DE60044827D1 - Polyoxyalkylen-konjugate als enzyminhibitoren - Google Patents

Polyoxyalkylen-konjugate als enzyminhibitoren

Info

Publication number
DE60044827D1
DE60044827D1 DE60044827T DE60044827T DE60044827D1 DE 60044827 D1 DE60044827 D1 DE 60044827D1 DE 60044827 T DE60044827 T DE 60044827T DE 60044827 T DE60044827 T DE 60044827T DE 60044827 D1 DE60044827 D1 DE 60044827D1
Authority
DE
Germany
Prior art keywords
enzyminhibitors
polyoxyalkylene
conjugates
polyoxyalkylene conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60044827T
Other languages
English (en)
Inventor
Scott Edward Osborne
Todd Laurence Underiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE60044827D1 publication Critical patent/DE60044827D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE60044827T 1999-09-10 2000-09-08 Polyoxyalkylen-konjugate als enzyminhibitoren Expired - Lifetime DE60044827D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15341899P 1999-09-10 1999-09-10
PCT/US2000/024712 WO2001017565A2 (en) 1999-09-10 2000-09-08 Polyoxyalkylenes conjugates as enzyme inhibitors

Publications (1)

Publication Number Publication Date
DE60044827D1 true DE60044827D1 (de) 2010-09-23

Family

ID=22547144

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60044827T Expired - Lifetime DE60044827D1 (de) 1999-09-10 2000-09-08 Polyoxyalkylen-konjugate als enzyminhibitoren
DE60024101T Expired - Lifetime DE60024101T2 (de) 1999-09-10 2000-09-08 Enzyminhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60024101T Expired - Lifetime DE60024101T2 (de) 1999-09-10 2000-09-08 Enzyminhibitoren

Country Status (9)

Country Link
US (1) US6541629B1 (de)
EP (2) EP1212097B1 (de)
JP (1) JP5020451B2 (de)
AR (2) AR023271A1 (de)
AT (2) ATE476998T1 (de)
AU (2) AU7126900A (de)
DE (2) DE60044827D1 (de)
PE (2) PE20010587A1 (de)
WO (2) WO2001017564A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803496B2 (en) 1997-09-10 2004-10-12 The Procter & Gamble Company Method for maintaining or improving skin health
US8795716B2 (en) 2001-10-01 2014-08-05 The Procter & Gamble Company Skin care compositions on a thin sanitary napkin
US8907154B2 (en) 2001-10-01 2014-12-09 The Procter & Gamble Company Sanitary napkins with hydrophobic lotions
US9035123B2 (en) 2002-10-01 2015-05-19 The Procter & Gamble Company Absorbent article having a lotioned topsheet
US7285570B2 (en) 2003-04-17 2007-10-23 The Procter & Gamble Company Compositions and methods for regulating mammalian keratinous tissue
KR101099409B1 (ko) * 2003-06-06 2011-12-27 아렉시스 악티에볼라그 피부 상태 또는 암 치료를 위한 ｓｃｃｅ 저해제로서의융합된 헤테로사이클 화합물의 용도
US7384113B2 (en) * 2004-04-19 2008-06-10 Hewlett-Packard Development Company, L.P. Fluid ejection device with address generator
US7265257B2 (en) * 2004-08-10 2007-09-04 Kimberly-Clark Worldwide, Inc. Absorbent articles comprising a bodily exudate modifying agent and a film-forming skin care formulation
US7642397B2 (en) * 2004-08-10 2010-01-05 Kimberly-Clark Worldwide, Inc. Absorbent articles comprising a bodily exudate modifying agent and a skin care formulation
MX2010008954A (es) * 2008-02-15 2010-09-07 Procter & Gamble Articulo absorbente con locion que comprende un material de polipropilenglicol.
WO2014030746A1 (ja) * 2012-08-24 2014-02-27 味の素株式会社 アシルジペプチド誘導体
JP7404031B2 (ja) 2019-10-29 2023-12-25 日本航空電子工業株式会社 アンテナ

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2211469A1 (en) 1972-12-21 1974-07-19 Air Liquide Enzyme purification, esp. ribonuclease, and (chymo) trypsin - by treatment with specific polyinhibitors and extraction or pptn of the complex formed
DE2433883C2 (de) * 1973-07-20 1986-03-27 Research Corp., New York, N.Y. Verwendung von physiologisch aktiven Polypeptiden
FR2252351A2 (en) 1973-11-28 1975-06-20 Air Liquide Isolation of enzymes by selective extraction - partition of polyinhibitor-enzyme complex between water and polyethylene glycol
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US5162307A (en) 1988-09-09 1992-11-10 Board Of Trustees Of The University Of Kentucky Polymer bound elastase inhibitors
FR2651125B1 (fr) * 1989-08-23 1992-10-02 Roussel Uclaf Compositions pharmaceutiques de type "pates a l'eau".
EP0452179B1 (de) 1990-03-28 1996-06-12 Nippon Oil And Fats Company, Limited Polymerkombiniertes Arzneimittel zur Magenbehandlung und Verfahren zu dessen Herstellung
JPH04182423A (ja) * 1990-11-16 1992-06-30 Shiseido Co Ltd 清浄・清拭剤組成物
US5880131A (en) 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
DE4342154A1 (de) 1993-12-10 1995-06-14 Behringwerke Ag Amidinophenylalaninderivate, Verfahren zu deren Herstellung, deren Verwendung und diese enthaltende Mittel als Antikoagulantien
JP3945544B2 (ja) * 1995-12-27 2007-07-18 ピジョン株式会社 ダイズエキスの製造方法
AU736806B2 (en) * 1997-01-10 2001-08-02 Novozymes A/S A modified enzyme for skin care
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6267952B1 (en) * 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
CA2322502C (en) * 1998-03-12 2006-10-17 The Procter & Gamble Company Protease inhibitors in absorbent articles
US6066673A (en) * 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
BR9908565A (pt) * 1998-03-12 2000-12-12 Procter & Gamble Artigo absorvente e processo para reduzir a atividade enzimática de uma enzima fecal em uma parte da pele de um usuário de um artigo absorvente
NZ512581A (en) 1999-01-08 2002-12-20 Univ Virginia Commonwealth Polymeric delivery agents comprising a polymer conjugated to a modified amino acid and derivatives thereof
JP2003509538A (ja) * 1999-09-10 2003-03-11 ザ、プロクター、エンド、ギャンブル、カンパニー 酵素インヒビター
EP1212034A1 (de) * 1999-09-10 2002-06-12 The Procter & Gamble Company Enzyminhibitoren

Also Published As

Publication number Publication date
WO2001017564A2 (en) 2001-03-15
WO2001017564A3 (en) 2002-01-24
JP2003508498A (ja) 2003-03-04
US6541629B1 (en) 2003-04-01
AU7126900A (en) 2001-04-10
PE20010586A1 (es) 2001-06-23
WO2001017565A3 (en) 2002-01-17
EP1212097B1 (de) 2005-11-16
ATE476998T1 (de) 2010-08-15
DE60024101T2 (de) 2006-07-27
EP1438073A2 (de) 2004-07-21
EP1212097A2 (de) 2002-06-12
ATE309824T1 (de) 2005-12-15
AU7125700A (en) 2001-04-10
AR023271A1 (es) 2002-09-04
EP1438073B1 (de) 2010-08-11
PE20010587A1 (es) 2001-07-07
AR022655A1 (es) 2002-09-04
DE60024101D1 (de) 2005-12-22
WO2001017565A2 (en) 2001-03-15
JP5020451B2 (ja) 2012-09-05

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