CN213853220U

CN213853220U - Liquid chromatography is cooling elution device for filler

Info

Publication number: CN213853220U
Application number: CN202022579814.9U
Authority: CN
Inventors: 赵士铭
Original assignee: Yangzhou Xiuxin Chemical Technology Co ltd
Current assignee: Yangzhou Xiuxin Chemical Technology Co ltd
Priority date: 2020-11-10
Filing date: 2020-11-10
Publication date: 2021-08-03
Anticipated expiration: 2030-11-10

Abstract

The utility model discloses a liquid chromatogram is cooling elution device for filler relates to filler elution technical field, and is not good for solving elution operation effect at normal atmospheric temperature, leads to the quick thorough elution of infiltration solvent in the liquid chromatogram filler to get off, and the effect after the liquid chromatogram filler elution can not satisfy user demand's problem. The device comprises a device frame, a supporting leg, a washing box, a packing body, an elution box, a second electromagnetic valve, a condensation pipeline and a liquid filling pump, wherein the supporting leg is arranged below the device frame and is in screwed connection with the device frame, the elution box is arranged inside the device frame and is in screwed connection with the device frame, the packing body is arranged inside the elution box, the elution box is arranged above the elution box, the first liquid filling pump is arranged on one side of the elution box, the elution box and the first liquid filling pump are both in screwed connection with the elution box, the elution pipes are arranged at two ends of the first liquid filling pump, the second electromagnetic valve is arranged outside the elution pipe, and the condensation pipeline is arranged outside the elution box.

Description

Liquid chromatography is cooling elution device for filler

Technical Field

The utility model relates to a filler elution technical field specifically is a liquid chromatogram is cooling elution device for filler.

Background

The liquid chromatogram utilizes the difference of the distribution ratio of the mixture between two liquid-solid or immiscible liquids to separate the mixture first and then analyze and identify the instrument, the filler generally refers to the material filled in other objects, the liquid chromatogram filler can be inorganic substance matrix with ceramic property or organic polymer matrix, the mobile phase permeates into the filler in the using process to cause the expansion of filler particles, consequently, mass transfer is reduced, and finally, the column efficiency is reduced, and the elution device utilizes the affinity characteristics of the substance in the eluent and the substance to be separated or the ligand to elute the substance to be separated from the affinity adsorbent.

At present, when the used elution device is used for eluting the liquid chromatography packing, the elution operation effect is poor at normal temperature, so that the solvent permeated in the liquid chromatography packing can not be quickly and thoroughly eluted, and the effect after the liquid chromatography packing is eluted can not meet the use requirement. Therefore, a cooling elution device for liquid chromatography packing is urgently needed in the market to solve the problems.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a liquid chromatogram is packed with cooling elution device to it is not good to carry out elution operation effect under normal atmospheric temperature to propose in solving above-mentioned background art, leads to the elution that osmotic solvent can not be thorough fast in the liquid chromatogram filler to get off, and the effect after the liquid chromatogram filler elution can not satisfy user demand's problem.

In order to achieve the above object, the utility model provides a following technical scheme: a cooling elution device for liquid chromatography packing comprises a device frame, wherein a supporting leg is arranged below the device frame, the supporting legs are connected with the device frame through screws, an elution box is arranged inside the device frame and is connected with the device frame through screws, a filler body is arranged in the elution box, an eluent box is arranged above the elution box, a first liquid injection pump is arranged on one side of the eluent box, the eluent box and the first liquid injection pump are both connected with the elution box through screws, both ends of the first liquid injection pump are provided with elution pipes, and the two ends of the elution tube respectively extend to the inside of the elution box and the elution liquid box, a second electromagnetic valve is arranged outside the elution tube, and the second solenoid valve sets up structure as an organic whole with the elution pipe, the outside of elution case is provided with the condensation duct, and the condensation duct laminates with the outer wall of elution case mutually.

Preferably, the top of elution case is provided with the mount pad, and mount pad and elution case joggle, the top of mount pad is provided with the motor, and the motor passes through the screw connection with the mount pad, the below of motor output is provided with the pivot, and the pivot passes through the coupling joint with the output of motor, the below of pivot is provided with the holding frame, and the holding frame passes through the screw connection with the pivot, the holding frame is connected with packing body block.

Preferably, one side of motor is provided with the cleaning fluid case, one side of cleaning fluid case is provided with the second priming pump, and cleaning fluid case and second priming pump all pass through the screw connection with the elution case, the both ends of second priming pump all are provided with the scavenge pipe, and the one end of scavenge pipe extends to the inside of elution case and cleaning fluid case respectively, the outside of scavenge pipe is provided with the third solenoid valve, and the third solenoid valve sets up structure as an organic whole with the scavenge pipe.

Preferably, the one end of elution pipe and scavenge pipe all is provided with the nozzle, and the nozzle and the equal threaded connection of elution pipe and scavenge pipe, the nozzle passes through the screw connection with the inner wall of elution case.

Preferably, the lower extreme of elution case is provided with the filter frame, and filters the frame and set up structure as an organic whole with the elution case, the lower extreme of device frame is provided with the drain pipe, and the drain pipe sets up structure as an organic whole with the device frame, the lower extreme of drain pipe is provided with first solenoid valve, and first solenoid valve passes through screw connection with the drain pipe.

Preferably, the filter screen is arranged below the filter frame, the filter screen is connected with the inner wall of the device frame in a laminating manner, the slag discharging pipe is arranged above the filter screen, one end of the slag discharging pipe extends to the outside of the device frame, the slag discharging pipe is connected with the device frame through screws, one end of the slag discharging pipe is provided with a discharging valve, and the discharging valve is connected with the slag discharging pipe through screws.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses a device passes through the setting of motor and condenser pipe, drives the packing body rotation with the help of pivot and holding frame under the effect of motor to make packing body and eluant or washing liquid stirring mix, accelerate packing body elution speed, thereby make the packing body elution more thorough, and the condenser pipe can be indirect cool down the elution case, thereby can further improve the elution effect. Solves the problem of poor elution efficiency of the filler at normal temperature.

2. The utility model discloses a device passes through the setting of second infusion pump and nozzle, can extract the washing liquid in the washing liquid case and pour into the elution case into through the scavenge pipe with the contact of the body that packs with the help of the second infusion pump and wash to can get rid of remaining eluant on the body that packs, and the nozzle can be so that eluant and washing liquid spout on the body that packs, thereby better and the body contact that packs. The problem that part of eluent still remains on the filler after the filler is eluted and the filler is not eluted completely is solved.

3. The utility model discloses a device is through the setting of filter screen, scum pipe and relief valve, and filter screen can filter the eluant after the filler elution, holds back the waste residue that thoughtlessly gets off in the eluant to improve the eluant effect, scum pipe and relief valve then can be with piling up the waste residue discharge on filter screen. Solves the problems that the filler waste residue is mixed in the eluent and the purity of the eluent is not good.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a connection diagram of the condensation pipeline and the elution box of the present invention;

FIG. 3 is a partial enlarged view of area A of the present invention;

fig. 4 is a partial enlarged view of the area B of the present invention.

In the figure: 1. a device frame; 2. supporting legs; 3. an elution tank; 4. a liquid outlet pipe; 5. a first solenoid valve; 6. filtering the screen; 7. a mounting seat; 8. a motor; 9. an eluent box; 10. a first liquid-filling pump; 11. an elution pipe; 12. a second solenoid valve; 13. a cleaning solution tank; 14. a second liquid injection pump; 15. cleaning the tube; 16. a third electromagnetic valve; 17. a filter frame; 18. a condensing duct; 19. a slag discharge pipe; 20. a discharge valve; 21. a filler body; 22. a clamping frame; 23. a rotating shaft; 24. and (4) a nozzle.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

Referring to fig. 1-4, the present invention provides an embodiment: a cooling elution device for liquid chromatography packing comprises a device frame 1, wherein supporting legs 2 are arranged below the device frame 1, the supporting legs 2 are connected with the device frame 1 through screws, an elution box 3 is arranged inside the device frame 1, the elution box 3 is connected with the device frame 1 through screws, a packing body 21 is arranged inside the elution box 3, an elution box 9 is arranged above the elution box 3, a first liquid injection pump 10 is arranged on one side of the elution box 9, the elution box 9 and the first liquid injection pump 10 are both connected with the elution box 3 through screws, elution tubes 11 are arranged at both ends of the first liquid injection pump 10, both ends of the elution tube 11 respectively extend into the elution box 3 and the elution box 9, a second electromagnetic valve 12 is arranged outside the elution tube 11, the second electromagnetic valve 12 and the elution tube 11 are arranged into an integral structure, the first liquid injection pump 10 can extract and inject the elution box 3 with the elution box 3 to contact with the packing body 21, thereby make the elution of packing body 21 more thorough, the outside of elution case 3 is provided with condensation duct 18, and condensation duct 18 laminates mutually with the outer wall of elution case 3, and condensation duct 18 can reduce the inside temperature of elution case 3 to elution effect has been improved.

Further, the top of elution case 3 is provided with mount pad 7, and

mount pad

7 and 3 joggles of elution case, and the top of mount pad 7 is provided with motor 8, and motor 8 passes through the screw connection with mount pad 7, and the below of motor 8 output is provided with pivot 23, and pivot 23 passes through the coupling joint with motor 8's output, and the below of pivot 23 is provided with holding frame 22, and holding frame 22 passes through the screw connection with pivot 23, and holding frame 22 is connected with the 21 block of packing body. Drive pivot 23 and holding frame 22 through motor 8 and rotate, can drive the filler body 21 along with holding frame 22 rotates and rotate to mix with eluent or washing liquid stirring, the contact of filler body 21 is more thorough.

Further, one side of motor 8 is provided with cleaning solution tank 13, one side of cleaning solution tank 13 is provided with second infusion pump 14, and cleaning solution tank 13 and second infusion pump 14 all pass through the screw connection with elution case 3, the both ends of second infusion pump 14 all are provided with scavenge pipe 15, and the one end of scavenge pipe 15 extends to the inside of elution case 3 and cleaning solution tank 13 respectively, the outside of scavenge pipe 15 is provided with third solenoid valve 16, and third solenoid valve 16 sets up structure as an organic whole with scavenge pipe 15. The cleaning liquid can be pumped and injected into the elution tank 3 by the second liquid injection pump 14 to contact with the packing 21, so that the residual eluent on the packing 21 can be removed.

Further, the one end of elution pipe 11 and purge tube 15 all is provided with nozzle 24, and nozzle 24 and the equal threaded connection of elution pipe 11 and purge tube 15, and nozzle 24 passes through bolted connection with the inner wall of elution case 3. The eluent or cleaning solution can be sprayed onto the filler bodies 21 through the nozzles 24 and can be better contacted with the filler bodies 21.

Further, the lower extreme of elution case 3 is provided with crosses filter stand 17, and crosses filter stand 17 and elution case 3 and set up to a body structure, and the lower extreme of device frame 1 is provided with drain pipe 4, and drain pipe 4 sets up to a body structure with device frame 1, and the lower extreme of drain pipe 4 is provided with first solenoid valve 5, and first solenoid valve 5 passes through screw connection with drain pipe 4. The solution eluted by the filler body 21 can be separated out through the filter frame 17, and the eluted solution can be discharged through the liquid outlet pipe 4.

Further, a filtering screen 6 is arranged below the filtering frame 17, the filtering screen 6 is attached to the inner wall of the device frame 1, a slag discharge pipe 19 is arranged above the filtering screen 6, one end of the slag discharge pipe 19 extends to the outside of the device frame 1, the slag discharge pipe 19 is connected with the device frame 1 through screws, a discharge valve 20 is arranged at one end of the slag discharge pipe 19, and the discharge valve 20 is connected with the slag discharge pipe 19 through screws. The eluted solution can be filtered by the filter screen 6, and the filler waste residues mixed in the eluted solution are retained and discharged by the slag discharge pipe 19.

The working principle is as follows: when the device is used, the packing body 21 is connected with the clamping frame 22 and is placed into the elution box 3, the second electromagnetic valve 12 is opened, the first liquid injection pump 10 is started to extract the eluent stored in the eluent box 9 and inject the eluent into the elution box 3 to be contacted with the packing body 21, so that the packing body 21 is eluted, cold water or cold air is injected into the condensation pipeline 18 in the elution process, so that the temperature in the elution box 3 is reduced, the elution effect of the packing body 21 is improved, the motor 8 is started in the elution process, the packing body 21 is driven to rotate under the action of the motor 8 to be stirred with the eluent, so that the packing body 21 and the eluent are mixed more thoroughly, the elution efficiency is improved, the eluted solution penetrates through the filter frame 17 and is filtered through the filter screen 6, so that the waste packing residues in the solution can be removed, the intercepted and filtered solution can be discharged by opening the first electromagnetic valve 5, after the completion of the elution, the cleaning liquid in the cleaning liquid tank 13 is extracted and injected into the elution tank 3 by opening the third electromagnetic valve 16 and the second liquid injection pump 14, so that the residual cleaning liquid on the filler 21 can be cleaned, and the waste material trapped and accumulated on the filter screen 6 can be discharged by opening the discharge valve 20.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. The utility model provides a liquid chromatography is cooling elution device for filler, includes device frame (1), its characterized in that: the device is characterized in that supporting legs (2) are arranged below the device frame (1), the supporting legs (2) are connected with the device frame (1) through screws, an elution box (3) is arranged inside the device frame (1), the elution box (3) is connected with the device frame (1) through screws, a filler body (21) is arranged inside the elution box (3), an elution box (9) is arranged above the elution box (3), a first liquid injection pump (10) is arranged on one side of the elution box (9), the elution box (9) and the first liquid injection pump (10) are both connected with the elution box (3) through screws, elution pipes (11) are arranged at both ends of the first liquid injection pump (10), both ends of the elution pipe (11) respectively extend to the insides of the elution box (3) and the elution box (9), and a second electromagnetic valve (12) is arranged outside the elution pipe (11), and second solenoid valve (12) set up structure as an organic whole with elution pipe (11), the outside of elution case (3) is provided with condensation duct (18), and condensation duct (18) laminate mutually with the outer wall of elution case (3).

2. The cooling elution device for the liquid chromatography packing according to claim 1, wherein: the top of elution case (3) is provided with mount pad (7), and mount pad (7) and elution case (3) joggle, the top of mount pad (7) is provided with motor (8), and motor (8) pass through the screw connection with mount pad (7), the below of motor (8) output is provided with pivot (23), and pivot (23) pass through the coupling joint with the output of motor (8), the below of pivot (23) is provided with holding frame (22), and holding frame (22) pass through the screw connection with pivot (23), holding frame (22) are connected with gland (21) block.

3. The cooling elution device for the liquid chromatography packing according to claim 2, characterized in that: one side of motor (8) is provided with cleaning solution case (13), one side of cleaning solution case (13) is provided with second infusion pump (14), and cleaning solution case (13) and second infusion pump (14) all pass through screw connection with elution case (3), the both ends of second infusion pump (14) all are provided with scavenge pipe (15), and the one end of scavenge pipe (15) extends to the inside of elution case (3) and cleaning solution case (13) respectively, the outside of scavenge pipe (15) is provided with third solenoid valve (16), and third solenoid valve (16) and scavenge pipe (15) set up structure as an organic whole.

4. The cooling elution device for the liquid chromatography packing according to claim 3, wherein: one end of the elution pipe (11) and one end of the cleaning pipe (15) are both provided with a nozzle (24), the nozzle (24) is in threaded connection with the elution pipe (11) and the cleaning pipe (15), and the nozzle (24) is connected with the inner wall of the elution box (3) through a screw.

5. The cooling elution device for the liquid chromatography packing according to claim 1, wherein: the lower extreme of elution case (3) is provided with filter stand (17), and filter stand (17) and elution case (3) set up structure as an organic whole, the lower extreme of device frame (1) is provided with drain pipe (4), and drain pipe (4) and device frame (1) set up structure as an organic whole, the lower extreme of drain pipe (4) is provided with first solenoid valve (5), and first solenoid valve (5) pass through screw connection with drain pipe (4).

6. The cooling elution device for the liquid chromatography packing according to claim 5, wherein: the utility model discloses a slag discharge device, including filter frame (17), filter screen (6), and the inner wall laminating of filter screen (6) and device frame (1) is connected, the top of filter screen (6) is provided with scum pipe (19), and the one end of scum pipe (19) extends to the outside of device frame (1), scum pipe (19) and device frame (1) pass through bolted connection, the one end of scum pipe (19) is provided with blow-off valve (20), and blow-off valve (20) and scum pipe (19) pass through bolted connection.