CY1114382T1 - 2-κυανοφαινυλ συντηγμενες ετεροκυκλικες ενωσεις, και συνθεσεις και χρησεις αυτων - Google Patents

2-κυανοφαινυλ συντηγμενες ετεροκυκλικες ενωσεις, και συνθεσεις και χρησεις αυτων

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Publication number
CY1114382T1
CY1114382T1 CY20131100796T CY131100796T CY1114382T1 CY 1114382 T1 CY1114382 T1 CY 1114382T1 CY 20131100796 T CY20131100796 T CY 20131100796T CY 131100796 T CY131100796 T CY 131100796T CY 1114382 T1 CY1114382 T1 CY 1114382T1
Authority
CY
Cyprus
Prior art keywords
heterocyclic compounds
compositions
cyanophenyl
synthetic heterocyclic
synthetic
Prior art date
Application number
CY20131100796T
Other languages
English (en)
Inventor
Zhi-Liang Wei
Matthew Alexander James Duncton
John Kincaid
Michael G Kelly
Donogh O΄MAHONY
Zhan Wang
Original Assignee
Evotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Ag filed Critical Evotec Ag
Publication of CY1114382T1 publication Critical patent/CY1114382T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Συντηγμένες ετεροκυκλικές ενώσεις παρέχονται σύμφωνα με τον τύπο (1) όπου: R1, R2, R3 και m και όπως ορίζονται στην παρούσα. Οι παρεχόμενες ενώσεις και οι φαρμακευτικές συνθέσεις αυτών είναι χρήσιμες για την πρόληψη και την θεραπεία μιας πληθώρας καταστάσεων σε θηλαστικά, συμπεριλαμβανομένων των ανθρώπων, συμπεριλαμβανομένων, μέσω μη περιοριστικών παραδειγμάτων, πόνου, φλεγμονής, γνωστικών διαταραχών, άγχους, κατάθλιψης και άλλων.
CY20131100796T 2007-04-17 2013-09-16 2-κυανοφαινυλ συντηγμενες ετεροκυκλικες ενωσεις, και συνθεσεις και χρησεις αυτων CY1114382T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92510907P 2007-04-17 2007-04-17
US1051208P 2008-01-08 2008-01-08
EP08742430.5A EP2139334B1 (en) 2007-04-17 2008-03-31 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

Publications (1)

Publication Number Publication Date
CY1114382T1 true CY1114382T1 (el) 2016-08-31

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ID=39875785

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Country Status (12)

Country Link
US (2) US8076345B2 (el)
EP (1) EP2139334B1 (el)
JP (1) JP5498374B2 (el)
CN (1) CN101677569B (el)
CA (1) CA2682692A1 (el)
CY (1) CY1114382T1 (el)
DK (1) DK2139334T3 (el)
ES (1) ES2427999T3 (el)
HR (1) HRP20130867T1 (el)
PL (1) PL2139334T3 (el)
PT (1) PT2139334E (el)
WO (1) WO2008130481A1 (el)

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KR20140025530A (ko) * 2011-06-27 2014-03-04 노파르티스 아게 테트라히드로-피리도-피리미딘 유도체의 고체 형태 및 염
EA029473B1 (ru) 2011-12-15 2018-03-30 Новартис Аг Применение ингибиторов pi3k для лечения острой и церебральной малярии
CN103497149A (zh) * 2013-10-08 2014-01-08 南京复兴生物科技有限公司 一种5-氨甲基吡啶衍生物的制备方法
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CN113727758A (zh) * 2019-03-01 2021-11-30 锐新医药公司 双环杂环基化合物及其用途
MA56020A (fr) 2019-05-31 2022-04-06 Chiesi Farm Spa Dérivés de pyridopyrimidines utilisés en tant qu'inhibiteurs de p2x3
KR20220016499A (ko) 2019-05-31 2022-02-09 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 아미노 퀴나졸린 유도체
CN116194446A (zh) * 2020-08-06 2023-05-30 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
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JP2023550830A (ja) 2020-11-27 2023-12-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体
EP4251273A1 (en) 2020-11-27 2023-10-04 Chiesi Farmaceutici S.p.A. Phthalazine derivatives as p2x3 inhibitors
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Publication number Publication date
WO2008130481A1 (en) 2008-10-30
JP5498374B2 (ja) 2014-05-21
EP2139334B1 (en) 2013-07-03
PL2139334T3 (pl) 2013-11-29
EP2139334A1 (en) 2010-01-06
US8076345B2 (en) 2011-12-13
PT2139334E (pt) 2013-10-02
US20080275037A1 (en) 2008-11-06
CA2682692A1 (en) 2008-10-30
ES2427999T3 (es) 2013-11-05
CN101677569B (zh) 2014-01-22
US20120149700A1 (en) 2012-06-14
JP2010524930A (ja) 2010-07-22
EP2139334A4 (en) 2011-06-22
HRP20130867T1 (hr) 2013-10-25
CN101677569A (zh) 2010-03-24
DK2139334T3 (da) 2013-09-23

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