GB1453644A - Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by - Google Patents
Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids byInfo
- Publication number
- GB1453644A GB1453644A GB2533876A GB2533876A GB1453644A GB 1453644 A GB1453644 A GB 1453644A GB 2533876 A GB2533876 A GB 2533876A GB 2533876 A GB2533876 A GB 2533876A GB 1453644 A GB1453644 A GB 1453644A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pivaloylbenzyl
- malonic acid
- diethyl ester
- acid diethyl
- bis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1453644 B - (p - pivaloylbenzyl)malonic acid diethyl ester SANDOZ Ltd 15 Feb 1974 [20 Feb 1973 3 Oct 1973] 25338/76 Divided out of 1453643 Heading C2C The novel compound, bis-(p-pivaloylbenzyl)- malonic acid diethyl ester, may be prepared by forming a Grignard reagent from 4-bromotoluene and reacting it with pivaloyl chloride to form p-pivaloyltoluene, subjecting this to free radical bromination to yield α-bromo-p-pivaloyltoluene which yields the required compound on reaction with diethylmalonate in the presence of strong base. Pharmaceutical compositions of the novel compound with the usual excipients show hypolipidemic, especially hypolipoproteinemic activity when administered orally.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33389273A | 1973-02-20 | 1973-02-20 | |
US40322573A | 1973-10-03 | 1973-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1453644A true GB1453644A (en) | 1976-10-27 |
Family
ID=26988943
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2533876A Expired GB1453644A (en) | 1973-02-20 | 1974-02-15 | Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by |
GB695374A Expired GB1453643A (en) | 1973-02-20 | 1974-02-15 | Bis-benzyl-acetic acid derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB695374A Expired GB1453643A (en) | 1973-02-20 | 1974-02-15 | Bis-benzyl-acetic acid derivatives |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS5029534A (en) |
AT (1) | AT346308B (en) |
CA (1) | CA1043807A (en) |
CH (1) | CH591418A5 (en) |
CS (1) | CS170510B2 (en) |
DD (1) | DD110033A5 (en) |
DE (1) | DE2406881A1 (en) |
ES (1) | ES423376A1 (en) |
FR (1) | FR2218106B1 (en) |
GB (2) | GB1453644A (en) |
HU (1) | HU168102B (en) |
IE (1) | IE39419B1 (en) |
IL (1) | IL44224A (en) |
NL (1) | NL7402093A (en) |
PH (1) | PH10682A (en) |
SE (1) | SE399554B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3607728A1 (en) * | 1986-01-25 | 1987-07-30 | Telefonbau & Normalzeit Gmbh | TERMINAL OF A TELECOMMUNICATION SYSTEM |
-
1974
- 1974-02-08 CH CH176774A patent/CH591418A5/xx not_active IP Right Cessation
- 1974-02-11 SE SE7401786A patent/SE399554B/en unknown
- 1974-02-13 DE DE19742406881 patent/DE2406881A1/en not_active Withdrawn
- 1974-02-15 GB GB2533876A patent/GB1453644A/en not_active Expired
- 1974-02-15 NL NL7402093A patent/NL7402093A/xx not_active Application Discontinuation
- 1974-02-15 GB GB695374A patent/GB1453643A/en not_active Expired
- 1974-02-18 CS CS1168A patent/CS170510B2/cs unknown
- 1974-02-18 AT AT125874A patent/AT346308B/en not_active IP Right Cessation
- 1974-02-18 DD DD176622A patent/DD110033A5/xx unknown
- 1974-02-18 JP JP49018655A patent/JPS5029534A/ja active Pending
- 1974-02-18 ES ES423376A patent/ES423376A1/en not_active Expired
- 1974-02-18 HU HUSA2595A patent/HU168102B/hu unknown
- 1974-02-18 CA CA192,776A patent/CA1043807A/en not_active Expired
- 1974-02-18 IL IL44224A patent/IL44224A/en unknown
- 1974-02-19 IE IE333/74A patent/IE39419B1/en unknown
- 1974-02-20 PH PH15530A patent/PH10682A/en unknown
- 1974-02-20 FR FR7405671A patent/FR2218106B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2218106B1 (en) | 1978-01-13 |
DE2406881A1 (en) | 1974-08-29 |
DD110033A5 (en) | 1974-12-05 |
AU6577274A (en) | 1975-08-21 |
HU168102B (en) | 1976-02-28 |
CA1043807A (en) | 1978-12-05 |
NL7402093A (en) | 1974-08-22 |
AT346308B (en) | 1978-11-10 |
IL44224A0 (en) | 1974-05-16 |
IE39419B1 (en) | 1978-10-11 |
CH591418A5 (en) | 1977-09-15 |
PH10682A (en) | 1977-08-10 |
ATA125874A (en) | 1978-03-15 |
ES423376A1 (en) | 1976-09-16 |
JPS5029534A (en) | 1975-03-25 |
GB1453643A (en) | 1976-10-27 |
CS170510B2 (en) | 1976-08-27 |
SE399554B (en) | 1978-02-20 |
IE39419L (en) | 1974-08-20 |
FR2218106A1 (en) | 1974-09-13 |
IL44224A (en) | 1977-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |