CN219161685U

CN219161685U - Automatic sampling device for measuring drug dissolution curve

Info

Publication number: CN219161685U
Application number: CN202223152776.4U
Authority: CN
Inventors: 邢金松
Original assignee: Shanghai Xihua Pharmaceutical Technology Co ltd
Current assignee: Shanghai Xihua Pharmaceutical Technology Co ltd
Priority date: 2022-11-27
Filing date: 2022-11-27
Publication date: 2023-06-09
Anticipated expiration: 2032-11-27

Abstract

The utility model relates to the technical field of dissolution instruments, in particular to an automatic sampling device for measuring a drug dissolution curve, which comprises a water bath box, wherein a control box is arranged at the rear side of the top of the water bath box, a plurality of groups of dissolution cups are arranged in the water bath box and positioned at the positions of cup holes, a rotating rod is arranged in the control box and corresponds to the positions of the dissolution cups, the bottom end of the rotating rod extends to the inside of the dissolution cups and is connected with a rotating basket, a sampling mechanism is arranged at the top of the right side of the water bath box, and a sample receiving mechanism is arranged at the left side of the water bath box.

Description

Automatic sampling device for measuring drug dissolution curve

Technical Field

The utility model relates to the technical field of dissolution instruments, in particular to an automatic sampling device for measuring a drug dissolution curve.

Background

The dissolution rate of the medicine can be detected by the dissolution rate meter, the absorption rate of the medicine in the body is often determined by the dissolution speed, the medicine in the solid preparation is required to be subjected to the processes of disintegration and dissolution and then conversion into a solution before being absorbed, if the medicine is not easy to release from the preparation or the dissolution speed of the medicine is extremely slow, the absorption speed or degree of the medicine in the preparation can be problematic, on the other hand, certain pharmacological effects are severe, the safety index is small, if the dissolution speed of the medicine which is absorbed rapidly is extremely fast, obvious adverse reactions can be generated, the time for maintaining the medicine effect can be shortened, and in this case, the dissolution rate of the medicine in the preparation can be controlled.

In the sampling link of the conventional dissolution rate meter, an experimenter usually uses a sampling needle tube to sample a solution in a dissolution cup manually and place the solution in a test tube, so that the mode is troublesome, and especially when more medicines are measured simultaneously, the sampling time of each tube of sample should be controlled within 30 seconds, and the detection result is affected by a little improper condition.

Therefore, it is important to design an automatic sampling device for measuring the dissolution profile of a drug to improve the overall practicality by changing the above technical drawbacks.

Disclosure of Invention

The present utility model is directed to an automatic sampling device for drug dissolution profile measurement, which solves the above-mentioned problems of the prior art.

In order to achieve the above purpose, the present utility model provides the following technical solutions:

the automatic sampling device for measuring the drug dissolution curve comprises a water bath box, wherein a control box is arranged at the rear side of the top of the water bath box, a plurality of groups of dissolution cups are placed in the water bath box and positioned at the positions of cup holes, a rotating rod is arranged in the control box and corresponds to the positions of the dissolution cups, the bottom end of the rotating rod extends to the inside of the dissolution cups and is connected with a rotating basket, a sampling mechanism is arranged at the top of the right side of the water bath box, and a sample receiving mechanism is arranged at the left side of the water bath box;

the sampling mechanism comprises a vertical plate support arranged on the right side of the top of the water bath tank, a positive motor and a negative motor are arranged at the top end of the vertical plate support, the output end of the positive motor penetrates through the vertical plate support and is connected with a screw rod, the outer side of the screw rod is in threaded connection with a screw rod sliding sleeve, the left side of the screw rod sliding sleeve is fixedly provided with a supporting transverse plate, a liquid outlet main pipe is arranged above the supporting transverse plate, a plurality of groups of liquid taking branch pipes are communicated and connected at the bottom of the liquid outlet main pipe and at positions corresponding to the dissolution cups, the bottom end of each liquid taking branch pipe is connected with a sampling needle head, and a sampling valve is arranged on the outer side of each liquid taking branch pipe;

the sampling mechanism comprises a box body fixed on the left side of the water bath box, a rotating motor with an upward output end is arranged in the box body, a driving gear is arranged at the output end of the rotating motor, a rotating shaft is connected with the box body in a rotating mode, a driven gear meshed with the driving gear is fixedly sleeved on the outer side of the rotating shaft, the top end of the rotating shaft penetrates through the top of the box body and is connected with a sampling bottle rotating seat, bottle inserting holes are uniformly formed in the sampling bottle rotating seat, and sampling bottles are inserted in the bottle inserting holes.

As a preferable scheme of the utility model, the control box is respectively connected with the positive and negative motor, the sampling valve and the rotating motor through wires, and the connection mode is electric connection.

As a preferable scheme of the utility model, two ends of the screw rod are respectively connected with the inner side of the vertical plate bracket and the top of the water bath box in a rotating way through bearing seats.

As a preferable scheme of the utility model, the liquid outlet end of the liquid outlet main pipe is arranged corresponding to the position of the sampling bottle.

As a preferable scheme of the utility model, a separable structural design is adopted between the sampling bottle rotating seat and the sampling bottle, and the internal structure size of the bottle body jack is correspondingly arranged with the external structure size of the sampling bottle.

As a preferable scheme of the utility model, the rubber protective sleeve is attached to the inside of the bottle jack.

Compared with the prior art, the utility model has the beneficial effects that:

according to the automatic sampling device for measuring the drug dissolution curve, when sampling is started, the positive and negative motor drives the screw rod to rotate, the screw rod sliding sleeve moves downwards under the action of threads, the supporting cross rod drives the liquid outlet main pipe and the liquid taking branch pipe to move downwards until the sampling needle head is inserted into the middle position of a solution in the dissolution cup, then sampling is started one by one according to left and right sequences, sampling valves at corresponding positions are opened, liquid in the corresponding dissolution cup is extracted through the special liquid taking branch pipe, then flows out through the liquid outlet main pipe and flows into the sampling bottle to be collected, then the sampling valves are closed, and the like, sampling of the second group of dissolution cups is started, meanwhile, the rotating motor drives the driving gear to rotate, the rotating shaft drives the sampling bottle rotating seat to rotate under the cooperation of the driven gear, so that a new sampling bottle is in place, multiple groups of sampling are automatically completed under the condition that a worker does not need to start hands, the time is greatly saved, the operation is convenient and the efficiency is high, and the sampling precision is improved.

Drawings

FIG. 1 is a front view of the overall structure of the present utility model;

FIG. 2 is a diagram of a sample receiving mechanism according to the present utility model;

FIG. 3 is a block diagram of a sampling mechanism according to the present utility model.

In the figure: 1. a water bath tank; 2. a control box; 3. a dissolution cup; 4. a rotating rod; 5. a rotating basket; 6. a sampling mechanism; 601. a vertical plate bracket; 602. a forward and reverse motor; 603. a screw rod; 604. a screw rod sliding sleeve; 605. a supporting cross plate; 606. a liquid outlet main pipe; 607. a liquid taking branch pipe; 608. a sampling needle; 609. a sampling valve; 7. a sample receiving mechanism; 701. a case; 702. a rotating electric machine; 703. a drive gear; 704. a rotating shaft; 705. a driven gear; 706. a sample bottle rotating seat; 707. bottle body jack; 708. sampling bottle.

Detailed Description

The technical solutions of the embodiments of the present utility model will be clearly and completely described below in conjunction with the embodiments of the present utility model, and it is apparent that the described embodiments are only some embodiments of the present utility model, but not all embodiments, and all other embodiments obtained by those skilled in the art without making any inventive effort based on the embodiments of the present utility model are within the scope of protection of the present utility model.

In order that the utility model may be readily understood, a more complete description of the utility model will be rendered by reference to the appended drawings. Several embodiments of the utility model are presented. This utility model may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

It will be understood that when an element is referred to as being "mounted" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this utility model belongs. The terminology used herein in the description of the utility model is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Referring to fig. 1-3, the present utility model provides a technical solution:

the utility model provides an automatic sampling device for medicine dissolves out curve survey, includes water bath 1, and the rear side at water bath 1 top is provided with control box 2, and multiunit dissolving cup 3 has been placed to the inside of water bath 1 and the position department that is located the cup hole, and the inside of control box 2 and the position department of corresponding dissolving cup 3 are provided with bull stick 4, and the bottom of bull stick 4 extends to the inside of dissolving cup 3 and is connected with basket 5, and the top on water bath 1 right side is provided with sampling mechanism 6, and the left side of water bath 1 is provided with connects appearance mechanism 7.

In this embodiment, referring to fig. 3, the sampling mechanism 6 includes a vertical plate support 601 mounted on the right side of the top of the water bath 1, a positive and negative motor 602 is mounted on the top end of the vertical plate support 601, the output end of the positive and negative motor 602 penetrates through the vertical plate support 601 and is connected with a screw rod 603, a screw rod sliding sleeve 604 is screwed on the outer side of the screw rod 603, a supporting transverse plate 605 is fixed on the left side of the screw rod sliding sleeve 604, a liquid outlet main pipe 606 is arranged above the supporting transverse plate 605, the bottom of the liquid outlet main pipe 606 and the position corresponding to the dissolution cup 3 are connected with a plurality of groups of liquid taking branch pipes 607 in a communicating manner, the bottom end of the liquid taking branch pipe 607 is connected with a sampling needle 608, a sampling valve 609 is mounted on the outer side of the liquid taking branch pipe 607 to enable the positive and negative motor 602 to drive the screw rod 603 to rotate, and enable the screw rod sliding sleeve 604 to move downwards under the action of the screw rod sliding sleeve to enable the supporting transverse rod 605 to drive the liquid outlet main pipe 606 and the liquid taking branch pipe 607 to move downwards until the sampling needle 608 is inserted into the position of the middle of the solution in the dissolution cup 3, then sampling valves 609 are started in left and right order, and left and right, the sampling valves 609 in corresponding positions are opened, so that liquid in the corresponding positions are pumped out through the dedicated liquid taking branch pipes 607;

the control box 2 is connected with the positive and negative motor 602 and the sampling valve 609 through wires respectively, and the connection mode is electric connection, two ends of the screw rod 603 are connected to the inner side of the vertical plate bracket 601 and the top of the water bath box 1 through bearing seats in a rotating mode respectively, and the liquid outlet end of the liquid outlet main pipe 606 is correspondingly arranged with the position of the sampling bottle 708.

In this embodiment, referring to fig. 2, the sample receiving mechanism 7 includes a box 701 fixed on the left side of the water bath tank 1, a rotating motor 702 with an upward output end is installed in the box 701, a driving gear 703 is installed at the output end of the rotating motor 702, a rotating shaft 704 is rotatably connected in the box 701, a driven gear 705 engaged with the driving gear 703 is fixedly sleeved on the outer side of the rotating shaft 704, the top end of the rotating shaft 704 penetrates through the top of the box 701 and is connected with a sampling bottle rotating seat 706, bottle body jacks 707 are uniformly formed in the sampling bottle rotating seat 706, sampling bottles 708 are inserted in the bottle body jacks 707, the rotating motor 702 drives the driving gear 703 to rotate, the rotating shaft 704 drives the sampling bottle 7 rotating seat 706 to start rotating under the cooperation of the driven gear 705, and new sampling bottles 708 are positioned in place;

the control box 2 is connected with the rotating motor 702 through a wire, and the connection mode is electric connection, a separable structural design is adopted between the sampling bottle rotating seat 706 and the sampling bottle 708, the internal structure size of the bottle jack 707 is correspondingly set with the external structure size of the sampling bottle 708, and a rubber protective sleeve is attached to the inside of the bottle jack 707, so that the attachment is tighter and the bottle jack is not rocked.

The working flow of the utility model is as follows: when the automatic sampling device for measuring the drug dissolution curve is used, distilled water is firstly injected into the water bath 1 to a waterline mark, then distilled water is heated, medicines are placed into the rotary basket 5, the rotary basket 5 is inserted into the dissolution cup 3 by adjusting the position of the rotary rod 4, after a certain time, the dissolved liquid starts to be sampled, firstly, the positive and negative motor 602 is started to drive the screw rod 603 to rotate, the screw rod sliding sleeve 604 is enabled to move downwards under the action of threads, the supporting cross rod 605 drives the liquid outlet main pipe 606 and the liquid taking branch pipe 607 to move downwards until the sampling needle 608 is inserted into the middle position of the solution in the dissolution cup 3, then sampling is started one by one according to the left-right sequence, the sampling valve 609 at the corresponding position is opened, the liquid in the corresponding dissolution cup 3 is extracted through the exclusive liquid taking branch pipe 607, then flows out through the liquid outlet main pipe 606 and flows into the sampling bottle 708 to be collected, then the sampling valve 609 is closed, the second group of dissolution cup 3 is started to sample the dissolution cup, meanwhile, the rotary motor 702 drives the driving gear 703 to rotate downwards, the rotation of the rotating shaft 704 is enabled under the action of the driven gear 705, the action of the rotation of the driving gear 704 drives the sampling shaft 706 to rotate the sampling bottle 706, the sampling bottle 706 rotates at the new rotation seat 706, the sampling seat is enabled to rotate, the sampling time is greatly saved, the sampling time is greatly saved, the sampling time is finished, the sampling time is convenient for a user can be completely occupied by a person in the sampling a person, and a user can take a sample in place, and a sample can be in a place.

Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. An automatic sampling device for measuring a drug dissolution curve comprises a water bath box (1), and is characterized in that: the water bath comprises a water bath box (1), and is characterized in that a control box (2) is arranged at the rear side of the top of the water bath box (1), a plurality of groups of dissolution cups (3) are placed in the water bath box (1) and located at the positions of cup holes, a rotating rod (4) is arranged in the control box (2) and located at the positions corresponding to the dissolution cups (3), the bottom end of the rotating rod (4) extends to the inside of the dissolution cups (3) and is connected with a rotating basket (5), a sampling mechanism (6) is arranged at the top of the right side of the water bath box (1), and a sample receiving mechanism (7) is arranged at the left side of the water bath box (1);

the sampling mechanism (6) comprises a vertical plate support (601) arranged on the right side of the top of the water bath box (1), a positive motor (602) is arranged at the top end of the vertical plate support (601), the output end of the positive motor (602) penetrates through the vertical plate support (601) and is connected with a screw rod (603), the outer side of the screw rod (603) is in threaded connection with a screw rod sliding sleeve (604), the left side of the screw rod sliding sleeve (604) is fixedly provided with a supporting transverse plate (605), a liquid outlet main pipe (606) is arranged above the supporting transverse plate (605), a plurality of groups of liquid taking branch pipes (607) are connected at the bottom of the liquid outlet main pipe (606) and correspond to the positions of the dissolution cups (3) in a communicating manner, the bottom end of each liquid taking branch pipe (607) is connected with a sampling needle head (608), and a sampling valve (609) is arranged on the outer side of each liquid taking branch pipe (607).

Connect appearance mechanism (7) including fixing at the left box (701) of water bath (1), internally mounted of box (701) has ascending rotating electrical machines (702) of output, driving gear (703) are installed to the output of rotating electrical machines (702), the inside rotation of box (701) is connected with axis of rotation (704), driven gear (705) that are connected with driving gear (703) meshing have been fixedly cup jointed in the outside of axis of rotation (704), the top of axis of rotation (704) runs through the top of box (701) and is connected with sample bottle roating seat (706), bottle jack (707) have evenly been seted up to the inside of sample bottle roating seat (706), sample bottle (708) have been inserted to the inside of bottle jack (707).

2. An automatic sampling device for drug dissolution profile determination as defined in claim 1, wherein: the control box (2) is connected with the positive and negative motor (602), the sampling valve (609) and the rotating motor (702) through wires respectively, and the connection mode is electric connection.

3. An automatic sampling device for drug dissolution profile determination as defined in claim 1, wherein: the two ends of the screw rod (603) are respectively connected to the inner side of the vertical plate bracket (601) and the top of the water bath box (1) through bearing seats in a rotating mode.

4. An automatic sampling device for drug dissolution profile determination as defined in claim 1, wherein: the liquid outlet end of the liquid outlet main pipe (606) is arranged corresponding to the position of the sampling bottle (708).

5. An automatic sampling device for drug dissolution profile determination as defined in claim 1, wherein: the detachable structural design is adopted between the sampling bottle rotating seat (706) and the sampling bottle (708), and the internal structure size of the bottle body jack (707) is correspondingly arranged with the external structure size of the sampling bottle (708).

6. An automatic sampling device for drug dissolution profile determination as defined in claim 1, wherein: and a rubber protective sleeve is attached to the inside of the bottle jack (707).