ES2273447T3 - Plantas transgenicas resistentes a insectos y procedimientos para mejorar la actividad frente a insectos. - Google Patents
Plantas transgenicas resistentes a insectos y procedimientos para mejorar la actividad frente a insectos. Download PDFInfo
- Publication number
- ES2273447T3 ES2273447T3 ES98964762T ES98964762T ES2273447T3 ES 2273447 T3 ES2273447 T3 ES 2273447T3 ES 98964762 T ES98964762 T ES 98964762T ES 98964762 T ES98964762 T ES 98964762T ES 2273447 T3 ES2273447 T3 ES 2273447T3
- Authority
- ES
- Spain
- Prior art keywords
- replaced
- asparagine
- arginine
- valine
- proline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000238631 Hexapoda Species 0.000 title 2
- 238000000034 method Methods 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 6
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 6
- 235000009582 asparagine Nutrition 0.000 abstract 6
- 229960001230 asparagine Drugs 0.000 abstract 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 5
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 5
- 235000014393 valine Nutrition 0.000 abstract 5
- 239000004474 valine Substances 0.000 abstract 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 4
- 239000004473 Threonine Substances 0.000 abstract 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 4
- 235000005772 leucine Nutrition 0.000 abstract 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 3
- 235000004279 alanine Nutrition 0.000 abstract 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 229940024606 amino acid Drugs 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 241000193388 Bacillus thuringiensis Species 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Un polipéptido Cry3Bb de B. thuringiensis modificado que comprende de uno a cinco cambios de aminoácidos en la secuencia principal del polipéptido Cry3Bb de la SEC DE ID Nº: 98, en la que dichos cambios de aminoácidos se seleccionan entre: Asp103 se sustituye por ácido glutámico; Thr154 se sustituye por glicina o fenilalanina; Pro155 se sustituye por histidina; Leu156 se sustituye por histidina; Leu158 se sustituye por arginina; Ser160 se sustituye por asparagina; Lys161 se sustituye por prolina; Arg162 se sustituye por histidina; Asp165 se sustituye por glicina; Lys189 se sustituye por glicina; Ser223 se sustituye por prolina; Tyr230 se sustituye por leucina o serina; His231 se sustituye por arginina, asparagina, serina o treonina; Thr241 se sustituye por serina; Tyr287 se sustituye por fenilalanina; Asp288 se sustituye por asparagina; Ile289 se sustituye por treonina o valina; Arg290 se sustituye por asparagina, leucina o valina; Leu291 se sustituye por arginina; Tyr292 se sustituye por fenilalanina; Ser293 se sustituye por arginina o prolina; Phe305 se sustituye por serina; Ser311 se sustituye por alanina, isoleucina, leucina, o treonina; Leu312 se sustituye por prolina o valina; Asn313 se sustituye por arginina, histidina, treonina o valina; Thr314 se sustituye por asparagina; Leu315 se sustituye por prolina; Gln316 se sustituye por ácido aspártico, leucina, metionina, o triptófano; Glu317 se sustituye por alanina, asparagina, lisina o valina; Tyr318 se sustituye por cisteína; Gln348 se sustituye por arginina; Val365 se sustituye por alanina; y Ala104 se suprime.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/993,170 US6063597A (en) | 1997-12-18 | 1997-12-18 | Polypeptide compositions toxic to coleopteran insects |
US08/996,441 US6023013A (en) | 1997-12-18 | 1997-12-18 | Insect-resistant transgenic plants |
US08/993,722 US6060594A (en) | 1997-12-18 | 1997-12-18 | Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins |
US08/993,775 US6077824A (en) | 1997-12-18 | 1997-12-18 | Methods for improving the activity of δ-endotoxins against insect pests |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2273447T3 true ES2273447T3 (es) | 2007-05-01 |
Family
ID=27506051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98964762T Expired - Lifetime ES2273447T3 (es) | 1997-12-18 | 1998-12-17 | Plantas transgenicas resistentes a insectos y procedimientos para mejorar la actividad frente a insectos. |
Country Status (13)
Country | Link |
---|---|
EP (3) | EP1801220B1 (es) |
CN (1) | CN100340666C (es) |
AR (3) | AR014144A1 (es) |
AT (3) | ATE544857T1 (es) |
AU (1) | AU2001399A (es) |
BR (1) | BR9814294B1 (es) |
CA (1) | CA2314429C (es) |
CY (1) | CY1106323T1 (es) |
DE (1) | DE69835538T2 (es) |
DK (1) | DK1040192T3 (es) |
ES (1) | ES2273447T3 (es) |
PT (1) | PT1040192E (es) |
WO (1) | WO1999031248A1 (es) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6060594A (en) | 1997-12-18 | 2000-05-09 | Ecogen, Inc. | Nucleic acid segments encoding modified bacillus thuringiensis coleopteran-toxic crystal proteins |
DE69943375D1 (de) | 1998-08-19 | 2011-06-01 | Monsanto Technology Llc | Pflanzliche expressionsvektoren |
US6501009B1 (en) | 1999-08-19 | 2002-12-31 | Monsanto Technology Llc | Expression of Cry3B insecticidal protein in plants |
CA2394984C (en) | 1999-12-16 | 2008-11-18 | Monsanto Technology Llc | Novel plant expression constructs |
US7214788B2 (en) | 2000-09-12 | 2007-05-08 | Monsanto Technology Llc | Insect inhibitory Bacillus thuringiensis proteins, fusions, and methods of use therefor |
US9816104B2 (en) | 2000-10-06 | 2017-11-14 | Monsanto Technology Llc | Compositions and methods for deploying a transgenic refuge as a seed blend |
US6586365B2 (en) | 2000-10-06 | 2003-07-01 | Monsanto Technology, Llc | Method for reducing pest damage to corn by treating transgenic corn seeds with clothianidin pesticide |
US6593273B2 (en) | 2000-10-06 | 2003-07-15 | Monsanto Technology Llc | Method for reducing pest damage to corn by treating transgenic corn seeds with pesticide |
US8080496B2 (en) * | 2000-10-06 | 2011-12-20 | Syngenta Crop Protection, Inc. | Method for reducing pest damage to corn by treating transgenic corn seeds with thiamethoxam pesticide |
FR2822157B1 (fr) * | 2001-03-19 | 2003-10-31 | Aventis Cropscience Sa | Toxine insecticide de bacillus thuringiensis modifiee sensible a la pepsine |
EP2272965A3 (en) | 2001-07-06 | 2011-01-19 | Monsanto Technology LLC | Methods for enhancing segregation of transgenes in plants and compositions thereof |
US7230167B2 (en) | 2001-08-31 | 2007-06-12 | Syngenta Participations Ag | Modified Cry3A toxins and nucleic acid sequences coding therefor |
US20040091505A1 (en) | 2002-06-26 | 2004-05-13 | E.I Du Pont De Nemours And Company | Genes encoding proteins with pesticidal activity |
US7462760B2 (en) | 2002-06-26 | 2008-12-09 | Pioneer Hi-Bred International, Inc. | Genes encoding plant protease-resistant pesticidal proteins and method of their use |
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US7524810B1 (en) | 2003-10-03 | 2009-04-28 | Dow Agrosciences Llc | Modified Cry34 proteins |
US7309785B1 (en) | 2003-10-03 | 2007-12-18 | Dow Agrosciences Llc | Modified chimeric Cry35 proteins |
PL1708560T3 (pl) | 2003-12-15 | 2015-10-30 | Monsanto Technology Llc | Roślina kukurydzy MON88017 oraz kompozycje i sposoby ich wykrywania |
ES2596317T3 (es) | 2004-03-25 | 2017-01-05 | Syngenta Participations Ag. | Evento de maíz MIR604 |
JP2010506597A (ja) | 2006-10-18 | 2010-03-04 | セミニス・ベジタブル・シーズ・インコーポレイテツド | 増加したリコピン含有量を有するニンジン |
US10036036B1 (en) * | 2007-03-15 | 2018-07-31 | Monsanto Technology Llc | Compositions and methods for deploying a transgenic refuge as a seed blend |
US8309516B2 (en) | 2007-03-28 | 2012-11-13 | Syngenta Participations Ag | Insecticidal proteins |
US9522937B2 (en) | 2007-03-28 | 2016-12-20 | Syngenta Participations Ag | Insecticidal proteins |
HUE032178T2 (en) * | 2009-02-05 | 2017-09-28 | Athenix Corp | Variable Axmi-Rl delta-endotoxin genes and methods for their use |
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-
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- 1998-12-17 DK DK98964762T patent/DK1040192T3/da active
- 1998-12-17 AU AU20013/99A patent/AU2001399A/en not_active Abandoned
- 1998-12-17 EP EP06118582A patent/EP1801220B1/en not_active Expired - Lifetime
- 1998-12-17 BR BRPI9814294-1A patent/BR9814294B1/pt not_active IP Right Cessation
- 1998-12-17 PT PT98964762T patent/PT1040192E/pt unknown
- 1998-12-17 CA CA002314429A patent/CA2314429C/en not_active Expired - Lifetime
- 1998-12-17 AT AT06118582T patent/ATE544857T1/de active
- 1998-12-17 AT AT98964762T patent/ATE335822T1/de active
- 1998-12-17 AT AT06118584T patent/ATE555123T1/de active
- 1998-12-17 CN CNB988137135A patent/CN100340666C/zh not_active Expired - Lifetime
- 1998-12-17 EP EP06118584A patent/EP1749834B1/en not_active Expired - Lifetime
- 1998-12-17 ES ES98964762T patent/ES2273447T3/es not_active Expired - Lifetime
- 1998-12-17 DE DE69835538T patent/DE69835538T2/de not_active Expired - Lifetime
- 1998-12-17 EP EP98964762A patent/EP1040192B1/en not_active Expired - Lifetime
- 1998-12-17 WO PCT/US1998/026852 patent/WO1999031248A1/en active IP Right Grant
- 1998-12-18 AR ARP980106508A patent/AR014144A1/es active IP Right Grant
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2000
- 2000-04-24 AR ARP000101927A patent/AR023762A2/es unknown
-
2006
- 2006-11-08 CY CY20061101610T patent/CY1106323T1/el unknown
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AR064767A2 (es) | 2009-04-22 |
AR023762A2 (es) | 2002-09-04 |
EP1040192A1 (en) | 2000-10-04 |
DE69835538D1 (de) | 2006-09-21 |
BR9814294A (pt) | 2001-10-23 |
EP1801220A2 (en) | 2007-06-27 |
ATE555123T1 (de) | 2012-05-15 |
EP1801220A3 (en) | 2007-08-22 |
EP1040192B1 (en) | 2006-08-09 |
DK1040192T3 (da) | 2006-12-18 |
EP1749834B1 (en) | 2012-04-25 |
ATE544857T1 (de) | 2012-02-15 |
CA2314429C (en) | 2010-03-02 |
DE69835538T2 (de) | 2008-01-03 |
WO1999031248A9 (en) | 1999-09-16 |
CN1286728A (zh) | 2001-03-07 |
BR9814294B1 (pt) | 2011-10-18 |
CY1106323T1 (el) | 2011-10-12 |
EP1749834A1 (en) | 2007-02-07 |
WO1999031248A1 (en) | 1999-06-24 |
CA2314429A1 (en) | 1999-06-24 |
PT1040192E (pt) | 2006-12-29 |
ATE335822T1 (de) | 2006-09-15 |
AR014144A1 (es) | 2001-02-07 |
EP1801220B1 (en) | 2012-02-08 |
AU2001399A (en) | 1999-07-05 |
CN100340666C (zh) | 2007-10-03 |
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