CN1660105A - 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片 - Google Patents
含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片 Download PDFInfo
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- CN1660105A CN1660105A CN 200410075803 CN200410075803A CN1660105A CN 1660105 A CN1660105 A CN 1660105A CN 200410075803 CN200410075803 CN 200410075803 CN 200410075803 A CN200410075803 A CN 200410075803A CN 1660105 A CN1660105 A CN 1660105A
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- CN
- China
- Prior art keywords
- cyclodextrin
- gimeracil
- hydroxypropyl
- oteracil potassium
- carboxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RYYCJUAHISIHTL-UHFFFAOYSA-N 5-azaorotic acid Chemical compound OC(=O)C1=NC(=O)NC(=O)N1 RYYCJUAHISIHTL-UHFFFAOYSA-N 0.000 title claims description 21
- 229950000193 oteracil Drugs 0.000 title claims description 21
- ZPLQIPFOCGIIHV-UHFFFAOYSA-N Gimeracil Chemical compound OC1=CC(=O)C(Cl)=CN1 ZPLQIPFOCGIIHV-UHFFFAOYSA-N 0.000 title claims description 20
- 229950009822 gimeracil Drugs 0.000 title claims description 19
- 210000000214 mouth Anatomy 0.000 title description 11
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
- 229910052731 fluorine Inorganic materials 0.000 title 1
- 239000011737 fluorine Substances 0.000 title 1
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 claims abstract description 25
- 229960001674 tegafur Drugs 0.000 claims abstract description 25
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 15
- 229930195725 Mannitol Natural products 0.000 claims description 15
- 239000000594 mannitol Substances 0.000 claims description 15
- 235000010355 mannitol Nutrition 0.000 claims description 15
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 229920000858 Cyclodextrin Polymers 0.000 claims description 11
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 11
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 8
- 239000011734 sodium Substances 0.000 claims description 8
- 229910052708 sodium Inorganic materials 0.000 claims description 8
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 7
- -1 hydroxypropyl Chemical group 0.000 claims description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 229940109275 cyclamate Drugs 0.000 claims description 6
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 229920002907 Guar gum Polymers 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- 241001597008 Nomeidae Species 0.000 claims description 3
- JVFGXECLSQXABC-UHFFFAOYSA-N ac1l3obq Chemical compound O1C(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(O)C2O)C(COCC(O)C)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC2C(O)C(O)C1OC2COCC(C)O JVFGXECLSQXABC-UHFFFAOYSA-N 0.000 claims description 3
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 235000019219 chocolate Nutrition 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 3
- 239000000665 guar gum Substances 0.000 claims description 3
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- 229960002154 guar gum Drugs 0.000 claims description 3
- 150000001261 hydroxy acids Chemical class 0.000 claims description 3
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
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- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 8
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000006191 orally-disintegrating tablet Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 20
- 238000002360 preparation method Methods 0.000 description 15
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 13
- 229960002949 fluorouracil Drugs 0.000 description 13
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- 230000000968 intestinal effect Effects 0.000 description 7
- 102100022334 Dihydropyrimidine dehydrogenase [NADP(+)] Human genes 0.000 description 6
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- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 4
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
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Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CNB200410075803XA CN100333726C (zh) | 2004-12-23 | 2004-12-23 | 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片 |
Applications Claiming Priority (1)
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CNB200410075803XA CN100333726C (zh) | 2004-12-23 | 2004-12-23 | 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片 |
Publications (2)
Publication Number | Publication Date |
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CN1660105A true CN1660105A (zh) | 2005-08-31 |
CN100333726C CN100333726C (zh) | 2007-08-29 |
Family
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CNB200410075803XA Expired - Fee Related CN100333726C (zh) | 2004-12-23 | 2004-12-23 | 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片 |
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CN (1) | CN100333726C (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2010235539A (ja) * | 2009-03-31 | 2010-10-21 | Taiho Yakuhin Kogyo Kk | 経口投与用医薬組成物 |
CN101711765B (zh) * | 2009-10-31 | 2011-03-23 | 山东新时代药业有限公司 | 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片 |
CN102028685A (zh) * | 2009-09-29 | 2011-04-27 | 北京卓越同创药物研究院 | 吉莫斯特的用途 |
CN102614183A (zh) * | 2012-03-05 | 2012-08-01 | 齐鲁制药(海南)有限公司 | 一种替吉奥的口服制剂 |
WO2012161240A1 (ja) | 2011-05-25 | 2012-11-29 | 大鵬薬品工業株式会社 | テガフール、ギメラシル、オテラシルカリウム含有有核錠 |
CN102895212A (zh) * | 2011-07-25 | 2013-01-30 | 大鹏药品工业株式会社 | 含有替加氟、吉美拉西、氧嗪酸钾的干压包衣片 |
JP5356255B2 (ja) * | 2007-12-27 | 2013-12-04 | 大鵬薬品工業株式会社 | 経口粉粒状抗腫瘍剤 |
CN104147012A (zh) * | 2014-08-22 | 2014-11-19 | 山东新时代药业有限公司 | 一种含有替加氟、吉莫斯特和奥替拉西钾的口腔崩解制剂 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5892123A (en) * | 1998-02-03 | 1999-04-06 | E. I. Du Pont De Nemours And Company | Process for reproducing a mixture containing cyclododecanone and cyclododecanol |
JP2000001473A (ja) * | 1998-04-14 | 2000-01-07 | Ube Ind Ltd | シクロドデシルハイドロパーオキサイドの製造方法 |
JP2000007668A (ja) * | 1998-04-20 | 2000-01-11 | Ube Ind Ltd | エポキシシクロドデカジエンを製造する方法 |
JP3752077B2 (ja) * | 1998-05-11 | 2006-03-08 | 住友化学株式会社 | オキソン酸カリウムの製造方法 |
-
2004
- 2004-12-23 CN CNB200410075803XA patent/CN100333726C/zh not_active Expired - Fee Related
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5356255B2 (ja) * | 2007-12-27 | 2013-12-04 | 大鵬薬品工業株式会社 | 経口粉粒状抗腫瘍剤 |
JP2014012705A (ja) * | 2007-12-27 | 2014-01-23 | Taiho Yakuhin Kogyo Kk | 経口粉粒状抗腫瘍剤 |
JP2010235539A (ja) * | 2009-03-31 | 2010-10-21 | Taiho Yakuhin Kogyo Kk | 経口投与用医薬組成物 |
CN102028685A (zh) * | 2009-09-29 | 2011-04-27 | 北京卓越同创药物研究院 | 吉莫斯特的用途 |
CN101711765B (zh) * | 2009-10-31 | 2011-03-23 | 山东新时代药业有限公司 | 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片 |
KR20140037879A (ko) | 2011-05-25 | 2014-03-27 | 다이호야쿠힌고교 가부시키가이샤 | 테가푸르, 기메라실 및 오테라실칼륨 함유 유핵정 |
WO2012161240A1 (ja) | 2011-05-25 | 2012-11-29 | 大鵬薬品工業株式会社 | テガフール、ギメラシル、オテラシルカリウム含有有核錠 |
JP2014218523A (ja) * | 2011-05-25 | 2014-11-20 | 大鵬薬品工業株式会社 | テガフール、ギメラシル、オテラシルカリウム含有有核錠 |
JP5689173B2 (ja) * | 2011-05-25 | 2015-03-25 | 大鵬薬品工業株式会社 | テガフール、ギメラシル、オテラシルカリウム含有有核錠 |
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CN102614183A (zh) * | 2012-03-05 | 2012-08-01 | 齐鲁制药(海南)有限公司 | 一种替吉奥的口服制剂 |
CN104147012A (zh) * | 2014-08-22 | 2014-11-19 | 山东新时代药业有限公司 | 一种含有替加氟、吉莫斯特和奥替拉西钾的口腔崩解制剂 |
CN104840464A (zh) * | 2014-08-22 | 2015-08-19 | 山东新时代药业有限公司 | 一种含有替加氟、吉莫斯特和奥替拉西钾的口腔崩解制剂 |
CN104147012B (zh) * | 2014-08-22 | 2016-08-24 | 山东新时代药业有限公司 | 一种含有替加氟、吉莫斯特和奥替拉西钾的口腔崩解制剂 |
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