EP2296692A4 - Isoform-specific insulin analogues - Google Patents

Isoform-specific insulin analogues

Info

Publication number
EP2296692A4
EP2296692A4 EP09734135A EP09734135A EP2296692A4 EP 2296692 A4 EP2296692 A4 EP 2296692A4 EP 09734135 A EP09734135 A EP 09734135A EP 09734135 A EP09734135 A EP 09734135A EP 2296692 A4 EP2296692 A4 EP 2296692A4
Authority
EP
European Patent Office
Prior art keywords
isoform
insulin analogues
specific insulin
specific
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09734135A
Other languages
German (de)
French (fr)
Other versions
EP2296692A2 (en
Inventor
Michael Weiss
Jonathan Whittaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of EP2296692A2 publication Critical patent/EP2296692A2/en
Publication of EP2296692A4 publication Critical patent/EP2296692A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP09734135A 2008-04-22 2009-04-22 Isoform-specific insulin analogues Withdrawn EP2296692A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4698508P 2008-04-22 2008-04-22
PCT/US2009/041439 WO2009132129A2 (en) 2008-04-22 2009-04-22 Isoform-specific insulin analogues

Publications (2)

Publication Number Publication Date
EP2296692A2 EP2296692A2 (en) 2011-03-23
EP2296692A4 true EP2296692A4 (en) 2012-06-06

Family

ID=41217411

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09734135A Withdrawn EP2296692A4 (en) 2008-04-22 2009-04-22 Isoform-specific insulin analogues

Country Status (12)

Country Link
US (1) US20110195896A1 (en)
EP (1) EP2296692A4 (en)
JP (1) JP2011521621A (en)
KR (1) KR20110021758A (en)
CN (1) CN102065885A (en)
AU (1) AU2009240636A1 (en)
BR (1) BRPI0911571A2 (en)
CA (1) CA2722168A1 (en)
MX (1) MX2010011329A (en)
NZ (1) NZ588857A (en)
RU (1) RU2010147076A (en)
WO (1) WO2009132129A2 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081824A2 (en) 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
WO2009129250A2 (en) 2008-04-14 2009-10-22 Case Western Reserve University Meal-time insulin analogues of enhanced stability
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (en) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 Insulin analogues with chlorinated amino acids
WO2011072288A2 (en) 2009-12-11 2011-06-16 Case Western Reserve University Insulin analogues with chlorinated amino acids
CA2747197A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
MA32970B1 (en) 2008-12-15 2012-01-02 Zealand Pharma As Isotope glucagon
EP2370460B1 (en) 2008-12-15 2014-04-30 Zealand Pharma A/S Glucagon analogues
CN102282166B (en) 2008-12-15 2015-04-01 西兰制药公司 Glucagon analogues
UA104766C2 (en) 2009-07-13 2014-03-11 Зіленд Фарма А/С Acylated glucagon analogues
US20120184488A1 (en) * 2009-09-01 2012-07-19 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
UY33462A (en) 2010-06-23 2012-01-31 Zealand Pharma As GLUCAGON ANALOGS
CN103068841A (en) 2010-06-24 2013-04-24 西兰制药公司 Glucagon analogues
WO2012098462A1 (en) 2011-01-20 2012-07-26 Zealand Pharma A/S Combination of acylated glucagon analogues with insulin analogues
US10995129B2 (en) * 2011-07-13 2021-05-04 Case Western Reserve University Non-standard insulin analogues
NZ702333A (en) 2012-05-03 2017-06-30 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods
MX356957B (en) 2012-07-23 2018-06-20 Zealand Pharma As Glucagon analogues.
TWI608013B (en) 2012-09-17 2017-12-11 西蘭製藥公司 Glucagon analogues
JP6584953B2 (en) * 2012-11-05 2019-10-02 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ Long-acting single-chain insulin analogue
US9707276B2 (en) 2012-12-03 2017-07-18 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues
JP2016516728A (en) * 2013-03-15 2016-06-09 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ Second site insulin analogue
TW201605470A (en) 2013-10-04 2016-02-16 默沙東藥廠 Glucose-responsive insulin conjugates
SG11201602965WA (en) 2013-10-17 2016-05-30 Zealand Pharma As Acylated glucagon analogues
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
CN105849122B (en) 2013-11-06 2021-04-30 西兰制药公司 GIP-GLP-1 dual agonist compounds and methods
TR201902516T4 (en) 2013-11-06 2019-03-21 Zealand Pharma As Glucagon-glp-1-envy triple agonist compounds.
US9901622B2 (en) 2014-01-13 2018-02-27 Thermalin Diabetes, Inc. Rapid action insulin formulations and pharmaceutical delivery systems
KR102569743B1 (en) 2014-10-06 2023-08-23 케이스 웨스턴 리저브 유니버시티 Biphasic Single-Chain Insulin Analogues
EP3212218B1 (en) 2014-10-29 2021-06-30 Zealand Pharma A/S Gip agonist compounds and methods
CN108064173B (en) 2014-11-21 2021-05-18 默沙东公司 Partial insulin receptor agonists
CN107636010B (en) 2015-04-16 2021-10-01 西兰制药公司 Acylated glucagon analogues
AR105616A1 (en) 2015-05-07 2017-10-25 Lilly Co Eli FUSION PROTEINS
UY36870A (en) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd NEW INSULIN ANALOGS
WO2017040363A1 (en) 2015-09-02 2017-03-09 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds
CN108348581B (en) 2015-09-04 2022-07-01 斯克利普斯研究所 Insulin immunoglobulin fusion proteins
US11583572B2 (en) * 2015-12-23 2023-02-21 Case Western Reserve University Encapsulation of ultra-stable insulin analogues with polymer melts
EP3448417A4 (en) 2016-04-26 2019-12-11 Merck Sharp & Dohme Corp. Insulin dimer-incretin conjugates
EP3463429A4 (en) 2016-05-24 2020-07-22 Merck Sharp & Dohme Corp. Insulin receptor partial agonists and glp-1 analogues
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
WO2017210077A1 (en) * 2016-06-02 2017-12-07 Indiana University Research And Technology Corporation Single chain insulin prodrugs
WO2018015330A1 (en) 2016-07-18 2018-01-25 Eth Zurich B-cell-mimetic cells
EP3272877A1 (en) 2016-07-18 2018-01-24 ETH Zurich B-cell-mimetic cells
AR110193A1 (en) * 2016-11-21 2019-03-06 Univ Case Western Reserve INSULIN ANALOGS OF FAST STABILITY IMPROVED ACTION
US11041009B2 (en) 2017-03-23 2021-06-22 Merck Sharp & Dohme Corp. Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes
CN114591417B (en) * 2022-04-22 2023-04-25 四川大学 Human single chain insulin analogues and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
WO2008043033A2 (en) * 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5149777A (en) * 1988-07-20 1992-09-22 Novo Nordisk A/S Human insulin analogs and preparations containing them
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (en) * 1988-12-29 1990-07-05 Hoechst Ag NEW INSULINE DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DE3936876A1 (en) * 1989-11-06 1991-05-23 Hoechst Ag NEW INSULINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THE SAME
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US20030104981A1 (en) * 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
DE19652713C2 (en) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Process for the purification of insulin and insulin derivatives by chromatography on a strongly acidic cation exchanger
DE19726167B4 (en) * 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, process for its preparation and pharmaceutical preparation containing it
BR9813111A (en) * 1997-10-24 2000-08-15 Lilly Co Eli Insoluble insulin compositions
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US7449443B2 (en) * 2000-03-23 2008-11-11 California Institute Of Technology Method for stabilization of proteins using non-natural amino acids
US7316999B2 (en) * 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
KR100449454B1 (en) * 2000-10-02 2004-09-21 이현철 Vector for Curing Diabetes Mellitus Containing Gene of Single-chain Insulin Analog
WO2003053460A1 (en) * 2001-12-19 2003-07-03 Eli Lilly And Company Crystalline compositions for controlling blood glucose
US20050014679A1 (en) * 2001-12-20 2005-01-20 Beals John Michael Insulin molecule having protracted time action
AU2003226619A1 (en) * 2002-03-26 2003-10-08 Council Of Scientific And Industrial Research An adipocyte insulin and a method of treating diabetes
WO2003093299A2 (en) * 2002-05-06 2003-11-13 Thomas Jefferson University Insulin-associated peptides with effects on cerebral health
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
CN1836047B (en) * 2003-06-17 2010-12-22 赛姆生物***遗传公司 Methods for the production of insulin in plants
EP1692168B1 (en) * 2003-12-03 2011-07-20 Novo Nordisk A/S Single-chain insulin
US7790677B2 (en) * 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
RU2524423C2 (en) * 2008-01-09 2014-07-27 Санофи-Авентис Дойчланд Гмбх Novel insulin derivatives with extremely delayed time/action profile
WO2009129250A2 (en) * 2008-04-14 2009-10-22 Case Western Reserve University Meal-time insulin analogues of enhanced stability
KR20120129875A (en) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 Insulin analogues with chlorinated amino acids
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
US20110103575A1 (en) * 2009-10-30 2011-05-05 Telect Inc. High-density splitter/patch telecommunications system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
WO2008043033A2 (en) * 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Also Published As

Publication number Publication date
NZ588857A (en) 2012-07-27
CA2722168A1 (en) 2009-10-29
EP2296692A2 (en) 2011-03-23
KR20110021758A (en) 2011-03-04
US20110195896A1 (en) 2011-08-11
CN102065885A (en) 2011-05-18
JP2011521621A (en) 2011-07-28
BRPI0911571A2 (en) 2018-04-03
MX2010011329A (en) 2011-03-15
RU2010147076A (en) 2012-05-27
WO2009132129A3 (en) 2010-01-21
AU2009240636A1 (en) 2009-10-29
WO2009132129A2 (en) 2009-10-29

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Legal Events

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Effective date: 20120507

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