HU9303249D0 - New perhydroisoindole derivatives, pharmaceutical preparatives containing them, and method for producing said compounds - Google Patents

New perhydroisoindole derivatives, pharmaceutical preparatives containing them, and method for producing said compounds

Info

Publication number: HU9303249D0
Authority: HU; Hungary
Prior art keywords: halogen; new; compounds; producing; perhydroisoindole derivatives
Prior art date: 1991-05-17

Application number

HU9303249A

Other languages

English (en)

Other versions

HUT67649A (en

Inventor

Daniel Archard

Serge Grisoni

Stephen Hanessian

Claude Moutonnoier

Jean-Francois Peyronel

Michel Tabart

Alain Truchon

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-17

Filing date

1992-05-15

Publication date

1994-03-28

1992-05-15 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1994-03-28 Publication of HU9303249D0 publication Critical patent/HU9303249D0/hu

1995-04-28 Publication of HUT67649A publication Critical patent/HUT67649A/hu

Links

ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229910052736 halogen Inorganic materials 0.000 abstract 4
125000005843 halogen group Chemical group 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 2
150000003254 radicals Chemical class 0.000 abstract 2
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
102100024304 Protachykinin-1 Human genes 0.000 abstract 1
101800003906 Substance P Proteins 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 abstract 1
125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
-1 phenyl radicals Chemical class 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HU9303249A 1991-05-17 1992-05-15 Novell derivatives of perhydroisoindol, their preperation and pharmaceutical compositions containing them HUT67649A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9106035A FR2676442B1 (fr)	1991-05-17	1991-05-17	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number	Publication Date
HU9303249D0 true HU9303249D0 (en)	1994-03-28
HUT67649A HUT67649A (en)	1995-04-28

Family

ID=9412907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9303249A HUT67649A (en)	1991-05-17	1992-05-15	Novell derivatives of perhydroisoindol, their preperation and pharmaceutical compositions containing them

Country Status (23)

Country	Link
US (1)	US5451601A (hu)
EP (2)	EP0586490B1 (hu)
JP (1)	JPH06507627A (hu)
AT (1)	ATE135687T1 (hu)
AU (1)	AU1883692A (hu)
CA (1)	CA2109298A1 (hu)
CZ (1)	CZ244793A3 (hu)
DE (1)	DE69209290T2 (hu)
DK (1)	DK0586490T3 (hu)
ES (1)	ES2085627T3 (hu)
FI (1)	FI935071A (hu)
FR (1)	FR2676442B1 (hu)
GR (1)	GR3019386T3 (hu)
HU (1)	HUT67649A (hu)
IE (1)	IE921578A1 (hu)
IL (1)	IL101866A0 (hu)
MX (1)	MX9202287A (hu)
NO (1)	NO933964L (hu)
NZ (1)	NZ242772A (hu)
SK (1)	SK126793A3 (hu)
TW (1)	TW200459B (hu)
WO (1)	WO1992020653A1 (hu)
ZA (1)	ZA923540B (hu)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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FR2689888B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5508424A (en) *	1993-03-26	1996-04-16	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2710842B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouvelle application thérapeutique de dérivés de perhydroisoindole.
FR2719476B1 (fr) *	1994-05-05	1997-05-23	Oreal	Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue.
US6203803B1 (en)	1994-12-14	2001-03-20	Societe L'oreal S.A.	Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
FR2719474B1 (fr)	1994-05-05	1996-05-31	Oreal	Utilisation d'un antagoniste de substance P dans une composition cosmétique et composition obtenue.
FR2727411B1 (fr) *	1994-11-30	1997-01-03	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
JP4907818B2 (ja)	1999-11-03	2012-04-04	エーエムアールテクノロジーインコーポレイテッド	アリールおよびヘテロアリール置換テトラヒドロイソキノリン、ならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを阻止するためのそれらの使用
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100430401C (zh)	2000-07-11	2008-11-05	Amr科技公司	新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
WO2006020049A2 (en)	2004-07-15	2006-02-23	Amr Technology, Inc.	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
KR101589551B1 (ko)	2005-07-15	2016-02-02	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
RS58936B1 (sr)	2007-01-10	2019-08-30	Msd Italia Srl	Indazoli supstituisani amidom kao inhibitori poli(adp-riboza)polimeraze (parp)
BRPI0807972A2 (pt)	2007-01-24	2014-06-10	Glaxo Group Ltd	Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1
US8389553B2 (en)	2007-06-27	2013-03-05	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
CA2760837C (en)	2009-05-12	2018-04-03	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
EP2429293B1 (en)	2009-05-12	2014-10-29	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
KR20120034644A (ko)	2009-05-12	2012-04-12	알바니 몰레큘라 리써치, 인크.	아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
CN104945382B (zh)	2009-10-14	2020-02-07	默沙东公司	提高p53活性的取代的哌啶和其用途
WO2012018754A2 (en)	2010-08-02	2012-02-09	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US9029341B2 (en)	2010-08-17	2015-05-12	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
EP2608669B1 (en)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
US9260471B2 (en)	2010-10-29	2016-02-16	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
US20140045847A1 (en)	2011-04-21	2014-02-13	Piramal Enterprises Limited	Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
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EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
FR2654726B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone et leur preparation.
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole et leur preparation.

1991
- 1991-05-17 FR FR9106035A patent/FR2676442B1/fr not_active Expired - Fee Related
1992
- 1992-05-14 IL IL101866A patent/IL101866A0/xx unknown
- 1992-05-15 JP JP4510462A patent/JPH06507627A/ja active Pending
- 1992-05-15 CA CA002109298A patent/CA2109298A1/fr not_active Abandoned
- 1992-05-15 EP EP92911474A patent/EP0586490B1/fr not_active Expired - Lifetime
- 1992-05-15 DK DK92911474.2T patent/DK0586490T3/da active
- 1992-05-15 AT AT92911474T patent/ATE135687T1/de active
- 1992-05-15 MX MX9202287A patent/MX9202287A/es unknown
- 1992-05-15 SK SK1267-93A patent/SK126793A3/sk unknown
- 1992-05-15 WO PCT/FR1992/000429 patent/WO1992020653A1/fr active IP Right Grant
- 1992-05-15 EP EP92401329A patent/EP0514273A1/fr active Pending
- 1992-05-15 ZA ZA923540A patent/ZA923540B/xx unknown
- 1992-05-15 ES ES92911474T patent/ES2085627T3/es not_active Expired - Lifetime
- 1992-05-15 HU HU9303249A patent/HUT67649A/hu unknown
- 1992-05-15 NZ NZ242772A patent/NZ242772A/en unknown
- 1992-05-15 TW TW081103795A patent/TW200459B/zh active
- 1992-05-15 AU AU18836/92A patent/AU1883692A/en not_active Abandoned
- 1992-05-15 DE DE69209290T patent/DE69209290T2/de not_active Expired - Fee Related
- 1992-05-15 US US08/146,143 patent/US5451601A/en not_active Expired - Fee Related
- 1992-05-15 CZ CS932447A patent/CZ244793A3/cs unknown
- 1992-07-01 IE IE157892A patent/IE921578A1/en not_active Application Discontinuation
1993
- 1993-11-02 NO NO933964A patent/NO933964L/no unknown
- 1993-11-16 FI FI935071A patent/FI935071A/fi unknown
1996
- 1996-03-21 GR GR950403441T patent/GR3019386T3/el unknown

Also Published As

Publication number	Publication date
TW200459B (hu)	1993-02-21
DE69209290T2 (de)	1996-10-31
FI935071A0 (fi)	1993-11-16
IE921578A1 (en)	1992-11-18
AU1883692A (en)	1992-12-30
FR2676442A1 (fr)	1992-11-20
NZ242772A (en)	1994-04-27
CZ244793A3 (en)	1994-03-16
FR2676442B1 (fr)	1993-08-06
SK126793A3 (en)	1994-11-09
EP0514273A1 (fr)	1992-11-19
GR3019386T3 (en)	1996-06-30
NO933964D0 (no)	1993-11-02
ES2085627T3 (es)	1996-06-01
WO1992020653A1 (fr)	1992-11-26
DK0586490T3 (da)	1996-04-15
NO933964L (no)	1993-11-02
HUT67649A (en)	1995-04-28
ATE135687T1 (de)	1996-04-15
JPH06507627A (ja)	1994-09-01
DE69209290D1 (de)	1996-04-25
IL101866A0 (en)	1992-12-30
MX9202287A (es)	1993-02-01
US5451601A (en)	1995-09-19
ZA923540B (en)	1993-01-27
EP0586490A1 (fr)	1994-03-16
EP0586490B1 (fr)	1996-03-20
CA2109298A1 (fr)	1992-11-18
FI935071A (fi)	1993-11-16

Legal Events

Date	Code	Title	Description
1996-02-28	DFD9	Temporary protection cancelled due to non-payment of fee

Publication	Publication Date	Title
HU9303249D0 (en)	1994-03-28	New perhydroisoindole derivatives, pharmaceutical preparatives containing them, and method for producing said compounds
HU907250D0 (en)	1991-05-28	Process for producing new isoindolone derivatives and pharmaceutical preparatives containing these compounds
TW234119B (hu)	1994-11-11
HU9502902D0 (en)	1995-11-28	Perhydroisoindole derivatives, preparation thereof and pharmaceutical compositions containing same
RU93058350A (ru)	1997-03-10	Производные пергидроизоиндола, способ их получения и содержащие их фармацевтические композиции