JP5514455B2 - 3次元の空隙形状を有する構造体上にリン酸カルシウム化合物を被覆する処理方法と該構造体の製造方法 - Google Patents
3次元の空隙形状を有する構造体上にリン酸カルシウム化合物を被覆する処理方法と該構造体の製造方法 Download PDFInfo
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- JP5514455B2 JP5514455B2 JP2009051994A JP2009051994A JP5514455B2 JP 5514455 B2 JP5514455 B2 JP 5514455B2 JP 2009051994 A JP2009051994 A JP 2009051994A JP 2009051994 A JP2009051994 A JP 2009051994A JP 5514455 B2 JP5514455 B2 JP 5514455B2
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- 238000000034 method Methods 0.000 title claims description 51
- 238000011282 treatment Methods 0.000 title claims description 29
- -1 calcium phosphate compound Chemical class 0.000 title claims description 25
- 239000001506 calcium phosphate Substances 0.000 title claims description 23
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims description 23
- 235000011010 calcium phosphates Nutrition 0.000 title claims description 23
- 238000000576 coating method Methods 0.000 title claims description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 239000011800 void material Substances 0.000 title claims description 14
- 239000011248 coating agent Substances 0.000 title description 18
- 239000000463 material Substances 0.000 claims description 55
- 239000000203 mixture Substances 0.000 claims description 45
- 238000010438 heat treatment Methods 0.000 claims description 43
- 239000012298 atmosphere Substances 0.000 claims description 32
- 238000007254 oxidation reaction Methods 0.000 claims description 30
- 230000003647 oxidation Effects 0.000 claims description 29
- 150000001875 compounds Chemical class 0.000 claims description 25
- 230000001590 oxidative effect Effects 0.000 claims description 22
- 239000007800 oxidant agent Substances 0.000 claims description 18
- 210000000988 bone and bone Anatomy 0.000 claims description 14
- 239000002243 precursor Substances 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 239000011521 glass Substances 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 239000003054 catalyst Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 230000009467 reduction Effects 0.000 claims description 8
- 230000001172 regenerating effect Effects 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 8
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 7
- 238000004113 cell culture Methods 0.000 claims description 7
- 239000000919 ceramic Substances 0.000 claims description 7
- 238000007877 drug screening Methods 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 239000012876 carrier material Substances 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 239000007789 gas Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000004440 column chromatography Methods 0.000 claims description 4
- QOSATHPSBFQAML-UHFFFAOYSA-N hydrogen peroxide;hydrate Chemical compound O.OO QOSATHPSBFQAML-UHFFFAOYSA-N 0.000 claims description 4
- 239000004745 nonwoven fabric Substances 0.000 claims description 4
- 239000011324 bead Substances 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims 2
- 239000010408 film Substances 0.000 description 26
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 25
- 229910052719 titanium Inorganic materials 0.000 description 25
- 239000010936 titanium Substances 0.000 description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 239000011575 calcium Substances 0.000 description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 10
- 229910052791 calcium Inorganic materials 0.000 description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 9
- JQVDAXLFBXTEQA-UHFFFAOYSA-N dibutylamine Chemical compound CCCCNCCCC JQVDAXLFBXTEQA-UHFFFAOYSA-N 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 239000013078 crystal Substances 0.000 description 8
- 238000007654 immersion Methods 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000002485 combustion reaction Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- 238000005470 impregnation Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000292 calcium oxide Substances 0.000 description 3
- 235000012255 calcium oxide Nutrition 0.000 description 3
- 239000011247 coating layer Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000003980 solgel method Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 229910000531 Co alloy Inorganic materials 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 150000004703 alkoxides Chemical class 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000007766 curtain coating Methods 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 229910002077 partially stabilized zirconia Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 229910052582 BN Inorganic materials 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- PRQPWJNTOJDODA-UHFFFAOYSA-N O.O.OP(O)(=O)OP(=O)(O)O.C(CCC)NCCCC Chemical compound O.O.OP(O)(=O)OP(=O)(O)O.C(CCC)NCCCC PRQPWJNTOJDODA-UHFFFAOYSA-N 0.000 description 1
- IYBHHMMESSPCSS-UHFFFAOYSA-J O.O.[Ca++].[Ca++].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O Chemical compound O.O.[Ca++].[Ca++].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O IYBHHMMESSPCSS-UHFFFAOYSA-J 0.000 description 1
- 229910052581 Si3N4 Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
- MJOQJPYNENPSSS-XQHKEYJVSA-N [(3r,4s,5r,6s)-4,5,6-triacetyloxyoxan-3-yl] acetate Chemical compound CC(=O)O[C@@H]1CO[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O MJOQJPYNENPSSS-XQHKEYJVSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 239000005313 bioactive glass Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- XQKKWWCELHKGKB-UHFFFAOYSA-L calcium acetate monohydrate Chemical compound O.[Ca+2].CC([O-])=O.CC([O-])=O XQKKWWCELHKGKB-UHFFFAOYSA-L 0.000 description 1
- 229940067460 calcium acetate monohydrate Drugs 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 229910000394 calcium triphosphate Inorganic materials 0.000 description 1
- AWWLNOYMFSDXPO-UHFFFAOYSA-L calcium;diacetate;dihydrate Chemical compound O.O.[Ca+2].CC([O-])=O.CC([O-])=O AWWLNOYMFSDXPO-UHFFFAOYSA-L 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- GFFBAXKJVPVOAP-UHFFFAOYSA-N dibutylazanium;phosphono hydrogen phosphate Chemical compound CCCCNCCCC.OP(O)(=O)OP(O)(O)=O GFFBAXKJVPVOAP-UHFFFAOYSA-N 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000012770 industrial material Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 231100000989 no adverse effect Toxicity 0.000 description 1
- 150000002903 organophosphorus compounds Chemical class 0.000 description 1
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000005240 physical vapour deposition Methods 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 239000005368 silicate glass Substances 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000005361 soda-lime glass Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- MTPVUVINMAGMJL-UHFFFAOYSA-N trimethyl(1,1,2,2,2-pentafluoroethyl)silane Chemical compound C[Si](C)(C)C(F)(F)C(F)(F)F MTPVUVINMAGMJL-UHFFFAOYSA-N 0.000 description 1
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- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Description
Claims (6)
- カラムクロマト充填材、触媒担持材、再生医療用細胞担体材(スキャフォールド)、細胞培養材、骨補填材、骨再建材、薬剤スクリーニング基材に用いられる3次元の空隙形状を有する構造体に分子プレカーサー法によりリン酸カルシウム化合物を形成できる溶液組成物を塗布した後、熱処理して該化合物を形成する際に、(A)酸化性雰囲気中300〜1100℃で加熱する酸化処理、(B)酸化剤を0.1wt%〜50wt%添加した溶液組成物を塗布した構造体を、酸化性雰囲気中または大気中300〜1100℃で加熱する酸化処理、(C)前記いずれかの加熱酸化処理後に酸化剤に浸漬もしくは浸漬後に100〜800℃で熱処理する酸化処理、から選ばれる1つ以上の酸化処理工程により、構造体の強度の低下、変形、脆化を抑制し、該化合物を全面または部分的に被覆処理することを特徴とする構造体の製造方法。
- 構造体の形状は、繊維集合(不織布)構造、メッシュ状構造、スポンジ状構造、ビーズ構造、カラム構造のいずれか1つを含むことを特徴とする請求項1に記載の構造体の製造方法。
- 構造体が金属、セラミックス、ガラスのいずれか1つを含むことを特徴とする請求項1に記載の構造体の製造方法。
- 被覆するリン酸カルシウム化合物が、アモルファスまたは結晶性で、組成が単一か、または、それらの混合物からなることを特徴とする請求項1に記載の構造体の製造方法。
- 酸化剤は、過酸化水素(水)、オゾン(水)から選ばれる1種以上の酸化剤であることを特徴とする請求項1に記載の構造体の製造方法。
- 熱処理時の酸化性雰囲気は、酸素、オゾンから選ばれる1種以上の酸化性の気体を30〜100%含む雰囲気であることを特徴とする請求項1に記載の構造体の製造方法。
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WO2018135568A1 (ja) * | 2017-01-20 | 2018-07-26 | 日本ピストンリング株式会社 | 医療部材および軟組織の治療方法 |
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CN114481010A (zh) * | 2021-12-30 | 2022-05-13 | 西安九洲生物材料有限公司 | 一种提高金属齿科医疗器械表面硬度和力学性能的方法 |
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JPS62116781A (ja) * | 1985-11-15 | 1987-05-28 | Agency Of Ind Science & Technol | リン酸カルシウム系被覆形成用組成物及びそれを用いた表面被覆方法 |
JPS6486975A (en) * | 1987-09-29 | 1989-03-31 | Permelec Electrode Ltd | Preparation of calcium phosphate compound coated composite material |
JPH1072666A (ja) * | 1996-08-30 | 1998-03-17 | Japan Steel Works Ltd:The | アパタイト薄膜の成膜方法 |
JP3846817B2 (ja) * | 1997-07-08 | 2006-11-15 | 日本特殊陶業株式会社 | リン酸カルシウム系被膜の製造方法 |
JP4515553B2 (ja) * | 1999-05-11 | 2010-08-04 | 日油株式会社 | ハイドロキシアパタイト複合体の製造方法、その複合体及び生体適合性材料 |
JP4332654B2 (ja) * | 2002-07-05 | 2009-09-16 | タマティーエルオー株式会社 | ヒドロキシアパタイト膜の作製方法 |
JP2005132659A (ja) * | 2003-10-29 | 2005-05-26 | Terubumi Sato | ヒドロキシアパタイトおよびその製造方法 |
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WO2018135568A1 (ja) * | 2017-01-20 | 2018-07-26 | 日本ピストンリング株式会社 | 医療部材および軟組織の治療方法 |
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