HUT71789A - Dna sequences used in the production of recombinant human bssl/cel in transgenic non-human mammals, and the produced bssl/cel used in infant formulas - Google Patents

Dna sequences used in the production of recombinant human bssl/cel in transgenic non-human mammals, and the produced bssl/cel used in infant formulas

Info

Publication number
HUT71789A
HUT71789A HU9403536A HU9403536A HUT71789A HU T71789 A HUT71789 A HU T71789A HU 9403536 A HU9403536 A HU 9403536A HU 9403536 A HU9403536 A HU 9403536A HU T71789 A HUT71789 A HU T71789A
Authority
HU
Hungary
Prior art keywords
cel
bssl
produced
production
dna sequences
Prior art date
Application number
HU9403536A
Other languages
English (en)
Other versions
HU220338B (hu
HU9403536D0 (en
Inventor
Stig Lennart Hansson
Karl Gunnar Bjursell
Peter Nils Ivar Carlsson
Curt Sven Magnus Enerbaeck
Ulf Fredrik Pontus Lidberg
Jeanette Annika Nilsson
Jan Briger Fredrik Toernell
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9201809A external-priority patent/SE9201809D0/xx
Priority claimed from SE9201826A external-priority patent/SE9201826D0/xx
Priority claimed from SE9202088A external-priority patent/SE9202088D0/xx
Priority claimed from SE9300902A external-priority patent/SE9300902D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of HU9403536D0 publication Critical patent/HU9403536D0/hu
Publication of HUT71789A publication Critical patent/HUT71789A/hu
Publication of HU220338B publication Critical patent/HU220338B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
HU9403536A 1992-06-11 1993-06-09 Rekombináns humán BSSL/CEL transzgénikus, nem-humán emlősökben való termelésében használt DNS-szekvenciák és ezt tartalmazó gyógyszerkészítmények HU220338B (hu)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9201809A SE9201809D0 (sv) 1992-06-11 1992-06-11 New dna sequences
SE9201826A SE9201826D0 (sv) 1992-06-12 1992-06-12 New dna sequences ii
SE9202088A SE9202088D0 (sv) 1992-07-03 1992-07-03 New dna sequences iii
SE9300902A SE9300902D0 (sv) 1993-03-19 1993-03-19 New dna sequences iv
PCT/SE1993/000515 WO1993025669A1 (en) 1992-06-11 1993-06-09 Dna sequences used in the production of recombinant human bssl/cel in transgenic non-human mammals, and the produced bssl/cel used in infant formulas

Publications (3)

Publication Number Publication Date
HU9403536D0 HU9403536D0 (en) 1995-02-28
HUT71789A true HUT71789A (en) 1996-02-28
HU220338B HU220338B (hu) 2001-12-28

Family

ID=27484751

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9403536A HU220338B (hu) 1992-06-11 1993-06-09 Rekombináns humán BSSL/CEL transzgénikus, nem-humán emlősökben való termelésében használt DNS-szekvenciák és ezt tartalmazó gyógyszerkészítmények

Country Status (31)

Country Link
US (2) US5616483A (hu)
EP (1) EP0651793B1 (hu)
JP (1) JP4231105B2 (hu)
KR (1) KR100357670B1 (hu)
CN (1) CN1071791C (hu)
AP (1) AP411A (hu)
AT (1) ATE447012T1 (hu)
AU (1) AU670598B2 (hu)
CA (1) CA2137815C (hu)
CZ (1) CZ288677B6 (hu)
DE (1) DE69334298D1 (hu)
DK (1) DK0651793T3 (hu)
ES (1) ES2335626T3 (hu)
FI (1) FI945793A (hu)
HR (1) HRP930935A2 (hu)
HU (1) HU220338B (hu)
IL (1) IL105874A (hu)
IS (1) IS4029A (hu)
MA (1) MA22905A1 (hu)
MX (1) MX9303439A (hu)
NO (1) NO944715L (hu)
NZ (1) NZ253391A (hu)
PH (1) PH31680A (hu)
PT (1) PT651793E (hu)
RU (1) RU2128708C1 (hu)
SG (1) SG52580A1 (hu)
SI (1) SI9300319A (hu)
SK (1) SK286993B6 (hu)
TN (1) TNSN93067A1 (hu)
UA (1) UA41322C2 (hu)
WO (1) WO1993025669A1 (hu)

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US7008776B1 (en) * 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
FR2763958A1 (fr) * 1997-05-29 1998-12-04 Transgene Sa Produit de combinaison associant un acide nucleique a une substance desorganisant la matrice extracellulaire pour la therapie genique
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
US6699672B1 (en) 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
SE9801424D0 (sv) * 1998-04-22 1998-04-22 Astra Ab Expression methods
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
WO2000052178A1 (en) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
EP1175503A1 (en) * 1999-04-09 2002-01-30 Human Genome Sciences, Inc. 49 human secreted proteins
AU5032600A (en) * 1999-05-19 2001-12-03 Barnes-Jewish Hospital Enhanced triglyceride digestion in a deficiency of bile salts
US7402660B2 (en) 2000-08-02 2008-07-22 The Johns Hopkins University Endothelial cell expression patterns
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US20020182243A1 (en) * 2001-05-14 2002-12-05 Medo Elena Maria Method of producing nutritional products from human milk tissue and compositions thereof
US20100268658A1 (en) * 2001-05-14 2010-10-21 Prolacta Bioscience Method for collecting, testing and distributing milk
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
US20030213007A1 (en) * 2002-03-27 2003-11-13 Slattery Charles Wilbur Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof
WO2004108065A2 (en) * 2003-06-09 2004-12-16 Insight Biopharmaceuticals Ltd. Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies
CA2623483A1 (en) * 2005-09-20 2007-03-29 Prolacta Bioscience, Inc. A method for testing milk
WO2007089133A1 (en) * 2006-02-03 2007-08-09 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for influencing interactions between dc-sign and dc-sign ligands
CN105123950A (zh) * 2006-11-29 2015-12-09 普罗莱克塔生物科学公司 人乳组合物及其制备和使用方法
CN101631469B (zh) 2006-12-08 2014-04-02 普罗莱克塔生物科学公司 人类脂质组合物及其制备和使用方法
PT2079445E (pt) 2007-02-20 2016-02-29 Allergan Pharmaceuticals Internat Ltd Composições de enzimas digestivas estáveis
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
JP2012510476A (ja) 2008-12-02 2012-05-10 プロラクタ バイオサイエンス，インコーポレイテッド ヒト乳透過組成物ならびにその製造および使用方法
CN103221036A (zh) 2010-10-01 2013-07-24 阿普塔利斯制药有限公司 肠溶包衣的低强度胰脂肪酶制剂
CA2812857A1 (en) * 2010-10-21 2012-04-26 Swedish Orphan Biovitrum Ab (Publ) Method to increase the growth velocity of human infants
JP5800907B2 (ja) * 2010-10-21 2015-10-28 スウェディッシュ オーファン バイオビトラム パブリーク アクチエボラグ ヒト乳児による不飽和脂肪酸の吸収を増大させる方法
CA2844045C (en) 2011-08-03 2018-05-08 Prolacta Bioscience, Inc. Microfiltration of human milk to reduce bacterial contamination
DK2741766T3 (en) 2011-08-08 2016-01-11 Aptalis Pharma Ltd Process for dissolving solid compositions containing digestive enzymes
CN103088000A (zh) * 2012-03-23 2013-05-08 北京济福霖生物技术有限公司 在哺乳动物乳腺中过表达胆盐激活脂酶的方法
KR20150037968A (ko) * 2012-07-12 2015-04-08 프로큐알 테라퓨틱스 엔.브이. 살아있는 세포 내에 존재하는 목적 rna 분자의 서열을 변화시키기 위한 올리고뉴클레오타이드
CN114794241A (zh) 2013-03-13 2022-07-29 普罗莱克塔生物科学公司 高脂人乳产品
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Also Published As

Publication number Publication date
AP9300538A0 (en) 1993-07-31
WO1993025669A1 (en) 1993-12-23
RU94046360A (ru) 1997-06-10
JPH07507687A (ja) 1995-08-31
US5616483A (en) 1997-04-01
EP0651793B1 (en) 2009-10-28
JP4231105B2 (ja) 2009-02-25
SI9300319A (en) 1994-03-31
HU220338B (hu) 2001-12-28
NZ253391A (en) 1996-01-26
RU2128708C1 (ru) 1999-04-10
PT651793E (pt) 2010-01-20
FI945793A (fi) 1995-02-09
MX9303439A (es) 1994-04-29
SK148694A3 (en) 1995-08-09
DE69334298D1 (de) 2009-12-10
IL105874A (en) 1998-12-27
HRP930935A2 (en) 1994-12-31
UA41322C2 (uk) 2001-09-17
CZ288677B6 (cs) 2001-08-15
IL105874A0 (en) 1993-10-20
HU9403536D0 (en) 1995-02-28
AU670598B2 (en) 1996-07-25
TNSN93067A1 (fr) 1994-03-17
SK286993B6 (sk) 2009-09-07
NO944715L (no) 1995-02-07
MA22905A1 (fr) 1993-12-31
PH31680A (en) 1999-01-18
CZ309194A3 (en) 1995-07-12
DK0651793T3 (da) 2010-03-15
EP0651793A1 (en) 1995-05-10
SG52580A1 (en) 1998-09-28
AU4366793A (en) 1994-01-04
ATE447012T1 (de) 2009-11-15
KR100357670B1 (ko) 2003-04-11
CA2137815C (en) 2010-11-09
US5716817A (en) 1998-02-10
FI945793A0 (fi) 1994-12-09
CA2137815A1 (en) 1993-12-23
CN1086262A (zh) 1994-05-04
IS4029A (is) 1993-12-12
NO944715D0 (no) 1994-12-07
CN1071791C (zh) 2001-09-26
AP411A (en) 1995-09-28
ES2335626T3 (es) 2010-03-30

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Owner name: AREXIS AB, SE

Free format text: FORMER OWNER(S): ASTRA AKTIEBOLAG, SE; ASTRAZENECA AB, SE

HC9A Change of name, address

Owner name: AREXIS AB, SE

Free format text: FORMER OWNER(S): ASTRA AKTIEBOLAG, SE; ASTRAZENECA AB, SE