EP1858509A4 - Novel cathepsin c inhibitors and their use - Google Patents

Novel cathepsin c inhibitors and their use

Info

Publication number: EP1858509A4
Authority: EP; European Patent Office
Prior art keywords: inhibitors; novel cathepsin; cathepsin; novel
Prior art date: 2005-03-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP06736473A

Other languages

German (de)

French (fr)

Other versions

EP1858509A1 (en

Inventor

David T Fosbenner

Ronggang Liu

Michael L Moore

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-02

Filing date

2006-03-01

Publication date

2009-03-18

2006-03-01 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2007-11-28 Publication of EP1858509A1 publication Critical patent/EP1858509A1/en

2009-03-18 Publication of EP1858509A4 publication Critical patent/EP1858509A4/en

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EP06736473A 2005-03-02 2006-03-01 Novel cathepsin c inhibitors and their use Withdrawn EP1858509A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65789705P	2005-03-02	2005-03-02
PCT/US2006/007162 WO2006094003A1 (en)	2005-03-02	2006-03-01	Novel cathepsin c inhibitors and their use

Publications (2)

Publication Number	Publication Date
EP1858509A1 EP1858509A1 (en)	2007-11-28
EP1858509A4 true EP1858509A4 (en)	2009-03-18

Family

ID=36941504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP06736473A Withdrawn EP1858509A4 (en)	2005-03-02	2006-03-01	Novel cathepsin c inhibitors and their use

Country Status (3)

Country	Link
EP (1)	EP1858509A4 (en)
JP (1)	JP2008531706A (en)
WO (1)	WO2006094003A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UY31299A1 (en) *	2007-08-20	2009-03-31		NEW CATEPSIN INHIBITORS AND THEIR USE
US8481547B2 (en) *	2009-12-18	2013-07-09	Janssen Pharmaceutica Nv	Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1
US8552032B2 (en) *	2009-12-18	2013-10-08	Janssen Pharmaceutica Nv	Bicyclic derivatives useful as inhibitors of DPP-1
WO2012119941A1 (en)	2011-03-04	2012-09-13	Prozymex A/S	Peptidyl nitrilcompounds as peptidase inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004106289A1 (en) *	2003-05-30	2004-12-09	Prozymex A/S	Protease inhibitors
WO2004110988A1 (en) *	2003-06-18	2004-12-23	Prozymex A/S	Protease inhibitors
WO2005000800A1 (en) *	2003-06-30	2005-01-06	Merck Frosst Canada Ltd.	Cathepsin cysteine protease inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2212080A1 (en) *	1971-03-15	1972-10-12	Eli Lilly and Co., Indianapolis, Ind. (V.StA.)	3-nitropyrazole derivatives

2006
- 2006-03-01 JP JP2007558151A patent/JP2008531706A/en active Pending
- 2006-03-01 WO PCT/US2006/007162 patent/WO2006094003A1/en active Application Filing
- 2006-03-01 EP EP06736473A patent/EP1858509A4/en not_active Withdrawn

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004106289A1 (en) *	2003-05-30	2004-12-09	Prozymex A/S	Protease inhibitors
WO2004110988A1 (en) *	2003-06-18	2004-12-23	Prozymex A/S	Protease inhibitors
WO2005000800A1 (en) *	2003-06-30	2005-01-06	Merck Frosst Canada Ltd.	Cathepsin cysteine protease inhibitors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEATON D N ET AL: "Novel and potent cyclic cyanamide-based cathepsin K inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 7, 1 April 2005 (2005-04-01), pages 1815 - 1819, XP025313507, ISSN: 0960-894X, [retrieved on 20050401] *
KIM S H ET AL: "Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 14, 15 July 2008 (2008-07-15), pages 3988 - 3991, XP022852880, ISSN: 0960-894X, [retrieved on 20080610] *
RYDZEWSKI ROBERT M ET AL: "Peptidic 1-cyanopyrrolidines: Synthesis and SAR of a series of potent, selective cathepsin inhibitors", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 10, no. 10, October 2002 (2002-10-01), pages 3277 - 3284, XP002512387, ISSN: 0968-0896 *
See also references of WO2006094003A1 *

Also Published As

Publication number	Publication date
EP1858509A1 (en)	2007-11-28
WO2006094003A1 (en)	2006-09-08
JP2008531706A (en)	2008-08-14

Legal Events

Date	Code	Title	Description
2007-10-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2007-11-28	17P	Request for examination filed	Effective date: 20070928
2007-11-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
2007-11-28	AX	Request for extension of the european patent	Extension state: HR
2008-06-11	RAX	Requested extension states of the european patent have changed	Extension state: HR Payment date: 20070928
2009-03-18	A4	Supplementary search report drawn up and despatched	Effective date: 20090217
2009-03-18	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 11/00 20060101ALI20090209BHEP Ipc: C07D 231/04 20060101ALI20090209BHEP Ipc: A61K 31/415 20060101AFI20060912BHEP
2009-10-16	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2009-11-18	18D	Application deemed to be withdrawn	Effective date: 20090519

Publication	Publication Date	Title
EP1812049A4 (en)	2012-12-26	Kallikrein inhibitors and uses thereof
GB0512940D0 (en)	2005-08-03	Compounds and their use
EP1951680A4 (en)	2011-08-10	Novel 2-aminopyrimidinone derivatives and their use
HRP20130828T1 (en)	2013-09-30	Novel hydroxy-6-heroarylphenanthridines and their use as pde4 inhibitors
EP1951682A4 (en)	2011-06-15	Novel 2-aminopyrimidinone or 2-aminopyridinone derivatives and their use
GB0520743D0 (en)	2005-11-23	Compounds and their use
HK1137756A1 (en)	2010-08-06	Substituted dihydropyrazolones and use thereof as hif-prolyl-4 -hydroxylase inhibitors hif--4-
EP1841419A4 (en)	2009-02-25	Cathepsin k inhibitors and obesity
IL189252A0 (en)	2008-08-07	Dihydroxyanthraquinones and their use
PL2215908T3 (en)	2012-03-30	2-Alkyl-cycloalk(en)yl-carboxamides and their use as fungizides
HK1161122A1 (en)	2012-08-24	Use of 24-norudca 24-norudca
EP1921066A4 (en)	2010-07-07	Pyridylphenol compound and use thereof
IL188850A0 (en)	2008-04-13	Cathepsin k inhibitors
EP2097378A4 (en)	2009-11-18	Novel seh inhibitors and their use
EP1858509A4 (en)	2009-03-18	Novel cathepsin c inhibitors and their use
EP1841730A4 (en)	2010-10-27	Cathepsin k inhibitors and atherosclerosis
EP1931370A4 (en)	2010-11-17	Use of des-aspartate-angiotensin i
IL192820A0 (en)	2009-02-11	Novel compounds and use thereof
GB0510304D0 (en)	2005-06-29	Cathepsin S Inhibitors
GB0427169D0 (en)	2005-01-12	Cathepsin S inhibitors
GB2425708B (en)	2009-12-16	Bracelet and use thereof
GB0513176D0 (en)	2005-08-03	Compounds and their use
GB0521278D0 (en)	2005-11-30	Compounds and their use
ZA200804378B (en)	2009-10-28	Iminopropene compound and use thereof
GB0401243D0 (en)	2004-02-25	Compounds and their use