FI941245A0 - Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi - Google Patents

Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi

Info

Publication number
FI941245A0
FI941245A0 FI941245A FI941245A FI941245A0 FI 941245 A0 FI941245 A0 FI 941245A0 FI 941245 A FI941245 A FI 941245A FI 941245 A FI941245 A FI 941245A FI 941245 A0 FI941245 A0 FI 941245A0
Authority
FI
Finland
Prior art keywords
acyl derivatives
deoxyguanocin
preparation
enhancing
haematopoesis
Prior art date
Application number
FI941245A
Other languages
English (en)
Swedish (sv)
Other versions
FI941245A (fi
FI97891B (fi
FI97891C (fi
Inventor
Borstel Reid Warren Von
Michael Kevin Bamat
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of FI941245A publication Critical patent/FI941245A/fi
Publication of FI941245A0 publication Critical patent/FI941245A0/fi
Publication of FI97891B publication Critical patent/FI97891B/fi
Application granted granted Critical
Publication of FI97891C publication Critical patent/FI97891C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
FI941245A 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi FI97891C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11592387A 1987-10-28 1987-10-28
US11592387 1987-10-28
US8803824 1988-10-27
PCT/US1988/003824 WO1989003838A1 (en) 1987-10-28 1988-10-27 Acyl deoxyribonucleoside derivatives and uses thereof
FI893100 1989-06-26
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi

Publications (4)

Publication Number Publication Date
FI941245A FI941245A (fi) 1994-03-16
FI941245A0 true FI941245A0 (fi) 1994-03-16
FI97891B FI97891B (fi) 1996-11-29
FI97891C FI97891C (fi) 1997-03-10

Family

ID=22364166

Family Applications (2)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
FI941245A FI97891C (fi) 1987-10-28 1994-03-16 Menetelmä 2'-deoksiguanosiinin asyylijohdannaisten valmistamiseksi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI893100A FI91764C (fi) 1987-10-28 1989-06-26 Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (1) US6020320A (fi)
EP (2) EP0355131B1 (fi)
JP (2) JP2637534B2 (fi)
KR (1) KR890701609A (fi)
AT (2) ATE142221T1 (fi)
CA (1) CA1329932C (fi)
DE (2) DE3856557T2 (fi)
DK (1) DK174400B1 (fi)
FI (2) FI91764C (fi)
HK (1) HK1004854A1 (fi)
IL (1) IL88204A (fi)
IN (1) IN167609B (fi)
NO (1) NO174392C (fi)
WO (1) WO1989003838A1 (fi)
ZA (1) ZA888083B (fi)

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US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US6743782B1 (en) * 1987-10-28 2004-06-01 Wellstat Therapeutics Corporation Acyl deoxyribonucleoside derivatives and uses thereof
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6060459A (en) 1987-10-28 2000-05-09 Pro-Neuron, Inc. Enhancing blood cell count with oxypurine nucleosides
US6329350B1 (en) * 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5736531A (en) 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5691320A (en) * 1987-10-28 1997-11-25 Pro-Neuron, Inc. Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
AU663309C (en) * 1991-02-08 2002-08-08 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DE69232070T2 (de) * 1991-07-05 2002-06-06 Pro-Neuron, Inc. Behandlung der toxischen wirkung von chemotherapeutischen und antiviralen wirkstoffen mit acylierten pyrimidinnukleosiden
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
EP1486210A1 (en) * 1992-12-08 2004-12-15 Wellstat Therapeutics Corporation Pyrimidine nucleotide precursors for treatment of inflammatory hepatitis
US5641758A (en) * 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof
MX9700109A (es) 1994-07-01 1997-04-30 Pro Neuron Inc Precursores nucleotidos de pirimidina para el tratamiento de inflamaciones sistemicas y hepatitis inflamatoria.
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US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
CA2340156C (en) 1998-08-10 2007-10-23 Novirio Pharmaceuticals Limited .beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b
KR100879559B1 (ko) 1999-02-23 2009-01-22 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 미토콘드리아 장애의 치료 또는 예방용 제약조성물
US6576619B2 (en) * 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
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US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
DE10117615A1 (de) * 2001-04-07 2002-10-10 Max Delbrueck Centrum Verwendung von Nucleosiden, Nucleobasen und deren Derivaten zur verbesserten Gewinnung von adulten Stammzellen
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
SI1572095T1 (sl) 2002-09-13 2015-12-31 Novartis Ag Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv
EP2187894B1 (en) 2007-08-16 2020-03-18 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. D. radiodurans extract containing nucleosides and manganese
CA2751563A1 (en) * 2009-02-04 2010-08-12 Jelena Mann Methods of inhibiting fibrogenesis and treating fibrotic disease
ES2647584T3 (es) 2010-04-29 2017-12-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Método para producir vacunas que comprende la irradiación de microorganismos en una composición que comprende aminoácidos y ortofosfato de manganeso
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Also Published As

Publication number Publication date
ZA888083B (en) 1990-06-27
HK1004854A1 (en) 1998-12-11
EP0712629A1 (en) 1996-05-22
DE3855513D1 (de) 1996-10-10
JPH02500373A (ja) 1990-02-08
JPH07267981A (ja) 1995-10-17
ATE243039T1 (de) 2003-07-15
FI941245A (fi) 1994-03-16
JP2637534B2 (ja) 1997-08-06
FI893100A0 (fi) 1989-06-26
FI91764B (fi) 1994-04-29
EP0355131A4 (en) 1990-12-05
IN167609B (fi) 1990-11-24
FI97891B (fi) 1996-11-29
CA1329932C (en) 1994-05-31
FI97891C (fi) 1997-03-10
NO174392C (no) 1994-04-27
JP2764014B2 (ja) 1998-06-11
FI893100A (fi) 1989-06-26
EP0355131A1 (en) 1990-02-28
NO174392B (no) 1994-01-17
KR890701609A (ko) 1989-12-21
ATE142221T1 (de) 1996-09-15
NO892642L (no) 1989-08-24
IL88204A0 (en) 1989-06-30
IL88204A (en) 1996-06-18
FI91764C (fi) 1994-08-10
NO892642D0 (no) 1989-06-26
US6020320A (en) 2000-02-01
DK318089D0 (da) 1989-06-27
DE3856557T2 (de) 2004-06-03
DK174400B1 (da) 2003-02-10
WO1989003838A1 (en) 1989-05-05
DE3856557D1 (de) 2003-07-24
DE3855513T2 (de) 1997-01-09
EP0712629B1 (en) 2003-06-18
EP0355131B1 (en) 1996-09-04
DK318089A (da) 1989-08-28

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