DK1711502T3 - Fremgangsmåder til at fremstille 3-O-beskyttede-morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater - Google Patents

Fremgangsmåder til at fremstille 3-O-beskyttede-morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater

Info

Publication number: DK1711502T3
Authority: DK; Denmark
Prior art keywords: protected; dieneol; carboxylates; preparing; methods
Prior art date: 2004-02-06

Application number

DK05712726T

Other languages

Danish (da)

English (en)

Inventor

Andreas Stumpf

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-06

Filing date

2005-02-04

Publication date

2008-12-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1711502(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-02-04 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

2008-12-01 Application granted granted Critical

2008-12-01 Publication of DK1711502T3 publication Critical patent/DK1711502T3/da

Links

150000007942 carboxylates Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

DK05712726T 2004-02-06 2005-02-04 Fremgangsmåder til at fremstille 3-O-beskyttede-morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater DK1711502T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US54271104P	2004-02-06	2004-02-06
PCT/US2005/003390 WO2005077957A2 (en)	2004-02-06	2005-02-04	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Publications (1)

Publication Number	Publication Date
DK1711502T3 true DK1711502T3 (da)	2008-12-01

Family

ID=34860329

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK07014411.8T DK1864987T3 (da)	2004-02-06	2005-02-04	Fremgangsmåder til fremstilling af 3-O-beskyttede morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater
DK05712726T DK1711502T3 (da)	2004-02-06	2005-02-04	Fremgangsmåder til at fremstille 3-O-beskyttede-morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK07014411.8T DK1864987T3 (da)	2004-02-06	2005-02-04	Fremgangsmåder til fremstilling af 3-O-beskyttede morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater

Country Status (34)

Country	Link
US (6)	US8003793B2 (de)
EP (3)	EP1711502B1 (de)
JP (1)	JP4963968B2 (de)
KR (4)	KR20070108956A (de)
CN (1)	CN1918168B (de)
AP (1)	AP2006003716A0 (de)
AT (2)	ATE406372T1 (de)
AU (1)	AU2005212258B2 (de)
BR (1)	BRPI0506607B8 (de)
CA (2)	CA2555215C (de)
CR (1)	CR8590A (de)
CY (2)	CY1108506T1 (de)
DE (2)	DE602005009321D1 (de)
DK (2)	DK1864987T3 (de)
EA (2)	EA012905B1 (de)
EC (1)	ECSP066824A (de)
ES (2)	ES2313299T3 (de)
GE (1)	GEP20084454B (de)
HK (2)	HK1103071A1 (de)
HR (2)	HRP20080618T3 (de)
IL (2)	IL177281A (de)
MA (1)	MA28346A1 (de)
MX (1)	MXPA06008931A (de)
NO (2)	NO20063989L (de)
NZ (2)	NZ548786A (de)
PL (2)	PL1711502T3 (de)
PT (2)	PT1711502E (de)
RS (2)	RS50663B (de)
SG (1)	SG150500A1 (de)
SI (2)	SI1864987T1 (de)
TN (1)	TNSN06248A1 (de)
UA (2)	UA88646C2 (de)
WO (1)	WO2005077957A2 (de)
ZA (1)	ZA200606252B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2555215C (en)	2004-02-06	2013-05-21	Euro-Celtique S.A.	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
EP2099764B1 (de) *	2006-09-20	2011-07-27	Mallinckrodt Inc.	Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
US9040726B2 (en)	2007-03-06	2015-05-26	Mallinckrodt Llc	Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
ES2540534T3 (es) *	2007-03-06	2015-07-10	Mallinckrodt Llc	Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano
US8148528B2 (en)	2008-05-27	2012-04-03	Mallinckrodt Llc	Processes and compounds for the preparation of normorphinans
WO2010028004A2 (en)	2008-09-03	2010-03-11	Mallinckrodt Inc.	Substituted berbines and processes for their synthesis
MX344846B (es)	2010-05-10	2017-01-10	Euro-Celtique S A *	Combinacion de granulos cargados activos con activos adicionales.
CH705273B1 (de)	2010-05-10	2016-06-15	Euro Celtique Sa	Pharmazeutische Zusammensetzung – umfassend Hydromorphon und Naloxon.
US9993433B2 (en)	2010-05-10	2018-06-12	Euro-Celtique S.A.	Manufacturing of active-free granules and tablets comprising the same
EP3068397A1 (de)	2013-11-13	2016-09-21	Euro-Celtique S.A.	Hydromorphon und naloxon zur behandlung von schmerzen und opioid-reizdarm-dysfunktionssyndrom
EP3357898B1 (de)	2015-09-30	2020-11-25	FUJIFILM Wako Pure Chemical Corporation	Verfahren zur herstellung einer organischen verbindung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2654756A (en)	1949-10-20	1953-10-06	Mallinckrodt Chemical Works	Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de)	1951-07-17	1954-01-21	Knoll Ag	Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) *	1974-04-10	1977-12-14	Macfarlan Smith Ltd	Dehydrohalogenation of codeinone derivatives
US4472253A (en)	1981-08-17	1984-09-18	The Florida Board Of Regents On Behalf Of The Florida State University	Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en)	1984-03-27	1992-05-12	Mallinckrodt Specialty Chemicals Company	Preparation of noroxymorphone from morphine
SE9003665D0 (sv)	1990-11-16	1990-11-16	Kabivitrum Ab	Morphine prodrugs
GB9116909D0 (en)	1991-08-06	1991-09-18	Salford Ultrafine Chem & Res	Morphine derivatives
US5821374A (en)	1995-11-21	1998-10-13	Hoffmann-La Roche Inc.	Process for the oxidation of alcohols
US5869669A (en)	1996-07-26	1999-02-09	Penick Corporation	Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) *	1997-06-30	1997-09-03	Johnson Matthey Plc	Preparation of opiates
US6177567B1 (en) *	1999-10-15	2001-01-23	Boehringer Ingelheim Chemicals, Inc.	Method for preparing oxycodone
US6596877B2 (en)	2001-10-17	2003-07-22	Novartis Ag	Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
CA2555215C (en)	2004-02-06	2013-05-21	Euro-Celtique S.A.	Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

2005
- 2005-02-04 CA CA2555215A patent/CA2555215C/en active Active
- 2005-02-04 CN CN2005800040830A patent/CN1918168B/zh active Active
- 2005-02-04 EP EP05712726A patent/EP1711502B1/de active Active
- 2005-02-04 CA CA2808199A patent/CA2808199C/en active Active
- 2005-02-04 ES ES05712726T patent/ES2313299T3/es active Active
- 2005-02-04 SG SG200900838-4A patent/SG150500A1/en unknown
- 2005-02-04 UA UAA200704105A patent/UA88646C2/uk unknown
- 2005-02-04 WO PCT/US2005/003390 patent/WO2005077957A2/en active Application Filing
- 2005-02-04 SI SI200530925T patent/SI1864987T1/sl unknown
- 2005-02-04 GE GEAP20059608A patent/GEP20084454B/en unknown
- 2005-02-04 ES ES07014411T patent/ES2338054T3/es active Active
- 2005-02-04 AT AT05712726T patent/ATE406372T1/de active
- 2005-02-04 RS RSP-2008/0553A patent/RS50663B/sr unknown
- 2005-02-04 EA EA200601394A patent/EA012905B1/ru not_active IP Right Cessation
- 2005-02-04 EP EP09015220A patent/EP2194059A3/de not_active Withdrawn
- 2005-02-04 NZ NZ548786A patent/NZ548786A/en unknown
- 2005-02-04 RS RSP-2010/0064A patent/RS51317B/sr unknown
- 2005-02-04 KR KR1020077025207A patent/KR20070108956A/ko not_active Application Discontinuation
- 2005-02-04 AU AU2005212258A patent/AU2005212258B2/en active Active
- 2005-02-04 EA EA200801811A patent/EA016062B1/ru not_active IP Right Cessation
- 2005-02-04 JP JP2006552236A patent/JP4963968B2/ja active Active
- 2005-02-04 AP AP2006003716A patent/AP2006003716A0/xx unknown
- 2005-02-04 PT PT05712726T patent/PT1711502E/pt unknown
- 2005-02-04 US US10/588,637 patent/US8003793B2/en active Active
- 2005-02-04 DE DE602005009321T patent/DE602005009321D1/de active Active
- 2005-02-04 MX MXPA06008931A patent/MXPA06008931A/es active IP Right Grant
- 2005-02-04 BR BRPI0506607A patent/BRPI0506607B8/pt active IP Right Grant
- 2005-02-04 PT PT07014411T patent/PT1864987E/pt unknown
- 2005-02-04 NZ NZ565355A patent/NZ565355A/en unknown
- 2005-02-04 PL PL05712726T patent/PL1711502T3/pl unknown
- 2005-02-04 KR KR1020077025206A patent/KR100921695B1/ko active IP Right Grant
- 2005-02-04 DK DK07014411.8T patent/DK1864987T3/da active
- 2005-02-04 DE DE602005018265T patent/DE602005018265D1/de active Active
- 2005-02-04 AT AT07014411T patent/ATE451374T1/de active
- 2005-02-04 DK DK05712726T patent/DK1711502T3/da active
- 2005-02-04 SI SI200530468T patent/SI1711502T1/sl unknown
- 2005-02-04 KR KR1020097016500A patent/KR101011460B1/ko active IP Right Grant
- 2005-02-04 EP EP07014411A patent/EP1864987B1/de active Active
- 2005-02-04 PL PL07014411T patent/PL1864987T3/pl unknown
- 2005-04-02 UA UAA200609622A patent/UA87833C2/uk unknown
2006
- 2006-07-28 ZA ZA200606252A patent/ZA200606252B/en unknown
- 2006-08-03 IL IL177281A patent/IL177281A/en active IP Right Grant
- 2006-08-04 MA MA29240A patent/MA28346A1/fr unknown
- 2006-08-04 TN TNP2006000248A patent/TNSN06248A1/fr unknown
- 2006-09-01 CR CR8590A patent/CR8590A/es unknown
- 2006-09-05 EC EC2006006824A patent/ECSP066824A/es unknown
- 2006-09-05 KR KR1020067018113A patent/KR100921696B1/ko active IP Right Grant
- 2006-09-06 NO NO20063989A patent/NO20063989L/no not_active Application Discontinuation
2007
- 2007-04-18 HK HK07104100.2A patent/HK1103071A1/xx unknown
- 2007-04-18 HK HK08106459.3A patent/HK1119160A1/xx unknown
2008
- 2008-11-12 CY CY20081101295T patent/CY1108506T1/el unknown
- 2008-11-26 HR HR20080618T patent/HRP20080618T3/xx unknown
2010
- 2010-02-25 CY CY20101100178T patent/CY1109838T1/el unknown
- 2010-03-05 HR HR20100123T patent/HRP20100123T1/hr unknown
- 2010-05-06 IL IL205596A patent/IL205596A/en active IP Right Grant
2011
- 2011-07-22 US US13/189,228 patent/US8198444B2/en active Active
2012
- 2012-05-15 US US13/472,227 patent/US8685996B2/en active Active
2014
- 2014-02-24 US US14/188,430 patent/US8975257B2/en active Active
2015
- 2015-03-02 NO NO20150276A patent/NO339083B1/no unknown
- 2015-03-03 US US14/637,129 patent/US9670218B2/en not_active Expired - Fee Related
2017
- 2017-05-04 US US15/587,118 patent/US20170233400A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA06008931A (es)	2007-01-26
EP1711502B1 (de)	2008-08-27
US8975257B2 (en)	2015-03-10
BRPI0506607A (pt)	2007-05-02
JP2007520563A (ja)	2007-07-26
ES2338054T3 (es)	2010-05-03
ATE406372T1 (de)	2008-09-15
CN1918168A (zh)	2007-02-21
TNSN06248A1 (fr)	2007-12-03
US20120022259A1 (en)	2012-01-26
US9670218B2 (en)	2017-06-06
NO339083B1 (no)	2016-11-14
EA200601394A1 (ru)	2006-12-29
HK1119160A1 (en)	2009-02-27
PL1864987T3 (pl)	2010-05-31
BRPI0506607B8 (pt)	2021-05-25
US8685996B2 (en)	2014-04-01
CA2555215A1 (en)	2005-08-25
PL1711502T3 (pl)	2009-02-27
DE602005009321D1 (de)	2008-10-09
GEP20084454B (en)	2008-08-10
US20150239898A1 (en)	2015-08-27
PT1711502E (pt)	2008-11-20
CN1918168B (zh)	2011-04-27
ZA200606252B (en)	2007-11-28
AP2006003716A0 (en)	2006-08-31
BRPI0506607B1 (pt)	2018-01-16
CR8590A (es)	2007-07-19
KR20090089486A (ko)	2009-08-21
DE602005018265D1 (de)	2010-01-21
EP1864987A3 (de)	2008-02-20
EP1711502A2 (de)	2006-10-18
HK1103071A1 (en)	2007-12-14
US8198444B2 (en)	2012-06-12
US8003793B2 (en)	2011-08-23
RS51317B (sr)	2010-12-31
US20080146804A1 (en)	2008-06-19
IL205596A (en)	2011-11-30
CA2808199C (en)	2015-10-27
NZ565355A (en)	2008-09-26
SG150500A1 (en)	2009-03-30
CY1108506T1 (el)	2014-04-09
KR100921696B1 (ko)	2009-10-15
KR20070026401A (ko)	2007-03-08
SI1864987T1 (sl)	2010-04-30
AU2005212258B2 (en)	2008-05-22
NO20150276L (no)	2006-10-31
EA016062B1 (ru)	2012-01-30
WO2005077957A2 (en)	2005-08-25
SI1711502T1 (sl)	2009-02-28
ATE451374T1 (de)	2009-12-15
KR20070108956A (ko)	2007-11-13
KR100921695B1 (ko)	2009-10-15
EP2194059A2 (de)	2010-06-09
ECSP066824A (es)	2006-12-29
EA200801811A1 (ru)	2008-12-30
HRP20100123T1 (hr)	2010-04-30
HRP20080618T3 (en)	2009-01-31
PT1864987E (pt)	2010-03-09
CY1109838T1 (el)	2014-09-10
IL177281A (en)	2012-02-29
NO20063989L (no)	2006-10-31
EP2194059A3 (de)	2010-09-22
EP1864987B1 (de)	2009-12-09
EA012905B1 (ru)	2010-02-26
JP4963968B2 (ja)	2012-06-27
KR101011460B1 (ko)	2011-01-28
US20170233400A1 (en)	2017-08-17
MA28346A1 (fr)	2006-12-01
CA2808199A1 (en)	2005-08-25
RS50663B (sr)	2010-06-30
IL177281A0 (en)	2006-12-10
UA88646C2 (uk)	2009-11-10
NZ548786A (en)	2008-08-29
WO2005077957A3 (en)	2006-05-04
UA87833C2 (uk)	2009-08-25
EP1864987A2 (de)	2007-12-12
CA2555215C (en)	2013-05-21
AU2005212258A1 (en)	2005-08-25
US20120225902A1 (en)	2012-09-06
DK1864987T3 (da)	2010-04-12
ES2313299T3 (es)	2009-03-01
US20140171643A1 (en)	2014-06-19
KR20070117701A (ko)	2007-12-12

Publication	Publication Date	Title
DK1711502T3 (da)	2008-12-01	Fremgangsmåder til at fremstille 3-O-beskyttede-morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater
DK1924577T3 (da)	2011-05-16	Substituerede benzimidazoler og fremgangsmåder til fremstilling
NO2017017I1 (no)	2017-05-04	umeklinidium og vilanterol
IS8204A (is)	2006-07-01	Tæki og aðferð til að hluta niður
DK1934179T3 (da)	2010-08-09	Fremgangsmåder og mellemprodukter
DK1715893T3 (da)	2009-11-09	Direkte kompressionsformulering og fremgangsmåde
DK3144240T3 (da)	2019-09-23	Stabelbar pakning og fremgangsmåde til tilvejebringelse heraf
DK1805312T3 (da)	2009-10-19	Fremgangsmåder og midler til fremstilling af hyaluronan
DK2479259T3 (da)	2024-02-19	Multi-kryokonserverede hepatocytter og fremgangsmåder til fremstillilng deraf
DK1937276T3 (da)	2013-02-11	Forbedret testosterongel og fremgangsmåde til anvendelse deraf
DK1712728T3 (da)	2009-01-05	Rörelevator og fremgangsmåde
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DK2147315T3 (da)	2013-09-23	Diabetesrelaterede biomarkører og fremgangsmåder til anvendelse deraf
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DK1969391T3 (da)	2014-10-27	Tyndfilm emitter-absorber indretning og fremgangsmåde
DK2120591T3 (da)	2013-01-14	Ny drikkeyoghurt og fremgangsmåde til fremstilling deraf
DK1760156T3 (da)	2013-03-18	Materialer og fremgangsmåder til effektiv mælkesyrefremstilling
DK1824475T3 (da)	2011-06-06	Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
DK1965763T3 (da)	2020-02-10	Stabile enzympræparater og fremgangsmåder til anvendelse heraf
DK2308900T3 (da)	2014-05-12	Immunogene sammensætninger og fremgangsmåder til anvendelse
DK1874557T3 (da)	2014-06-10	Identitetsdokument og fremgangsmåde til fremstilling deraf
DK1922309T3 (da)	2014-08-25	N-phenyl-2-pyrimidin-aminderivater og fremgangsmåde til fremstillingen deraf
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