GB1427761A - Process for the manufacture of steroid epoxides - Google Patents
Process for the manufacture of steroid epoxidesInfo
- Publication number
- GB1427761A GB1427761A GB2310573A GB2310573A GB1427761A GB 1427761 A GB1427761 A GB 1427761A GB 2310573 A GB2310573 A GB 2310573A GB 2310573 A GB2310573 A GB 2310573A GB 1427761 A GB1427761 A GB 1427761A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroid
- epoxy
- manufacture
- steroid epoxides
- fluorohydrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1427761 Preparation of 5α,6α-epoxy-steroids CIBA-GEIGY AG 15 May 1973 [19 May 1972] 23105/73 Heading C2U A 5α,6α-epoxy-steroid is prepared by reacting a 5α,6#-dihydroxy-steroid in an inert organic solvent with an amine of the formula wherein X 1 is F or Cl, X 2 is Cl, F or CF 3 , and R and R<SP>1</SP> are each alkyl or -NBR<SP>1</SP> is a 5- to 7- ring membered heterocyclie radical. The process is desirably effected under anhydrous conditions, and in the presence of an organic nitrogen base to prevent a secondary slow reaction in which the formed epoxide is converted to a 6#,5α - fluorohydrin. (See Specification 1,427,762.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH747972A CH596238A5 (en) | 1972-05-19 | 1972-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1427761A true GB1427761A (en) | 1976-03-10 |
Family
ID=4325765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2310573A Expired GB1427761A (en) | 1972-05-19 | 1973-05-15 | Process for the manufacture of steroid epoxides |
Country Status (9)
Country | Link |
---|---|
JP (1) | JPS4941356A (en) |
CA (1) | CA1020541A (en) |
CH (1) | CH596238A5 (en) |
DD (1) | DD103641A5 (en) |
DE (1) | DE2324158A1 (en) |
ES (1) | ES414828A1 (en) |
FR (1) | FR2185619B1 (en) |
GB (1) | GB1427761A (en) |
NL (1) | NL7306923A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7615669B2 (en) | 2005-03-28 | 2009-11-10 | Tosoh F-Tech, Inc. | Process for producing fluoro-compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3364241A (en) * | 1966-07-29 | 1968-01-16 | Upjohn Co | Process for the production of 6alpha-fluoro-16alpha-halo pregnanes and the intermediates therefor |
-
1972
- 1972-05-19 CH CH747972A patent/CH596238A5/xx not_active IP Right Cessation
-
1973
- 1973-05-09 CA CA170,802A patent/CA1020541A/en not_active Expired
- 1973-05-12 DE DE19732324158 patent/DE2324158A1/en active Pending
- 1973-05-15 GB GB2310573A patent/GB1427761A/en not_active Expired
- 1973-05-16 FR FR7317661A patent/FR2185619B1/fr not_active Expired
- 1973-05-17 DD DD17089373A patent/DD103641A5/xx unknown
- 1973-05-17 NL NL7306923A patent/NL7306923A/xx unknown
- 1973-05-17 ES ES0414828A patent/ES414828A1/en not_active Expired
- 1973-05-19 JP JP5624673A patent/JPS4941356A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7615669B2 (en) | 2005-03-28 | 2009-11-10 | Tosoh F-Tech, Inc. | Process for producing fluoro-compounds |
Also Published As
Publication number | Publication date |
---|---|
CA1020541A (en) | 1977-11-08 |
JPS4941356A (en) | 1974-04-18 |
DE2324158A1 (en) | 1973-11-29 |
FR2185619B1 (en) | 1977-12-30 |
DD103641A5 (en) | 1974-02-05 |
NL7306923A (en) | 1973-11-21 |
ES414828A1 (en) | 1976-02-01 |
CH596238A5 (en) | 1978-03-15 |
FR2185619A1 (en) | 1974-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |