ES2062985T3 - Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado. - Google Patents

Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado.

Info

Publication number
ES2062985T3
ES2062985T3 ES87308921T ES87308921T ES2062985T3 ES 2062985 T3 ES2062985 T3 ES 2062985T3 ES 87308921 T ES87308921 T ES 87308921T ES 87308921 T ES87308921 T ES 87308921T ES 2062985 T3 ES2062985 T3 ES 2062985T3
Authority
ES
Spain
Prior art keywords
preparation
compounds
procedure
hydroxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87308921T
Other languages
English (en)
Inventor
Edward C Taylor
George S K Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Application granted granted Critical
Publication of ES2062985T3 publication Critical patent/ES2062985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PREPARAN 2-AMINO-4-HIDROXI-6[2-(4-CARBOXIFENIL)ALQU-1-EN-IL]PIRIDO [2,3-D]PIRIMIDINAS Y 2-AMINO-4-HIDROXI-6[2-(4-CARBOXIFENIL)ALQU-1-IN-IL] PIRIDO[2,3-D]PIRIMIDINAS A TRAVES DE LA REACCION DE UN COMPUESTO HALOAROMATICO Y UN COMPUESTO NO SATURADO EN PRESENCIA DE UN CATALIZADOR DE PALADIO. LOS PRODUCTOS SON INTERMEDIOS QUIMICOS PARA LA OBTENCION DE AGENTES ANTINEOPLASTICOS. UNA INCORPORACION TIPICA ES LA REACCION DE UNA 2-AMINO-4-HIDROXI-6-ETINILPIRIDO[2,3-D]PIRIMIDINA Y UN ESTER DE ACIDO 4-YODOBENZOICO.
ES87308921T 1986-10-20 1987-10-08 Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado. Expired - Lifetime ES2062985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/922,511 US4818819A (en) 1986-10-20 1986-10-20 Process for the preparation of fused pyridine compounds

Publications (1)

Publication Number Publication Date
ES2062985T3 true ES2062985T3 (es) 1995-01-01

Family

ID=25447136

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87308921T Expired - Lifetime ES2062985T3 (es) 1986-10-20 1987-10-08 Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado.

Country Status (7)

Country Link
US (1) US4818819A (es)
EP (1) EP0265126B1 (es)
JP (2) JPH07103120B2 (es)
AT (1) ATE104297T1 (es)
CA (1) CA1301157C (es)
DE (1) DE3789599T2 (es)
ES (1) ES2062985T3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US5008391A (en) * 1989-07-07 1991-04-16 Eli Lilly And Company Enantioselective synthesis of antifolates
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
GB9013615D0 (en) 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
ATE212632T1 (de) * 1995-09-08 2002-02-15 Univ Princeton Nicht-klassische antifolate
JP4164028B2 (ja) 2001-10-12 2008-10-08 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー アルキンマトリックスメタロプロテイナーゼ阻害剤
US6962922B2 (en) * 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
SV2003001289A (es) * 2001-10-12 2003-06-24 Warner Lambert Co Compuestos pirimidina de anillo fusionado alquinilado
WO2003033477A1 (en) * 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) * 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US20040006077A1 (en) * 2002-06-25 2004-01-08 Bernard Gaudilliere Thiazine and oxazine derivatives as MMP-13 inhibitors
AU2002331362A1 (en) * 2002-07-12 2004-02-02 Warner-Lambert Company Llc New alkynylated quinazolin compounds as mmp-13 inhibitors
AU2003281168A1 (en) * 2002-07-17 2004-02-02 Warner-Lambert Company Llc Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with a selective inhibitor of cyclooxygenase-2 that is not celecoxib or valdecoxib
AU2003249505A1 (en) * 2002-07-17 2004-02-02 Warner-Lambert Company Llc Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
WO2005016926A1 (en) * 2003-08-19 2005-02-24 Warner-Lambert Company Llc Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
GB0428475D0 (en) * 2004-12-30 2005-02-02 4 Aza Bioscience Nv Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
GB0503506D0 (en) * 2005-02-21 2005-03-30 4 Aza Bioscience Nv Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
WO2006135993A1 (en) * 2005-06-24 2006-12-28 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis c.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections
TW200840584A (en) * 2006-12-26 2008-10-16 Gilead Sciences Inc Pyrido(3,2-d)pyrimidines useful for treating viral infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
BE852095A (fr) * 1976-03-05 1977-07-01 Stanford Research Inst Composition pharmaceutique pour le traitement de la leucemie et de tumeurs
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
US4172200A (en) * 1978-06-15 1979-10-23 Southern Research Institute Process for the preparation of 10-deazaaminopterin and related compounds
EP0031237B1 (en) * 1979-12-19 1984-10-17 National Research Development Corporation Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4512992A (en) * 1980-06-13 1985-04-23 Burroughs Wellcome Co. Treatment with dialkoxy pyridopyrimidine compounds
US4431805A (en) * 1981-09-25 1984-02-14 Southern Research Institute Pyrido[2,3-d]-pyrimidines
US4526964A (en) * 1982-01-11 1985-07-02 Southern Research Institute 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4536575A (en) * 1982-01-11 1985-08-20 Southern Research Institute 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
JPS61500845A (ja) * 1983-12-27 1986-05-01 エス・ア−ル・アイ・インタ−ナシヨナル ８，１０―ジデアザミノプテリン及び抗白血病剤組成物
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives

Also Published As

Publication number Publication date
JPH08119968A (ja) 1996-05-14
US4818819A (en) 1989-04-04
EP0265126A3 (en) 1989-08-30
ATE104297T1 (de) 1994-04-15
CA1301157C (en) 1992-05-19
EP0265126B1 (en) 1994-04-13
JPH07103120B2 (ja) 1995-11-08
EP0265126A2 (en) 1988-04-27
DE3789599D1 (de) 1994-05-19
JP2558086B2 (ja) 1996-11-27
DE3789599T2 (de) 1994-07-21
JPS63183580A (ja) 1988-07-28

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