ES8706711A1 - Procedimiento para la fabricacion de nuevos derivados gan- gliosidos - Google Patents
Procedimiento para la fabricacion de nuevos derivados gan- gliosidosInfo
- Publication number
- ES8706711A1 ES8706711A1 ES544574A ES544574A ES8706711A1 ES 8706711 A1 ES8706711 A1 ES 8706711A1 ES 544574 A ES544574 A ES 544574A ES 544574 A ES544574 A ES 544574A ES 8706711 A1 ES8706711 A1 ES 8706711A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- ganglioside derivatives
- new ganglioside
- new
- gangliosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002270 gangliosides Chemical class 0.000 title abstract 3
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
METODO PARA PREPARAR NUEVOS DERIVADOS GANGLIOSIDOS. CONSISTE EN: A) TRATAR UN GANGLIOSIDO, MEZCLA DE GANGLIOSIDOS O UN DERIVADO PERACILADO DE LOS MISMOS DE MANERA QUE SUS GRUPOS HIDROXILO CON PERACILADOS CON UN COMBINADOR DE IONES DE TIPO ACIDO, CON LO QUE LOS GRUPOS CARBOXILO SE CONVIERTEN EN UNA SAL PARA PRODUCIR UNA SAL METALICA; Y B) MEZCLAR LA SAL METALICA PRODUCIDA DE ESTE MODO CON UN DIAZOALCANO EN UN ALCOHOL CORRESPONDIENTE, CONTENIENDO DICHO DIAZOALCANO Y EL ALCOHOL UN HIDROCARBURO O GRUPO HETEROCICLICO QUE SE DESEA UNIR CON EL ENLACE ESTER A LOS GRUPOS CARBOXILICOS DE LOS RESIDUOS DE ACIDO ASIALICO DE DICHOS GANGLIOSIDOS. TIENE APLICACIONES TERAPEUTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48492/84A IT1199116B (it) | 1984-07-03 | 1984-07-03 | Derivati di gangliosidi |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8706711A1 true ES8706711A1 (es) | 1987-07-01 |
ES544574A0 ES544574A0 (es) | 1987-07-01 |
Family
ID=11266890
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544574A Expired ES8706711A1 (es) | 1984-07-03 | 1985-06-26 | Procedimiento para la fabricacion de nuevos derivados gan- gliosidos |
ES552826A Expired ES8802055A1 (es) | 1984-07-03 | 1986-02-28 | Procedimiento para la fabricacion de derivados gangliosidos |
ES557807A Expired ES8801925A1 (es) | 1984-07-03 | 1987-12-16 | Procedimiento para la fabricacion de derivados gangliosidos |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552826A Expired ES8802055A1 (es) | 1984-07-03 | 1986-02-28 | Procedimiento para la fabricacion de derivados gangliosidos |
ES557807A Expired ES8801925A1 (es) | 1984-07-03 | 1987-12-16 | Procedimiento para la fabricacion de derivados gangliosidos |
Country Status (31)
Country | Link |
---|---|
US (2) | US4713374A (es) |
EP (1) | EP0167449B1 (es) |
JP (1) | JPS6163691A (es) |
KR (1) | KR880001232B1 (es) |
CN (2) | CN1021574C (es) |
AR (1) | AR242219A1 (es) |
AT (1) | ATE58739T1 (es) |
AU (1) | AU578706B2 (es) |
BE (1) | BE902750A (es) |
CA (1) | CA1263954A (es) |
CH (1) | CH670645A5 (es) |
DE (1) | DE3580710D1 (es) |
DK (2) | DK289885A (es) |
ES (3) | ES8706711A1 (es) |
FI (1) | FI84074C (es) |
FR (1) | FR2567131B1 (es) |
GR (1) | GR851573B (es) |
HU (2) | HUT38652A (es) |
IE (1) | IE59376B1 (es) |
IL (1) | IL75640A0 (es) |
IN (1) | IN164786B (es) |
IT (1) | IT1199116B (es) |
LU (1) | LU85972A1 (es) |
MX (1) | MX163384B (es) |
NO (1) | NO164545C (es) |
NZ (1) | NZ212540A (es) |
PH (1) | PH27021A (es) |
PL (2) | PL151829B1 (es) |
PT (1) | PT80724B (es) |
YU (1) | YU46603B (es) |
ZA (1) | ZA854807B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1199116B (it) * | 1984-07-03 | 1988-12-30 | Fidia Farmaceutici | Derivati di gangliosidi |
IT1177863B (it) * | 1984-07-03 | 1987-08-26 | Fidia Farmaceutici | Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche |
AU582758B2 (en) * | 1984-06-28 | 1989-04-13 | Mect Corporation | Sialic acid derivatives, galactose derivatives and method for producing the same |
JPS6168418A (ja) * | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
US4769362A (en) * | 1985-10-01 | 1988-09-06 | Trustees Of Boston University | Increased vascular perfusion following administration of lipids |
FR2598434B1 (fr) * | 1986-05-12 | 1988-09-16 | Pf Medicament | Nouveaux immunomodulateurs obtenus par hemisynthese a partir d'un polysaccharide bacterien isole d'une souche mutante non capsulee de klebsiella pneumoniae |
EP0255717A3 (en) * | 1986-08-06 | 1990-12-05 | Mect Corporation | Ganglioside related compounds and method of producing the same |
JPS6368526A (ja) * | 1986-09-11 | 1988-03-28 | Mect Corp | シアリルグリセライドからなる神経障害疾患治療剤 |
NZ222192A (en) * | 1986-10-20 | 1991-03-26 | Kanto Ishi Pharma Co Ltd | Glycolipid containing n-glycolylneuraminic acid, and preparation thereof |
FR2614306B1 (fr) * | 1987-04-22 | 1989-07-28 | Pf Medicament | Nouveau derive de d.25, procede de preparation, utilisation a titre d'agent immunostimulant et compositions pharmaceutiques le contenant. |
JP2517293B2 (ja) * | 1987-06-25 | 1996-07-24 | メクト株式会社 | 細胞、組織修復剤 |
IT1212041B (it) * | 1987-11-02 | 1989-11-08 | Fidia Farmaceutici | Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche |
US5169636A (en) * | 1988-03-17 | 1992-12-08 | Nippon Fine Chemical Co., Ltd. | Liposomes |
IT1224513B (it) * | 1988-07-19 | 1990-10-04 | Fidia Farmaceutici | Uso terapeutico del derivato estere isopropilico del monosialogangliosi de in patologie ad interessamento nervoso con componente infiammatoria |
DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
US6407072B1 (en) * | 1988-12-02 | 2002-06-18 | Fidia S.P.A. | Lysoganglioside derivatives |
IT1232175B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Analoghi semisintetici di gangliosidi |
IT1232176B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Derivati di-lisogangliosidi |
IN172427B (es) * | 1989-11-14 | 1993-07-24 | Fidia Spa | |
IT1238346B (it) * | 1989-11-14 | 1993-07-13 | Gangliosidi modificati e loro derivati funzionali. | |
DK238190D0 (da) * | 1990-10-03 | 1990-10-03 | Lundbeck & Co As H | Depotderivater |
IT1251540B (it) * | 1991-05-31 | 1995-05-17 | Fidia Spa | Uso di un derivato gangliosidico. |
WO1993002686A1 (en) * | 1991-07-31 | 1993-02-18 | The Regents Of The University Of California | Gangliosides with immunosuppressive ceramide moieties |
IT1253832B (it) * | 1991-08-01 | 1995-08-29 | Fidia Spa | Derivati di gangliosidi |
AU674293B2 (en) * | 1991-11-11 | 1996-12-19 | Hans Goran Magnusson | Ganglioside analogs |
IT1254706B (it) | 1991-12-23 | 1995-10-09 | Fidia Spa | Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale |
DE4204907A1 (de) * | 1992-02-14 | 1993-08-19 | Reutter Werner | Neuartige glykokonjugate mit n-substituierten neuraminsaeuren als mittel zur stimulierung des immunsystems |
IT1254280B (it) * | 1992-03-13 | 1995-09-14 | Fidia Spa | Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson |
WO1995007102A1 (en) * | 1993-09-09 | 1995-03-16 | Duke University | A method of promoting cellular function |
US5567684A (en) * | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
IT1302530B1 (it) * | 1998-12-16 | 2000-09-05 | Fidia Spa In Amministrazione S | Processo di preparazione del ganglioside gm3 e dei suoi lisoderivati apartire dal ganglioside gm1. |
JP2005500058A (ja) | 2001-08-17 | 2005-01-06 | ネオーズ テクノロジーズ, インコーポレイテッド | シアリル化したオリゴサッカリドの化学的酵素的合成 |
JP2005527467A (ja) | 2001-08-29 | 2005-09-15 | ネオーズ テクノロジーズ, インコーポレイテッド | 新規な合成ガングリオシド誘導体およびその組成物 |
MXPA05009480A (es) | 2003-03-06 | 2006-02-22 | Neose Technologies Inc | Metodos y composiciones para la sintesis enzimatica de gangliosidos. |
JP2007003173A (ja) * | 2005-05-26 | 2007-01-11 | Matsushita Electric Ind Co Ltd | 冷蔵庫 |
US7943750B2 (en) | 2007-06-18 | 2011-05-17 | Laboratoire Medidom S.A. | Process for obtaining pure monosialoganglioside GM1 for medical use |
CA2692417C (en) | 2007-07-03 | 2017-03-21 | Children's Hospital & Research Center At Oakland | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting |
CA2690440A1 (en) * | 2007-07-03 | 2009-01-08 | Children's Hospital & Research Center At Oakland | Oligosialic acid derivatives, methods of manufacture, and immunological uses |
JP5597130B2 (ja) * | 2007-07-03 | 2014-10-01 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | ポリシアル酸脱n−アセチラーゼの阻害剤及びその使用方法 |
EP3175857A1 (en) | 2009-03-25 | 2017-06-07 | Seneb Biosciences Inc. | Glycolipids as treatment for disease |
RU2567661C2 (ru) | 2009-09-01 | 2015-11-10 | Лз Терапьютикс, Инк. | Способы выделения и очистки ганглиозидов |
US9556467B2 (en) | 2012-01-20 | 2017-01-31 | Garnet Bio Therapeutics, Inc. | Methods of ganglioside production |
CA2905700A1 (en) * | 2013-03-15 | 2014-09-18 | Garnet Biotherapeutics, Inc. | Ganglioside compositions |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4098995A (en) * | 1976-07-12 | 1978-07-04 | American Cyanamid Company | Polygalactosido-sucrose poly(h-)sulfate salts |
FR2478104B1 (fr) * | 1980-03-17 | 1986-08-08 | Merieux Inst | Nouveaux derives de gangliosides, leur preparation et leur application |
US4435389A (en) * | 1980-07-07 | 1984-03-06 | Kabushiki Kaisha Yakult Honsha | Composition for promoting growth of bifidobacteria |
DE3071815D1 (en) * | 1980-08-05 | 1986-12-11 | Debat Lab | Use of glycosylglucanes in the treatment of infections of the large intestines |
US4476119A (en) * | 1981-08-04 | 1984-10-09 | Fidia S.P.A. | Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions |
US4469795A (en) * | 1981-08-26 | 1984-09-04 | Edward Ginns | Radioassay for monosialoglycosphingolipid (GM1) ganglioside concentration |
NL8104293A (nl) * | 1981-09-17 | 1983-04-18 | Ihc Holland Nv | Werkwijze voor het opzuigen van grond of slib met een sleepzuiger alsmede sleepzuiger voor het toepassen van de werkwijze. |
CH658458A5 (fr) * | 1981-12-17 | 1986-11-14 | Lucchini Lab Sa | Procede pour l'obtention du lacto-n-norhexaosyl ceramide. |
EP0146810A3 (de) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
IT1199116B (it) * | 1984-07-03 | 1988-12-30 | Fidia Farmaceutici | Derivati di gangliosidi |
-
1984
- 1984-07-03 IT IT48492/84A patent/IT1199116B/it active
-
1985
- 1985-06-25 NZ NZ212540A patent/NZ212540A/xx unknown
- 1985-06-25 FR FR858509634A patent/FR2567131B1/fr not_active Expired - Fee Related
- 1985-06-25 MX MX85205775A patent/MX163384B/es unknown
- 1985-06-26 ZA ZA854807A patent/ZA854807B/xx unknown
- 1985-06-26 IE IE160885A patent/IE59376B1/en not_active IP Right Cessation
- 1985-06-26 LU LU85972A patent/LU85972A1/fr unknown
- 1985-06-26 GR GR851573A patent/GR851573B/el unknown
- 1985-06-26 IN IN477/CAL/85A patent/IN164786B/en unknown
- 1985-06-26 US US06/749,092 patent/US4713374A/en not_active Expired - Lifetime
- 1985-06-26 PH PH32459A patent/PH27021A/en unknown
- 1985-06-26 YU YU107285A patent/YU46603B/sh unknown
- 1985-06-26 ES ES544574A patent/ES8706711A1/es not_active Expired
- 1985-06-26 HU HU852498A patent/HUT38652A/hu not_active IP Right Cessation
- 1985-06-26 DK DK289885A patent/DK289885A/da not_active Application Discontinuation
- 1985-06-26 NO NO852565A patent/NO164545C/no unknown
- 1985-06-26 IL IL75640A patent/IL75640A0/xx unknown
- 1985-06-26 HU HU852498D patent/HU199860B/hu not_active IP Right Cessation
- 1985-06-26 DE DE8585401291T patent/DE3580710D1/de not_active Expired - Lifetime
- 1985-06-26 CA CA000485372A patent/CA1263954A/en not_active Expired
- 1985-06-26 FI FI852515A patent/FI84074C/fi not_active IP Right Cessation
- 1985-06-26 AU AU44208/85A patent/AU578706B2/en not_active Ceased
- 1985-06-26 AT AT85401291T patent/ATE58739T1/de not_active IP Right Cessation
- 1985-06-26 EP EP85401291A patent/EP0167449B1/en not_active Expired - Lifetime
- 1985-06-27 PT PT80724A patent/PT80724B/pt not_active IP Right Cessation
- 1985-06-27 BE BE1/11279A patent/BE902750A/fr not_active IP Right Cessation
- 1985-06-27 JP JP60142362A patent/JPS6163691A/ja active Pending
- 1985-06-27 PL PL1985261619A patent/PL151829B1/pl unknown
- 1985-06-27 AR AR85300832A patent/AR242219A1/es active
- 1985-06-27 CN CN91102374A patent/CN1021574C/zh not_active Expired - Fee Related
- 1985-06-27 KR KR1019850004587A patent/KR880001232B1/ko not_active IP Right Cessation
- 1985-06-27 CN CN85104937A patent/CN1021333C/zh not_active Expired - Fee Related
- 1985-06-27 PL PL1985254207A patent/PL151289B1/pl unknown
- 1985-07-02 CH CH2837/85A patent/CH670645A5/fr not_active IP Right Cessation
-
1986
- 1986-02-28 ES ES552826A patent/ES8802055A1/es not_active Expired
-
1987
- 1987-09-11 US US07/095,223 patent/US4849413A/en not_active Expired - Lifetime
- 1987-12-16 ES ES557807A patent/ES8801925A1/es not_active Expired
-
1992
- 1992-06-12 DK DK92785A patent/DK78592D0/da not_active Application Discontinuation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970612 |