CN216933177U - Optical coherence tomography system based on superlens - Google Patents
Optical coherence tomography system based on superlens Download PDFInfo
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- CN216933177U CN216933177U CN202220020082.6U CN202220020082U CN216933177U CN 216933177 U CN216933177 U CN 216933177U CN 202220020082 U CN202220020082 U CN 202220020082U CN 216933177 U CN216933177 U CN 216933177U
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Abstract
The application provides an optical coherence tomography system based on super lens, includes: the reference arm is provided with a first super lens, the first super lens is configured to collimate reference light and irradiate the collimated reference light on the surface of the sample, and the reflected light of the surface of the sample is transmitted to an optical fiber connected with the reference arm in a focusing manner; a sample arm for irradiating sample light to a sample and receiving sample scattered light; the optical fiber coupler is respectively connected with the reference arm and the sample arm through optical fibers; a coherent light source connected to the fiber coupler through an optical fiber; and the detector is connected with the optical fiber coupler. The sample arm includes: the sample arm optical fiber is wrapped with a coating layer, and the tail end of the sample arm optical fiber is provided with an inclined end face; a second superlens disposed on the end surface, configured to converge the sample light and irradiate the converged sample light on a specific surface inside the sample, and input the scattered light of the specific surface to the sample arm optical fiber; and the rotating joint is connected with the sample arm optical fiber.
Description
Technical Field
The application belongs to the field of medical and biological equipment, and particularly relates to an optical coherence tomography system based on a superlens.
Background
Optical Coherence Tomography (OCT) is a novel non-contact non-invasive imaging technique based on the principle of low coherent light interference, which uses the Coherence of the backscattered/reflected light of a sample and reference light to provide a real-time scanning image with micron-sized resolution, such as one-dimensional depth, two-dimensional cross-sectional Tomography and three-dimensional volume. The OCT technology has the advantages of non-contact, no damage, high image resolution, simplicity in operation, portability and the like, is mainly applied to the field of biomedical imaging and diagnosis, and overcomes the defects of low imaging penetration depth and low ultrasonic imaging resolution of a confocal microscope.
The sample arm and the reference arm in the existing OCT device are heavy and have low imaging speed due to the optical components arranged in the sample arm and the reference arm.
SUMMERY OF THE UTILITY MODEL
The technical problem to be solved by the present application is to provide an optical coherence tomography system to address the above-mentioned drawbacks of the prior art.
The application provides an optical coherence tomography system based on super lens, includes:
a sample arm and a reference arm; and
the optical fiber coupler is used for dividing light rays from the coherent light source into sample light rays and reference light rays, and respectively transmitting the sample light rays and the reference light rays to the sample arm and the reference arm;
the reference arm is provided with a first superlens, the first superlens is configured to collimate reference light and irradiate the collimated reference light on the surface of the sample, and the reflected light on the surface of the sample is transmitted to a reference arm optical fiber in a focusing manner; and
wherein the sample arm comprises a sample arm optical fiber, and a second superlens; the second superlens is configured to converge the sample light to irradiate a specific surface inside the sample, and input scattered light of the specific surface to the sample arm optical fiber.
Preferably, the sample arm optical fiber is wrapped by a coating layer, and an inclined end face is arranged at the tail end of the sample arm optical fiber; the second super lens is arranged on the end face.
Preferably, the end face is a convex curved surface, an
The second super lens is a curved super lens matched with the end face in shape.
Preferably, the sample arm further comprises a rotary joint in optical fiber connection with the sample arm.
Preferably, the first superlens comprises a first substrate and a first super-surface structure; the first super-surface structure comprises a plurality of first structural units arranged in an array, and the first structural units comprise nano-structures.
Preferably, the second superlens comprises a second substrate and a second super-surface structure; the second super-surface structure comprises a plurality of second structural units arranged in an array, and the second structural units comprise nano-structures.
Preferably, the first structural unit and/or the second structural unit is a regular hexagon, and each vertex and/or central position of the regular hexagon is provided with at least one nano structure.
Preferably, the first structural unit and/or the second structural unit is a square, and at least one nano structure is arranged at each vertex and/or central position of the square.
Preferably, the nanostructure is a polarization-dependent structure or a polarization-independent structure;
wherein the polarization-dependent structure comprises nanofins or nanoellipsoids and the polarization-independent structure comprises nanocylinders or nanosquares.
Preferably, the nanostructure side of the first superlens and/or the second superlens is provided with a protective layer.
Preferably, the coherent light source is a broadband light source with a coherence length of 1um to 10 um.
Preferably, the coherent light source is a near-infrared light source with a wavelength of 700um to 1500 um.
Preferably, the detector is an array charge coupled device.
The beneficial effects of this application technical scheme are:
the reference arm and the sample arm both use the superlens to replace the traditional lens, so that the OCT system has the advantages of light weight, thinness, simplicity, cheapness and high productivity, and is lighter and more convenient for practical application. On the other hand, through the sample arm super lens, the sample light is focused and then projected on a certain surface in the sample, scattering occurs on the back surface of the sample, and the light scattered back by the sample arm carries the two-dimensional information of the sample. Compared with confocal single-point imaging in the prior art, the OCT system based on the superlens in the application performs in-plane two-dimensional imaging, and the imaging speed is higher. In the preferred embodiment, the curved superlens is applied to the sample arm, so that the focusing effect is better, and the sample is scanned more finely.
Drawings
FIG. 1 is a schematic view of a sample arm in an embodiment of the present application;
FIG. 2 is a schematic view of a reference arm in an embodiment of the present application;
FIG. 3 is a schematic diagram of an overall architecture of an optical coherence tomography system in an embodiment of the present application;
FIG. 4 is a schematic diagram of a hexagonal structural unit in an embodiment;
FIG. 5 is a schematic diagram of a square structural unit in the example;
FIG. 6 is a schematic view of a nanopillar in a building block;
FIG. 7 is a schematic diagram of a nanofin in a building block;
FIG. 8 is a schematic diagram of an embodiment of a sample arm employing a curved superlens.
The drawing is marked with:
11 a first superlens; 12 a reference arm optical fiber;
21 a sample arm fiber; 22 coating layer; 23 end faces; 24 a second superlens; 25 rotating the joint; 26 a second super-surface structure; 27 a second superlens substrate; 28 a protective layer;
3, an optical fiber; 4 samples.
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present application. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present application, as detailed in the appended claims.
The terminology used in the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. As used in this specification and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
It is to be understood that although the terms first, second, third, etc. may be used herein to describe various information, such information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the present application. The word "if" as used herein may be interpreted as "at … …" or "when … …" or "in response to a determination", depending on the context. The features of the following examples and embodiments may be combined with each other without conflict.
The technical solution of the present application will be clearly and completely described below with reference to the accompanying drawings and exemplary embodiments.
Example 1
The present embodiment relates to a sample arm for Optical Coherence Tomography (OCT) comprising an optical fiber inside the sample arm, wrapped with a coating 22 and provided with an inclined end face 23 at the end. The sample arm optical fiber 21 further includes a second superlens 24 attached to the end surface 23 of the optical fiber as shown in fig. 1, and the second superlens 24 is configured to converge the sample light and irradiate the sample light on a specific surface inside the sample, and to input the scattered light of the specific surface to the sample arm optical fiber 21. It should be understood that the above-described attachment of the second superlens 24 to the fiber-optic endface 23 includes, but is not limited to, adhesive bonding, structural attachment, splicing, heat staking, placing an auxiliary structural attachment, etc. A rotary joint 25 is included to enable the sample arm to rotate and ensure that the transmission of light within the fibre is not affected whilst rotating. The sample arm may further include a housing, a sleeve, and the like, which are similar to those of the prior art and are not described herein again.
In a preferred embodiment, the second superlens 24 is dimensioned at the base of the fiber end face 23 and aligned at the edges to ensure alignment of the super-surface structure portions with the fiber core.
In a preferred embodiment, a protective layer is disposed on the super-surface structure side of the second super-lens 24 and is attached to the end surface 23 of the optical fiber, and the protective layer may be a layered structure plated on the second super-lens 24, and should partially or completely cover the super-surface structure, so as to avoid damage to the super-surface structure during the assembly process. The protective layer should be a material that is transparent with respect to the operating band. The super surface structure faces to the inner side, so that the damage to the super surface structure in the operation process can be avoided.
In the preferred embodiment of embodiment 1, the fiber-end face 23 may be provided obliquely, and further, may be provided as a flat surface or a convex curved surface. The inclined end face can enable the sample light to turn, the sample can be flexibly scanned by matching with the rotating joint 25, and the structure is simpler than that of the prior technical scheme. The curved-surface-based super lens has a better focusing effect, and the generated focal point is smaller when the same light beam is incident.
It should be noted that, in the above embodiment, the structure in embodiment 1 can control the sample arm to perform two-dimensional scanning of the sample by rotating the optical fiber connector, and the converging lens is the second superlens 24. The schematic structure and light propagation path of the sample arm are shown in fig. 1. Light entering the sample arm passes through the second superlens 24 and then irradiates a certain surface of the sample, scattering occurs on the back surface of the sample, and the light scattered back by the sample arm carries two-dimensional information of the sample. Compared with confocal single-point imaging, the imaging speed is higher in the in-plane two-dimensional imaging of the embodiment. The optical fiber coating layer 22 is used for protecting the surface of the optical fiber from being scratched by damp gas and external force, improving the microbending resistance of the optical fiber and reducing the microbending additional loss function of the optical fiber, and the optical fiber coating layer 22 can be a layer of ultraviolet-cured elastic coating, such as acrylate, silicone rubber, nylon and other materials.
In a preferred embodiment, as shown in fig. 8, the end surface is a convex curved surface, and the second superlens is a curved superlens adapted to the shape of the end surface. The curved surface super lens has better focusing effect.
Example 2
The present embodiment relates to a reference arm for an optical coherence tomography system, such as the reference arm shown in fig. 2 and an optical path diagram therein, which includes a first superlens 11 for collimating light, and may further include a housing, a sleeve, and the like, which are the same as those in the prior art, and are not described herein again.
In a preferred embodiment, the first superlens 11 is dimensioned at the base of the fiber end face with the edges aligned to ensure alignment of the supersurface structure portion with the fiber core.
In a preferred embodiment, a protective layer is disposed on the super-surface structure side of the first superlens 11 and is attached to the end face of the optical fiber, and the protective layer may be a layered structure plated on the first superlens 11, and should partially or completely cover the super-surface structure, so as to avoid damage to the super-surface structure during the assembly process. The protective layer should be a material that is transparent with respect to the operating band. The super surface structure faces to the inner side, so that the damage to the super surface structure in the operation process can be avoided.
The supplementary explanation of embodiment 2 is that the light entering the reference arm is collimated by the first superlens 11 and then uniformly irradiates the surface of the sample, and is reflected by the surface of the sample and then focused into the optical fiber by the first superlens 11. Compared with the prior art, the super-lens is applied, and the super-lens has the advantages of light weight, small size and simple structure and production process.
A supplementary explanation of the above examples 1 and 2 is that the sample arm and the reference arm are specifically used for: incident light is changed into two beams of light after passing through the optical fiber coupler, and one beam of light enters the reference arm and irradiates a sample after passing through the collimating lens; the other beam of light enters the sample arm, passes through the super lens and then irradiates a certain surface of the sample, the back surface of the sample is scattered, and the light scattered back by the sample arm carries two-dimensional information of the sample. The back reflected light and the reference beam reflected by the sample plane interfere in the fiber coupler. The depth information of the sample can be obtained by carrying out Fourier transform on interference light signals at different moments, and then a three-dimensional image of the sample can be obtained by scanning two transverse dimensions.
Supplementary to the above embodiments 1 and 2, the first superlens 11 and the second superlens 24, which are configured differently, each include the following structural features: a substrate and a super-surface structure. The substrate is a transparent substrate of a target waveband. The super-surface structure is composed of structural units arranged on the surface of the substrate, and the structural units are periodically arranged on the surface of the substrate in an array shape. The first and second superlenses 11, 24 are configured for different optical functions, focusing and collimating, respectively, due to their respective different super-surface structures, and the specific selection of the super-surface structure is selected according to a super-surface database.
The structural unit is composed of a nano structure arranged on the surface of a substrate. It should be understood that the structural units are nanostructures arranged in a specific regular pattern, and further, multiple groups of structural units are arranged in an array to jointly form a super-surface structure. It should be understood that a superlens is a kind of supersurface. The super surface is a layer of sub-wavelength artificial nano-structure film, and incident light can be modulated according to super surface structure units on the super surface. The super-surface structure unit comprises a full-medium or plasma nano antenna, and the phase, amplitude, polarization and other characteristics of light can be directly adjusted and controlled.
In a preferred embodiment, as shown in fig. 4, the structural unit is a regular hexagon, and each vertex and/or central position of the regular hexagon is provided with at least one nano structure. The nano-structure comprises a central nano-structure, wherein 6 peripheral nano-structures with equal distances to the central nano-structure are surrounded around the central nano-structure, and the peripheral nano-structures are uniformly distributed on the circumference to form a regular hexagon, which can also be understood as the mutual combination of regular triangles formed by a plurality of nano-structures.
In a preferred embodiment, as shown in fig. 5, the structural unit is a square, and at least one nanostructure is arranged at each vertex and/or central position of the square. Is a central nanostructure surrounded by 4 peripheral nanostructures at equal distances to form a square.
Supplementary explanation to the embodiment is that the nano structure is an all-dielectric structural unit, and has high transmittance in the visible light band, and in the preferred embodiment, the following materials can be selected: titanium oxide, silicon nitride, fused silica, aluminum oxide, gallium nitride, gallium phosphide, amorphous silicon, crystalline silicon, hydrogenated amorphous silicon, and the like. It should be understood that the actual product may have the loss of nanostructures at the edges of the superlens due to the limitations of the superlens shape, making it less than a full hexagon/square. The nanostructure with the closest phase can be searched in the nanostructure database according to the phase required by the nanostructure at different wavelengths.
In a preferred embodiment, the nanostructure is a polarization dependent structure, in particular comprising nanofins or nanoellipsoids. Such structures impart a geometric phase to the incident light.
In a preferred embodiment, the nanostructures are or polarization independent structures, in particular comprising nanocylinders or nanosquares. Such structures impose a propagation phase on the incident light.
In a preferred embodiment, the operating band of the super-surface is an infrared band. The nano-structures can be filled with air or other transparent or semitransparent materials with other working wave bands, and the absolute value of the difference between the refractive index of the materials and the refractive index of the nano-structures is more than or equal to 0.5.
In a preferred embodiment, the nanostructured material comprises: silicon oxide, aluminum oxide, silicon nitride, titanium oxide, gallium nitride. It will be appreciated that the nanostructure material may be selected to be otherwise transparent in the operating band of the superlens.
Example 3
The present embodiment relates to a superlens-based optical coherence tomography system, which comprises a reference arm as described in implementation 2; and a sample arm as described in example 1, for irradiating sample light to the sample and receiving sample scattered light; further comprising: the optical fiber coupler is respectively connected with the reference arm and the sample arm through optical fibers; a coherent light source connected to the fiber coupler through an optical fiber; and the detector is connected with the optical fiber coupler. The above-described structures or modules are configured as shown in fig. 3. The collimating lens identified in the figure is the first superlens shown in embodiment 2, and the converging lens is the second superlens shown in embodiment 1. On one hand, the optical fiber coupler divides the light of the coherent light source into two parts, one part enters the sample arm, and the other part enters the reference arm; on the other hand, the light reflected from the reference arm interferes with the coupling of light obtained by back scattering from the sample.
In a preferred embodiment, the light source optionally comprises a broadband light source with a short coherence length of 1-10um, and has a high longitudinal resolution; the near-infrared light source with the wavelength of 700-1500nm is selected, so that the biological tissue penetration depth is higher, and more biological tissue information is obtained (the biological tissue absorbs the near-infrared light less strongly and scatters multiple times less strongly).
In a preferred embodiment, the superlenses of both the sample arm and the reference arm are provided with a protective layer. The protective layer is arranged on one side of the super lens with the super surface structure. The super lens is jointed with the corresponding optical fiber, and the jointing surface can be the side with the protective layer or the side without the protective layer. Furthermore, the bonding may be by adhesive bonding, or may be by fastening, sleeving, or adsorbing.
In the preferred embodiment, the detector is an array CCD, the integration time is short, and the scanning sensitivity is high.
A supplementary explanation to the above embodiment is that incident light becomes two beams of light after passing through the fiber coupler, and one beam of light enters the reference arm and illuminates a sample after passing through the collimating lens; the other beam of light enters the sample arm, passes through the super lens and then irradiates a certain surface of the sample, the back surface of the sample is scattered, and the light scattered back by the sample arm carries two-dimensional information of the sample. The back reflected light and the reference beam reflected by the sample plane interfere in the fiber coupler. The depth information of the sample can be obtained by carrying out Fourier transform on interference light signals at different moments, and then a three-dimensional image of the sample can be obtained by scanning two transverse dimensions.
The reference arm and the sample arm in the above embodiments both use superlenses to replace traditional lenses, and have the advantages of "light", "thin", "simple", "cheap", and high productivity, and the OCT system is lighter and more convenient for practical application. On the other hand, through the sample arm super lens, the sample light is focused and then projected on a certain surface in the sample, scattering occurs on the back surface of the sample, and the light scattered back by the sample arm carries the two-dimensional information of the sample. Compared with confocal single-point imaging in the prior art, the OCT system based on the superlens performs in-plane two-dimensional imaging, and the imaging speed is higher.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (13)
1. A superlens-based optical coherence tomography system, comprising:
a sample arm, a reference arm, and a coherent light source; and
the optical fiber coupler is used for dividing light rays from the coherent light source into sample light rays and reference light rays, and respectively transmitting the sample light rays and the reference light rays to the sample arm and the reference arm;
wherein the reference arm is provided with a first superlens (11), the first superlens (11) is configured to collimate the reference light and irradiate the collimated reference light on the surface of the sample (4), and focus and transmit the reflected light of the surface of the sample to a reference arm optical fiber (12); and
wherein the sample arm comprises a sample arm optical fiber (21), and a second superlens (24); the second superlens (24) is configured to converge the sample light and irradiate a specific surface inside the sample (4), and to input the scattered light of the specific surface to the sample arm optical fiber (21).
2. The superlens-based optical coherence tomography system of claim 1, wherein the sample arm fiber (21) is wrapped with a coating (22) and provided with a beveled end face (23) at a distal end; and the second super lens (24) is arranged on the end face (23).
3. The superlens-based optical coherence tomography system of claim 2, wherein the end face (23) is convexly curved, and
the second super lens (24) is a curved super lens matched with the end face (23) in shape.
4. The superlens-based optical coherence tomography system of claim 1, wherein the sample arm further comprises a rotary joint (25) connected to the sample arm fiber (21).
5. The superlens-based optical coherence tomography system of claim 1, wherein the first superlens (11) comprises a first substrate and a first supersurface structure; the first super-surface structure comprises a plurality of first structural units arranged in an array, and the first structural units comprise nano-structures.
6. The superlens-based optical coherence tomography system of claim 1, wherein the second superlens (24) comprises a second substrate and a second supersurface structure; the second super-surface structure comprises a plurality of second structural units arranged in an array, and the second structural units comprise nano-structures.
7. The superlens-based optical coherence tomography system of claim 5 or 6, wherein the first structural unit and/or the second structural unit is a regular hexagon, each vertex and/or center of the regular hexagon being provided with at least one nanostructure.
8. The superlens-based optical coherence tomography system of claim 5 or 6, wherein the first structural unit and/or the second structural unit is a square, and at least one nanostructure is disposed at each vertex and/or center position of the square.
9. The superlens-based optical coherence tomography system of claim 5 or 6, wherein the nanostructure is a polarization-dependent structure or a polarization-independent structure;
wherein the polarization-dependent structure comprises nanofins or nanoellipsoids and the polarization-independent structure comprises nanocylinders or nanosquares.
10. Superlens-based optical coherence tomography system according to claim 5 or 6, wherein the nanostructure side of the first and/or second superlenses (11, 24) is provided with a protective layer (28).
11. The superlens-based optical coherence tomography system of claim 1, wherein the coherent light source is specifically a broadband light source with a coherence length of 1um to 10 um.
12. The superlens-based optical coherence tomography system of claim 1, wherein the coherent light source is specifically a near infrared light source with a wavelength of 700um to 1500 um.
13. The superlens-based optical coherence tomography system of claim 1, wherein the detector is an array charge coupled device.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11927769B2 (en) | 2022-03-31 | 2024-03-12 | Metalenz, Inc. | Polarization sorting metasurface microlens array device |
| US11978752B2 (en) | 2019-07-26 | 2024-05-07 | Metalenz, Inc. | Aperture-metasurface and hybrid refractive-metasurface imaging systems |
| US11988844B2 (en) | 2017-08-31 | 2024-05-21 | Metalenz, Inc. | Transmissive metasurface lens integration |
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2022
- 2022-01-05 CN CN202220020082.6U patent/CN216933177U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11988844B2 (en) | 2017-08-31 | 2024-05-21 | Metalenz, Inc. | Transmissive metasurface lens integration |
| US11978752B2 (en) | 2019-07-26 | 2024-05-07 | Metalenz, Inc. | Aperture-metasurface and hybrid refractive-metasurface imaging systems |
| US11927769B2 (en) | 2022-03-31 | 2024-03-12 | Metalenz, Inc. | Polarization sorting metasurface microlens array device |
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