CN1362121A - Nano Shangqing medicine and its preparation - Google Patents
Nano Shangqing medicine and its preparation Download PDFInfo
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- CN1362121A CN1362121A CN 01100174 CN01100174A CN1362121A CN 1362121 A CN1362121 A CN 1362121A CN 01100174 CN01100174 CN 01100174 CN 01100174 A CN01100174 A CN 01100174A CN 1362121 A CN1362121 A CN 1362121A
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Abstract
The present invention discloses a nano Shangqing preparation medicine. It is made up by using 12 Chinese medicinal materials of nano chrysanthemum, nano mint, nano ligusticum, nano angelica and nano schizonepeta as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of clearing away heat to dispel wind, detoxifcation, relieving constipation, cure mainly the nanometer Shangqing ' medicine of aphtha of the mouth and tongue, constipation, the invention still further relates to the method for this medication preparation.
Shangqing pill is a kind of classical Chinese patent medicine, mainly contains effects such as clearing away heat to dispel wind, detoxifcation, relieving constipation, is used for dizziness and tinnitus, conjunctival congestion, sinusitis, aphtha of the mouth and tongue, gingival swelling and pain, constipation.But traditional shangqing pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer Shangqing ' medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer Shangqing ' medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Flos Chrysanthemi 36-84 part nanometer Herba Menthae 6-14 part nanometer Rhizoma Chuanxiong 6-14 part
Nano angelica root 36-84 part nanometer Herba Schizonepetae 6-14 part nanometer Radix Saposhnikoviae 10-30 part
Nanometer Radix Platycodonis 10-30 part nanometer Fructus Forsythiae 36-84 part nanometer Fructus Gardeniae 10-30 part
Nanometer Radix Scutellariae (wine stir-fry) 60-140 part nano phellodendron bark (wine stir-fry) 22-58 part nano rhubarb (wine stir-fry) 75-165 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Flos Chrysanthemi 50-70 part nanometer Herba Menthae 8-12 part nanometer Rhizoma Chuanxiong 8-12 part
Nano angelica root 50-70 part nanometer Herba Schizonepetae 8-12 part nanometer Radix Saposhnikoviae 15-25 part
Nanometer Radix Platycodonis 15-25 part nanometer Fructus Forsythiae 50-70 part nanometer Fructus Gardeniae 15-25 part
Nanometer Radix Scutellariae (wine stir-fry) 80-120 part nano phellodendron bark (wine stir-fry) 32-48 part nano rhubarb (wine stir-fry) 100-140 part
The optimum weight proportioning of medicine of the present invention is:
10 parts of 10 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Herba Menthaes of nanometer Flos Chrysanthemi
20 parts of 10 parts of nanometer Radix Saposhnikoviaes of 60 parts of nanometer Herba Schizonepetae of nano angelica root
20 parts of 60 parts of nanometer Fructus Gardeniaes of 20 parts of nanometer Fructus Forsythiaes of nanometer Radix Platycodonis
120 parts of 40 parts of nano rhubarbs of 100 parts of nano phellodendron barks of nanometer Radix Scutellariae (wine stir-fry) (wine stir-fry) (wine stir-fry)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Shangqing ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer Shangqing ' medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common shangqing pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer Shangqing ' medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for dizziness and tinnitus, conjunctival congestion, and sinusitis, aphtha of the mouth and tongue, gingival swelling and pain, treatment of conditions such as constipation, clinical efficacy significantly is better than traditional shangqing pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
10 parts of 10 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Herba Menthaes of nanometer Flos Chrysanthemi
20 parts of 10 parts of nanometer Radix Saposhnikoviaes of 60 parts of nanometer Herba Schizonepetae of nano angelica root
20 parts of 60 parts of nanometer Fructus Gardeniaes of 20 parts of nanometer Fructus Forsythiaes of nanometer Radix Platycodonis
120 parts of 40 parts of nano rhubarbs of 100 parts of nano phellodendron barks of nanometer Radix Scutellariae (wine stir-fry) (wine stir-fry) (wine stir-fry)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
10 parts of 10 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Herba Menthaes of nanometer Flos Chrysanthemi
20 parts of 10 parts of nanometer Radix Saposhnikoviaes of 60 parts of nanometer Herba Schizonepetae of nano angelica root
20 parts of 60 parts of nanometer Fructus Gardeniaes of 20 parts of nanometer Fructus Forsythiaes of nanometer Radix Platycodonis
120 parts of 40 parts of nano rhubarbs of 100 parts of nano phellodendron barks of nanometer Radix Scutellariae (wine stir-fry) (wine stir-fry) (wine stir-fry)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer supernatant powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
10 parts of 10 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Herba Menthaes of nanometer Flos Chrysanthemi
20 parts of 10 parts of nanometer Radix Saposhnikoviaes of 60 parts of nanometer Herba Schizonepetae of nano angelica root
20 parts of 60 parts of nanometer Fructus Gardeniaes of 20 parts of nanometer Fructus Forsythiaes of nanometer Radix Platycodonis
120 parts of 40 parts of nano rhubarbs of 100 parts of nano phellodendron barks of nanometer Radix Scutellariae (wine stir-fry) (wine stir-fry) (wine stir-fry)
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer supernatant membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer Shangqing ' medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Flos Chrysanthemi 36-84 part nanometer Herba Menthae 6-14 part nanometer Rhizoma Chuanxiong 6-14 part
Nano angelica root 36-84 part nanometer Herba Schizonepetae 6-14 part nanometer Radix Saposhnikoviae 10-30 part
Nanometer Radix Platycodonis 10-30 part nanometer Fructus Forsythiae 36-84 part nanometer Fructus Gardeniae 10-30 part
Nanometer Radix Scutellariae (wine stir-fry) 60-140 part nano phellodendron bark (wine stir-fry) 22-58 part nano rhubarb (wine stir-fry) 75-165 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer Shangqing ' medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Flos Chrysanthemi 50-70 part nanometer Herba Menthae 8-12 part nanometer Rhizoma Chuanxiong 8-12 part
Nano angelica root 50-70 part nanometer Herba Schizonepetae 8-12 part nanometer Radix Saposhnikoviae 15-25 part
Nanometer Radix Platycodonis 15-25 part nanometer Fructus Forsythiae 50-70 part nanometer Fructus Gardeniae 15-25 part
Nanometer Radix Scutellariae (wine stir-fry) 80-120 part nano phellodendron bark (wine stir-fry) 32-48 part nano rhubarb (wine stir-fry) 100-140 part
3, nanometer Shangqing ' medicine according to claim 1, wherein the weight proportion of each nano raw material is:
10 parts of 10 parts of nanometer Rhizoma Chuanxiongs of 60 parts of nanometer Herba Menthaes of nanometer Flos Chrysanthemi
20 parts of 10 parts of nanometer Radix Saposhnikoviaes of 60 parts of nanometer Herba Schizonepetae of nano angelica root
20 parts of 60 parts of nanometer Fructus Gardeniaes of 20 parts of nanometer Fructus Forsythiaes of nanometer Radix Platycodonis
120 parts of 40 parts of nano rhubarbs of 100 parts of nano phellodendron barks of nanometer Radix Scutellariae (wine stir-fry) (wine stir-fry) (wine stir-fry)
4, according to claim 1 or 2 or 3 described nanometer Shangqing ' medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer Shangqing ' medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100174 CN1362121A (en) | 2001-01-04 | 2001-01-04 | Nano Shangqing medicine and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100174 CN1362121A (en) | 2001-01-04 | 2001-01-04 | Nano Shangqing medicine and its preparation |
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| CN1362121A true CN1362121A (en) | 2002-08-07 |
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| CN 01100174 Pending CN1362121A (en) | 2001-01-04 | 2001-01-04 | Nano Shangqing medicine and its preparation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011477B (en) * | 2006-12-16 | 2010-12-08 | 田平林 | Shangqing pills formula and its production process |
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2001
- 2001-01-04 CN CN 01100174 patent/CN1362121A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101011477B (en) * | 2006-12-16 | 2010-12-08 | 田平林 | Shangqing pills formula and its production process |
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