FR2451191A1 - THERAPEUTIC COMPOSITIONS BASED ON HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE - Google Patents
THERAPEUTIC COMPOSITIONS BASED ON HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINEInfo
- Publication number
- FR2451191A1 FR2451191A1 FR8005277A FR8005277A FR2451191A1 FR 2451191 A1 FR2451191 A1 FR 2451191A1 FR 8005277 A FR8005277 A FR 8005277A FR 8005277 A FR8005277 A FR 8005277A FR 2451191 A1 FR2451191 A1 FR 2451191A1
- Authority
- FR
- France
- Prior art keywords
- therapeutic compositions
- isopropylamino
- pyrimidine
- hydroxyl derivatives
- compositions based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES COMPOSITIONS THERAPEUTIQUES CONTENANT COMME PRINCIPE ACTIF AU MOINS UN DES DERIVES HYDROXYLES DE L'ISOPROPYLAMINO-2 PYRIMIDINE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE A, A ET A REPRESENTENT CHACUN: -UN ATOME D'HYDROGENE; -UN RADICAL HYDROXY, AVEC LA RESTRICTION QU'AU MOINS L'UN DES SUBSTITUANTS A, A ET A N'EST PAS UN ATOME D'HYDROGENE, ASSOCIE A UN EXCIPIENT APPROPRIE, AINSI QUE DES COMPOSITIONS THERAPEUTIQUES SELON LA REVENDICATION 1 COMPORTANT DE 1 A 20MG DE PRINCIPE ACTIF PAR UNITE DE DOSAGE.THE INVENTION CONCERNS THERAPEUTIC COMPOSITIONS CONTAINING AS ACTIVE PRINCIPLE AT LEAST ONE OF THE HYDROXYL DERIVATIVES OF 2-ISOPROPYLAMINO-PYRIMIDINE OF GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH A, A AND A REPRESENTROGENE EACHH: -DUN: -DUN ; -A RADICAL HYDROXY, WITH THE RESTRICTION THAT AT LEAST ONE OF THE SUBSTITUTES A, A AND A IS NOT A HYDROGEN ATOM, ASSOCIATED WITH A SUITABLE EXCIPIENT, AS WELL AS THERAPEUTIC COMPOSITIONS ACCORDING TO CLAIM 1 INCLUDING 1 AT 20MG OF ACTIVE PRINCIPLE PER DOSAGE UNIT.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7908494 | 1979-03-10 | ||
GB7914987 | 1979-04-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2451191A1 true FR2451191A1 (en) | 1980-10-10 |
FR2451191B1 FR2451191B1 (en) | 1983-04-29 |
Family
ID=26270867
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8005278A Granted FR2451370A1 (en) | 1979-03-10 | 1980-03-10 | HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE AND THEIR PREPARATION |
FR8005277A Granted FR2451191A1 (en) | 1979-03-10 | 1980-03-10 | THERAPEUTIC COMPOSITIONS BASED ON HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8005278A Granted FR2451370A1 (en) | 1979-03-10 | 1980-03-10 | HYDROXYL DERIVATIVES OF ISOPROPYLAMINO-2 PYRIMIDINE AND THEIR PREPARATION |
Country Status (24)
Country | Link |
---|---|
JP (1) | JPS55122768A (en) |
AR (1) | AR222691A1 (en) |
AU (1) | AU533547B2 (en) |
BE (1) | BE881752A (en) |
CA (1) | CA1132561A (en) |
CH (1) | CH644368A5 (en) |
DE (3) | DE3009071C2 (en) |
EG (1) | EG14282A (en) |
FI (1) | FI66357C (en) |
FR (2) | FR2451370A1 (en) |
GB (1) | GB2045756B (en) |
HK (1) | HK55383A (en) |
IE (1) | IE49547B1 (en) |
IN (1) | IN153791B (en) |
LU (1) | LU82185A1 (en) |
MX (1) | MX6218E (en) |
MY (1) | MY8400200A (en) |
NL (1) | NL184833C (en) |
NO (1) | NO154054C (en) |
NZ (1) | NZ192927A (en) |
OA (1) | OA06484A (en) |
PT (1) | PT70882A (en) |
SE (1) | SE435180B (en) |
SG (1) | SG22683G (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE894517A (en) * | 1981-10-16 | 1983-01-17 | Sod Conseils Rech Applic | NEW ISOPROPYLAMINO PYRIMIDINE DERIVATIVE, ITS PREPARATION AND THERAPEUTIC COMPOSITION BASED ON ITS COMPOUNDS |
US4673677A (en) * | 1983-10-03 | 1987-06-16 | Pfizer Inc. | Method for treatment of gastrointestinal disorders |
US4554276A (en) * | 1983-10-03 | 1985-11-19 | Pfizer Inc. | 2-Amino-5-hydroxy-4-methylpyrimidine derivatives |
US4711888A (en) | 1985-07-24 | 1987-12-08 | Pfizer Inc. | Hydroxy and alkoxy pyrimidines |
WO1989000423A1 (en) * | 1987-07-09 | 1989-01-26 | Pfizer Inc. | 2-amino-5-hydroxy-4-pyrimidones |
US4910204A (en) * | 1988-06-28 | 1990-03-20 | Pfizer Inc. | 2-amino-5-hydroxy-4-pyrimidones |
HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
US5264435A (en) * | 1988-12-29 | 1993-11-23 | Mitsui Petrochemical Industries, Ltd. | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines |
US4940712A (en) * | 1989-05-26 | 1990-07-10 | Pfizer Inc. | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors |
US5270319A (en) * | 1991-09-09 | 1993-12-14 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents |
US5220025A (en) * | 1992-02-24 | 1993-06-15 | Warner-Lambert Company | 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
US5196431A (en) * | 1992-02-24 | 1993-03-23 | Warner-Lambert Company | 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents |
US9133212B1 (en) * | 2005-06-15 | 2015-09-15 | Vanderbilt University | Inhibitors of hemeprotein-catalyzed lipid peroxidation |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB756189A (en) * | 1954-02-01 | 1956-08-29 | Ici Ltd | New pyrimidine derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB741667A (en) * | 1952-12-05 | 1955-12-07 | Ici Ltd | New pyrimidine derivatives |
ZA711152B (en) * | 1970-03-02 | 1971-11-24 | Ici Ltd | Manufacture of pyrimidines |
GB1525995A (en) * | 1976-02-18 | 1978-09-27 | Soc D Etudes Prod Chimique | Aminopyrimidine salt |
-
1980
- 1980-02-12 IN IN103/DEL/80A patent/IN153791B/en unknown
- 1980-02-15 BE BE0/199421A patent/BE881752A/en not_active IP Right Cessation
- 1980-02-20 NZ NZ192927A patent/NZ192927A/en unknown
- 1980-02-20 LU LU82185A patent/LU82185A1/en unknown
- 1980-02-26 FI FI800566A patent/FI66357C/en not_active IP Right Cessation
- 1980-02-27 AR AR280106A patent/AR222691A1/en active
- 1980-02-29 PT PT70882A patent/PT70882A/en unknown
- 1980-03-03 CH CH165080A patent/CH644368A5/en not_active IP Right Cessation
- 1980-03-04 CA CA346,981A patent/CA1132561A/en not_active Expired
- 1980-03-04 NL NLAANVRAGE8001289,A patent/NL184833C/en not_active IP Right Cessation
- 1980-03-07 IE IE477/80A patent/IE49547B1/en unknown
- 1980-03-07 GB GB8007908A patent/GB2045756B/en not_active Expired
- 1980-03-07 AU AU56248/80A patent/AU533547B2/en not_active Ceased
- 1980-03-07 SE SE8001812A patent/SE435180B/en not_active IP Right Cessation
- 1980-03-07 NO NO800664A patent/NO154054C/en unknown
- 1980-03-09 EG EG131/80A patent/EG14282A/en active
- 1980-03-10 JP JP2931280A patent/JPS55122768A/en active Granted
- 1980-03-10 MX MX808702U patent/MX6218E/en unknown
- 1980-03-10 OA OA57049A patent/OA06484A/en unknown
- 1980-03-10 DE DE3009071A patent/DE3009071C2/en not_active Expired
- 1980-03-10 DE DE3050999A patent/DE3050999C2/en not_active Expired
- 1980-03-10 FR FR8005278A patent/FR2451370A1/en active Granted
- 1980-03-10 FR FR8005277A patent/FR2451191A1/en active Granted
- 1980-04-30 DE DE19803016752 patent/DE3016752A1/en active Granted
-
1983
- 1983-04-28 SG SG226/83A patent/SG22683G/en unknown
- 1983-11-17 HK HK553/83A patent/HK55383A/en unknown
-
1984
- 1984-12-30 MY MY200/84A patent/MY8400200A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB756189A (en) * | 1954-02-01 | 1956-08-29 | Ici Ltd | New pyrimidine derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |