ES2721280T3 - Nuevos inhibidores de la FYN quinasa - Google Patents
Nuevos inhibidores de la FYN quinasa Download PDFInfo
- Publication number
- ES2721280T3 ES2721280T3 ES15825936T ES15825936T ES2721280T3 ES 2721280 T3 ES2721280 T3 ES 2721280T3 ES 15825936 T ES15825936 T ES 15825936T ES 15825936 T ES15825936 T ES 15825936T ES 2721280 T3 ES2721280 T3 ES 2721280T3
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- ES
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- Prior art keywords
- cycloalkyl
- alkyl
- independently selected
- alkoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de Fórmula (I):**Fórmula** en la que: A se selecciona entre fenilo, anillo heterocíclico de 5-6 miembros que contiene uno o más heteroátomos seleccionados de N, S y O y cicloalquilo(C5-C7), donde dicho fenilo está opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halógeno, trifluorometilo, trifluorometoxi, alquilo (C1-C4), alcoxi (C1-C3), cicloalquilo (C3- C6), cicloalquiloxi (C3-C6), nitro, amino, hidroxilo, ciano, carboxamida, sulfonamida, metanosulfonilo, dicho anillo heterocíclico de 5-6 miembros es un heteroarilo de 5-6 miembros opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halógeno, trifluorometilo, trifluorometoxi, alquilo (C1- C4), alcoxi (C1-C3), cicloalquilo (C3-C6), cicloalquiloxi (C3-C6), nitro, amino, hidroxilo, ciano, carboxamida, sulfonamida, metansulfonilo o un anillo heterocíclico de 5 miembros opcionalmente sustituido con alquilo (C1-C3); dicho cicloalquilo (C5-C7) está opcionalmente sustituido independientemente con uno o dos alquilo (C1-C4); B se selecciona independientemente de -CONH-, -NHCO-, -SO2NH-, -NHCONH-; W es un grupo fenilo o heteroarilo que comprende uno o dos heteroátomos seleccionados de N, O y S, siendo dicho fenilo o dicho heteroarilo opcionalmente sustituido independientemente con uno o dos alquilo (C1-C4), alcoxi (C1-C3), cicloalquilo (C3-C6), cicloalquiloxi (C3-C6); R y R1 se seleccionan independientemente de un grupo que consiste en H, alquilo (C1-C3) y alcoxi (C1-C3); m es 2; n es 1; X es N; Y se selecciona independientemente entre H, CH3, CH2-OH, CN; G es un grup
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15159604.6A EP3070084A1 (en) | 2015-03-18 | 2015-03-18 | New fyn kinase inhibitors |
PCT/EP2015/081124 WO2016146220A1 (en) | 2015-03-18 | 2015-12-23 | New fyn kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2721280T3 true ES2721280T3 (es) | 2019-07-30 |
Family
ID=52779492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES15825936T Active ES2721280T3 (es) | 2015-03-18 | 2015-12-23 | Nuevos inhibidores de la FYN quinasa |
Country Status (7)
Country | Link |
---|---|
US (1) | US10125121B2 (es) |
EP (2) | EP3070084A1 (es) |
JP (1) | JP6467059B2 (es) |
CN (1) | CN107406428B (es) |
CA (1) | CA2979758C (es) |
ES (1) | ES2721280T3 (es) |
WO (1) | WO2016146220A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017212018A1 (en) * | 2016-06-10 | 2017-12-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
CN112469414A (zh) | 2018-05-25 | 2021-03-09 | 昂科库博疗法有限责任公司 | 作为新型候选抗癌药物的高效力tacc3抑制剂 |
CN112204025B (zh) | 2018-05-29 | 2022-05-31 | 瑟赛治疗公司 | 用于治疗疼痛的化合物,包含其的组合物以及使用其的方法 |
JP2022531453A (ja) | 2019-05-10 | 2022-07-06 | セルシィ セラピューティクス,インコーポレーテッド | チアゾリン抗痛覚過敏薬の製造方法及び多形体 |
WO2021115560A1 (en) * | 2019-12-09 | 2021-06-17 | Rottapharm Biotech S.R.L. | New fyn and vegfr2 kinase inhibitors |
CN111171064B (zh) * | 2020-01-09 | 2022-09-16 | 上海健康医学院 | 氮杂氟硼二吡咯类化合物及其制备方法和作为Fyn激酶抑制剂的应用 |
JP2024518711A (ja) * | 2021-04-12 | 2024-05-02 | エーツーエー ファーマシューティカルズ インコーポレーテッド | 癌を処置するための組成物及び方法 |
TW202400575A (zh) | 2022-03-24 | 2024-01-01 | 美商A2A製藥公司 | 治療癌症的組合物和方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03002294A (es) * | 2000-09-15 | 2005-09-08 | Vertex Pharma | Compuestos de pirazol utiles como inhibidores de proteina cinasa. |
WO2003078426A1 (en) * | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazine as inhibitors of protein kinases |
WO2007023382A2 (en) * | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
EP2170867A1 (en) * | 2007-06-15 | 2010-04-07 | Irm Llc | Protein kinase inhibitors and methods for using thereof |
-
2015
- 2015-03-18 EP EP15159604.6A patent/EP3070084A1/en not_active Withdrawn
- 2015-12-23 CA CA2979758A patent/CA2979758C/en active Active
- 2015-12-23 JP JP2017543827A patent/JP6467059B2/ja active Active
- 2015-12-23 EP EP15825936.6A patent/EP3271348B1/en active Active
- 2015-12-23 CN CN201580077482.3A patent/CN107406428B/zh active Active
- 2015-12-23 ES ES15825936T patent/ES2721280T3/es active Active
- 2015-12-23 WO PCT/EP2015/081124 patent/WO2016146220A1/en active Application Filing
- 2015-12-23 US US15/559,341 patent/US10125121B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN107406428B (zh) | 2021-06-04 |
WO2016146220A1 (en) | 2016-09-22 |
EP3271348B1 (en) | 2019-01-30 |
EP3070084A1 (en) | 2016-09-21 |
JP6467059B2 (ja) | 2019-02-06 |
JP2018507857A (ja) | 2018-03-22 |
US20180111919A1 (en) | 2018-04-26 |
US10125121B2 (en) | 2018-11-13 |
EP3271348A1 (en) | 2018-01-24 |
CN107406428A (zh) | 2017-11-28 |
CA2979758C (en) | 2018-12-04 |
CA2979758A1 (en) | 2016-09-22 |
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