CN215415064U - Quick detection helicobacter pylori kit of blowing - Google Patents
Quick detection helicobacter pylori kit of blowing Download PDFInfo
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- CN215415064U CN215415064U CN202120571153.7U CN202120571153U CN215415064U CN 215415064 U CN215415064 U CN 215415064U CN 202120571153 U CN202120571153 U CN 202120571153U CN 215415064 U CN215415064 U CN 215415064U
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Abstract
The application provides a kit for rapidly detecting helicobacter pylori insufflation. During detection, an inspector only needs to rinse the mouth for about 2 minutes by using about 5ml of water with the pH value of about 4.0, then the liquid after rinsing the mouth is blown into the reagent kit from the end A of the reagent kit, and the serious condition of helicobacter pylori infection is judged through the color change of the observation window of the reagent kit.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a kit for rapidly detecting helicobacter pylori blowing, belonging to the field of medicines.
Background
Helicobacter pylori lives in the pylorus and oral cavity of the human stomach, and is one of the most common bacterial pathogens. Most of the world's population is infected with H.pylori, and in some countries almost 90% of people are infected with this bacterium. People are usually infected at early age, reaching 50% under 5 years of age. This bacterial infection first causes chronic gastritis and leads to gastric ulcers and gastric atrophy, and in severe cases gastric cancer. According to statistics, the incidence rate of atrophic gastritis and gastric cancer of people with early age of the initial helicobacter pylori infection is high, and the helicobacter pylori infection and the death rate of gastric cancer are in parallel. Helicobacter pylori is parasitic in the tissues of the gastric mucosa, and 67% to 80% of gastric ulcers and 95% of duodenal ulcers are caused by helicobacter pylori. The common symptoms of patients with chronic gastritis and peptic ulcer are: after eating, the upper abdomen is full, uncomfortable or painful, often accompanied by other adverse symptoms such as belching, abdominal distension, acid regurgitation, anorexia, etc. Some patients may also have recurrent severe abdominal pain, minor upper gastrointestinal bleeding, etc. Therefore, experts think that people who find helicobacter pylori infection as soon as possible can kill helicobacter pylori with antibiotics timely and effectively, and the method has great significance for preventing and controlling gastric cancer. Since Krajden succeeded in isolating and culturing Hp from plaque in patients with gastritis in 1989, the oral cavity was essentially established as another accumulation of Hp. The literature shows three pathways for Hp propagation: mouth-mouth, stool-mouth, stomach-mouth. It can be seen that Hp in the mouth plays a significant role in gastric Hp transmission.
Currently, there are many methods for detecting helicobacter pylori infection, such as biopsy, isolated culture of helicobacter pylori, rapid urease test, urea breath test, urinary ammonia excretion test, serology test, polymerase chain reaction, and the like. In contrast, the most widespread detection method of clinical use is mainly the urea breath test based on the rapid urease test. The detection method is mainly based on the production of urease by helicobacter pylori and the production of CO by urea decomposition by the urease2And NH3. The existing method is mainly used for clinical examination in hospitals and is not suitable for household use, so that helicobacter pylori examination of ordinary people is a key for eliminating and preventing cancer. Strengthening the detection of helicobacter pylori of the general population is in accordance with the health 2030 strategy advocated by the nation. The reagent is simple and easy to operate for ordinary people to use, and can be independently operated by reading a specification or a figure, like the test paper for early pregnancy. With this aim and this point in mind, the present application provides an insufflation kit for the detection of H.pylori. The whole structure of the device is shown in figure 1, and the device consists of a rod body and a balloon. The rod body is composed of two half ellipse long rods from the section view of the A end, the section view is shown as figure 2, the section view is unfolded as figure 3, from the section view of the B end balloon, the section view is shown as figure 4, and the section view is unfolded as figure 5. The whole reagent kit is the most important part of the whole reagent kit, and the whole key reaction process of detection is completed. The urease can be dissolved in water, and has stronger activity under the acidic condition, so that a tester only needs to rinse the mouth with about 5ml of water with the pH value of about 4.0 for about 2 minutes, because helicobacter pylori exists in the oral cavity, the helicobacter pylori in the oral cavity can enter the stomach, but the urease secreted by the helicobacter pylori still exists in the oral cavity and has activity in a certain time, and meanwhile, part of the helicobacter pylori in the stomach can enter the oral cavity through the esophagus, so that the secreted urease can be left in the oral cavity. The test subject rinses with about 5ml of water for 2 minutes to ensure that the urease is sufficiently soluble in the water. Meanwhile, 5ml of water can ensure the concentration of urease, so that the reaction time is not too long due to too low concentration, liquid gargled by a person to be detected is blown into the reagent kit from the end A of the reagent kit, the gargled water containing the urease is adsorbed by the liquid absorption pad, and urea can be decomposed to generate ammonia, so that the pH value of the whole environment of the liquid absorption pad is increased, and the indicator is discolored. Because the size of each liquid absorption pad is determined, when the first liquid absorption pad is saturated in adsorption, redundant liquid can continuously flow to the next liquid absorption pad, the flow can be accelerated by blowing air by a detected person, the next liquid absorption pad can have the same reaction with the previous liquid absorption pad, and by analogy, urea with different doses and indicator changing color under different pH values are only required to be added into the liquid absorption pads, the severity of helicobacter pylori infection can be reflected according to the color changing condition, and finally the redundant liquid is blown into the saccule and is adsorbed by sponge in the saccule. The whole device is used for detecting helicobacter pylori, is simple and easy to operate, and is more suitable for self-detection of patients at ordinary times.
Disclosure of Invention
The application aims to provide a kit for rapidly detecting helicobacter pylori insufflation. When the kit is used in a medical insurance institution, the working efficiency of detection personnel can be greatly improved, and the range of people using the kit can be enlarged, for example, children, pregnant women and the like which can not be detected by using an air blowing method. The medical instrument can be used in non-medical institutions, and can enable people to detect the medical instrument by themselves.
The application relates to a kit for rapidly detecting helicobacter pylori by blowing, which mainly comprises a card shell 1, a liquid guiding negative film 2 and a liquid absorbing pad 3.
The kit for rapidly detecting helicobacter pylori insufflation is characterized in that the clamping shell consists of a rod body and a saccule, the saccule consists of two oval hemispheres, and the saccule is filled with a liquid absorbing sponge. The rod body consists of two semi-elliptical long pipes, wherein one semi-ellipse is provided with an observation window, and the structural schematic diagram of the rod body is shown in figure 1, figure 2, figure 3, figure 4 and figure 5.
The reagent kit for rapidly detecting helicobacter pylori insufflation is characterized in that the liquid absorbing pad is adhered to the liquid guiding negative film, and the schematic structural diagram is shown in figure 6.
The kit for rapidly detecting helicobacter pylori insufflation is characterized in that the liquid guide bottom sheet and the liquid absorption pad are arranged in the bar body, the liquid absorption pad is just positioned in the observation window of the bar body, and the schematic structural diagram is shown in figure 7.
The kit for rapid detection of helicobacter pylori insufflation as described above is characterized in that the liquid-absorbing pad adsorbs urea as a substrate and an indicator, and the indicator contained in the liquid-absorbing pad from the position of the observation window at the A-end of the stick body to the position of the observation window at the B-end of the stick body changes from a low color point to a high color point.
The kit for rapidly detecting helicobacter pylori insufflation is characterized in that during detection, a patient rinses with about 5ml of water with the pH value of about 4.0 for about 2 minutes, then the rinsed liquid is insufflated into the balloon from the rod body at the A end for about 3-5 minutes, the color change of the liquid absorption pad in the observation window is observed, the specified colors appear from the A end to the B end in sequence, and the more the number of the specified colors is, the more serious helicobacter pylori infection is indicated.
Drawings
FIG. 1 is a schematic diagram showing the structure of an insufflation kit for rapid detection of helicobacter pylori
FIG. 2 is a schematic view of a cross-sectional structure of a rod viewed from the A end
FIG. 3 is a schematic view of the cross-sectional expanded structure of the rod viewed from the end A
FIG. 4 is a schematic view of the sectional structure of the balloon when viewed from the end B
FIG. 5 is a schematic view of the balloon section expanded structure viewed from the end B
FIG. 6 is a schematic view of the liquid absorbent pad attached to a liquid-permeable base sheet
FIG. 7 is a schematic view of the structure of the liquid absorption pad and the liquid guiding negative plate on the inner tangent plane of the rod body when viewed from the end A
The following is a further description of specific embodiments of the present application with reference to the drawings
Detailed Description
In the figure, 1 is the whole body of the rod-shaped balloon, 2 is a liquid absorption pad, 3 is a liquid guide bottom plate, 101 is an observation window on the rod, 102 is the rod, and 103 is the balloon. The balloon is filled with absorbent sponge or other liquid-absorbing materials, fig. 2 is a cross-sectional view of the rod body, and fig. 3 is a cross-sectional development view of the rod body. The cross section and the development figure show that the bar body is composed of two semi-elliptic materials which are connected through a clamping groove, a liquid absorption pad containing urea and an indicator and a liquid guiding negative plate can be fixed in the bar body to form a flat conduit with the liquid absorption pad and the liquid guiding negative plate inside, an observation window capable of observing color change is arranged on a flat surface on one side, the size of the water absorption pad 2 is consistent with that of the observation window, the size can partially extend out of the observation window, the liquid guiding negative plate is free of urea and the indicator and plays a role of connecting each liquid absorption pad, and the liquid guiding pad is connected with the liquid absorption pad as shown in figure 6. When a tester blows in the solution dissolved with the oral urease from the end A, the solution can be quickly guided to each liquid absorption pad through the liquid guide bottom sheet until the liquid absorption pads are saturated, redundant liquid can be absorbed by the water absorption material in the balloon, and the cross section view and the cross section development view of the balloon are shown in fig. 4 and fig. 5. FIG. 7 is a cross-sectional view of the liquid absorption pad and the liquid guiding plate installed in the rod. When a patient is detected, about 5ml of water with the pH value of about 4.0 is used for gargling for about 2 minutes, then gargling liquid is blown into the balloon from the rod body at the A end for about 3-5 minutes, the color change of the liquid absorption pad in the observation window is observed, specified colors appear from the A end to the B end in sequence, and the more the number of the specified colors is met, the more serious the infection of helicobacter pylori is. To eliminate the interference of saliva pH, the water used to rinse the mouth had a pH of about 4.0, which was slightly elevated after rinsing but below the color change point of the indicator in the first absorbent pad at the A-end of the body. The amount of mouthwash liquid is controlled to about 5ml, which ensures the concentration of mouthwash solution dissolved. The color of the liquid absorption pad in the observation window is observed about 3-5 minutes after the rod is blown in, so that the urease in the gargle liquid can be ensured to fully react with urea in the liquid absorption pad.
Claims (2)
1. A blowing kit for rapidly detecting helicobacter pylori is characterized by comprising a clamping shell, a liquid guiding negative film and a liquid absorbing pad; the clamping shell consists of a rod body and a sacculus, the sacculus consists of two elliptic hemispheres, and imbibition sponge is filled in the sacculus; the bar body consists of two semi-elliptical long pipes; the liquid absorbing pad is adhered to the liquid guiding negative film; the liquid-conducting backsheet and the absorbent pad are in the body, and the absorbent pad is positioned just inside the viewing window of the body.
2. The reagent kit for rapid detection of helicobacter pylori insufflation of claim 1, wherein the liquid absorbing pad adsorbs urea as a substrate together with the indicator, and the indicator contained in the liquid absorbing pad from the liquid absorbing pad in the observation window position at the A end of the stick to the liquid absorbing pad in the observation window position at the B end of the stick changes from low to high in color point.
Priority Applications (1)
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CN202120571153.7U CN215415064U (en) | 2021-03-19 | 2021-03-19 | Quick detection helicobacter pylori kit of blowing |
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CN202120571153.7U CN215415064U (en) | 2021-03-19 | 2021-03-19 | Quick detection helicobacter pylori kit of blowing |
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2021
- 2021-03-19 CN CN202120571153.7U patent/CN215415064U/en active Active
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