FI915919A0 - Inhibitorer foer blodplaettarnas aggregation. - Google Patents

Inhibitorer foer blodplaettarnas aggregation.

Info

Publication number
FI915919A0
FI915919A0 FI915919A FI915919A FI915919A0 FI 915919 A0 FI915919 A0 FI 915919A0 FI 915919 A FI915919 A FI 915919A FI 915919 A FI915919 A FI 915919A FI 915919 A0 FI915919 A0 FI 915919A0
Authority
FI
Finland
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Application number
FI915919A
Other languages
English (en)
Other versions
FI104364B (fi
Inventor
Robert M Scarborough
David Lawrence Wolf
Israel F Charo
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI915919(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of FI915919A0 publication Critical patent/FI915919A0/fi
Application granted granted Critical
Publication of FI104364B publication Critical patent/FI104364B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
FI915919A 1989-06-16 1991-12-16 Menetelmiä trombosyytien aggregaation inhibiittoreiden valmistamiseksi FI104364B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US36750989 1989-06-16
US41802889A 1989-10-06 1989-10-06
US41802889 1989-10-06
US48322990 1990-02-20
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
US9003417 1990-06-15
PCT/US1990/003417 WO1990015620A1 (en) 1989-06-16 1990-06-15 Platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
FI915919A0 true FI915919A0 (fi) 1991-12-16
FI104364B FI104364B (fi) 2000-01-14

Family

ID=27408820

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915919A FI104364B (fi) 1989-06-16 1991-12-16 Menetelmiä trombosyytien aggregaation inhibiittoreiden valmistamiseksi

Country Status (16)

Country Link
US (4) US5318899A (fi)
EP (2) EP0477295B2 (fi)
JP (1) JP3281370B2 (fi)
KR (1) KR0180918B1 (fi)
AT (1) ATE146969T1 (fi)
CA (2) CA2388770A1 (fi)
DE (2) DE69029579T3 (fi)
DK (1) DK0477295T4 (fi)
ES (1) ES2097150T5 (fi)
FI (1) FI104364B (fi)
HU (1) HU216318B (fi)
LU (1) LU90488I2 (fi)
NL (1) NL990043I2 (fi)
NO (3) NO304267B1 (fi)
RU (1) RU2156468C2 (fi)
WO (1) WO1990015620A1 (fi)

Families Citing this family (67)

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US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5795867A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
AU660926B2 (en) * 1990-04-06 1995-07-13 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
CA2092315A1 (en) * 1990-11-02 1992-05-03 John P. Burnier Platelet aggregation inhibitors
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
JPH06509551A (ja) * 1991-04-05 1994-10-27 ジェネンテク，インコーポレイテッド Ｇｐ　ＩＩ↓ｂＩＩＩ↓ａに対する高い特異性を有する血小板凝集阻害剤
US5674865A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
ATE168380T1 (de) * 1992-06-04 1998-08-15 Merrell Pharma Inc In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
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WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
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US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
EP0835135A2 (en) * 1995-06-07 1998-04-15 Centocor, Inc. Platelet-specific chimeric immunoglobulin and methods of use therefor
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
WO1997025999A1 (en) * 1996-01-16 1997-07-24 Rensselaer Polytechnic Institute Peptides for altering osteoblast adhesion
JP2001500875A (ja) * 1996-09-18 2001-01-23 メルク エンド カンパニー インコーポレーテッド 心臓血管系疾患関連の危険性を減らす併用治療法
CA2271684A1 (en) * 1996-11-21 1998-05-28 Merck & Co., Inc. Detection of antagonist-dependent gpiib/iiia receptor antibodies
FR2764389B1 (fr) 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
WO1999013898A1 (en) * 1997-08-15 1999-03-25 Stefan Niewiarowski EC-3, AN INHIBITOR OF α4β1 AND α4β7 INTEGRINS
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
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US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
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EP1322322A4 (en) * 2000-09-11 2005-04-06 Univ Temple COMPOUNDS AND METHODS FOR INHIBITING INTEGRINS ALPHA-1 BETA-1
JP4328625B2 (ja) * 2001-11-05 2009-09-09 アイアールエム エルエルシー 標識試薬とその使用方法
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US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
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CN107080846A (zh) 2010-07-09 2017-08-22 詹姆斯.特林卡.格林 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送***
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
CN104540874B (zh) 2012-08-09 2018-05-01 威士伯采购公司 聚碳酸酯
CN104583347B (zh) 2012-08-09 2016-11-16 威士伯采购公司 稳定剂和其涂料组合物
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
ES2886576T3 (es) 2015-08-05 2021-12-20 Shaanxi Micot Tech Limited Company Compuesto de múltiples dianas con actividad anticoagulante y antiplaquetaria, método de preparación para el mismo y uso del mismo
CA3072163C (en) * 2017-08-09 2022-09-20 National Cheng Kung University Disintegrin variants and uses thereof

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Also Published As

Publication number Publication date
KR0180918B1 (ko) 1999-04-01
AU636159B2 (en) 1993-04-22
NO304267B1 (no) 1998-11-23
DK0477295T3 (da) 1997-07-07
DE19975072I1 (de) 2000-03-09
NO914962L (no) 1992-01-31
CA2059124C (en) 2002-08-20
NO312965B1 (no) 2002-07-22
CA2059124A1 (en) 1990-12-17
WO1990015620A1 (en) 1990-12-27
ES2097150T5 (es) 2006-06-16
EP0477295A1 (en) 1992-04-01
US5736339A (en) 1998-04-07
EP0751219A1 (en) 1997-01-02
EP0477295A4 (en) 1992-10-07
JPH05500750A (ja) 1993-02-18
RU2156468C2 (ru) 2000-09-20
HU905490D0 (en) 1992-03-30
AU6036990A (en) 1991-01-08
US5958732A (en) 1999-09-28
NO982249L (no) 1992-01-31
DE69029579D1 (de) 1997-02-13
DK0477295T4 (da) 2005-12-12
NL990043I1 (nl) 2000-02-01
KR920702627A (ko) 1992-10-06
LU90488I2 (fr) 2000-02-15
CA2388770A1 (en) 1990-12-27
DE69029579T3 (de) 2006-06-22
FI104364B (fi) 2000-01-14
JP3281370B2 (ja) 2002-05-13
HU216318B (hu) 1999-06-28
NL990043I2 (nl) 2000-04-03
NO2000008I2 (no) 2006-01-16
ATE146969T1 (de) 1997-01-15
DE69029579T2 (de) 1997-07-24
NO914962D0 (no) 1991-12-16
HUT59835A (en) 1992-07-28
NO982249D0 (no) 1998-05-15
ES2097150T3 (es) 1997-04-01
EP0477295B1 (en) 1997-01-02
EP0477295B2 (en) 2005-11-16
DE19975072I2 (de) 2011-01-20
US5318899A (en) 1994-06-07
US5496724A (en) 1996-03-05

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