FI83660B - Foerfarande foer framstaellning bukspottskoertelns grf hos maenniskan. - Google Patents
Foerfarande foer framstaellning bukspottskoertelns grf hos maenniskan. Download PDFInfo
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- FI83660B FI83660B FI842166A FI842166A FI83660B FI 83660 B FI83660 B FI 83660B FI 842166 A FI842166 A FI 842166A FI 842166 A FI842166 A FI 842166A FI 83660 B FI83660 B FI 83660B
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical group C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/843—Digestive system
- Y10S530/845—Pancreas
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Prostheses (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Machine Tool Sensing Apparatuses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (2)
1. Förfarande för framställning av peptider med farmaceutisk aktivitet och med formeln (I): H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-D-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-1 le-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-NH2 10 eller en vid C-terminalen förkortad version därav omfatt- ande minst 27 aminosyror, kännetecknat därav, att man a) bildar en förening, som innehäller ätminstone en skyddsgrupp och med formeln (II): 15 Xx-Tyr ( X2) -Ala-Asp( X3) -Ala-Ile-Phe-Thr ( X4 ) -Asn( X5) -Ser ( X4) -Tyr (X2) -Arg( X6) -Lys( X7) -Val-Leu-D-Ala-Gln( X5) -Leu-Ser (X4) -Ala-Arg( X6)-Lys( X7)-Leu-Leu-Gln( X5) -Asp( X3) -Ile-Met-Ser(X4 ) -Arg( X6) -Gln( X5) -Gln( X5) -Gly-Glu( X3) -Ser( X4) -Asn( X5) -Gln( X5) -20 Glu (X3) - Arg (X6) -Gly-Ala-X8 eller en vid C-terminalen ändamälsenligt förkortad version därav, väri X1 är väte eller en a-aminoskyddsgrupp;
25 X2 är väte eller en skyddsgrupp för den fenoliska hydroxyl- gruppen i Tyr; X3 är väte eller en skyddsgrupp för karboxylgruppen i Asp eller Glu; X4 är väte eller en skyddsgrupp för den alkoholiska hydr-30 oxylgruppen i Ser eller Thr; X5 är väte eller en skyddsgrupp för sidokedjeamidogruppen i Asn eller Gin; X6 är väte eller en skyddsgrupp för guanidinogruppen i Arg; X7 är väte eller en skyddsgrupp för sidokedjeaminogruppen 35 i Lys; och X® är en hartsbärare; 22 83660 genom att i ordningsföld koppia de skyddade aminosyrorna i förhällandet ca en millimol skyddad aminosyra per gram harts i lämpligt lösningsmedel företrädesvis metylenklorid eller dimetylformamid eller en blandning därav, och 5 b) avlägsnar skyddsgrupperna och lösgör peptiden frän hartsbäraren genom att använda TFA i lämpligt lösningsmedel och därefter genom att använda HF vid läg tem-peratur, varefter peptiden löses i ett lämpligt lösningsmedel och renas enligt kända metoder. 10 2. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att X8 är -NH-parametylbenshydryl-amin(MBHA)hartsbärare·
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43266382 | 1982-10-04 | ||
US06/432,663 US4563352A (en) | 1982-10-04 | 1982-10-04 | Human pancreatic GRF |
US8301564 | 1983-10-03 | ||
PCT/US1983/001564 WO1984001379A1 (en) | 1982-10-04 | 1983-10-03 | Human pancreatic grf |
Publications (4)
Publication Number | Publication Date |
---|---|
FI842166A0 FI842166A0 (fi) | 1984-05-30 |
FI842166A FI842166A (fi) | 1984-05-30 |
FI83660B true FI83660B (fi) | 1991-04-30 |
FI83660C FI83660C (sv) | 1991-08-12 |
Family
ID=23717095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI842166A FI83660C (sv) | 1982-10-04 | 1984-05-30 | Förfarande för framställning bukspottskörtelns GRF hos människan |
Country Status (25)
Country | Link |
---|---|
US (1) | US4563352A (sv) |
EP (1) | EP0105759B1 (sv) |
JP (1) | JPS59501951A (sv) |
KR (1) | KR900006712B1 (sv) |
AT (1) | ATE24919T1 (sv) |
AU (1) | AU566180B2 (sv) |
CA (1) | CA1243016A (sv) |
DE (1) | DE3369144D1 (sv) |
DK (1) | DK269284A (sv) |
ES (1) | ES8606399A1 (sv) |
FI (1) | FI83660C (sv) |
GR (1) | GR79698B (sv) |
HU (1) | HU191263B (sv) |
IE (1) | IE56175B1 (sv) |
IL (1) | IL69897A (sv) |
MX (1) | MX7701E (sv) |
NO (1) | NO167866C (sv) |
NZ (1) | NZ205745A (sv) |
PH (1) | PH20333A (sv) |
PT (1) | PT77453B (sv) |
RO (1) | RO91186B (sv) |
SU (1) | SU1426455A3 (sv) |
WO (1) | WO1984001379A1 (sv) |
YU (1) | YU45575B (sv) |
ZA (1) | ZA837208B (sv) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703035A (en) * | 1982-10-04 | 1987-10-27 | The Salk Institute For Biological Studies | Human pancreatic GRF amidated fragments |
US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
US4581168A (en) * | 1983-02-21 | 1986-04-08 | Sanofi | Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides |
ZA844380B (en) * | 1983-07-05 | 1985-01-30 | Salk Inst For Biological Studi | Dna encoding a grf precursor |
AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
US4528190A (en) * | 1983-10-25 | 1985-07-09 | The Salk Institute For Biological Studies | GRF Analogs IV |
FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
US4649131A (en) * | 1984-09-24 | 1987-03-10 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
EP0189673B1 (en) * | 1984-12-24 | 1990-09-26 | Sumitomo Pharmaceuticals Company, Limited | Stable growth hormone releasing factor preparation |
US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
US4880778A (en) * | 1986-05-12 | 1989-11-14 | Eastman Kodak Company | Combinations having synergistic growth hormone releasing activity and methods for use thereof |
FR2599038B1 (fr) * | 1986-05-26 | 1990-06-29 | Sanofi Sa | Procede de preparation de nonacosapeptides et peptides intermediaires |
IL84758A (en) * | 1987-01-13 | 1992-03-29 | Salk Inst For Biological Studi | Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them |
US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
US4801456A (en) * | 1987-07-09 | 1989-01-31 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
US4880777A (en) * | 1987-09-01 | 1989-11-14 | Eastman Kodak Company | Synthetic peptides having growth hormone releasing activity |
ATE122357T1 (de) * | 1988-01-28 | 1995-05-15 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
US5043322A (en) * | 1988-07-22 | 1991-08-27 | The Salk Institute For Biological Studies | Cyclic GRF analogs |
US5153175A (en) * | 1989-05-25 | 1992-10-06 | University Of Tennesee Research Corporation | Method of inducing sleep with GHRH complementary peptide compositions |
US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
EP0544706A4 (en) * | 1990-06-29 | 1993-10-13 | Hoffmann-La Roche Inc. | Histidine substituted growth hormone releasing factor analogs |
ATE119916T1 (de) * | 1990-12-10 | 1995-04-15 | Hoffmann La Roche | Verfahren zur enzymatischen herstellung von grf(1-44)nh2. |
CA2084061A1 (en) * | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
US5246920A (en) * | 1992-06-15 | 1993-09-21 | University Of South Florida | Treatment of hyperprolactinemia |
US5811074A (en) * | 1992-06-29 | 1998-09-22 | University Of South Florida | Method of diagnosing pituitary dependent growth hormone deficiency |
US5631225A (en) * | 1994-10-13 | 1997-05-20 | Novo Nordisk A/S | Pharmaceutical formulation |
EP0880969A1 (en) * | 1997-05-28 | 1998-12-02 | Applied Research Systems ARS Holdings N.V. | Pharmaceutical compositions of peptides having low solubility in physiological medium |
EP0922446A1 (en) * | 1997-12-03 | 1999-06-16 | Applied Research Systems Ars Holding N.V. | Solution-phase site-specific preparation of GRF-PEG conjugates |
CN1491233A (zh) * | 2001-02-02 | 2004-04-21 | 康久化学公司 | 长效生长激素释放因子衍生物 |
US20060128615A1 (en) * | 2002-09-18 | 2006-06-15 | Pierrette Gaudreau | Ghrh analogues |
WO2009009727A2 (en) * | 2007-07-12 | 2009-01-15 | Akela Pharma Srl | Ghrh analogs and therapeutic uses thereof |
CN107936090B (zh) * | 2017-12-08 | 2021-09-24 | 陕西慧康生物科技有限责任公司 | 一种低成本合成ARK-Cu的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3904753A (en) * | 1970-02-20 | 1975-09-09 | Research Corp | Clinically active bovine growth hormone fraction |
US3664925A (en) * | 1970-02-20 | 1972-05-23 | Martin Sonenberg | Clinically active bovine growth hormone fraction |
US3853833A (en) * | 1971-04-27 | 1974-12-10 | Hormone Res Foundation | Synthetic human growth-promoting and lactogenic hormones and method of producing same |
US4056520A (en) * | 1972-03-31 | 1977-11-01 | Research Corporation | Clinically active bovine growth hormone fraction |
PH14681A (en) * | 1977-11-30 | 1981-11-10 | Pfizer | Phenylglycinamides useful in the treatment of ischaemic heart disease |
-
1982
- 1982-10-04 US US06/432,663 patent/US4563352A/en not_active Expired - Lifetime
-
1983
- 1983-09-26 NZ NZ205745A patent/NZ205745A/en unknown
- 1983-09-27 ZA ZA837208A patent/ZA837208B/xx unknown
- 1983-10-03 JP JP83503459A patent/JPS59501951A/ja active Pending
- 1983-10-03 IE IE2333/83A patent/IE56175B1/en not_active IP Right Cessation
- 1983-10-03 ES ES526201A patent/ES8606399A1/es not_active Expired
- 1983-10-03 PH PH29648A patent/PH20333A/en unknown
- 1983-10-03 GR GR72605A patent/GR79698B/el unknown
- 1983-10-03 WO PCT/US1983/001564 patent/WO1984001379A1/en active IP Right Grant
- 1983-10-03 AU AU21269/83A patent/AU566180B2/en not_active Expired
- 1983-10-03 HU HU8497A patent/HU191263B/hu unknown
- 1983-10-04 AT AT83306008T patent/ATE24919T1/de not_active IP Right Cessation
- 1983-10-04 EP EP83306008A patent/EP0105759B1/en not_active Expired
- 1983-10-04 PT PT77453A patent/PT77453B/pt not_active IP Right Cessation
- 1983-10-04 YU YU200083A patent/YU45575B/sh unknown
- 1983-10-04 DE DE8383306008T patent/DE3369144D1/de not_active Expired
- 1983-10-04 IL IL69897A patent/IL69897A/xx not_active IP Right Cessation
- 1983-10-04 MX MX831019U patent/MX7701E/es unknown
- 1983-10-04 CA CA000438354A patent/CA1243016A/en not_active Expired
- 1983-10-26 KR KR1019830005067A patent/KR900006712B1/ko not_active IP Right Cessation
-
1984
- 1984-05-30 FI FI842166A patent/FI83660C/sv not_active IP Right Cessation
- 1984-05-30 DK DK269284A patent/DK269284A/da not_active Application Discontinuation
- 1984-05-30 NO NO84842148A patent/NO167866C/no not_active IP Right Cessation
- 1984-06-01 SU SU843750475A patent/SU1426455A3/ru active
- 1984-06-01 RO RO114739A patent/RO91186B/ro unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |
Owner name: THE SALK INSTITUTE FOR BIOLOGICAL |