FR2381740A1 - Procede de preparation de 2-nitrate de 1,4:3,6-dianhydro-d-glucitol - Google Patents
Procede de preparation de 2-nitrate de 1,4:3,6-dianhydro-d-glucitolInfo
- Publication number
- FR2381740A1 FR2381740A1 FR7736081A FR7736081A FR2381740A1 FR 2381740 A1 FR2381740 A1 FR 2381740A1 FR 7736081 A FR7736081 A FR 7736081A FR 7736081 A FR7736081 A FR 7736081A FR 2381740 A1 FR2381740 A1 FR 2381740A1
- Authority
- FR
- France
- Prior art keywords
- dianhydro
- glucitol
- nitrate
- preparing
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
L'invention est relative à un nouveau procédé de préparation de 2-nitrate de 1,4:3,6-dianhydro-D-glucitol. Ce nouveau procédé comprend l'acylation de 1,4:3,6-dianhydro-D-glucitol avec 0,5 à 1,5 équivalent molaire d'un anhydride d'acide alcanoïque inférieur en présence d'un catalyseur acide, la nitration du produit obtenu avec un mélange d'acide nitrique et d'anhydride acétique, l'hydrolyse du produit obtenu en présence d'une base minérale et l'isolement du 2-nitrate de 1,4 :3,6-dianhydro-D-glucitol. Le produit ainsi obtenu, avec un rendement élevé de production, convient comme vasodilatateur des vaisseaux coronaires.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/771,860 US4065488A (en) | 1977-02-24 | 1977-02-24 | Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2381740A1 true FR2381740A1 (fr) | 1978-09-22 |
FR2381740B1 FR2381740B1 (fr) | 1983-09-09 |
Family
ID=25093167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7736081A Granted FR2381740A1 (fr) | 1977-02-24 | 1977-11-30 | Procede de preparation de 2-nitrate de 1,4:3,6-dianhydro-d-glucitol |
Country Status (25)
Country | Link |
---|---|
US (1) | US4065488A (fr) |
JP (1) | JPS53105493A (fr) |
AT (1) | AT355047B (fr) |
AU (1) | AU512051B2 (fr) |
BE (1) | BE861112A (fr) |
CA (1) | CA1103262A (fr) |
CH (1) | CH625244A5 (fr) |
CS (1) | CS208199B2 (fr) |
DD (1) | DD136616A5 (fr) |
DE (1) | DE2751934A1 (fr) |
DK (1) | DK467377A (fr) |
ES (1) | ES463805A1 (fr) |
FI (1) | FI773012A (fr) |
FR (1) | FR2381740A1 (fr) |
GB (1) | GB1540024A (fr) |
HK (1) | HK32080A (fr) |
HU (1) | HU174663B (fr) |
IE (1) | IE45705B1 (fr) |
IL (1) | IL53096A (fr) |
IN (1) | IN147112B (fr) |
NL (1) | NL7711240A (fr) |
PH (1) | PH13842A (fr) |
PL (1) | PL201607A1 (fr) |
SE (1) | SE7711110L (fr) |
ZA (1) | ZA775920B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2903927C2 (de) * | 1979-02-02 | 1981-03-12 | Sanol Schwarz-Monheim Gmbh, 4019 Monheim | Verfahren zur selektiven Herstellung von Isosorbid-5-nitrat |
DE3028273A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate |
DE3028340C2 (de) * | 1980-07-25 | 1987-02-05 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Amino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
DE3028272A1 (de) * | 1980-07-25 | 1982-02-25 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung |
DE3028873C2 (de) * | 1980-07-30 | 1983-10-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Herstellung von 1,4 zu 3,6-Dianhydro-D-glucit-5-nitrat (Isosorbid-5-nitrat) |
DE3102947A1 (de) * | 1981-01-29 | 1982-09-02 | Heinrich Mack Nachf., 7918 Illertissen | Verfahren zur herstellung von isosorbid-5-nitrat |
DE3123719C1 (de) * | 1981-06-15 | 1983-01-13 | Boehringer Ingelheim KG, 6507 Ingelheim | Verfahren zur Herstellung von Isomannidmononitrat |
DE3124410A1 (de) * | 1981-06-22 | 1983-01-05 | Heinrich Mack Nachf., 7918 Illertissen | Verfahren zur herstellung von isosorbid-2-nitrat |
DE3128102A1 (de) * | 1981-07-16 | 1983-02-03 | Cassella Ag, 6000 Frankfurt | Verfahren zur herstellung von isosorbid-2-acylaten |
DE3248548A1 (de) * | 1982-12-29 | 1984-07-05 | Heinrich Mack Nachf., 7918 Illertissen | Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
EP0266450B1 (fr) * | 1986-11-05 | 1992-01-15 | Consiglio Nazionale Delle Ricerche | Procédé de préparation sélective du 2-mononitrate d'isosorbide au départ du 2,5-dinitrate d'isosorbide |
EP0267924A1 (fr) * | 1986-05-09 | 1988-05-25 | BAUDET, Pierre | Esters nitriques de benzothiazepinones |
DE58908065D1 (de) * | 1988-09-07 | 1994-08-25 | Ciba Geigy Ag | Disazoverbindungen mit langkettigen Alkylester- oder Alkylamidresten. |
EP0442846A3 (en) * | 1990-02-15 | 1992-09-16 | Ciba-Geigy Ag | Disazo compounds with long-chain alkylester- or alkylamide moieties |
US5306831A (en) * | 1992-10-15 | 1994-04-26 | Shell Oil Company | Sorbitan ester purification process |
DE4410997A1 (de) * | 1994-03-30 | 1995-10-26 | Isis Pharma Gmbh | Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen |
IT1311986B1 (it) * | 1999-03-26 | 2002-03-22 | Dinamite Dipharma S P A In For | Procedimento per la preparazione di monoesteri nitrici di compostidiidrossialchilici e diidrossicicloalchilici. |
JP4188058B2 (ja) * | 2002-11-05 | 2008-11-26 | ダイセル化学工業株式会社 | フォトレジスト用高分子化合物及びフォトレジスト用樹脂組成物 |
DE102008050597A1 (de) | 2008-10-09 | 2010-04-15 | Actavis Deutschland Gmbh & Co. Kg | Pharmazeutische Zubereitungen zur Anwendung in einem Verfahren zur therapeutischen Behandlung von Hörsturz |
CN103874524B (zh) | 2011-08-04 | 2016-08-17 | 伦敦国王学院 | 连续机械手 |
CN113105470A (zh) * | 2021-03-15 | 2021-07-13 | 海南通用康力制药有限公司 | 单硝酸异山梨酯的合成方法及应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2134698A1 (fr) * | 1971-04-29 | 1972-12-08 | American Home Prod |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE620263A (fr) * | 1961-07-17 |
-
1977
- 1977-02-24 US US05/771,860 patent/US4065488A/en not_active Expired - Lifetime
- 1977-09-29 CA CA287,803A patent/CA1103262A/fr not_active Expired
- 1977-10-03 IE IE2016/77A patent/IE45705B1/en unknown
- 1977-10-04 SE SE7711110A patent/SE7711110L/xx not_active Application Discontinuation
- 1977-10-04 ZA ZA00775920A patent/ZA775920B/xx unknown
- 1977-10-07 AU AU29477/77A patent/AU512051B2/en not_active Expired
- 1977-10-10 IL IL53096A patent/IL53096A/xx unknown
- 1977-10-11 FI FI773012A patent/FI773012A/fi not_active Application Discontinuation
- 1977-10-13 NL NL7711240A patent/NL7711240A/xx not_active Application Discontinuation
- 1977-10-14 AT AT736977A patent/AT355047B/de not_active IP Right Cessation
- 1977-10-15 JP JP12397777A patent/JPS53105493A/ja active Pending
- 1977-10-18 IN IN1522/CAL/77A patent/IN147112B/en unknown
- 1977-10-18 GB GB43187/77A patent/GB1540024A/en not_active Expired
- 1977-10-18 CS CS776765A patent/CS208199B2/cs unknown
- 1977-10-19 PL PL20160777A patent/PL201607A1/xx unknown
- 1977-10-20 DK DK467377A patent/DK467377A/da not_active Application Discontinuation
- 1977-10-25 HU HU77AE514A patent/HU174663B/hu unknown
- 1977-11-02 PH PH20393A patent/PH13842A/en unknown
- 1977-11-03 ES ES463805A patent/ES463805A1/es not_active Expired
- 1977-11-21 DE DE19772751934 patent/DE2751934A1/de not_active Withdrawn
- 1977-11-22 CH CH1430177A patent/CH625244A5/fr not_active IP Right Cessation
- 1977-11-23 BE BE182863A patent/BE861112A/fr not_active IP Right Cessation
- 1977-11-30 FR FR7736081A patent/FR2381740A1/fr active Granted
- 1977-11-30 DD DD77202325A patent/DD136616A5/xx unknown
-
1980
- 1980-06-12 HK HK320/80A patent/HK32080A/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2134698A1 (fr) * | 1971-04-29 | 1972-12-08 | American Home Prod |
Non-Patent Citations (1)
Title |
---|
EXBK/38 * |
Also Published As
Publication number | Publication date |
---|---|
DD136616A5 (de) | 1979-07-18 |
US4065488A (en) | 1977-12-27 |
NL7711240A (nl) | 1978-08-28 |
PL201607A1 (pl) | 1978-12-18 |
CA1103262A (fr) | 1981-06-16 |
IN147112B (fr) | 1979-11-17 |
ATA736977A (de) | 1979-07-15 |
AT355047B (de) | 1980-02-11 |
PH13842A (en) | 1980-10-16 |
SE7711110L (sv) | 1978-08-25 |
JPS53105493A (en) | 1978-09-13 |
BE861112A (fr) | 1978-05-23 |
FI773012A (fi) | 1978-08-25 |
ZA775920B (en) | 1978-05-30 |
CH625244A5 (fr) | 1981-09-15 |
CS208199B2 (en) | 1981-08-31 |
IL53096A0 (en) | 1977-12-30 |
IE45705L (en) | 1978-08-24 |
GB1540024A (en) | 1979-02-07 |
HK32080A (en) | 1980-06-20 |
DE2751934A1 (de) | 1978-08-31 |
AU2947777A (en) | 1979-04-12 |
HU174663B (hu) | 1980-03-28 |
FR2381740B1 (fr) | 1983-09-09 |
DK467377A (da) | 1978-08-25 |
AU512051B2 (en) | 1980-09-18 |
IE45705B1 (en) | 1982-11-03 |
IL53096A (en) | 1980-11-30 |
ES463805A1 (es) | 1978-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |