ES2046141A1 - Process for obtaining 2-((2,6-dichlorophenyl)amino) phenylacetoxy acetic acid - Google Patents
Process for obtaining 2-((2,6-dichlorophenyl)amino) phenylacetoxy acetic acidInfo
- Publication number
- ES2046141A1 ES2046141A1 ES9201472A ES9201472A ES2046141A1 ES 2046141 A1 ES2046141 A1 ES 2046141A1 ES 9201472 A ES9201472 A ES 9201472A ES 9201472 A ES9201472 A ES 9201472A ES 2046141 A1 ES2046141 A1 ES 2046141A1
- Authority
- ES
- Spain
- Prior art keywords
- acetic acid
- phenylacetoxy
- dichlorophenyl
- amino
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for obtaining 2-((2,6-dichlorophenyl)amino) phenylacetoxy acetic acid, known as aceclofenac, of formula I < IMAGE > based on selective reaction of the 2-tetrahydrofuranilic ester of 2-((2,6-dichlorophenyl) amino) phenylacetoxy acetic acid of formula II < IMAGE > with acetic acid, in a mixture of solvents. Aceclofenac has activity as an anti-inflammatory and analgesic.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201472A ES2046141B1 (en) | 1992-07-15 | 1992-07-15 | "PROCEDURE FOR OBTAINING ACID 2 - ((2,6-DICHLOROPHENYL) AMINO) PHENYLACETOXIACETIC" |
KR93000173A KR960009569B1 (en) | 1992-07-15 | 1993-01-08 | Process for preparation of 2-£(2,6-dichlorophenyl)amino|phenyl acethoxy acetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201472A ES2046141B1 (en) | 1992-07-15 | 1992-07-15 | "PROCEDURE FOR OBTAINING ACID 2 - ((2,6-DICHLOROPHENYL) AMINO) PHENYLACETOXIACETIC" |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2046141A1 true ES2046141A1 (en) | 1994-01-16 |
ES2046141B1 ES2046141B1 (en) | 1994-06-16 |
Family
ID=8277664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09201472A Expired - Fee Related ES2046141B1 (en) | 1992-07-15 | 1992-07-15 | "PROCEDURE FOR OBTAINING ACID 2 - ((2,6-DICHLOROPHENYL) AMINO) PHENYLACETOXIACETIC" |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR960009569B1 (en) |
ES (1) | ES2046141B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005073163A1 (en) * | 2004-01-30 | 2005-08-11 | J.B.Chemicals & Pharmaceuticals Ltd. | A process for the preparation of [2-(2,6-dichloro anilino) phenyl] acetoxy acetic acid |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8404783A1 (en) * | 1983-03-21 | 1984-05-16 | Prodes Sa | New 2-((2,6-dichlorophenyl)amine)phenylacetoxyacetyl derivatives, the process for preparing the same and their use in therapeutics. |
EP0380712A1 (en) * | 1989-01-27 | 1990-08-08 | HEUMANN PHARMA GMBH & CO | Process for the preparation of 2,6-dichlorodiphenylaminoacetic-acid derivatives |
ES2020146A6 (en) * | 1990-05-29 | 1991-07-16 | Prodesfarma Sa | Process for obtaining 2-[(2,6-dichlorophenyl)amino]- phenylacetoxyacetic acid |
-
1992
- 1992-07-15 ES ES09201472A patent/ES2046141B1/en not_active Expired - Fee Related
-
1993
- 1993-01-08 KR KR93000173A patent/KR960009569B1/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8404783A1 (en) * | 1983-03-21 | 1984-05-16 | Prodes Sa | New 2-((2,6-dichlorophenyl)amine)phenylacetoxyacetyl derivatives, the process for preparing the same and their use in therapeutics. |
EP0380712A1 (en) * | 1989-01-27 | 1990-08-08 | HEUMANN PHARMA GMBH & CO | Process for the preparation of 2,6-dichlorodiphenylaminoacetic-acid derivatives |
ES2020146A6 (en) * | 1990-05-29 | 1991-07-16 | Prodesfarma Sa | Process for obtaining 2-[(2,6-dichlorophenyl)amino]- phenylacetoxyacetic acid |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005073163A1 (en) * | 2004-01-30 | 2005-08-11 | J.B.Chemicals & Pharmaceuticals Ltd. | A process for the preparation of [2-(2,6-dichloro anilino) phenyl] acetoxy acetic acid |
Also Published As
Publication number | Publication date |
---|---|
KR940002216A (en) | 1994-02-16 |
KR960009569B1 (en) | 1996-07-20 |
ES2046141B1 (en) | 1994-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU45346B (en) | Process for obtaining pharmaceutical active 1-substituted oxindole-3-carboxamide | |
IE830310L (en) | 1,2,5-trisubstituted pyrroles | |
AU633070B2 (en) | Protected amino acids and process for the preparation thereof | |
ES2046141A1 (en) | Process for obtaining 2-((2,6-dichlorophenyl)amino) phenylacetoxy acetic acid | |
AU6740296A (en) | Process for the preparation of potassium clavulanate | |
GR3035865T3 (en) | Process for preparation of 5-hydroxymethylthiazole | |
EP0775751A3 (en) | Cell transfection | |
EP1193253A4 (en) | Process for producing optically active azetidine-2-carboxylic acids | |
IE46001L (en) | Process for the manufacture of 5-methyl isoxazole-4-¹carboxylic acid anilide derivatives | |
IE771967L (en) | Pharmaceutical compostions | |
ES2020146A6 (en) | Process for obtaining 2-[(2,6-dichlorophenyl)amino]- phenylacetoxyacetic acid | |
ES2020145A6 (en) | Process for obtaining esters of 2-(2,6- dichlorophenyl)amino)phenylacetoxyacetic acid | |
HU9302786D0 (en) | New thiophene-2-carboxylic acid derivatives and process for preparing them | |
GB9316863D0 (en) | Chemical process | |
JPS51115489A (en) | Method for preparing antibiotics | |
CA2509366A1 (en) | Process for the preparation of pregnanes | |
ES8302633A1 (en) | Process for the removal of the formyl group from N-formyl peptides and esters thereof | |
JPS5262237A (en) | Process for preparation of alpha-substituted phenylalkane carboxylic a cid | |
RU2001123589A (en) | METHOD FOR REDUCING THE CONTENT OF 3-DIMETHYLAMINO-2-PhenylPROPHYLIC ACID ETHYL ETHER IN SOLUTIONS OF 2-DIMETHYLAMINO-1-Phenyl-3-Cyclohexene-1-Carboxylic Acid Ethylene Ether Solutions | |
ES8307712A1 (en) | A novel vasodilator compound, process for the preparation thereof and pharmaceutical compositions thereform. | |
ES2007236A6 (en) | N-hydroxy:ethyl isobutyl-phenyl propionamide prepn. | |
HK1050181A1 (en) | Method for reducing 3-dimethylamino-2-phenylpropion-acid ethyl ester-content in solutions of 2-dimethylamino-1-phenyl-3-cyclohexene-1-carboxy acid ethyl ester. | |
ES2050594A1 (en) | Procedure for obtaining 6-fluoro-1,4-dihydro-4-oxo-7- piperazinequinoline-3-carboxylic acids substituted in 1-N | |
JPS5259130A (en) | Process for preparation of nitro-substituted benzoic amides | |
KR960009053B1 (en) | PROCESS FOR PRODUCING N-BENZYL-OXYCARBONYL-N'-HYDROXYMETHYL-Ñß-L-ASPARTYL-L-PHENYLALANINE METHYLESTER |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent | ||
FD2A | Announcement of lapse in spain |
Effective date: 20180806 |