ES2195543T3 - Derivados de 5'-deoxicitidina. - Google Patents

Derivados de 5'-deoxicitidina.

Info

Publication number
ES2195543T3
ES2195543T3 ES99907492T ES99907492T ES2195543T3 ES 2195543 T3 ES2195543 T3 ES 2195543T3 ES 99907492 T ES99907492 T ES 99907492T ES 99907492 T ES99907492 T ES 99907492T ES 2195543 T3 ES2195543 T3 ES 2195543T3
Authority
ES
Spain
Prior art keywords
lower alkyl
alkyl
cycloalkyl
groups
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99907492T
Other languages
English (en)
Inventor
Kazuo Hattori
Tohru Ishikawa
Hideo Ishitsuka
Yasunori Kohchi
Nobuhiro Oikawa
Nobuo Shimma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2195543T3 publication Critical patent/ES2195543T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto representado por la fórmula general (I) en el que R1 es cada uno independientemente hidrógeno o un grupo fácilmente hidrolizable en condiciones fisiológicas; R2 es - (CH2)n - cicloalquilo [en donde cicloalquilo consiste en de 3 a 5 átomos de carbono, n es un entero de 0 a 4], heteroaril - (alquilo - inferior), (alcoxi - inferior) - (alquilo - inferior), ariloxi - (alquilo - inferior), aralquiloxi - (alquilo - inferior), (alquiltio - inferior) - (alquilo - inferior), ariltio - (alquilo - inferior), aralquiltio - (alquilo - inferior), oxo - (alquilo - inferior), acilamino - (alquilo - inferior), amino cíclico - (alquilo - inferior), (amino 2 - oxocíclico) - (alquilo - inferior), en donde la cadena alquileno puede estar sustituida adicionalmente con uno o dos grupos alquilo - inferior y R3 es yodo, un grupo vinilo o etinilo [los cuales grupos pueden estar sustituidos con átomos de halógeno, alquilo C1-4, cicloalquilo, aralquilo, o un anillo aromático que puede presentar uno o másheteroátomos].
ES99907492T 1998-02-06 1999-02-03 Derivados de 5'-deoxicitidina. Expired - Lifetime ES2195543T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98102080 1998-02-06
EP98108321 1998-05-07

Publications (1)

Publication Number Publication Date
ES2195543T3 true ES2195543T3 (es) 2003-12-01

Family

ID=26149007

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99907492T Expired - Lifetime ES2195543T3 (es) 1998-02-06 1999-02-03 Derivados de 5'-deoxicitidina.

Country Status (19)

Country Link
US (1) US6005098A (es)
EP (1) EP1060183B1 (es)
JP (2) JP3625276B2 (es)
KR (1) KR100381516B1 (es)
CN (1) CN1260240C (es)
AR (1) AR014539A1 (es)
AT (1) ATE238335T1 (es)
AU (1) AU757136B2 (es)
BR (1) BR9907672A (es)
CA (1) CA2318848C (es)
CO (1) CO5070642A1 (es)
DE (1) DE69907161T2 (es)
DK (1) DK1060183T3 (es)
ES (1) ES2195543T3 (es)
MA (1) MA26606A1 (es)
PE (1) PE20000244A1 (es)
PT (1) PT1060183E (es)
TR (1) TR200002297T2 (es)
WO (1) WO1999040099A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030119724A1 (en) * 1995-11-22 2003-06-26 Ts`O Paul O.P. Ligands to enhance cellular uptake of biomolecules
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
DE60013957T2 (de) 1999-05-26 2006-02-23 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Vinylpyrimidinderivaten
KR100631754B1 (ko) * 2000-08-09 2006-10-09 주식회사 코오롱 Ｎ-알킬옥시카르보닐-5-플루오로사이토신 유도체 및 그의제조방법
AU2002217980A1 (en) 2000-12-01 2002-06-11 Cell Works Inc. Conjugates of glycosylated/galactosylated peptide
CN100383128C (zh) * 2004-02-23 2008-04-23 上海迪赛诺医药发展有限公司 N4－氧羰基胞嘧啶衍生物及制备方法与应用
DE112006000873T5 (de) * 2005-04-12 2008-03-06 Elan Pharma International Ltd. Zusammensetzungen mit modifizierter Freisetzung, umfassend ein Fluorcytidin-Derivate zur Behandlung von Krebs
JP6866113B2 (ja) * 2016-11-01 2021-04-28 日本化薬株式会社 カペシタビンを有効成分とする医薬製剤
JP6792418B2 (ja) * 2016-11-08 2020-11-25 日本化薬株式会社 カペシタビンを有効成分とする医薬製剤の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561290A (en) * 1975-10-16 1980-02-20 Nyegaard & Co As Pyrimid - 2 - ones
JPS54129131A (en) * 1978-03-27 1979-10-06 Taiho Pharmaceutical Co Ltd Antiimalignant tumor agent composition
GB2016921B (en) * 1978-03-27 1982-08-18 Taiho Pharmaceutical Co Ltd Anti cancer compositions containing uracil derivatives
US4328229A (en) * 1978-03-29 1982-05-04 Taiho Pharmaceutical Company Limited Anti-cancer composition for delivering 5-fluorouracil to cancer tissues
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
DK0539442T3 (da) * 1990-07-19 1998-09-07 Wellcome Found Enzyminaktivatorer
GB9020930D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
EP0543015B1 (en) * 1991-05-27 1998-11-11 Taiho Pharmaceutical Co., Ltd. Composition, method and kit for potentiating antitumor activity and for curing tumor
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (es) * 1992-12-18 1995-08-21 Hoffmann La Roche
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives

Also Published As

Publication number Publication date
CA2318848A1 (en) 1999-08-12
DE69907161T2 (de) 2004-02-05
AR014539A1 (es) 2001-02-28
JP2004339230A (ja) 2004-12-02
DE69907161D1 (de) 2003-05-28
JP2002502857A (ja) 2002-01-29
CA2318848C (en) 2008-09-02
MA26606A1 (fr) 2004-12-20
KR100381516B1 (ko) 2003-04-23
US6005098A (en) 1999-12-21
EP1060183B1 (en) 2003-04-23
AU2722799A (en) 1999-08-23
CN1290269A (zh) 2001-04-04
WO1999040099A1 (en) 1999-08-12
DK1060183T3 (da) 2003-08-11
KR20010072543A (ko) 2001-07-31
EP1060183A1 (en) 2000-12-20
CO5070642A1 (es) 2001-08-28
ATE238335T1 (de) 2003-05-15
PT1060183E (pt) 2003-08-29
CN1260240C (zh) 2006-06-21
TR200002297T2 (tr) 2000-12-21
JP3625276B2 (ja) 2005-03-02
PE20000244A1 (es) 2000-04-10
BR9907672A (pt) 2000-11-28
AU757136B2 (en) 2003-02-06

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