DK1487763T3 - Anvendelse af mikrofremstillede indretninger til radiosyntese - Google Patents
Anvendelse af mikrofremstillede indretninger til radiosynteseInfo
- Publication number
- DK1487763T3 DK1487763T3 DK03712355.1T DK03712355T DK1487763T3 DK 1487763 T3 DK1487763 T3 DK 1487763T3 DK 03712355 T DK03712355 T DK 03712355T DK 1487763 T3 DK1487763 T3 DK 1487763T3
- Authority
- DK
- Denmark
- Prior art keywords
- micro
- manufactured devices
- radio synthesis
- synthesis
- radio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/48—N-alkylated amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00905—Separation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/0095—Control aspects
- B01J2219/00952—Sensing operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/005—Sugars; Derivatives thereof; Nucleosides; Nucleotides; Nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nuclear Medicine (AREA)
- Prostheses (AREA)
- Transceivers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Circuits Of Receivers In General (AREA)
- Support Of Aerials (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0206117.4A GB0206117D0 (en) | 2002-03-15 | 2002-03-15 | Use of microfabricated devices |
PCT/GB2003/001097 WO2003078358A2 (en) | 2002-03-15 | 2003-03-14 | Use of microfabricated devices for radiosynthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1487763T3 true DK1487763T3 (da) | 2010-11-22 |
Family
ID=9933027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03712355.1T DK1487763T3 (da) | 2002-03-15 | 2003-03-14 | Anvendelse af mikrofremstillede indretninger til radiosyntese |
Country Status (10)
Country | Link |
---|---|
US (2) | US20050226776A1 (da) |
EP (1) | EP1487763B1 (da) |
JP (2) | JP2005520827A (da) |
AT (1) | ATE477224T1 (da) |
AU (1) | AU2003216820A1 (da) |
DE (1) | DE60333736D1 (da) |
DK (1) | DK1487763T3 (da) |
ES (1) | ES2349692T3 (da) |
GB (1) | GB0206117D0 (da) |
WO (1) | WO2003078358A2 (da) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2523189A1 (en) * | 2003-04-22 | 2004-11-04 | Molecular Technologies, Inc. | System and method for synthesis of molecular imaging probes including fdg |
GB0329812D0 (en) * | 2003-12-23 | 2004-01-28 | Amersham Plc | Romp polymer synthesis |
US20050276751A1 (en) * | 2004-01-20 | 2005-12-15 | Chao K S C | System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents |
US20050232387A1 (en) * | 2004-04-20 | 2005-10-20 | Padgett Henry C | Microfluidic apparatus and method for synthesis of molecular imaging probes |
FI20041388A0 (fi) * | 2004-10-27 | 2004-10-27 | Kari Hartonen | Ainakin yhden vetyisotoopin käsittävien substraattien valmistus |
JP2008522795A (ja) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | 化学反応回路を有するマイクロ流体装置 |
AU2006262502A1 (en) | 2005-06-23 | 2007-01-04 | Emory Univerisity | Imaging agents |
JP5349960B2 (ja) * | 2005-06-23 | 2013-11-20 | エモリー ユニバーシティー | 腫瘍画像化のためのアミノ酸類似体の立体選択的合成 |
CA2624243C (en) | 2005-09-29 | 2013-12-31 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
EP1772157A1 (de) * | 2005-10-06 | 2007-04-11 | Karl-Heinz Jansen | Modul-Bausatz und Syntheseverfahren zum Herstellen von Radiopharmaka und Radionukliden |
JP4920301B2 (ja) * | 2006-05-10 | 2012-04-18 | 住友重機械工業株式会社 | Ri化合物合成装置及びri化合物合成方法 |
US7998418B1 (en) | 2006-06-01 | 2011-08-16 | Nanotek, Llc | Evaporator and concentrator in reactor and loading system |
US7641860B2 (en) | 2006-06-01 | 2010-01-05 | Nanotek, Llc | Modular and reconfigurable multi-stage microreactor cartridge apparatus |
EP1889849A1 (en) * | 2006-07-18 | 2008-02-20 | Lonza Ag | Grignard reactions in microreactors |
US8309054B2 (en) * | 2006-08-03 | 2012-11-13 | Hammersmith Imanet Limited | Method for the purification of radiolabelled compounds |
US7854902B2 (en) | 2006-08-23 | 2010-12-21 | Nanotek, Llc | Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same |
AU2007292578B2 (en) * | 2006-09-06 | 2012-11-29 | Nihon Medi-Physics Co., Ltd. | Process for producing radioactive fluorine labeled organic compound, and relevant synthetic apparatus and program |
KR20090093992A (ko) * | 2006-12-21 | 2009-09-02 | 해머스미쓰 이마네트 리미티드 | 미세 제조 장치를 사용하는 친핵 방사성 불화 |
ES2677024T3 (es) | 2007-01-01 | 2018-07-27 | Bayer Healthcare Llc | Sistemas para generación, preparación, transporte y administración de productos radiofarmacéuticos integrados |
US7829032B2 (en) | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
US7797988B2 (en) | 2007-03-23 | 2010-09-21 | Advion Biosystems, Inc. | Liquid chromatography-mass spectrometry |
US8071035B2 (en) | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
CA2684220A1 (en) * | 2007-04-12 | 2008-10-23 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
JP5309312B2 (ja) | 2007-11-01 | 2013-10-09 | Jfeテクノス株式会社 | マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法 |
US8246752B2 (en) | 2008-01-25 | 2012-08-21 | Clear Catheter Systems, Inc. | Methods and devices to clear obstructions from medical tubes |
US8951480B2 (en) | 2008-08-19 | 2015-02-10 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
EP2349977A4 (en) | 2008-10-21 | 2012-03-28 | Nutech Ventures | FLUORATION OF AROMATIC RING SYSTEMS |
US9302990B2 (en) | 2008-10-21 | 2016-04-05 | Nutech Ventures | Fluorination of aromatic ring systems |
WO2010101118A1 (ja) * | 2009-03-04 | 2010-09-10 | 株式会社島津製作所 | マイクロ合成技術を用いた[18f]sfbの合成方法 |
JP5237880B2 (ja) * | 2009-04-30 | 2013-07-17 | Jfeテクノス株式会社 | マイクロチップを用いたpet用標識化合物の製造方法及び装置 |
US8273300B2 (en) | 2009-07-09 | 2012-09-25 | Siemens Medical Solutions Usa, Inc. | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure |
US8377704B2 (en) * | 2009-10-20 | 2013-02-19 | Nutech Ventures | Detection and quantification of anions |
US8546578B2 (en) * | 2010-02-04 | 2013-10-01 | Nutech Ventures | Iodonium Cyclophanes for SECURE arene functionalization |
CN102939120B (zh) | 2010-06-04 | 2016-12-07 | 拜耳医药保健有限责任公司 | 用于规划和监测在放射性药物注射器上的多剂量放射性药物使用的***和方法 |
DE102010017511A1 (de) | 2010-06-22 | 2012-02-02 | Abx Advanced Biochemical Compounds Gmbh | Vorrichtung und Verfahren zur Herstellung radiochemischer Verbindungen |
US8980185B2 (en) | 2010-08-26 | 2015-03-17 | The Board Of Trustees Of The University Of Illinois | Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate |
US20130005958A1 (en) * | 2011-06-30 | 2013-01-03 | General Electric Company | Devices and methods for reducing radiolysis of radioisotopes |
US20130004414A1 (en) * | 2011-06-30 | 2013-01-03 | General Electric Company | Devices and methods for reducing radiolysis of radioisotopes |
JP5885548B2 (ja) * | 2012-03-12 | 2016-03-15 | 株式会社神戸製鋼所 | 多流路機器の運転方法及び多流路機器 |
US10473668B2 (en) * | 2014-06-06 | 2019-11-12 | The Regents Of The University Of California | Self-shielded, benchtop radio chemistry system with a plurality shielded carriers containing a disposable chip cassette |
GB201418893D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Monolithic body |
GB201418897D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Methods and apparatus for the analysis of compounds |
GB201418899D0 (en) * | 2014-10-23 | 2014-12-10 | Univ Hull | System for radiopharmaceutical production |
CN105985385B (zh) * | 2015-05-07 | 2018-12-21 | 陕西正泽生物技术有限公司 | 一种集成流路板合成18f-fdg的方法 |
US10295512B2 (en) * | 2015-12-08 | 2019-05-21 | Dionex Corporation | Multi-lumen mixing device for chromatography |
FR3072301B1 (fr) * | 2017-10-18 | 2022-01-07 | P M B | Cassette microfluidique de synthese d'un radio-traceur et procede de synthese d'un radio-traceur avec une telle cassette |
JP7127164B2 (ja) * | 2021-01-19 | 2022-08-29 | 日本メジフィジックス株式会社 | 2-[18f]フルオロ-2-デオキシ-d-グルコースの製造方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59216830A (ja) * | 1983-05-25 | 1984-12-06 | Takeda Chem Ind Ltd | 放射性物質を含む化合物の小型自動合成装置 |
JPH0698303B2 (ja) * | 1985-04-25 | 1994-12-07 | 住友重機械工業株式会社 | ミクロ反応及び分取装置 |
DE69406945T2 (de) | 1993-10-18 | 1998-03-12 | Ici Plc | Katalytisches verfahren |
US6001229A (en) * | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
US5808020A (en) * | 1996-08-12 | 1998-09-15 | Associated Universities, Inc. | Optical reaction cell and light source for 18F! fluoride radiotracer synthesis |
EP1030733A1 (en) * | 1997-02-05 | 2000-08-30 | California Institute Of Technology | Microfluidic sub-millisecond mixers |
US6391622B1 (en) * | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
JP3654481B2 (ja) * | 1997-06-05 | 2005-06-02 | 独立行政法人理化学研究所 | 生化学反応用マイクロリアクタ |
GB9808836D0 (en) * | 1998-04-27 | 1998-06-24 | Amersham Pharm Biotech Uk Ltd | Microfabricated apparatus for cell based assays |
WO2001034291A2 (en) * | 1999-11-09 | 2001-05-17 | Sri International | High-throughput synthesis, screening and characterization of combinatorial libraries |
AU1476501A (en) * | 1999-11-09 | 2001-06-06 | Sri International | Screening and analysis of polymers, specialty chemicals and catalysts using radiography |
US7485454B1 (en) * | 2000-03-10 | 2009-02-03 | Bioprocessors Corp. | Microreactor |
GB0115927D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
GB0115929D0 (en) | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase electrophilic fluorination |
-
2002
- 2002-03-15 GB GBGB0206117.4A patent/GB0206117D0/en not_active Ceased
-
2003
- 2003-03-14 WO PCT/GB2003/001097 patent/WO2003078358A2/en active Application Filing
- 2003-03-14 DK DK03712355.1T patent/DK1487763T3/da active
- 2003-03-14 AU AU2003216820A patent/AU2003216820A1/en not_active Abandoned
- 2003-03-14 US US10/507,964 patent/US20050226776A1/en not_active Abandoned
- 2003-03-14 JP JP2003576367A patent/JP2005520827A/ja active Pending
- 2003-03-14 AT AT03712355T patent/ATE477224T1/de active
- 2003-03-14 ES ES03712355T patent/ES2349692T3/es not_active Expired - Lifetime
- 2003-03-14 EP EP03712355A patent/EP1487763B1/en not_active Expired - Lifetime
- 2003-03-14 DE DE60333736T patent/DE60333736D1/de not_active Expired - Lifetime
-
2013
- 2013-08-12 JP JP2013167217A patent/JP2014012684A/ja active Pending
-
2014
- 2014-04-15 US US14/253,049 patent/US9169284B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2005520827A (ja) | 2005-07-14 |
AU2003216820A1 (en) | 2003-09-29 |
US9169284B2 (en) | 2015-10-27 |
AU2003216820A8 (en) | 2003-09-29 |
US20050226776A1 (en) | 2005-10-13 |
EP1487763B1 (en) | 2010-08-11 |
GB0206117D0 (en) | 2002-04-24 |
JP2014012684A (ja) | 2014-01-23 |
ATE477224T1 (de) | 2010-08-15 |
US20140316130A1 (en) | 2014-10-23 |
EP1487763A2 (en) | 2004-12-22 |
WO2003078358A2 (en) | 2003-09-25 |
ES2349692T3 (es) | 2011-01-10 |
WO2003078358A3 (en) | 2003-12-31 |
DE60333736D1 (de) | 2010-09-23 |
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