JP2022016703A - パップ剤 - Google Patents
パップ剤 Download PDFInfo
- Publication number
- JP2022016703A JP2022016703A JP2021193433A JP2021193433A JP2022016703A JP 2022016703 A JP2022016703 A JP 2022016703A JP 2021193433 A JP2021193433 A JP 2021193433A JP 2021193433 A JP2021193433 A JP 2021193433A JP 2022016703 A JP2022016703 A JP 2022016703A
- Authority
- JP
- Japan
- Prior art keywords
- water
- extract
- plaster layer
- content
- poultice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
【解決手段】 基布上に膏体層を備えるパップ剤であって、前記膏体層は、サリチル酸グリコール、水溶性高分子、水、ポリ(アクリル酸メチル/アクリル酸2-エチルヘキシル)、ソルビトール及びグリセリンを含有し、前記水溶性高分子が、カルボキシメチルセルロースナトリウムを含まず、前記水溶性高分子は、ゼラチンを含み、グリセリンの含有量が、質量基準で、サリチル酸グリコールの含有量の8~15倍であり、前記膏体層のpHが4.7~5.1である、パップ剤(但し、インドメタシンを含有するパップ剤を除く。)。
【選択図】なし
Description
表1の記載の組成にしたがい、各成分を十分に混合し、膏体液を調製した。得られた膏体液を剥離ライナー上に均一に展延し、その上に基布を積層して、剥離ライナーを剥離することにより、実施例1~8及び比較例1、2のパップ剤をそれぞれ得た。
日本薬局方の記載に準じて、得られたパップ剤の膏体層のpHを測定し、その値を表2に示した。また、各パップ剤を60℃にて1か月間保管した後、膏体層に含まれるサリチル酸グリコールの含有量をガスクロマトグラフ法にて測定した。調製時のパップ剤におけるサリチル酸グリコールの含有量(初期値)に対する、保管後のパップ剤におけるサリチル酸グリコールの含有量を表2に示した。
表3の記載の組成にしたがい、各成分を十分に混合し、膏体液を調製した。得られた膏体液を剥離ライナー上に均一に展延し、その上に基布を積層して、剥離ライナーを剥離することにより、実施例9~12のパップ剤をそれぞれ得た。
日本薬局方の記載に準じて、得られたパップ剤の膏体層のpHを測定し、その値を表4に示した。また、各パップ剤を60℃にて1か月間保管した後、膏体層に含まれるサリチル酸グリコールの含有量をガスクロマトグラフ法にて測定した。調製時のパップ剤におけるサリチル酸グリコールの含有量に対する、保管後のパップ剤におけるサリチル酸グリコールの含有量を表4に示した。
Claims (4)
- 基布上に膏体層を備えるパップ剤であって、
前記膏体層は、サリチル酸グリコール、水溶性高分子、水、ポリ(アクリル酸メチル/アクリル酸2-エチルヘキシル)、ソルビトール及びグリセリンを含有し、
前記水溶性高分子が、カルボキシメチルセルロースナトリウムを含まず、
前記水溶性高分子は、ゼラチンを含み、
グリセリンの含有量が、質量基準で、サリチル酸グリコールの含有量の8~15倍であり、
前記膏体層のpHが4.7~5.1である、パップ剤(但し、インドメタシンを含有するパップ剤を除く。)。 - 前記水溶性高分子は、ポリアクリル酸又はポリアクリル酸中和物を更に含む、請求項1に記載のパップ剤。
- 基布上に膏体層を備えるパップ剤の製造方法であって、
サリチル酸グリコール、水溶性高分子、水、ポリ(アクリル酸メチル/アクリル酸2-エチルヘキシル)、ソルビトール及びグリセリンを混合して得られる膏体液から膏体層を形成する工程を含み、
前記水溶性高分子が、カルボキシメチルセルロースナトリウムを含まず、
前記水溶性高分子は、ゼラチンを含み、
グリセリンの含有量が、質量基準で、サリチル酸グリコールの含有量の8~15倍であり、前記膏体層のpHは4.7~5.1となるように調整される、パップ剤の製造方法。 - 基布上に膏体層を備えるパップ剤における、サリチル酸グリコールの保存安定性の向上方法であって、
サリチル酸グリコール、水溶性高分子、水、ポリ(アクリル酸メチル/アクリル酸2-エチルヘキシル)、ソルビトール及びグリセリンを混合して得られる膏体液から膏体層を形成することと、
前記水溶性高分子が、カルボキシメチルセルロースナトリウムを含まず、
前記水溶性高分子は、ゼラチンを含み、
グリセリンの含有量が、質量基準で、サリチル酸グリコールの含有量の8~15倍であることと、
前記膏体層のpHは4.7~5.1となるように調整されることと、を含む、方法。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59110616A (ja) * | 1982-12-17 | 1984-06-26 | Lion Corp | 湿布剤 |
WO1997028793A1 (fr) * | 1996-02-07 | 1997-08-14 | Lead Chemical Co., Ltd. | Preparation a usage externe comprenant du tranilast et processus de production de cette preparation |
WO2006090782A1 (ja) * | 2005-02-23 | 2006-08-31 | Saitama Daiichi Pharmaceutical Co., Ltd. | 含水系外用貼付剤用組成物及びこの組成物を用いた貼付剤 |
WO2013027840A1 (ja) * | 2011-08-25 | 2013-02-28 | ニプロパッチ株式会社 | 含水貼付剤 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5940853A (ja) * | 1982-08-31 | 1984-03-06 | 第一製薬株式会社 | 乳化型パツプ剤 |
JPS6112614A (ja) * | 1984-06-27 | 1986-01-21 | Lion Corp | 水性パップ剤 |
JPS61200918A (ja) * | 1985-03-04 | 1986-09-05 | Shiseido Co Ltd | 外用消炎鎮痛剤 |
JP3258576B2 (ja) | 1996-10-09 | 2002-02-18 | 協和化学工業株式会社 | パップ剤 |
JP2001302503A (ja) * | 2000-04-17 | 2001-10-31 | Oishi Koseido:Kk | 貼付剤 |
JP4324465B2 (ja) * | 2001-06-12 | 2009-09-02 | 久光製薬株式会社 | シート状貼付剤 |
JP4073231B2 (ja) * | 2002-03-28 | 2008-04-09 | 久光製薬株式会社 | シ−ト状貼付剤 |
JP4318467B2 (ja) * | 2003-02-24 | 2009-08-26 | 大協薬品工業株式会社 | 低皮膚刺激性硬膏剤及びその製造法 |
JP4596751B2 (ja) * | 2003-06-11 | 2010-12-15 | 帝國製薬株式会社 | 消炎鎮痛貼付剤 |
JP2005126341A (ja) * | 2003-10-22 | 2005-05-19 | Lion Corp | 外用消炎鎮痛貼付剤 |
JP2006321720A (ja) | 2005-05-17 | 2006-11-30 | Life Kea Giken Kk | 貼付剤 |
JP5285279B2 (ja) * | 2005-12-28 | 2013-09-11 | 久光製薬株式会社 | 経皮吸収型製剤 |
JP2008231010A (ja) | 2007-03-20 | 2008-10-02 | Shiseido Co Ltd | 皮膚外用剤 |
EP2156827A4 (en) * | 2007-05-17 | 2012-11-07 | Nipro Patch Co Ltd | CATAPLASM AND PROCESS FOR PRODUCTION OF CATAPLASM |
JP5319950B2 (ja) * | 2008-04-08 | 2013-10-16 | 帝國製薬株式会社 | 塩酸ブテナフィン含有水性貼付剤 |
US8097275B2 (en) * | 2008-04-23 | 2012-01-17 | Kowa Company, Ltd. | External skin patch |
JP5999875B2 (ja) * | 2011-03-30 | 2016-09-28 | 小林製薬株式会社 | ゲル状医薬組成物 |
-
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59110616A (ja) * | 1982-12-17 | 1984-06-26 | Lion Corp | 湿布剤 |
WO1997028793A1 (fr) * | 1996-02-07 | 1997-08-14 | Lead Chemical Co., Ltd. | Preparation a usage externe comprenant du tranilast et processus de production de cette preparation |
WO2006090782A1 (ja) * | 2005-02-23 | 2006-08-31 | Saitama Daiichi Pharmaceutical Co., Ltd. | 含水系外用貼付剤用組成物及びこの組成物を用いた貼付剤 |
WO2013027840A1 (ja) * | 2011-08-25 | 2013-02-28 | ニプロパッチ株式会社 | 含水貼付剤 |
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