DE60004850D1 - Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure - Google Patents

Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure

Info

Publication number
DE60004850D1
DE60004850D1 DE60004850T DE60004850T DE60004850D1 DE 60004850 D1 DE60004850 D1 DE 60004850D1 DE 60004850 T DE60004850 T DE 60004850T DE 60004850 T DE60004850 T DE 60004850T DE 60004850 D1 DE60004850 D1 DE 60004850D1
Authority
DE
Germany
Prior art keywords
aminocarnitine
derivatives
producing
asparginic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004850T
Other languages
English (en)
Other versions
DE60004850T2 (de
Inventor
Fabio Giannessi
Uomo Natalina Dell
Ornella Tinti
Angelis Francesco De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE60004850D1 publication Critical patent/DE60004850D1/de
Application granted granted Critical
Publication of DE60004850T2 publication Critical patent/DE60004850T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE60004850T 1999-06-30 2000-06-23 Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure Expired - Lifetime DE60004850T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM990418 1999-06-30
IT1999RM000418A IT1306162B1 (it) 1999-06-30 1999-06-30 Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.
PCT/IT2000/000258 WO2001002341A1 (en) 1999-06-30 2000-06-23 Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid

Publications (2)

Publication Number Publication Date
DE60004850D1 true DE60004850D1 (de) 2003-10-02
DE60004850T2 DE60004850T2 (de) 2004-05-27

Family

ID=11406859

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004850T Expired - Lifetime DE60004850T2 (de) 1999-06-30 2000-06-23 Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure

Country Status (10)

Country Link
US (1) US6528684B1 (de)
EP (1) EP1194398B1 (de)
AT (1) ATE248141T1 (de)
AU (1) AU5844800A (de)
DE (1) DE60004850T2 (de)
DK (1) DK1194398T3 (de)
ES (1) ES2204644T3 (de)
IT (1) IT1306162B1 (de)
PT (1) PT1194398E (de)
WO (1) WO2001002341A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US20030153783A1 (en) * 1999-06-30 2003-08-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US6822115B2 (en) * 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
US8410150B2 (en) * 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2694724C (en) * 2007-08-01 2017-09-12 University Health Network Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
IT1261489B (it) * 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.

Also Published As

Publication number Publication date
US6528684B1 (en) 2003-03-04
ITRM990418A1 (it) 2000-12-30
IT1306162B1 (it) 2001-05-30
PT1194398E (pt) 2004-01-30
WO2001002341A1 (en) 2001-01-11
ITRM990418A0 (it) 1999-06-30
EP1194398A1 (de) 2002-04-10
DE60004850T2 (de) 2004-05-27
AU5844800A (en) 2001-01-22
DK1194398T3 (da) 2003-12-22
ES2204644T3 (es) 2004-05-01
ATE248141T1 (de) 2003-09-15
EP1194398B1 (de) 2003-08-27

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