FI83660B - Foerfarande foer framstaellning bukspottskoertelns grf hos maenniskan. - Google Patents

Foerfarande foer framstaellning bukspottskoertelns grf hos maenniskan. Download PDF

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Publication number
FI83660B
FI83660B FI842166A FI842166A FI83660B FI 83660 B FI83660 B FI 83660B FI 842166 A FI842166 A FI 842166A FI 842166 A FI842166 A FI 842166A FI 83660 B FI83660 B FI 83660B
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FI
Finland
Prior art keywords
gln
ala
ser
arg
leu
Prior art date
Application number
FI842166A
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English (en)
Finnish (fi)
Other versions
FI842166A0 (fi
FI83660C (sv
FI842166A (fi
Inventor
Joachim Spiess
Jean E F Rivier
Jr Wylie Vale
Original Assignee
Salk Inst For Biological Studi
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Publication date
Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi
Publication of FI842166A0 publication Critical patent/FI842166A0/fi
Publication of FI842166A publication Critical patent/FI842166A/fi
Application granted granted Critical
Publication of FI83660B publication Critical patent/FI83660B/fi
Publication of FI83660C publication Critical patent/FI83660C/sv

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/843Digestive system
    • Y10S530/845Pancreas
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Machine Tool Sensing Apparatuses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (2)

1. Förfarande för framställning av peptider med farmaceutisk aktivitet och med formeln (I): H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-D-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-1 le-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-NH2 10 eller en vid C-terminalen förkortad version därav omfatt- ande minst 27 aminosyror, kännetecknat därav, att man a) bildar en förening, som innehäller ätminstone en skyddsgrupp och med formeln (II): 15 Xx-Tyr ( X2) -Ala-Asp( X3) -Ala-Ile-Phe-Thr ( X4 ) -Asn( X5) -Ser ( X4) -Tyr (X2) -Arg( X6) -Lys( X7) -Val-Leu-D-Ala-Gln( X5) -Leu-Ser (X4) -Ala-Arg( X6)-Lys( X7)-Leu-Leu-Gln( X5) -Asp( X3) -Ile-Met-Ser(X4 ) -Arg( X6) -Gln( X5) -Gln( X5) -Gly-Glu( X3) -Ser( X4) -Asn( X5) -Gln( X5) -20 Glu (X3) - Arg (X6) -Gly-Ala-X8 eller en vid C-terminalen ändamälsenligt förkortad version därav, väri X1 är väte eller en a-aminoskyddsgrupp;
25 X2 är väte eller en skyddsgrupp för den fenoliska hydroxyl- gruppen i Tyr; X3 är väte eller en skyddsgrupp för karboxylgruppen i Asp eller Glu; X4 är väte eller en skyddsgrupp för den alkoholiska hydr-30 oxylgruppen i Ser eller Thr; X5 är väte eller en skyddsgrupp för sidokedjeamidogruppen i Asn eller Gin; X6 är väte eller en skyddsgrupp för guanidinogruppen i Arg; X7 är väte eller en skyddsgrupp för sidokedjeaminogruppen 35 i Lys; och X® är en hartsbärare; 22 83660 genom att i ordningsföld koppia de skyddade aminosyrorna i förhällandet ca en millimol skyddad aminosyra per gram harts i lämpligt lösningsmedel företrädesvis metylenklorid eller dimetylformamid eller en blandning därav, och 5 b) avlägsnar skyddsgrupperna och lösgör peptiden frän hartsbäraren genom att använda TFA i lämpligt lösningsmedel och därefter genom att använda HF vid läg tem-peratur, varefter peptiden löses i ett lämpligt lösningsmedel och renas enligt kända metoder. 10 2. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att X8 är -NH-parametylbenshydryl-amin(MBHA)hartsbärare·
FI842166A 1982-10-04 1984-05-30 Förfarande för framställning bukspottskörtelns GRF hos människan FI83660C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43266382 1982-10-04
US06/432,663 US4563352A (en) 1982-10-04 1982-10-04 Human pancreatic GRF
US8301564 1983-10-03
PCT/US1983/001564 WO1984001379A1 (en) 1982-10-04 1983-10-03 Human pancreatic grf

Publications (4)

Publication Number Publication Date
FI842166A0 FI842166A0 (fi) 1984-05-30
FI842166A FI842166A (fi) 1984-05-30
FI83660B true FI83660B (fi) 1991-04-30
FI83660C FI83660C (sv) 1991-08-12

Family

ID=23717095

Family Applications (1)

Application Number Title Priority Date Filing Date
FI842166A FI83660C (sv) 1982-10-04 1984-05-30 Förfarande för framställning bukspottskörtelns GRF hos människan

Country Status (25)

Country Link
US (1) US4563352A (sv)
EP (1) EP0105759B1 (sv)
JP (1) JPS59501951A (sv)
KR (1) KR900006712B1 (sv)
AT (1) ATE24919T1 (sv)
AU (1) AU566180B2 (sv)
CA (1) CA1243016A (sv)
DE (1) DE3369144D1 (sv)
DK (1) DK269284A (sv)
ES (1) ES8606399A1 (sv)
FI (1) FI83660C (sv)
GR (1) GR79698B (sv)
HU (1) HU191263B (sv)
IE (1) IE56175B1 (sv)
IL (1) IL69897A (sv)
MX (1) MX7701E (sv)
NO (1) NO167866C (sv)
NZ (1) NZ205745A (sv)
PH (1) PH20333A (sv)
PT (1) PT77453B (sv)
RO (1) RO91186B (sv)
SU (1) SU1426455A3 (sv)
WO (1) WO1984001379A1 (sv)
YU (1) YU45575B (sv)
ZA (1) ZA837208B (sv)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703035A (en) * 1982-10-04 1987-10-27 The Salk Institute For Biological Studies Human pancreatic GRF amidated fragments
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4581168A (en) * 1983-02-21 1986-04-08 Sanofi Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
ZA844380B (en) * 1983-07-05 1985-01-30 Salk Inst For Biological Studi Dna encoding a grf precursor
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
EP0189673B1 (en) * 1984-12-24 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Stable growth hormone releasing factor preparation
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
FR2599038B1 (fr) * 1986-05-26 1990-06-29 Sanofi Sa Procede de preparation de nonacosapeptides et peptides intermediaires
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4801456A (en) * 1987-07-09 1989-01-31 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
USRE33699E (en) * 1987-07-09 1991-09-24 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
ATE122357T1 (de) * 1988-01-28 1995-05-15 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5153175A (en) * 1989-05-25 1992-10-06 University Of Tennesee Research Corporation Method of inducing sleep with GHRH complementary peptide compositions
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
EP0544706A4 (en) * 1990-06-29 1993-10-13 Hoffmann-La Roche Inc. Histidine substituted growth hormone releasing factor analogs
ATE119916T1 (de) * 1990-12-10 1995-04-15 Hoffmann La Roche Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
CA2084061A1 (en) * 1991-04-09 1992-10-10 Arthur M. Felix Growth hormone releasing factor analogs
US5246920A (en) * 1992-06-15 1993-09-21 University Of South Florida Treatment of hyperprolactinemia
US5811074A (en) * 1992-06-29 1998-09-22 University Of South Florida Method of diagnosing pituitary dependent growth hormone deficiency
US5631225A (en) * 1994-10-13 1997-05-20 Novo Nordisk A/S Pharmaceutical formulation
EP0880969A1 (en) * 1997-05-28 1998-12-02 Applied Research Systems ARS Holdings N.V. Pharmaceutical compositions of peptides having low solubility in physiological medium
EP0922446A1 (en) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Solution-phase site-specific preparation of GRF-PEG conjugates
CN1491233A (zh) * 2001-02-02 2004-04-21 康久化学公司 长效生长激素释放因子衍生物
US20060128615A1 (en) * 2002-09-18 2006-06-15 Pierrette Gaudreau Ghrh analogues
WO2009009727A2 (en) * 2007-07-12 2009-01-15 Akela Pharma Srl Ghrh analogs and therapeutic uses thereof
CN107936090B (zh) * 2017-12-08 2021-09-24 陕西慧康生物科技有限责任公司 一种低成本合成ARK-Cu的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904753A (en) * 1970-02-20 1975-09-09 Research Corp Clinically active bovine growth hormone fraction
US3664925A (en) * 1970-02-20 1972-05-23 Martin Sonenberg Clinically active bovine growth hormone fraction
US3853833A (en) * 1971-04-27 1974-12-10 Hormone Res Foundation Synthetic human growth-promoting and lactogenic hormones and method of producing same
US4056520A (en) * 1972-03-31 1977-11-01 Research Corporation Clinically active bovine growth hormone fraction
PH14681A (en) * 1977-11-30 1981-11-10 Pfizer Phenylglycinamides useful in the treatment of ischaemic heart disease

Also Published As

Publication number Publication date
NZ205745A (en) 1987-07-31
YU45575B (sh) 1992-07-20
ZA837208B (en) 1984-05-30
IL69897A (en) 1986-12-31
EP0105759B1 (en) 1987-01-14
EP0105759A2 (en) 1984-04-18
ATE24919T1 (de) 1987-01-15
HU191263B (en) 1987-01-28
DK269284D0 (da) 1984-05-30
FI842166A0 (fi) 1984-05-30
FI83660C (sv) 1991-08-12
AU566180B2 (en) 1987-10-08
ES526201A0 (es) 1986-04-16
AU2126983A (en) 1984-04-24
SU1426455A3 (ru) 1988-09-23
RO91186A (ro) 1987-07-30
FI842166A (fi) 1984-05-30
IE56175B1 (en) 1991-05-08
JPS59501951A (ja) 1984-11-22
ES8606399A1 (es) 1986-04-16
IL69897A0 (en) 1984-01-31
EP0105759A3 (en) 1985-05-08
NO842148L (no) 1984-05-30
KR850003417A (ko) 1985-06-17
MX7701E (es) 1990-09-20
US4563352A (en) 1986-01-07
YU200083A (en) 1986-06-30
IE832333L (en) 1984-04-04
KR900006712B1 (ko) 1990-09-17
PT77453A (en) 1983-11-01
NO167866B (no) 1991-09-09
GR79698B (sv) 1984-10-31
PT77453B (en) 1986-02-26
DE3369144D1 (en) 1987-02-19
WO1984001379A1 (en) 1984-04-12
CA1243016A (en) 1988-10-11
DK269284A (da) 1984-05-30
NO167866C (no) 1991-12-18
RO91186B (ro) 1987-07-31
PH20333A (en) 1986-12-02

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MA Patent expired

Owner name: THE SALK INSTITUTE FOR BIOLOGICAL