CN1943620A - 一种治疗心脑血管疾病的中药组合物及其制备方法 - Google Patents
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Abstract
Description
组别 | 剂量(g/kg) | 动物数(n) | 每分钟100脑重的脑血流量[ml/(min·100g脑重)] | ||||
给药前 | 15min | 30min | 45min | 60min | |||
生理盐水组 | 5ml | 6 | 109±17 | 108±17 | 107±17 | 107±17 | 108±17 |
罂粟碱组 | 0.005 | 6 | 101±18 | 110±18* | 123±24* | 121±22* | 113±23 |
受试药物小剂量组 | 2 | 6 | 108±17 | 120±21* | 120±18* | 118±19 | 110±18 |
受试药物大剂量组 | 4 | 6 | 104±17 | 122±19* | 120±23* | 118±23* | 112±16 |
组别 | 剂量(g/kg) | 动物数(n) | 脑血管阻力[kPa/(100g脑重·ml/min)] | ||||
给药前 | 15min | 30min | 45min | 60min | |||
生理盐水组 | 5ml | 6 | 0.153±0.019 | 0.152±0.019 | 0.152±0.019 | 0.153±0.019 | 0.153±0.019 |
罂粟碱组 | 0.005 | 6 | 0.153±0.019 | 0.125±0.012** | 0.131±0.013* | 0.138±0.012* | 0.146±0.017 |
受试药物小剂量组 | 2 | 6 | 0.149±0.017 | 0.129±0.016* | 0.133±0.016* | 0.137±0.012 | 0.143±0.014 |
受试药物大剂量组 | 4 | 6 | 0.147±0.016 | 0.128±0.015* | 0.125±0.017** | 0.131±0.014* | 0.130±0.015 |
生理盐水组(5ml/kg) | 罂粟碱组(0.005g/kg) | 受试药物小剂量组(2g/kg) | 受试药物大剂量组(4g/kg) | |||||||||||||
SAP(kPa) | DAP(kPa) | MAP(kPa) | HR(b/min) | SAP(kPa) | DAP(kPa) | MAP(kPa) | HR(b/min) | SAP(kPa) | DAP(kPa) | MAP(kPa) | HR(b/min) | SAP(kPa) | DAP(kPa) | MAP(kPa) | HR(b/min) | |
给药前 | 22±3 | 15±2 | 18±2 | 175±21 | 23±3 | 16±2 | 19±2 | 163±18 | 24±5 | 17±3 | 18±3 | 193±28 | 23±3 | 16±2 | 17±3 | 187±21 |
15min | 23±3 | 15±2 | 17±2 | 168±27 | 22±3 | 15±2 | 18±2 | 181±24* | 24±4 | 17±3 | 18±4 | 183±24 | 25±4 | 17±3 | 18±4 | 185±24 |
30min | 23±3 | 16±2 | 17±2 | 164±28 | 21±4 | 15±3 | 17±3 | 183±24* | 23±3 | 18±4 | 19±4 | 190±34 | 24±5 | 16±3 | 18±4 | 193±26 |
45min | 22±2 | 15±2 | 18±2 | 169±24 | 21±3 | 15±3 | 18±3 | 176±28 | 24±3 | 18±3 | 18±4 | 187±31 | 24±4 | 17±4 | 17±3 | 198±29 |
60min | 22±3 | 15±2 | 18±2 | 166±26 | 22±3 | 15±4 | 18±3 | 170±26 | 24±3 | 18±3 | 17±4 | 197±38 | 23±4 | 16±3 | 17±3 | 203±32 |
组别 | 剂量(g/kg) | 动物数(n) | 凝血时间(min) |
空白对照组 | 10ml | 10 | 1.8±0.9 |
肝素钠组 | 4000u | 10 | 5.7±1.5** |
受试药物小剂量组 | 0.4 | 10 | 2.8±0.9* |
受试药物中剂量组 | 1.2 | 10 | 2.7±0.8* |
受试药物大剂量组 | 2.4 | 10 | 3.2±1.1** |
Claims (6)
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101181327B (zh) * | 2007-11-30 | 2010-11-24 | 李钦 | 防治中风和胸痹的中药复方制剂及其制备方法 |
CN102824406A (zh) * | 2012-09-24 | 2012-12-19 | 南京正亮医药科技有限公司 | 龙丹通络胶囊在制备抑制mj细胞增殖药物中的应用 |
CN104116779A (zh) * | 2014-07-30 | 2014-10-29 | 哈尔滨圣泰生物制药有限公司 | 一种治疗气虚血瘀型心脑疾病的中药组合物及其胶囊剂和制法 |
CN105709012A (zh) * | 2015-06-09 | 2016-06-29 | 曹贤生 | 治疗心脑血管疾病的中药组合物 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN85106091A (zh) * | 1985-04-01 | 1986-07-16 | 辽阳制药厂 | 生产抗栓再造丸的方法 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101181327B (zh) * | 2007-11-30 | 2010-11-24 | 李钦 | 防治中风和胸痹的中药复方制剂及其制备方法 |
CN102824406A (zh) * | 2012-09-24 | 2012-12-19 | 南京正亮医药科技有限公司 | 龙丹通络胶囊在制备抑制mj细胞增殖药物中的应用 |
CN102824406B (zh) * | 2012-09-24 | 2016-01-27 | 汪蕾 | 龙丹通络胶囊在制备抑制mj细胞增殖药物中的应用 |
CN104116779A (zh) * | 2014-07-30 | 2014-10-29 | 哈尔滨圣泰生物制药有限公司 | 一种治疗气虚血瘀型心脑疾病的中药组合物及其胶囊剂和制法 |
CN104116779B (zh) * | 2014-07-30 | 2018-03-09 | 哈尔滨圣泰生物制药有限公司 | 一种具有抗脑缺血和抗心肌缺血作用的中药组合物及其胶囊剂和制法 |
CN105709012A (zh) * | 2015-06-09 | 2016-06-29 | 曹贤生 | 治疗心脑血管疾病的中药组合物 |
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