IE800477L - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
IE800477L
IE800477L IE800477A IE47780A IE800477L IE 800477 L IE800477 L IE 800477L IE 800477 A IE800477 A IE 800477A IE 47780 A IE47780 A IE 47780A IE 800477 L IE800477 L IE 800477L
Authority
IE
Ireland
Prior art keywords
compounds
excluded
image
general formula
pyrimidine derivatives
Prior art date
Application number
IE800477A
Other versions
IE49547B1 (en
Original Assignee
Soc D Etudes Prod Chimique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26270867&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE800477(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Soc D Etudes Prod Chimique filed Critical Soc D Etudes Prod Chimique
Publication of IE800477L publication Critical patent/IE800477L/en
Publication of IE49547B1 publication Critical patent/IE49547B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are provided compounds of the general formula <IMAGE> A4=H or OH A5=H or OH A6=H or OH A4=A5=A6=H excluded These compounds are prepared by reacting compounds of the general formula <IMAGE> A4=H or OH A5=H or OH A6=H or OH A4=A5=A6=H excluded with isopropylamino under pressure in a non-polar solvent at from 100 DEG C to 120 DEG C. There are of interest in the field of nervous regeneration and in the treatment of muscular distrophy. Therapeutic compositions containing them are disclosed. [GB2045756A]
IE477/80A 1979-03-10 1980-03-07 Pyrimidine derivatives IE49547B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7908494 1979-03-10
GB7914987 1979-04-30

Publications (2)

Publication Number Publication Date
IE800477L true IE800477L (en) 1980-09-10
IE49547B1 IE49547B1 (en) 1985-10-30

Family

ID=26270867

Family Applications (1)

Application Number Title Priority Date Filing Date
IE477/80A IE49547B1 (en) 1979-03-10 1980-03-07 Pyrimidine derivatives

Country Status (24)

Country Link
JP (1) JPS55122768A (en)
AR (1) AR222691A1 (en)
AU (1) AU533547B2 (en)
BE (1) BE881752A (en)
CA (1) CA1132561A (en)
CH (1) CH644368A5 (en)
DE (3) DE3009071C2 (en)
EG (1) EG14282A (en)
FI (1) FI66357C (en)
FR (2) FR2451370A1 (en)
GB (1) GB2045756B (en)
HK (1) HK55383A (en)
IE (1) IE49547B1 (en)
IN (1) IN153791B (en)
LU (1) LU82185A1 (en)
MX (1) MX6218E (en)
MY (1) MY8400200A (en)
NL (1) NL184833C (en)
NO (1) NO154054C (en)
NZ (1) NZ192927A (en)
OA (1) OA06484A (en)
PT (1) PT70882A (en)
SE (1) SE435180B (en)
SG (1) SG22683G (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE894517A (en) * 1981-10-16 1983-01-17 Sod Conseils Rech Applic NEW ISOPROPYLAMINO PYRIMIDINE DERIVATIVE, ITS PREPARATION AND THERAPEUTIC COMPOSITION BASED ON ITS COMPOUNDS
US4673677A (en) * 1983-10-03 1987-06-16 Pfizer Inc. Method for treatment of gastrointestinal disorders
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
US4711888A (en) 1985-07-24 1987-12-08 Pfizer Inc. Hydroxy and alkoxy pyrimidines
WO1989000423A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. 2-amino-5-hydroxy-4-pyrimidones
US4910204A (en) * 1988-06-28 1990-03-20 Pfizer Inc. 2-amino-5-hydroxy-4-pyrimidones
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
US5264435A (en) * 1988-12-29 1993-11-23 Mitsui Petrochemical Industries, Ltd. Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
US4940712A (en) * 1989-05-26 1990-07-10 Pfizer Inc. Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors
US5270319A (en) * 1991-09-09 1993-12-14 Warner-Lambert Company 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents
US5220025A (en) * 1992-02-24 1993-06-15 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5196431A (en) * 1992-02-24 1993-03-23 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US9133212B1 (en) * 2005-06-15 2015-09-15 Vanderbilt University Inhibitors of hemeprotein-catalyzed lipid peroxidation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB741667A (en) * 1952-12-05 1955-12-07 Ici Ltd New pyrimidine derivatives
GB756189A (en) * 1954-02-01 1956-08-29 Ici Ltd New pyrimidine derivatives
ZA711152B (en) * 1970-03-02 1971-11-24 Ici Ltd Manufacture of pyrimidines
GB1525995A (en) * 1976-02-18 1978-09-27 Soc D Etudes Prod Chimique Aminopyrimidine salt

Also Published As

Publication number Publication date
BE881752A (en) 1980-05-30
NL184833C (en) 1989-11-16
GB2045756A (en) 1980-11-05
LU82185A1 (en) 1980-06-06
SE435180B (en) 1984-09-10
AU5624880A (en) 1980-09-18
PT70882A (en) 1980-03-01
FI66357C (en) 1984-10-10
FR2451370A1 (en) 1980-10-10
JPS6126996B2 (en) 1986-06-23
NZ192927A (en) 1981-07-13
FI66357B (en) 1984-06-29
DE3016752C2 (en) 1987-06-25
GB2045756B (en) 1983-01-26
MX6218E (en) 1984-12-21
DE3050999A1 (en) 1985-08-14
JPS55122768A (en) 1980-09-20
DE3009071A1 (en) 1980-09-11
FR2451191B1 (en) 1983-04-29
HK55383A (en) 1983-11-25
MY8400200A (en) 1984-12-31
NO154054C (en) 1986-07-09
IN153791B (en) 1984-08-18
CA1132561A (en) 1982-09-28
AU533547B2 (en) 1983-12-01
AR222691A1 (en) 1981-06-15
NL184833B (en) 1989-06-16
DE3016752A1 (en) 1980-12-04
CH644368A5 (en) 1984-07-31
SG22683G (en) 1983-12-16
SE8001812L (en) 1980-09-11
NL8001289A (en) 1980-09-12
DE3009071C2 (en) 1985-11-14
NO154054B (en) 1986-04-01
NL184468B (en) 1989-03-01
FR2451370B1 (en) 1983-05-13
FR2451191A1 (en) 1980-10-10
IE49547B1 (en) 1985-10-30
EG14282A (en) 1983-09-30
NO800664L (en) 1980-09-11
DE3050999C2 (en) 1986-08-14
OA06484A (en) 1981-07-31
FI800566A (en) 1980-09-11

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