GB1493941A - Pharmaceutical product for treatment of all leukaemia forms and neurotic syndromes - Google Patents
Pharmaceutical product for treatment of all leukaemia forms and neurotic syndromesInfo
- Publication number
- GB1493941A GB1493941A GB33039/74A GB3303974A GB1493941A GB 1493941 A GB1493941 A GB 1493941A GB 33039/74 A GB33039/74 A GB 33039/74A GB 3303974 A GB3303974 A GB 3303974A GB 1493941 A GB1493941 A GB 1493941A
- Authority
- GB
- United Kingdom
- Prior art keywords
- indole
- treatment
- tryptamine
- aminoethyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
N-Acetyl-5-methoxy-tryptamine is obtained, starting from indigo, by the following reactions: (a) dry distillation of indigo mixed with zinc powder, to obtain indole; (b) conversion of the indole to 5-hydroxy-indole by treating the former with methanol in water and in the presence of ferric chloride; (c) converting the 5-hydroxy-indole to 3-(2-aminoethyl)-5-hydroxy-indole by treatment of the former with 2-amino-1-chloroethane in the presence of ethyl acetate and iron filings; (d) treating the product obtained from item (c) with dimethyl sulphate at a temperature not exceeding 25 DEG C; and (e) treating the (2-aminoethyl)-5-oxymethyl-indole, obtained under (d), with acetyl chloride at a temperature not exceeding 10 DEG C. The novel compound obtained is effective in the treatment of leucoses in their various forms. Its action can be boosted if it is used in combination with one of its derivatives, such as 5-methoxy-tryptamine, 3-(2-aminoethyl)-5-methoxyindole and 5-hydroxyacetyl-tryptamine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4011573 | 1973-12-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1493941A true GB1493941A (en) | 1977-11-30 |
Family
ID=11248376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB33039/74A Expired GB1493941A (en) | 1973-12-31 | 1974-12-31 | Pharmaceutical product for treatment of all leukaemia forms and neurotic syndromes |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS5096565A (en) |
AT (1) | ATA617674A (en) |
AU (1) | AU7194974A (en) |
BE (1) | BE824022A (en) |
CH (1) | CH625218A5 (en) |
DE (1) | DE2435365A1 (en) |
FR (1) | FR2255897A1 (en) |
GB (1) | GB1493941A (en) |
NL (1) | NL7417046A (en) |
ZA (1) | ZA748264B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989004659A1 (en) * | 1987-11-19 | 1989-06-01 | Cellena (Cell Engineering) A.G. | Use of melatonin or derivatives thereof for the production of pharmaceutical compositions effective to counteract the effects of aging |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4506080A (en) * | 1983-07-01 | 1985-03-19 | Nestec S. A. | Preparation of serotonine and derivatives |
GR900100024A (en) * | 1989-01-17 | 1991-06-07 | Amr Int | Method of treating pre-menstual syndrome |
IT1243193B (en) * | 1990-08-10 | 1994-05-24 | Medea Res Srl | ORAL PHARMACEUTICAL COMPOSITIONS BASED ON MELATONIN |
-
1974
- 1974-07-19 DE DE2435365A patent/DE2435365A1/en active Pending
- 1974-07-26 AT AT617674A patent/ATA617674A/en not_active Application Discontinuation
- 1974-08-01 AU AU71949/74A patent/AU7194974A/en not_active Expired
- 1974-11-28 FR FR7440379A patent/FR2255897A1/fr not_active Withdrawn
- 1974-12-11 CH CH1649974A patent/CH625218A5/en not_active IP Right Cessation
- 1974-12-27 JP JP49149047A patent/JPS5096565A/ja active Pending
- 1974-12-30 ZA ZA00748264A patent/ZA748264B/en unknown
- 1974-12-31 GB GB33039/74A patent/GB1493941A/en not_active Expired
- 1974-12-31 NL NL7417046A patent/NL7417046A/en unknown
- 1974-12-31 BE BE152074A patent/BE824022A/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989004659A1 (en) * | 1987-11-19 | 1989-06-01 | Cellena (Cell Engineering) A.G. | Use of melatonin or derivatives thereof for the production of pharmaceutical compositions effective to counteract the effects of aging |
Also Published As
Publication number | Publication date |
---|---|
DE2435365A1 (en) | 1976-01-29 |
NL7417046A (en) | 1975-07-02 |
ZA748264B (en) | 1976-01-28 |
AU7194974A (en) | 1976-02-05 |
ATA617674A (en) | 1976-11-15 |
FR2255897A1 (en) | 1975-07-25 |
JPS5096565A (en) | 1975-07-31 |
BE824022A (en) | 1975-04-16 |
CH625218A5 (en) | 1981-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1493941A (en) | Pharmaceutical product for treatment of all leukaemia forms and neurotic syndromes | |
McKillop et al. | Acetoxythallation-induced lactonization of 2-endo-norbornenecarboxylic acids | |
SE7413652L (en) | ||
JPS5265226A (en) | Preparation of halogenosilanes | |
ES450350A1 (en) | Perfume based on glycosyloxy derivatives and said scenttcontained smoking material and method of preparation of perfume based on glycosyloxy derivatives | |
CH608785A5 (en) | Process for producing new N-acylglutamines | |
ES412246A1 (en) | Hair shampoos | |
GB1538775A (en) | Preparation of 6,11-dihydro-11-oxodibenz(b,e)-oxepin-alkanoic acids | |
GB983492A (en) | Novel dilactones | |
SU700191A1 (en) | Coating composition for containers of high-pressure and high-temperature apparatus | |
GB1399065A (en) | Process for the production of tetrabromophthalic anhydride | |
ES433940A1 (en) | Process for the preparation of 7-oxo-7h-dibenzo-(d e,h)-quinolin-2-ol | |
ES390243A1 (en) | Phenanthrotriazolyl derivatives | |
ES406542A1 (en) | Derivatives of 22-fluoro-digoxins | |
ES403938A1 (en) | Cyclic decapeptides comprising an l-tyrosine radical | |
JPS51121597A (en) | Process for producing tryptophan and its derivatives | |
GB1467225A (en) | 7-alkoxy-4,6-dihydroxy-quinoline derivatives and pharmaceuti cal compositions thereof | |
JPS5626859A (en) | Alpha-halogeno-beta-aminopropionitrile | |
ES452753A1 (en) | Procedure for the preparation of sulfametoxazol-lysine salt. (Machine-translation by Google Translate, not legally binding) | |
ES424847A1 (en) | Monoazo pigment and process for its manufacture | |
AU494291B2 (en) | Conversion of modified synthesis gas to oxygenated organic chemicals | |
ES406790A1 (en) | Alumina | |
GB1228303A (en) | ||
ES447297A1 (en) | Process for the preparation of N-acetoacetyl-2,5-dimethoxy-4-chloroanilide | |
ES431523A1 (en) | A procedure for preparing a derivative of ftalazone. (Machine-translation by Google Translate, not legally binding) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |