の少なくとも一部分に相当する透明な材料から作られており、それにより、該内部血流キャビティを通って流れる血液への光進入路を提供し、かつ、
該血液チャンバは、青色の付いたチャンバ本体の部分を少なくとも有し、該チャンバ本体の青色の付いた部分は、第3の波長(λ 3 )の赤色光に対して不透明であり、かつ、それ以外の可視光に対しては透明であり、かつ、前記チャンバ本体を通過して前記内部血流キャビティに入る周辺光のうち前記第3の波長(λ 3 )の赤色光を減衰させるように構成されており、
レンズ本体を有し、該レンズ本体は、該チャンバ本体に取り付けられているかまたは該チャンバ本体と一体的に形成されている平坦な内壁を有し、それにより、該チャンバ本体の該平坦な内壁および周壁と一緒になって該内部血流キャビティを形成し、該レンズ本体は、該レンズの該平坦な内壁により該チャンバ本体に取り付けられており、該レンズの該平坦な内壁は、該チャンバ本体の該平坦な内壁に対して実質的に平行であり、そしてまた、予め定められた一定のインスタンス(instance)だけ該チャンバ本体の該平坦な内壁から分離されており、かつ、該レンズ本体は、観察レンズを有し、該観察レンズは、該レンズ本体の該平坦な内壁の少なくとも一部分に相当する透明な材料から作られており、それにより、該内部血流キャビティを流れる血液への光進入路を提供し、
センサアセンブリを有し、該センサアセンブリは、該血液チャンバを流れる患者の血液をモニタリングするものであり、該センサアセンブリは、第3の光エミッタを有し、該第3の光エミッタは、該観察レンズ、および、該血液チャンバの該内部血流キャビティを流れる血液を通る該第3の波長(λ3)の赤色光を放出するためのものであり、該センサアセンブリは、第1の光エミッタを有し、該第1の光エミッタは、該観察レンズ、および、該血液チャンバの該内部血流キャビティを流れる血液を通る第1の波長(λ1)の赤外光を放出するためのものであり、かつ、該センサアセンブリは、少なくとも1つの光検出器を有し、該少なくとも1つの光検出器は、該第3(λ3)および第1(λ1)の波長の各々の光の強度を、該光が、該観察レンズ、および該血液チャンバの該内部血流キャビティを流れる血液を通過した後に、検出するためのものである、
前記光学的血液モニタリングシステム。 - 前記観察レンズが、透明なポリカーボネート材料から成形されており、かつ、前記青色の付いたチャンバ本体の部分が、青色の付いたポリカーボネート材料から成形されており、かつ、さらに、該チャンバ本体の該青色の付いた部分が、前記透明な観察レンズに溶接されている、請求項8に記載の光学的血液モニタリングシステム。
- 前記観察レンズが、透明なポリカーボネート材料から成形されており、かつ、前記青色の付いたチャンバ本体の部分が、青色の付いたポリカーボネート材料から成形されている、請求項8に記載の光学的血液モニタリングシステム。
- 前記チャンバ本体の青色の付いた部分が、赤色光の全スペクトルに対して不透明な材料から作られている、請求項8に記載の光学的血液モニタリングシステム。
- 前記観察レンズのそれぞれの全体が透明なポリカーボネート材料から成形されている、請求項8に記載の光学的血液モニタリングシステム。
- 前記内部血流キャビティが、前記観察レンズ同士の間の観察エリアの周囲に堀を有する、請求項8に記載の光学的血液モニタリングシステム。
- 前記チャンバ本体が、軸方向に位置合わせされた入力ポートと出力ポートを含んでいる、請求項8に記載の光学的血液モニタリングシステム。
- 体外のチューブを流れる血液を光学的にモニタリングするための、該体外のチューブに接続された血液チャンバであって、当該血液チャンバは、
チャンバ本体を有し、該チャンバ本体は、内部血流キャビティを形成しており、該内部血流キャビティは、流れる血液のための流れの経路を提供し、かつ、該内部血流キャビティは、血液の光学的モニタリングのための平坦な観察エリアを含んでおり、該チャンバ本体は手段を含んでおり、前記手段は、前記内部血流キャビティを通って流れる血液の可視化を可能にするように該チャンバ本体を透明に維持しながらも、該チャンバ本体を通過して前記内部血流キャビティ内に入る周辺光のうちの赤色光を減衰させる手段であり、
透明な材料製の向かい合ったレンズを有し、これらレンズは、前記内部血流キャビティを通過する、光エミッタからの光を伝播するために、前記チャンバ本体の前記平坦な観察エリア内に、取り付けられているかまたは一体的に形成されており、かつ、
周壁を有し、該周壁は、前記光エミッタを含んだクリップに噛み合うために、前記の向かい合ったレンズのそれぞれの周りに延びている、
前記血液チャンバ。 - 前記の向かい合ったレンズが、透明なポリカーボネート材料から成形されており、かつ、前記の赤色光を減衰させるための手段が、青色の付いたポリカーボネート材料から成形された、チャンバ本体の部分を含んでいる、請求項15に記載の血液チャンバ。
- 前記チャンバ本体が、軸方向に位置合わせされた入力ポートと出力ポートを含んでいる、請求項15に記載の血液チャンバ。
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CA2808252C (en) | 2018-02-27 |
CN103124519A (zh) | 2013-05-29 |
AU2011299393B2 (en) | 2014-09-11 |
US20120059234A1 (en) | 2012-03-08 |
JP2013543578A (ja) | 2013-12-05 |
CA2808252A1 (en) | 2012-03-15 |
MX341335B (es) | 2016-08-16 |
WO2012033738A1 (en) | 2012-03-15 |
US9194792B2 (en) | 2015-11-24 |
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