ES2187112T3 - Procedimiento para la preparacion de n-(amino-4,6-dihalogenopirimidin)-formamidas. - Google Patents

Procedimiento para la preparacion de n-(amino-4,6-dihalogenopirimidin)-formamidas.

Info

Publication number
ES2187112T3
ES2187112T3 ES99125042T ES99125042T ES2187112T3 ES 2187112 T3 ES2187112 T3 ES 2187112T3 ES 99125042 T ES99125042 T ES 99125042T ES 99125042 T ES99125042 T ES 99125042T ES 2187112 T3 ES2187112 T3 ES 2187112T3
Authority
ES
Spain
Prior art keywords
formula
amino
preparation
formamids
dihalogenopirimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99125042T
Other languages
English (en)
Inventor
Elie Dr Saikali
Walter Dr Brieden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2187112T3 publication Critical patent/ES2187112T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento para la preparación de N-(amino-4, 6-dihalógenopirimidin)formamidas de la fórmula I **(Fórmula)** en la cual X significa un átomo de halógeno, que abarca la reacción de una 2, 5-diamino-4, 6dihalógenopirimidina de la fórmula general II **(Fórmula)** en la cual X tiene el significado dado, o una de sus sales, con un ácido fórmico al 70 a 80%, a una temperatura de 20 a 60°C, para dar el producto final conforme a la fórmula I.
ES99125042T 1998-12-21 1999-12-15 Procedimiento para la preparacion de n-(amino-4,6-dihalogenopirimidin)-formamidas. Expired - Lifetime ES2187112T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98124188 1998-12-21
EP99100788 1999-01-18
EP99107161 1999-04-12
US14610699P 1999-07-29 1999-07-29

Publications (1)

Publication Number Publication Date
ES2187112T3 true ES2187112T3 (es) 2003-05-16

Family

ID=27443679

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01130001T Expired - Lifetime ES2204798T3 (es) 1998-12-21 1999-12-15 Procedimiento para la preparacion de 2,5-diamino-4,6-dihalogenopirimidina.
ES99125042T Expired - Lifetime ES2187112T3 (es) 1998-12-21 1999-12-15 Procedimiento para la preparacion de n-(amino-4,6-dihalogenopirimidin)-formamidas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01130001T Expired - Lifetime ES2204798T3 (es) 1998-12-21 1999-12-15 Procedimiento para la preparacion de 2,5-diamino-4,6-dihalogenopirimidina.

Country Status (16)

Country Link
US (2) US6271376B1 (es)
EP (2) EP1188750B1 (es)
JP (1) JP3543709B2 (es)
KR (1) KR100645270B1 (es)
CN (1) CN1156449C (es)
AT (2) ATE228508T1 (es)
CA (1) CA2293011C (es)
CZ (2) CZ296753B6 (es)
DE (2) DE59907401D1 (es)
DK (1) DK1013647T3 (es)
ES (2) ES2204798T3 (es)
HU (1) HUP9904608A3 (es)
NO (1) NO313878B1 (es)
PL (1) PL337354A1 (es)
PT (1) PT1013647E (es)
SK (2) SK283681B6 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) * 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
GB2344550A (en) * 1998-12-09 2000-06-14 Ibm Pad design for electronic package
EP1582180B1 (en) 2000-10-16 2008-02-27 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US20040204756A1 (en) * 2004-02-11 2004-10-14 Diaz Stephen Hunter Absorbent article with improved liquid acquisition capacity
US7056338B2 (en) * 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20040249443A1 (en) * 2001-08-20 2004-12-09 Shanley John F. Expandable medical device for treating cardiac arrhythmias
AU2003234670B2 (en) * 2002-05-24 2010-06-10 Angiotech International Ag Compositions and methods for coating medical implants
US20040142014A1 (en) * 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
KR20130032407A (ko) * 2002-11-08 2013-04-01 코너 메드시스템즈, 엘엘씨 허혈성 상해 후에 조직 손상을 감소시키기 위한 방법 및 장치
JP2006505364A (ja) * 2002-11-08 2006-02-16 コナー　メドシステムズ，　インコーポレイテッド 血管新生因子の局所供給を用いる、慢性全梗塞を処置するための拡張可能な医療装置および方法
FR2849030A1 (fr) * 2002-12-20 2004-06-25 Isochem Sa Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides
US20040202692A1 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
EP1610823B1 (en) 2003-03-28 2011-09-28 Innovational Holdings, LLC Implantable medical device with continuous agent concentration gradient
US20050010170A1 (en) * 2004-02-11 2005-01-13 Shanley John F Implantable medical device with beneficial agent concentration gradient
WO2004103979A1 (ja) * 2003-05-26 2004-12-02 Sumitomo Chemical Company, Limited Ｎ－（２－アミノ－４，６－ジクロロピリミジン－５－イル）ホルムアミドの製造方法
US7208596B2 (en) * 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US20050287287A1 (en) * 2004-06-24 2005-12-29 Parker Theodore L Methods and systems for loading an implantable medical device with beneficial agent
CN101003511B (zh) * 2007-01-19 2010-06-09 中国科学院上海有机化学研究所 制备2-氨基-4,6-二氯-5-甲酰氨基嘧啶的方法
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
WO2014023681A1 (en) * 2012-08-06 2014-02-13 Enantia, S.L. A process for the preparation of an intermediate for a triazolopyrimidine carbonucleoside
CN103936681B (zh) * 2014-04-04 2015-07-29 苏州开元民生科技股份有限公司 2-氨基-4,6-二氯-5-甲酰胺基嘧啶的制备方法
CN115536595B (zh) * 2022-11-29 2023-03-10 苏州开元民生科技股份有限公司 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445293A1 (de) * 1984-12-12 1986-06-12 Bayer Ag, 5090 Leverkusen Neue 2,4-diaminopyrimidine
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
CN1019575B (zh) * 1988-02-19 1992-12-23 石原产业株式会社 2-氨基-4，6-二氯嘧啶的生产方法
DE3900471A1 (de) * 1989-01-10 1990-07-12 Basf Ag Verfahren zur herstellung von 2-amino-4-fluorpyrimidinderivaten
GB8916698D0 (en) * 1989-07-21 1989-09-06 Beecham Group Plc Novel process
SK279618B6 (sk) * 1992-01-22 1999-01-11 Lonza A.G. (Dir.:Basel) N-5-chránené 2,5-diamino-4,6-dichlórpyrimidíny a s
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
AT402924B (de) * 1994-05-13 1997-09-25 Chemie Linz Gmbh Verfahren zur herstellung von 2-amino-4,6-dichloro-pyrimidin

Also Published As

Publication number Publication date
EP1013647A3 (de) 2000-10-04
JP2000191647A (ja) 2000-07-11
CZ9904598A3 (cs) 2001-03-14
JP3543709B2 (ja) 2004-07-21
HUP9904608A3 (en) 2001-03-28
CZ296832B6 (cs) 2006-06-14
SK178499A3 (en) 2000-09-12
EP1013647A2 (de) 2000-06-28
US6271376B1 (en) 2001-08-07
DK1013647T3 (da) 2003-03-10
CN1265393A (zh) 2000-09-06
EP1013647B1 (de) 2002-11-27
EP1188750A1 (de) 2002-03-20
US6716981B2 (en) 2004-04-06
DE59907401D1 (de) 2003-11-20
EP1188750B1 (de) 2003-10-15
CZ296753B6 (cs) 2006-06-14
US20010031868A1 (en) 2001-10-18
PT1013647E (pt) 2003-04-30
SK285222B6 (sk) 2006-09-07
HU9904608D0 (en) 2000-03-28
NO996325D0 (no) 1999-12-20
CN1156449C (zh) 2004-07-07
KR20000052540A (ko) 2000-08-25
DE59903535D1 (de) 2003-01-09
ATE228508T1 (de) 2002-12-15
HUP9904608A2 (hu) 2000-08-28
PL337354A1 (en) 2000-07-03
ATE252087T1 (de) 2003-11-15
CA2293011A1 (en) 2000-06-21
ES2204798T3 (es) 2004-05-01
KR100645270B1 (ko) 2006-11-13
SK283681B6 (sk) 2003-11-04
NO313878B1 (no) 2002-12-16
CA2293011C (en) 2004-08-10
NO996325L (no) 2000-06-22

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