IT1270660B - Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi - Google Patents
Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasiInfo
- Publication number
- IT1270660B IT1270660B ITMI942094A ITMI942094A IT1270660B IT 1270660 B IT1270660 B IT 1270660B IT MI942094 A ITMI942094 A IT MI942094A IT MI942094 A ITMI942094 A IT MI942094A IT 1270660 B IT1270660 B IT 1270660B
- Authority
- IT
- Italy
- Prior art keywords
- enzyme
- inhibitors
- replaced
- products
- carboss
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002906 microbiologic effect Effects 0.000 title abstract 2
- 230000036983 biotransformation Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/02—Dehydrogenating; Dehydroxylating
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invenzione riguarda un procedimento microbiologico per la trasformazione di 4-azaandrostan-3-oni-17? - sostituiti e l'uso del prodotti di biotrasformazione come inibitori dell'enzima 5? - riduttasi.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI942094A IT1270660B (it) | 1994-10-13 | 1994-10-13 | Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi |
PT98124126T PT922770E (pt) | 1994-10-13 | 1995-10-10 | Processo microbiologico para a transformacao de 3-oxo-4-azaesteroides 17-beta-carboxi-substituidos e utilizacao de tais prodtos inibidores da enzima 5-alfa-reductase |
EP98124126A EP0922770B1 (en) | 1994-10-13 | 1995-10-10 | A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase |
AT98124126T ATE224451T1 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches verfahren zur transformation von 17-beta-carboxy-substituierten 3-oxo-4- azasteroiden und die verwendung solcher produkte als inhibitoren des enzyms 5-alpha-reduktase |
EP95935926A EP0786011B1 (en) | 1994-10-13 | 1995-10-10 | Microbiological process for the preparation of 1-unsaturated 17-beta-carboxysubstituted 3-oxo-4-azaandrostan-3-ones |
ES98124126T ES2184192T3 (es) | 1994-10-13 | 1995-10-10 | Procedimiento microbiologico para la transformacion de 3-oxo-4-azaesteroides 17beta-carboxisustituidos y uso de tales productos como inhibidores de la enzima 5alfa-reductasa. |
DE69516162T DE69516162T2 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches Verfahren zur Herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3-Oxo-4-Azaandrostan-3-onen |
AT95935926T ATE191508T1 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen |
DK98124126T DK0922770T3 (da) | 1994-10-13 | 1995-10-10 | Mikrobiologisk fremgangsmåde til omdannelsen af 17-beta-carboxysubstituerede 3-oxo-4-azasteroider og anvendelsen af sådanne produkter som hæmmere af enzymet 5-alfa-reduktase |
ES95935926T ES2106698T3 (es) | 1994-10-13 | 1995-10-10 | Procedimiento microbiologico para la preparacion de 3-oxo-4-azaandrostan-3-onas 17beta-carboxi sustituidas. |
AU38050/95A AU3805095A (en) | 1994-10-13 | 1995-10-10 | A microbiological process for the preparation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase |
PCT/EP1995/003992 WO1996012034A1 (en) | 1994-10-13 | 1995-10-10 | A microbiological process for the preparation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase |
DE69528296T DE69528296T2 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches Verfahren zur Transformation von 17-beta-Carboxy-substituierten 3-Oxo-4-Azasteroiden und die Verwendung solcher Produkte als Inhibitoren des Enzyms 5-alpha-Reduktase |
PT95935926T PT786011E (pt) | 1994-10-13 | 1995-10-10 | Processo microbiologico para a preparacao de 3-oxo-4-aza-androstan-3-onas carboxi-substituidas em posicao 17 e comportando uma ligacao dupla em posicao 1 |
TR95/01260A TR199501260A2 (tr) | 1994-10-13 | 1995-10-13 | 17-betakarboksi ikameli 3-okso-4-azasteroidlerin hazirlanmasi icin mikrobiyolojik bir islem ve bu tür ürünlerin 5alfa-redüktaz enzimi inhibitörleri olarak kullanimi. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI942094A IT1270660B (it) | 1994-10-13 | 1994-10-13 | Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI942094A0 ITMI942094A0 (it) | 1994-10-13 |
ITMI942094A1 ITMI942094A1 (it) | 1996-04-13 |
IT1270660B true IT1270660B (it) | 1997-05-07 |
Family
ID=11369703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI942094A IT1270660B (it) | 1994-10-13 | 1994-10-13 | Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP0922770B1 (it) |
AT (2) | ATE191508T1 (it) |
AU (1) | AU3805095A (it) |
DE (2) | DE69516162T2 (it) |
DK (1) | DK0922770T3 (it) |
ES (2) | ES2106698T3 (it) |
IT (1) | IT1270660B (it) |
PT (2) | PT786011E (it) |
TR (1) | TR199501260A2 (it) |
WO (1) | WO1996012034A1 (it) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001004342A1 (en) * | 1999-07-07 | 2001-01-18 | Pharmacia & Upjohn Company | Process to prepare exemestane |
CA2484173A1 (en) | 2002-04-30 | 2003-11-13 | Merck & Co., Inc. | 4-azasteroid derivatives as androgen receptor modulators |
HU227117B1 (en) | 2002-05-10 | 2010-07-28 | Richter Gedeon Nyrt | Process for dehydrogenation of aza-androstane compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1070176B (de) * | 1959-12-03 | American Cyanamid Company, New York, N. Y. (V. St. A.) | Verfahren zur Herstellung neuer Steroidverbindungen der 1, 4 - Pregnadienreihe | |
US2969304A (en) * | 1954-07-15 | 1961-01-24 | Ciba Pharm Prod Inc | Manufacture of polyoxygenated steroids |
US4379842A (en) * | 1980-02-13 | 1983-04-12 | Hoffmann-La Roche Inc. | Process for the manufacture of 1α-hydroxydehydroepiandrosterone |
JP2680870B2 (ja) * | 1987-03-12 | 1997-11-19 | ジ・アップジョン・カンパニー | エイ・シンプレックスでのステロイド21‐エステル類の1,2‐脱水素化 |
US5468860A (en) * | 1992-11-19 | 1995-11-21 | Merck & Co., Inc. | New finasteride processes |
-
1994
- 1994-10-13 IT ITMI942094A patent/IT1270660B/it active IP Right Grant
-
1995
- 1995-10-10 EP EP98124126A patent/EP0922770B1/en not_active Expired - Lifetime
- 1995-10-10 DE DE69516162T patent/DE69516162T2/de not_active Expired - Lifetime
- 1995-10-10 AU AU38050/95A patent/AU3805095A/en not_active Abandoned
- 1995-10-10 DK DK98124126T patent/DK0922770T3/da active
- 1995-10-10 AT AT95935926T patent/ATE191508T1/de not_active IP Right Cessation
- 1995-10-10 ES ES95935926T patent/ES2106698T3/es not_active Expired - Lifetime
- 1995-10-10 DE DE69528296T patent/DE69528296T2/de not_active Expired - Lifetime
- 1995-10-10 ES ES98124126T patent/ES2184192T3/es not_active Expired - Lifetime
- 1995-10-10 PT PT95935926T patent/PT786011E/pt unknown
- 1995-10-10 EP EP95935926A patent/EP0786011B1/en not_active Expired - Lifetime
- 1995-10-10 AT AT98124126T patent/ATE224451T1/de active
- 1995-10-10 PT PT98124126T patent/PT922770E/pt unknown
- 1995-10-10 WO PCT/EP1995/003992 patent/WO1996012034A1/en active IP Right Grant
- 1995-10-13 TR TR95/01260A patent/TR199501260A2/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69516162D1 (de) | 2000-05-11 |
EP0922770B1 (en) | 2002-09-18 |
TR199501260A2 (tr) | 1996-06-21 |
EP0922770A2 (en) | 1999-06-16 |
ATE191508T1 (de) | 2000-04-15 |
ITMI942094A0 (it) | 1994-10-13 |
EP0786011A1 (en) | 1997-07-30 |
ATE224451T1 (de) | 2002-10-15 |
ES2184192T3 (es) | 2003-04-01 |
WO1996012034A1 (en) | 1996-04-25 |
PT922770E (pt) | 2003-01-31 |
ES2106698T1 (es) | 1997-11-16 |
ITMI942094A1 (it) | 1996-04-13 |
DE69528296T2 (de) | 2003-10-09 |
DE69516162T2 (de) | 2000-09-14 |
EP0786011B1 (en) | 2000-04-05 |
ES2106698T3 (es) | 2000-06-01 |
PT786011E (pt) | 2000-07-31 |
EP0922770A3 (en) | 1999-06-30 |
DE69528296D1 (de) | 2002-10-24 |
AU3805095A (en) | 1996-05-06 |
DK0922770T3 (da) | 2003-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971029 |