GB1453644A - Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by - Google Patents

Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by

Info

Publication number
GB1453644A
GB1453644A GB2533876A GB2533876A GB1453644A GB 1453644 A GB1453644 A GB 1453644A GB 2533876 A GB2533876 A GB 2533876A GB 2533876 A GB2533876 A GB 2533876A GB 1453644 A GB1453644 A GB 1453644A
Authority
GB
United Kingdom
Prior art keywords
pivaloylbenzyl
malonic acid
diethyl ester
acid diethyl
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2533876A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1453644A publication Critical patent/GB1453644A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1453644 B - (p - pivaloylbenzyl)malonic acid diethyl ester SANDOZ Ltd 15 Feb 1974 [20 Feb 1973 3 Oct 1973] 25338/76 Divided out of 1453643 Heading C2C The novel compound, bis-(p-pivaloylbenzyl)- malonic acid diethyl ester, may be prepared by forming a Grignard reagent from 4-bromotoluene and reacting it with pivaloyl chloride to form p-pivaloyltoluene, subjecting this to free radical bromination to yield α-bromo-p-pivaloyltoluene which yields the required compound on reaction with diethylmalonate in the presence of strong base. Pharmaceutical compositions of the novel compound with the usual excipients show hypolipidemic, especially hypolipoproteinemic activity when administered orally.
GB2533876A 1973-02-20 1974-02-15 Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by Expired GB1453644A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33389273A 1973-02-20 1973-02-20
US40322573A 1973-10-03 1973-10-03

Publications (1)

Publication Number Publication Date
GB1453644A true GB1453644A (en) 1976-10-27

Family

ID=26988943

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2533876A Expired GB1453644A (en) 1973-02-20 1974-02-15 Bis-p-pivaloylbenzyl-malonic acid diethyl ester apparatus and method for purifying contaminated liquids by
GB695374A Expired GB1453643A (en) 1973-02-20 1974-02-15 Bis-benzyl-acetic acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB695374A Expired GB1453643A (en) 1973-02-20 1974-02-15 Bis-benzyl-acetic acid derivatives

Country Status (16)

Country Link
JP (1) JPS5029534A (en)
AT (1) AT346308B (en)
CA (1) CA1043807A (en)
CH (1) CH591418A5 (en)
CS (1) CS170510B2 (en)
DD (1) DD110033A5 (en)
DE (1) DE2406881A1 (en)
ES (1) ES423376A1 (en)
FR (1) FR2218106B1 (en)
GB (2) GB1453644A (en)
HU (1) HU168102B (en)
IE (1) IE39419B1 (en)
IL (1) IL44224A (en)
NL (1) NL7402093A (en)
PH (1) PH10682A (en)
SE (1) SE399554B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3607728A1 (en) * 1986-01-25 1987-07-30 Telefonbau & Normalzeit Gmbh TERMINAL OF A TELECOMMUNICATION SYSTEM

Also Published As

Publication number Publication date
FR2218106B1 (en) 1978-01-13
DE2406881A1 (en) 1974-08-29
DD110033A5 (en) 1974-12-05
AU6577274A (en) 1975-08-21
HU168102B (en) 1976-02-28
CA1043807A (en) 1978-12-05
NL7402093A (en) 1974-08-22
AT346308B (en) 1978-11-10
IL44224A0 (en) 1974-05-16
IE39419B1 (en) 1978-10-11
CH591418A5 (en) 1977-09-15
PH10682A (en) 1977-08-10
ATA125874A (en) 1978-03-15
ES423376A1 (en) 1976-09-16
JPS5029534A (en) 1975-03-25
GB1453643A (en) 1976-10-27
CS170510B2 (en) 1976-08-27
SE399554B (en) 1978-02-20
IE39419L (en) 1974-08-20
FR2218106A1 (en) 1974-09-13
IL44224A (en) 1977-11-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee