ES8604957A1 - Procedimiento para la preparacion del (+n-) 14,15-dihidro- (3b,14x,16x)-20,21-dinoreburnamenin-14-ol - Google Patents
Procedimiento para la preparacion del (+n-) 14,15-dihidro- (3b,14x,16x)-20,21-dinoreburnamenin-14-olInfo
- Publication number
- ES8604957A1 ES8604957A1 ES549399A ES549399A ES8604957A1 ES 8604957 A1 ES8604957 A1 ES 8604957A1 ES 549399 A ES549399 A ES 549399A ES 549399 A ES549399 A ES 549399A ES 8604957 A1 ES8604957 A1 ES 8604957A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- reaction
- dihydro
- dinoreburunamenine
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DEL(B/C) 14,15-DIHIDRO-(3B,14A,16A)-20,21-DINOREBURNAMENIN-14-OL, DE FORMULA (I). CONSISTE EN LA REACCION DE LA (B/C) (3B,16A)-EBURNAMENINA CON PEROXIDO DE HIDROGENO, EN REACCION DE OXIDACION-REDUCCION EN FASE HETEROGENEA CATALIZADA POR UNA SAL REDUCTORA DE AMONIO CUATERNARIO, TAL COMO BOROHIDRURO DE TETRABUTILAMONIO, EN UNA MEZCLA DE DICLOROMETANO E HIDROXIDO SODICO EN AGUA AL 20%, EN PRESENCIA DE BROMURO DE ETILO, A LA TEMPERATURA DE 20JC; SEGUIDA DE HIDROLISIS SUAVE Y PURIFICACION DEL PRODUCTO OBTENIDO MEDIANTE CROMATOGRAFIA PREPARATIVA. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE INSUFICIENCIAS CEREBRALES.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES549399A ES8604957A1 (es) | 1985-11-28 | 1985-11-28 | Procedimiento para la preparacion del (+n-) 14,15-dihidro- (3b,14x,16x)-20,21-dinoreburnamenin-14-ol |
JP61283026A JPH0662617B2 (ja) | 1985-11-28 | 1986-11-26 | (+/−)14,15−ジヒドロ−(3β,14α,16α)−20,21−ジノルエブルナメニン−14−オ−ルの調製方法 |
FR868616623A FR2590572B1 (fr) | 1985-11-28 | 1986-11-28 | Procede pour la preparation du (+/-)14, 15-dihydro-(3 b, 14 a, 16 a)-20,21,dinoreburnamenine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES549399A ES8604957A1 (es) | 1985-11-28 | 1985-11-28 | Procedimiento para la preparacion del (+n-) 14,15-dihidro- (3b,14x,16x)-20,21-dinoreburnamenin-14-ol |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604957A1 true ES8604957A1 (es) | 1986-03-16 |
ES549399A0 ES549399A0 (es) | 1986-03-16 |
Family
ID=8490315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549399A Expired ES8604957A1 (es) | 1985-11-28 | 1985-11-28 | Procedimiento para la preparacion del (+n-) 14,15-dihidro- (3b,14x,16x)-20,21-dinoreburnamenin-14-ol |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPH0662617B2 (es) |
ES (1) | ES8604957A1 (es) |
FR (1) | FR2590572B1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2623503B1 (es) * | 1987-11-19 | 1991-04-05 | Roussel Uclaf | |
FR2623501B1 (fr) * | 1987-11-19 | 1990-03-16 | Roussel Uclaf | Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
FR2865650B1 (fr) * | 2004-01-30 | 2008-06-13 | Biocortech | Utilisation du 14,15 dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures et les desordres du cycle veille-sommeil |
FR2865649A1 (fr) * | 2004-01-30 | 2005-08-05 | Biocortech | Utilisation du 14,15-dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures |
-
1985
- 1985-11-28 ES ES549399A patent/ES8604957A1/es not_active Expired
-
1986
- 1986-11-26 JP JP61283026A patent/JPH0662617B2/ja not_active Expired - Lifetime
- 1986-11-28 FR FR868616623A patent/FR2590572B1/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES549399A0 (es) | 1986-03-16 |
FR2590572B1 (fr) | 1990-05-25 |
FR2590572A1 (fr) | 1987-05-29 |
JPS62145082A (ja) | 1987-06-29 |
JPH0662617B2 (ja) | 1994-08-17 |
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