FI873924A - Foerfarande foer framstaellning av aettiksyraestern av haloperidol och denna innehaollande farmaceutiska preparat. - Google Patents

Foerfarande foer framstaellning av aettiksyraestern av haloperidol och denna innehaollande farmaceutiska preparat. Download PDF

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Publication number
FI873924A
FI873924A FI873924A FI873924A FI873924A FI 873924 A FI873924 A FI 873924A FI 873924 A FI873924 A FI 873924A FI 873924 A FI873924 A FI 873924A FI 873924 A FI873924 A FI 873924A
Authority
FI
Finland
Prior art keywords
haloperidol
aettiksyraestern
denna
och
pharmaceutical preparation
Prior art date
Application number
FI873924A
Other languages
English (en)
Other versions
FI88155C (fi
FI873924A0 (fi
FI88155B (fi
Inventor
Jens Kristian Perregaard
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of FI873924A0 publication Critical patent/FI873924A0/fi
Publication of FI873924A publication Critical patent/FI873924A/fi
Application granted granted Critical
Publication of FI88155B publication Critical patent/FI88155B/fi
Publication of FI88155C publication Critical patent/FI88155C/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
FI873924A 1986-09-11 1987-09-10 Foerfarande foer framstaellning av en terapeutiskt anvaendbar aettiksyraester av 4-(4-(4-klorfenyl)-4-hydroxi-1-piperidinyl)-1-(4-fluorfenyl)-1-butanon FI88155C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8621892 1986-09-11
GB868621892A GB8621892D0 (en) 1986-09-11 1986-09-11 Organic compound

Publications (4)

Publication Number Publication Date
FI873924A0 FI873924A0 (fi) 1987-09-10
FI873924A true FI873924A (fi) 1988-03-12
FI88155B FI88155B (fi) 1992-12-31
FI88155C FI88155C (fi) 1993-04-13

Family

ID=10604021

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873924A FI88155C (fi) 1986-09-11 1987-09-10 Foerfarande foer framstaellning av en terapeutiskt anvaendbar aettiksyraester av 4-(4-(4-klorfenyl)-4-hydroxi-1-piperidinyl)-1-(4-fluorfenyl)-1-butanon

Country Status (16)

Country Link
US (1) US4855307A (fi)
EP (1) EP0260070B1 (fi)
JP (1) JPS6377857A (fi)
AT (1) ATE92917T1 (fi)
AU (1) AU591334B2 (fi)
DE (1) DE3786966T2 (fi)
DK (1) DK166320C (fi)
ES (1) ES2058120T3 (fi)
FI (1) FI88155C (fi)
GB (1) GB8621892D0 (fi)
IE (1) IE60902B1 (fi)
IL (1) IL83819A (fi)
NO (1) NO169893C (fi)
NZ (1) NZ221711A (fi)
PT (1) PT85678B (fi)
ZA (1) ZA876819B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3742580C1 (de) * 1987-12-16 1989-05-11 Schaper & Bruemmer Gmbh Verwendung des alpha,alpha-Diphenyl-alpha-(3-carboxy-propionyloxy)-essigsaeure-4-(N-methylpiperidyl)-esters zur Behandlung hypertoner Funktionszustaende im Bereich der Harnblase
US5776963A (en) 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DK238190D0 (da) * 1990-10-03 1990-10-03 Lundbeck & Co As H Depotderivater
EP1787984B1 (en) * 2000-03-06 2016-10-19 Acadia Pharmaceuticals Inc. Azacyclic compounds for use in the treatment of serotonin related diseases
WO2001066521A1 (en) 2000-03-06 2001-09-13 Acadia Pharmaceuticals, Inc. Azacyclic compounds for use in the treatment of serotonin related diseases
WO2003057698A2 (en) 2001-12-28 2003-07-17 Acadia Pharmaceuticals, Inc. Spiroazacyclic compounds as monoamine receptor modulators
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
IL165907A0 (en) 2002-06-24 2006-01-15 Acadia Pharm Inc N-substituted piperidine derivatives as serotonin receptor agents
PT1587789E (pt) 2003-01-16 2008-12-16 Acadia Pharm Inc Agonistas inversos selectivos para receptores 2a/2c da serotonina como agentes terapêuticos para doenças neurodegenerativas
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
CN101035759B (zh) 2004-09-27 2011-06-15 阿卡蒂亚药品公司 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
ES2423485T3 (es) 2007-03-19 2013-09-20 Acadia Pharmaceuticals Inc. Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos
SI3325444T1 (sl) 2015-07-20 2021-11-30 Acadia Pharmaceuticals Inc. Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
US20210077479A1 (en) 2017-08-30 2021-03-18 Acadia Pharmaceuticals Inc. Formulations of pimavanserin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB895309A (en) * 1959-11-18 1962-05-02 Res Lab Dr C Janssen Nv Pyrrolidine and piperidine derivatives
US3408356A (en) * 1965-08-31 1968-10-29 Squibb & Sons Inc Long chain esters of 4'-fluoro-4-[4-hydroxy-4-(alpha, alpha, alpha-trifluorotolyl)piperi-dino]butyrophenone and the like
DE1695194A1 (de) * 1966-07-11 1971-03-18 Hoffmann La Roche Verfahren zur Herstellung von Piperidinderivaten
US4070473A (en) * 1973-01-26 1978-01-24 Ab Ferrosan Piperidino-butyrophenones
JPS568318A (en) * 1979-06-28 1981-01-28 Janssen Pharmaceutica Nv Non oral long acting composition of haloperidol and bromperidol derivative

Also Published As

Publication number Publication date
DE3786966T2 (de) 1994-03-17
DK166320C (da) 1993-08-23
ATE92917T1 (de) 1993-08-15
IE60902B1 (en) 1994-08-24
IL83819A0 (en) 1988-02-29
FI88155C (fi) 1993-04-13
IL83819A (en) 1992-02-16
NO169893B (no) 1992-05-11
IE872366L (en) 1988-03-11
JPS6377857A (ja) 1988-04-08
NO873785L (no) 1988-03-14
NZ221711A (en) 1989-11-28
AU7823287A (en) 1988-03-17
FI873924A0 (fi) 1987-09-10
AU591334B2 (en) 1989-11-30
PT85678B (pt) 1990-05-31
EP0260070A1 (en) 1988-03-16
DE3786966D1 (de) 1993-09-16
EP0260070B1 (en) 1993-08-11
ZA876819B (en) 1988-06-29
NO873785D0 (no) 1987-09-10
FI88155B (fi) 1992-12-31
DK166320B (da) 1993-04-05
US4855307A (en) 1989-08-08
DK479587A (da) 1988-03-12
DK479587D0 (da) 1987-09-11
GB8621892D0 (en) 1986-10-15
PT85678A (en) 1987-10-01
ES2058120T3 (es) 1994-11-01
NO169893C (no) 1992-08-19

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Owner name: H. LUNDBECK A/S