EP3313989A4 - Modified crispr rna and modified single crispr rna and uses thereof - Google Patents

Modified crispr rna and modified single crispr rna and uses thereof Download PDF

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Publication number
EP3313989A4
EP3313989A4 EP16818724.3A EP16818724A EP3313989A4 EP 3313989 A4 EP3313989 A4 EP 3313989A4 EP 16818724 A EP16818724 A EP 16818724A EP 3313989 A4 EP3313989 A4 EP 3313989A4
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EP
European Patent Office
Prior art keywords
crispr rna
modified
modified single
rna
single crispr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP16818724.3A
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German (de)
French (fr)
Other versions
EP3313989A1 (en
Inventor
Meghdad RAHDAR
Thazha P. Prakash
Eric E. Swayze
Frank C. Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of EP3313989A1 publication Critical patent/EP3313989A1/en
Publication of EP3313989A4 publication Critical patent/EP3313989A4/en
Pending legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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EP16818724.3A 2015-06-29 2016-06-29 Modified crispr rna and modified single crispr rna and uses thereof Pending EP3313989A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562186363P 2015-06-29 2015-06-29
US201562233281P 2015-09-25 2015-09-25
US201562256649P 2015-11-17 2015-11-17
PCT/US2016/040191 WO2017004261A1 (en) 2015-06-29 2016-06-29 Modified crispr rna and modified single crispr rna and uses thereof

Publications (2)

Publication Number Publication Date
EP3313989A1 EP3313989A1 (en) 2018-05-02
EP3313989A4 true EP3313989A4 (en) 2018-12-05

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EP16818724.3A Pending EP3313989A4 (en) 2015-06-29 2016-06-29 Modified crispr rna and modified single crispr rna and uses thereof

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US (2) US11414657B2 (en)
EP (1) EP3313989A4 (en)
JP (1) JP2018519811A (en)
AU (1) AU2016285724A1 (en)
CA (1) CA2990699A1 (en)
WO (1) WO2017004261A1 (en)

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