ES2062985T3 - Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado. - Google Patents
Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado.Info
- Publication number
- ES2062985T3 ES2062985T3 ES87308921T ES87308921T ES2062985T3 ES 2062985 T3 ES2062985 T3 ES 2062985T3 ES 87308921 T ES87308921 T ES 87308921T ES 87308921 T ES87308921 T ES 87308921T ES 2062985 T3 ES2062985 T3 ES 2062985T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- compounds
- procedure
- hydroxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
SE PREPARAN 2-AMINO-4-HIDROXI-6[2-(4-CARBOXIFENIL)ALQU-1-EN-IL]PIRIDO [2,3-D]PIRIMIDINAS Y 2-AMINO-4-HIDROXI-6[2-(4-CARBOXIFENIL)ALQU-1-IN-IL] PIRIDO[2,3-D]PIRIMIDINAS A TRAVES DE LA REACCION DE UN COMPUESTO HALOAROMATICO Y UN COMPUESTO NO SATURADO EN PRESENCIA DE UN CATALIZADOR DE PALADIO. LOS PRODUCTOS SON INTERMEDIOS QUIMICOS PARA LA OBTENCION DE AGENTES ANTINEOPLASTICOS. UNA INCORPORACION TIPICA ES LA REACCION DE UNA 2-AMINO-4-HIDROXI-6-ETINILPIRIDO[2,3-D]PIRIMIDINA Y UN ESTER DE ACIDO 4-YODOBENZOICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/922,511 US4818819A (en) | 1986-10-20 | 1986-10-20 | Process for the preparation of fused pyridine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062985T3 true ES2062985T3 (es) | 1995-01-01 |
Family
ID=25447136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87308921T Expired - Lifetime ES2062985T3 (es) | 1986-10-20 | 1987-10-08 | Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4818819A (es) |
EP (1) | EP0265126B1 (es) |
JP (2) | JPH07103120B2 (es) |
AT (1) | ATE104297T1 (es) |
CA (1) | CA1301157C (es) |
DE (1) | DE3789599T2 (es) |
ES (1) | ES2062985T3 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4902796A (en) * | 1986-10-20 | 1990-02-20 | The Trustees Of Princeton University | 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines |
US5008391A (en) * | 1989-07-07 | 1991-04-16 | Eli Lilly And Company | Enantioselective synthesis of antifolates |
US5028608A (en) * | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
IL96531A (en) * | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
US6762188B1 (en) | 1990-06-19 | 2004-07-13 | Smithkline Beecham Corporation | Pharmaceutically active benzoquinazoline compounds |
GB9013615D0 (en) | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
US5426187A (en) * | 1993-11-30 | 1995-06-20 | Eli Lilly And Company | Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates |
ATE212632T1 (de) * | 1995-09-08 | 2002-02-15 | Univ Princeton | Nicht-klassische antifolate |
JP4164028B2 (ja) | 2001-10-12 | 2008-10-08 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アルキンマトリックスメタロプロテイナーゼ阻害剤 |
US6962922B2 (en) * | 2001-10-12 | 2005-11-08 | Warner-Lambert Company Llc | Alkynylated quinazoline compounds |
SV2003001289A (es) * | 2001-10-12 | 2003-06-24 | Warner Lambert Co | Compuestos pirimidina de anillo fusionado alquinilado |
WO2003033477A1 (en) * | 2001-10-12 | 2003-04-24 | Warner-Lambert Company Llc | Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor |
US6747147B2 (en) | 2002-03-08 | 2004-06-08 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US6894057B2 (en) * | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
US20040006077A1 (en) * | 2002-06-25 | 2004-01-08 | Bernard Gaudilliere | Thiazine and oxazine derivatives as MMP-13 inhibitors |
AU2002331362A1 (en) * | 2002-07-12 | 2004-02-02 | Warner-Lambert Company Llc | New alkynylated quinazolin compounds as mmp-13 inhibitors |
AU2003281168A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib |
AU2003249505A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
WO2005016926A1 (en) * | 2003-08-19 | 2005-02-24 | Warner-Lambert Company Llc | Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors |
GB0428475D0 (en) * | 2004-12-30 | 2005-02-02 | 4 Aza Bioscience Nv | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
GB0503506D0 (en) * | 2005-02-21 | 2005-03-30 | 4 Aza Bioscience Nv | Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
WO2006135993A1 (en) * | 2005-06-24 | 2006-12-28 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c. |
US8338435B2 (en) * | 2006-07-20 | 2012-12-25 | Gilead Sciences, Inc. | Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections |
TW200840584A (en) * | 2006-12-26 | 2008-10-16 | Gilead Sciences Inc | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3856959A (en) * | 1972-07-24 | 1974-12-24 | Department Of Health Education | Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate |
BE852095A (fr) * | 1976-03-05 | 1977-07-01 | Stanford Research Inst | Composition pharmaceutique pour le traitement de la leucemie et de tumeurs |
US4393064A (en) * | 1976-03-05 | 1983-07-12 | Sri International | Process and composition for treatment of leukemia and process for preparing the same |
US4172200A (en) * | 1978-06-15 | 1979-10-23 | Southern Research Institute | Process for the preparation of 10-deazaaminopterin and related compounds |
EP0031237B1 (en) * | 1979-12-19 | 1984-10-17 | National Research Development Corporation | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
US4512992A (en) * | 1980-06-13 | 1985-04-23 | Burroughs Wellcome Co. | Treatment with dialkoxy pyridopyrimidine compounds |
US4431805A (en) * | 1981-09-25 | 1984-02-14 | Southern Research Institute | Pyrido[2,3-d]-pyrimidines |
US4526964A (en) * | 1982-01-11 | 1985-07-02 | Southern Research Institute | 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine |
US4536575A (en) * | 1982-01-11 | 1985-08-20 | Southern Research Institute | 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino |
US4460591A (en) * | 1982-08-26 | 1984-07-17 | Sri International | 8,10-Dideazaminopterins |
US4532241A (en) * | 1982-08-26 | 1985-07-30 | Sri International | 8,10-Dideazaminopterins |
US4432981A (en) * | 1982-11-05 | 1984-02-21 | Sterling Drug Inc. | 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones |
JPS61500845A (ja) * | 1983-12-27 | 1986-05-01 | エス・ア−ル・アイ・インタ−ナシヨナル | 8,10―ジデアザミノプテリン及び抗白血病剤組成物 |
ZA861235B (en) * | 1985-03-08 | 1986-10-29 | Univ Princeton | Pyrido(2,3-d)pyrimidine derivatives |
-
1986
- 1986-10-20 US US06/922,511 patent/US4818819A/en not_active Expired - Lifetime
-
1987
- 1987-10-08 DE DE3789599T patent/DE3789599T2/de not_active Expired - Fee Related
- 1987-10-08 AT AT87308921T patent/ATE104297T1/de not_active IP Right Cessation
- 1987-10-08 EP EP87308921A patent/EP0265126B1/en not_active Expired - Lifetime
- 1987-10-08 ES ES87308921T patent/ES2062985T3/es not_active Expired - Lifetime
- 1987-10-19 CA CA000549572A patent/CA1301157C/en not_active Expired - Lifetime
- 1987-10-20 JP JP62265194A patent/JPH07103120B2/ja not_active Expired - Fee Related
-
1995
- 1995-04-14 JP JP7089769A patent/JP2558086B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH08119968A (ja) | 1996-05-14 |
US4818819A (en) | 1989-04-04 |
EP0265126A3 (en) | 1989-08-30 |
ATE104297T1 (de) | 1994-04-15 |
CA1301157C (en) | 1992-05-19 |
EP0265126B1 (en) | 1994-04-13 |
JPH07103120B2 (ja) | 1995-11-08 |
EP0265126A2 (en) | 1988-04-27 |
DE3789599D1 (de) | 1994-05-19 |
JP2558086B2 (ja) | 1996-11-27 |
DE3789599T2 (de) | 1994-07-21 |
JPS63183580A (ja) | 1988-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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