FI80709B - Foerfarande foer framstaellning av terapeutiskt anvaendbara salter av 5'-metyltio-5'deoxiadenocin med laong alkylkedja innehaollande sulfonsyror. - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara salter av 5'-metyltio-5'deoxiadenocin med laong alkylkedja innehaollande sulfonsyror. Download PDFInfo
- Publication number
- FI80709B FI80709B FI854800A FI854800A FI80709B FI 80709 B FI80709 B FI 80709B FI 854800 A FI854800 A FI 854800A FI 854800 A FI854800 A FI 854800A FI 80709 B FI80709 B FI 80709B
- Authority
- FI
- Finland
- Prior art keywords
- mta
- liters
- sulfonate
- distilled water
- dissolved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Claims (5)
1. Förfarande för framställning av terapeutiskt användbara salter mellan 5'-metyltio-5'-deoxiadenosin och 5 en läng alkylkedja innehällande sulfonsyror med den all-männa formeln (I) Θ nh3
10 CX x> N ^ch2_s_ch3 . rso® (,) w
15 OH OH väri R är en 6 - 18 kolatomer innehällande alkylgrupp med rak eller förgrenad kedja, kännetecknat där-av, att natriumsaltet av den valda sulfonsyran upplöses i destillerat vatten, MTA upplöses i destillerat vatten, 20 vilket tillsatts koncentrerad H2 S04, dessa tvä lösningar omsätts med varandra för att utfälla MTA-sulfonatet och det sist nämnda saltet tillvaratages i synnerligen ren form.
2. Förfarande enligt patentkravet 1, k ä n n e -25 tecknat därav, att natriumsaltet av sulfonsyran upplöses vid en temperatur av 35 - 60° C och att per en mol sait användes följande mängder vatten: 3 liter för hexan-sulfonat, 10 liter för oktansulfonat, 15 liter för dekan-sulfonat, 20 liter för dodekansulfonat, 30 liter för tet-30 radekansulfonat, 40 liter för hexadekansulfonat och 50 liter för oktadekansulfonat.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att MTA upplöses vid en temperatur av 40 - 60° C i en blandning av destillerat vatten och
35 H2 S04, vilken blandning innehäller 2 liter vatten och 15 80709 0,5 mol H2S04 per mol MTA.
4. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att reaktlonen utförs genom att sätta den tili 15 - 25° C kylda MTA-lösningen tili lösning-5 en av sulfonsyrans natriumsalt vid en temperatur av 35-60°C under samtidig omrörning, varvid bäda reagenser an-vänds i ekvimolära mängder, och att blandningen hälls under omrörning och avkyld tili 15 - 25° C under 0,5 - 20 timmar. 10
5. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att MTA tillvaratages genom filt-rering under tryck eller genom centrifugering, varefter MTA tvättas med destiHerat vatten och torkas under vakuum vid en temperatur av 40°C.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2393184 | 1984-12-06 | ||
| IT23931/84A IT1177373B (it) | 1984-12-06 | 1984-12-06 | Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI854800A0 FI854800A0 (fi) | 1985-12-04 |
| FI854800A FI854800A (fi) | 1986-06-07 |
| FI80709B true FI80709B (fi) | 1990-03-30 |
| FI80709C FI80709C (sv) | 1990-07-10 |
Family
ID=11210968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI854800A FI80709C (sv) | 1984-12-06 | 1985-12-04 | Förfarande för framställning av terapeutiskt användbara salter av 5'-m etyltio-5'-deoxiadenocin med lång alkylkedja innehållande sulfonsyror |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4973678A (sv) |
| EP (1) | EP0184248B1 (sv) |
| JP (1) | JPS61140599A (sv) |
| KR (1) | KR900006238B1 (sv) |
| AR (1) | AR241708A1 (sv) |
| AT (1) | ATE45163T1 (sv) |
| AU (1) | AU574247B2 (sv) |
| CA (1) | CA1270482A (sv) |
| DE (1) | DE3571989D1 (sv) |
| DK (1) | DK164323C (sv) |
| ES (1) | ES8606384A1 (sv) |
| FI (1) | FI80709C (sv) |
| IT (1) | IT1177373B (sv) |
| MX (1) | MX5721A (sv) |
| NO (1) | NO162861C (sv) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
| JPS61171423A (ja) * | 1985-01-24 | 1986-08-02 | Advance Res & Dev Co Ltd | 抗う蝕乃至抗歯周症剤 |
| IT1188178B (it) * | 1985-07-05 | 1988-01-07 | Bioresearch Spa | Sali della citidin-difospocolina particolarmente idonei per uso orale |
| IT1251160B (it) * | 1991-08-07 | 1995-05-04 | Bioresearch Spa | Impiego di composti adenosinici nel trattamento dell'ischemia |
| EP1190277B1 (en) | 1999-06-10 | 2009-10-07 | AlliedSignal Inc. | Semiconductor having spin-on-glass anti-reflective coatings for photolithography |
| US6824879B2 (en) | 1999-06-10 | 2004-11-30 | Honeywell International Inc. | Spin-on-glass anti-reflective coatings for photolithography |
| KR20040066124A (ko) | 2001-11-15 | 2004-07-23 | 허니웰 인터내셔널 인코포레이티드 | 포토리소그라피용 스핀온 반사 방지 피막 |
| US8053159B2 (en) | 2003-11-18 | 2011-11-08 | Honeywell International Inc. | Antireflective coatings for via fill and photolithography applications and methods of preparation thereof |
| US8642246B2 (en) | 2007-02-26 | 2014-02-04 | Honeywell International Inc. | Compositions, coatings and films for tri-layer patterning applications and methods of preparation thereof |
| US8557877B2 (en) | 2009-06-10 | 2013-10-15 | Honeywell International Inc. | Anti-reflective coatings for optically transparent substrates |
| US8864898B2 (en) | 2011-05-31 | 2014-10-21 | Honeywell International Inc. | Coating formulations for optical elements |
| JP6803842B2 (ja) | 2015-04-13 | 2020-12-23 | ハネウェル・インターナショナル・インコーポレーテッドＨｏｎｅｙｗｅｌｌ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃ． | オプトエレクトロニクス用途のためのポリシロキサン製剤及びコーティング |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR221676A1 (es) * | 1974-07-12 | 1981-03-13 | Bioresearch Sas | Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico |
| IT1193529B (it) * | 1980-04-22 | 1988-07-08 | Bioresearch Srl | Derivati adenosinici ad attivita' antinfiammatoria ed analgesica e composizioni terapeutiche che li contengono come principio attivo |
| IT1137640B (it) * | 1981-08-24 | 1986-09-10 | Bioresearch Srl | Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo |
| IT1173992B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale |
| IT1173990B (it) * | 1984-05-16 | 1987-06-24 | Bioresearch Spa | Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale |
-
1984
- 1984-12-06 IT IT23931/84A patent/IT1177373B/it active
-
1985
- 1985-11-14 DE DE8585201878T patent/DE3571989D1/de not_active Expired
- 1985-11-14 AT AT85201878T patent/ATE45163T1/de not_active IP Right Cessation
- 1985-11-14 EP EP85201878A patent/EP0184248B1/en not_active Expired
- 1985-11-18 US US06/798,847 patent/US4973678A/en not_active Expired - Fee Related
- 1985-11-28 CA CA000496487A patent/CA1270482A/en not_active Expired - Fee Related
- 1985-12-04 FI FI854800A patent/FI80709C/sv not_active IP Right Cessation
- 1985-12-04 AR AR85302465A patent/AR241708A1/es active
- 1985-12-05 KR KR1019850009145A patent/KR900006238B1/ko not_active IP Right Cessation
- 1985-12-05 DK DK562885A patent/DK164323C/da not_active IP Right Cessation
- 1985-12-05 NO NO854905A patent/NO162861C/no unknown
- 1985-12-05 ES ES549598A patent/ES8606384A1/es not_active Expired
- 1985-12-05 AU AU50822/85A patent/AU574247B2/en not_active Ceased
- 1985-12-06 MX MX572185A patent/MX5721A/es unknown
- 1985-12-06 JP JP60273534A patent/JPS61140599A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FI854800A0 (fi) | 1985-12-04 |
| FI854800A (fi) | 1986-06-07 |
| DK562885D0 (da) | 1985-12-05 |
| AU5082285A (en) | 1986-07-10 |
| EP0184248A3 (en) | 1987-05-06 |
| ES549598A0 (es) | 1986-04-16 |
| US4973678A (en) | 1990-11-27 |
| FI80709C (sv) | 1990-07-10 |
| KR860004910A (ko) | 1986-07-16 |
| AR241708A1 (es) | 1992-11-30 |
| DK164323B (da) | 1992-06-09 |
| JPH0160478B2 (sv) | 1989-12-22 |
| ES8606384A1 (es) | 1986-04-16 |
| DE3571989D1 (en) | 1989-09-07 |
| IT1177373B (it) | 1987-08-26 |
| JPS61140599A (ja) | 1986-06-27 |
| CA1270482A (en) | 1990-06-19 |
| NO854905L (no) | 1986-06-09 |
| MX5721A (es) | 1993-12-01 |
| EP0184248A2 (en) | 1986-06-11 |
| IT8423931A0 (it) | 1984-12-06 |
| EP0184248B1 (en) | 1989-08-02 |
| KR900006238B1 (ko) | 1990-08-27 |
| ATE45163T1 (de) | 1989-08-15 |
| AU574247B2 (en) | 1988-06-30 |
| NO162861B (no) | 1989-11-20 |
| NO162861C (no) | 1990-02-28 |
| DK562885A (da) | 1986-06-07 |
| DK164323C (da) | 1992-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: BIORESEARCH S.P.A. |