DK1951870T3 - DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferens - Google Patents
DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferensInfo
- Publication number
- DK1951870T3 DK1951870T3 DK06805529.2T DK06805529T DK1951870T3 DK 1951870 T3 DK1951870 T3 DK 1951870T3 DK 06805529 T DK06805529 T DK 06805529T DK 1951870 T3 DK1951870 T3 DK 1951870T3
- Authority
- DK
- Denmark
- Prior art keywords
- gene expression
- rna interference
- dna constructs
- specific inhibition
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05025727 | 2005-11-25 | ||
PCT/DE2006/002083 WO2007059760A1 (de) | 2005-11-25 | 2006-11-22 | Dna-konstrukte zur spezifischen hemmung der genexpression durch rna-interferenz |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1951870T3 true DK1951870T3 (da) | 2013-07-29 |
Family
ID=37776452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06805529.2T DK1951870T3 (da) | 2005-11-25 | 2006-11-22 | DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferens |
Country Status (13)
Country | Link |
---|---|
US (1) | US9012620B2 (da) |
EP (1) | EP1951870B1 (da) |
JP (1) | JP5186381B2 (da) |
CN (1) | CN101313067B (da) |
AU (1) | AU2006317222B2 (da) |
BR (1) | BRPI0618907A2 (da) |
CA (1) | CA2627443C (da) |
DE (1) | DE112006003704A5 (da) |
DK (1) | DK1951870T3 (da) |
ES (1) | ES2421314T3 (da) |
HK (1) | HK1125407A1 (da) |
RU (1) | RU2410431C2 (da) |
WO (1) | WO2007059760A1 (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1918293A (zh) * | 2004-02-20 | 2007-02-21 | 莫洛根股份公司 | 用于对人及高等动物进行治疗性和预防性免疫刺激的取代的非编码核酸分子 |
JP5529895B2 (ja) * | 2009-02-04 | 2014-06-25 | ソンギュングヮン ユニバーシティ ファウンデーション フォー コーポレート コラボレーション | 細胞内の伝達能が増加した低分子干渉rna複合体 |
WO2010141511A2 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
US8889645B2 (en) | 2009-06-03 | 2014-11-18 | Regado Biosciences, Inc. | Nucleic acid modulators of glycoprotein VI |
CA2764449A1 (en) * | 2009-06-03 | 2010-12-09 | Regado Biosciences, Inc. | Nucleic acid modulators of glycoprotein vi |
US8889646B2 (en) | 2009-06-03 | 2014-11-18 | Regado Biosciences, Inc. | Nucleic acid modulators of glycoprotein VI |
AU2016312530A1 (en) | 2015-08-24 | 2018-03-01 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotide nanoparticles for the modulation of gene expression and uses thereof |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
CN109844134B (zh) * | 2016-08-16 | 2023-05-05 | 塔驰莱特Ip有限公司 | 闭合线性dna的生产 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050059016A1 (en) | 2002-11-05 | 2005-03-17 | Ecker David J. | Structural motifs and oligomeric compounds and their use in gene modulation |
DE19648625A1 (de) | 1996-11-13 | 1998-05-14 | Soft Gene Gmbh | Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer |
US6471968B1 (en) | 2000-05-12 | 2002-10-29 | Regents Of The University Of Michigan | Multifunctional nanodevice platform |
DE10048417A1 (de) | 2000-09-29 | 2002-04-11 | Roche Diagnostics Gmbh | Verbindungen mit verzweigtem Linker |
US20040053876A1 (en) * | 2002-03-26 | 2004-03-18 | The Regents Of The University Of Michigan | siRNAs and uses therof |
DE10393455D2 (de) * | 2002-07-19 | 2005-06-16 | Mologen Ag | DNA-Expressionskonstrukt zur multiplen Genexpression |
DK1749096T3 (da) | 2004-05-28 | 2013-10-28 | Mologen Ag | Fremgangsmåde til fremstilling af egnede DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferens |
-
2006
- 2006-11-22 CN CN200680043264.9A patent/CN101313067B/zh not_active Expired - Fee Related
- 2006-11-22 DE DE112006003704T patent/DE112006003704A5/de not_active Withdrawn
- 2006-11-22 EP EP06805529.2A patent/EP1951870B1/de not_active Not-in-force
- 2006-11-22 CA CA2627443A patent/CA2627443C/en not_active Expired - Fee Related
- 2006-11-22 AU AU2006317222A patent/AU2006317222B2/en not_active Ceased
- 2006-11-22 BR BRPI0618907-5A patent/BRPI0618907A2/pt not_active IP Right Cessation
- 2006-11-22 ES ES06805529T patent/ES2421314T3/es active Active
- 2006-11-22 US US12/095,062 patent/US9012620B2/en not_active Expired - Fee Related
- 2006-11-22 RU RU2008125849/10A patent/RU2410431C2/ru not_active IP Right Cessation
- 2006-11-22 WO PCT/DE2006/002083 patent/WO2007059760A1/de active Application Filing
- 2006-11-22 DK DK06805529.2T patent/DK1951870T3/da active
- 2006-11-22 JP JP2008541587A patent/JP5186381B2/ja not_active Expired - Fee Related
-
2009
- 2009-05-12 HK HK09104334.8A patent/HK1125407A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5186381B2 (ja) | 2013-04-17 |
RU2008125849A (ru) | 2009-12-27 |
CN101313067B (zh) | 2014-04-02 |
DE112006003704A5 (de) | 2008-10-23 |
CN101313067A (zh) | 2008-11-26 |
ES2421314T3 (es) | 2013-08-30 |
BRPI0618907A2 (pt) | 2012-04-17 |
AU2006317222B2 (en) | 2011-06-30 |
US20080311630A1 (en) | 2008-12-18 |
AU2006317222A1 (en) | 2007-05-31 |
EP1951870A1 (de) | 2008-08-06 |
JP2009521210A (ja) | 2009-06-04 |
CA2627443C (en) | 2013-10-01 |
HK1125407A1 (en) | 2009-08-07 |
WO2007059760A1 (de) | 2007-05-31 |
EP1951870B1 (de) | 2013-04-24 |
RU2410431C2 (ru) | 2011-01-27 |
CA2627443A1 (en) | 2007-05-31 |
US9012620B2 (en) | 2015-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1951870T3 (da) | DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferens | |
IL190114A0 (en) | Inhibition of viral gene expression using small interfering rna | |
LTC2059534I2 (lt) | Genų inžinerijos būdu pagaminti anti-IL-23P19 antikūnai | |
HK1200487A1 (en) | Silencing of csn5 gene expression using interfering rna rna csn5 | |
DK1828411T3 (da) | Fremgangsmåde til forenkling af mikrobielle nukleinsyrer ved kemisk modifikation af cytosiner | |
IL186689A0 (en) | Methods of enhancing isolation of rna from biological samples | |
ZA200908342B (en) | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA | |
EP2601293A4 (en) | CATENIN RNA INTERFERENCE-INHIBITING INHIBITION (CADHERIN-ASSOCIATED PROTEIN), EXPRESSION OF BETA-1 GENE (CTNNB1) USING SMALL INTERFERING NUCLEIC ACID (SIAN) | |
EP2238251A4 (en) | SILENCING OF POLO-LIKE KINASE EXPRESSION USING INTERFERENCE RNA | |
EP2050819A4 (en) | NUCLEOTIDE-amplification | |
DK2527471T3 (da) | Diagnosticering af cancer ved anvendelse af genomsekvensering | |
EP1986697A4 (en) | COMPOSITIONS AND METHODS FOR GENE SILENCING INHIBITION USING RNA INTERFERENCE | |
DK1974058T3 (da) | Genekspressionsmarkører til prognosticering af kolorektal cancer | |
DK2074211T3 (da) | DNA polymeraser til inkorporation af farvestof-mærkede nukleotid-analoger | |
EP1842558A4 (en) | COMPOSITION FOR INHIBITING THE EXPRESSION OF A TARGET | |
EP1742958A4 (en) | METHODS AND COMPOSITIONS FOR SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE STRANDED RNA | |
DK2049671T3 (da) | Regulatoriske nukleinsyreelementer | |
BRPI0811755A2 (pt) | Amplificação específica de senquência de dna específicas de tumor. | |
IL194290A0 (en) | Small internally segmented interfering rna | |
BRPI0915886A2 (pt) | método para amplificação direta a partir de amostras brutas de ácido nucléico | |
ATE510923T1 (de) | Nukleinsäure | |
EP2010670A4 (en) | METHOD FOR THE AMPLIFICATION OF AN UNKNOWN DNA SEQUENCE OUTSTANDING A KNOWN SEQUENCE | |
DK2080811T3 (da) | Fremgangsmåde til evaluering af DNA-integriteten af mikroorganismer | |
EP2609106A4 (en) | RNA INTERFERENCE-MEDIATED INHIBITION OF EXPRESSION OF PHD2 GENE (PROLYL HYDROXYLASE DOMAIN 2) USING SMALL INTERFERING NUCLEIC ACID (PANI) | |
DK1926821T3 (da) | Fremgangsmåde til enantioselektiv enzymatisk reduktion af ketoforbindelser |