CN1322543A - 一种降血脂药的制备方法 - Google Patents
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Abstract
本发明是一种降血脂药的制备方法,其制备过程为以荜拨为原料经乙醇浸泡、氢氧化钾洗和苯溶解、脱水等过程提取七种有效成分胡椒碱、荜拨宁酰胺、二氢荜拨宁酰胺、胡椒杀虫胺、荜拨奎宁素、荜拨九炭碱、荜拨十一炭碱。以这七种有效成分为主药加赋型药淀粉、葡萄糖、糊精按比例配制成成药。本制备方法科学合理,提取的有效成分纯度高。用本方法制作出的降血脂药对高血脂及高血脂糖尿病有显著的疗效,且服用它无任何毒副作用。
Description
本发明涉及一种降血脂药的制备方法，属于蒙药的制备方法，方法包括从胡椒科植物荜拨的果实中提取有效成份再和赋型药配制。
高血脂症很容易引起动脉粥样硬化，而导致心血管病。我国死亡率最高的疾病是心血管病。心血管病的主要原因之一是高血脂症。随着我国人民生活水平的提高，食用含高脂肪食物较多，高血脂症也在增加。关于治疗高血脂病的中药及其制备方法已有专利申请，其配方和生产工艺各异，疗效也不同。
本发明的目的是提供一种降血脂药的制备方法，这种药对高血脂患者有显著的疗效。它以荜拨的有效成份为主药加赋型药制备而成。
本发明的目的是由如下措施完成的：
将荜拨粉放入浓度为95％的乙醇中浸泡24小时，减压回收乙醇后得油状物，油状物放置48小时后产生了淡黄色结晶，取了结晶后的油状物中再加浓度为10％的氢氧化钾液水浴加热1小时，放冷后倒入分液漏斗加苯振荡静置，待分成溶苯与不溶苯的两层后，取溶苯部分，用水洗二次，再用蒸馏水洗一次，将洗液混于不溶苯的部分，然后苯液中加无水硫酸钠脱水，次日滤过，取滤液在水浴上加热回收苯，得油状物，即是荜拨的有效成份，放置数日后又产生许多结晶，是胡椒碱；结晶滤过后的油状物为不皂化物(荜拨宁酰胺、二氢荜拨宁酰胺、胡椒杀虫胺、荜拨奎宁素、荜拨九炭碱、荜拨十一炭碱)，将荜拨的七种有效成份(主药)和淀粉、葡萄糖粉、糊精(赋型药)配制即为成药。
成药中各成份的重量百分比为荜拔的有效成份6-8％、淀粉50-65％、葡萄糖粉25-35％、糊精3-4％。
本发明的优点是：
由于本降血脂药中主药为荜拨的有效成份，这7种成份有显著的降血脂、降胆固醇作用，同时对甘油三酯和血脂性糖尿病的血糖也有降低作用。本制方法科学合理，提取的有效成份纯度很高。降血脂药对高血脂及高血脂糖尿病有着显著的疗效，且口服它无任何毒副作用。
附图说明：
本附图为降血脂药的制备工艺配方图
实施例：
将荜拨粉放入浓度为95％的乙醇中浸泡24小时，减压回收乙醇后得油状物，放置48小时后产生了淡黄色结晶，取了结晶后的油状物中再加浓度为10％的氢氧化钾液水浴加热1小时，放冷后倒入分液漏斗加苯振荡静置，待分成溶苯与不溶苯的两层后，取溶苯部分，用水洗二次，再用蒸馏水洗一次，将洗液混于不溶苯的部分，然后苯液中加无水硫酸钠脱水，次日滤过，取滤液在水浴上加热回收苯，得油状物，即是荜拨的有效成份，放置数日后又产生许多结晶，是胡椒碱；将结晶滤过后的油状物为不皂化物(荜拨宁酰胺、二氢荜拨宁酰胺、胡椒杀虫胺、荜拨奎宁素、荜拨九炭碱、荜拨十一炭碱)，荜拨的七种有效成份(主药)和淀粉、葡萄糖粉、糊精(赋型药)配制即为成药。
成药中各成份的重量百分比为荜拨的有效成份6.7％、淀粉60％、葡萄糖粉30％、糊精3.3％。
Claims (2)
1．一种降血脂药的制备方法，包括从胡椒科植物荜拨的果实中提取有效成份再和赋型药配制，其特征在于将荜拨粉放入浓度为95％的乙醇中浸泡24小时，减压回收乙醇后得油状物，放置48小时后产生了淡黄色结晶，取了结晶后的油状物中再加浓度为10％的氢氧化钾液水浴加热1小时，放冷后倒入分液漏斗加苯振荡静置，待分成溶苯与不溶苯的两层后，取溶苯部分，用水洗二次，再用蒸馏水洗一次，将洗液混于不溶苯的部分，然后苯液中加无水硫酸钠脱水，次日滤过，取滤液在水浴上加热回收苯，得油状物，即是荜拨的有效成份，放置数日后又产生许多结晶，是胡椒碱；将结晶滤过后的油状物为不皂化物(荜拨宁酰胺、二氢荜拨宁酰胺、胡椒杀虫胺、荜拨奎宁素、荜拨九炭碱、荜拨十一炭碱)，将荜拨的七种有效成份(主药)和淀粉、葡萄糖粉、糊精(赋型药)配制即为成药。
2．根据权利要求1所述的降血脂药，其特征在于成药中各成份的重量百分比为荜拨的有效成份6-8％、淀粉50-65％、葡萄糖粉25-35％、糊精3-4％。
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376243C (zh) * | 2004-12-03 | 2008-03-26 | 内蒙古大学 | 胡椒酸酯类化合物在制备降血脂药物或保健品中的应用 |
| WO2009027956A3 (en) * | 2007-08-31 | 2009-05-22 | Shannon Minerals Patents Ltd | Syndrome x composition and method of lowering blood pressure and glycemic index |
| CN101791336A (zh) * | 2010-04-08 | 2010-08-04 | 首都医科大学 | 来自荜茇的提取物及其制备方法与应用 |
| CN101352487B (zh) * | 2008-08-04 | 2011-04-06 | 北京宝泰宁堂医药科技有限公司 | 荜茇提取物、其制备方法、其药物组合物及其应用 |
| CN101554409B (zh) * | 2008-04-10 | 2011-11-09 | 周亚伟 | 荜茇生物碱及其制备方法、制剂和用途 |
| CN106456690A (zh) * | 2014-03-21 | 2017-02-22 | 同和药品株式会社 | 包含来自荜茇的提取物的用于预防、治疗和改善排尿功能障碍的组合物 |
-
2000
- 2000-05-17 CN CN 00114892 patent/CN1322543A/zh active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376243C (zh) * | 2004-12-03 | 2008-03-26 | 内蒙古大学 | 胡椒酸酯类化合物在制备降血脂药物或保健品中的应用 |
| WO2009027956A3 (en) * | 2007-08-31 | 2009-05-22 | Shannon Minerals Patents Ltd | Syndrome x composition and method of lowering blood pressure and glycemic index |
| CN101554409B (zh) * | 2008-04-10 | 2011-11-09 | 周亚伟 | 荜茇生物碱及其制备方法、制剂和用途 |
| CN101352487B (zh) * | 2008-08-04 | 2011-04-06 | 北京宝泰宁堂医药科技有限公司 | 荜茇提取物、其制备方法、其药物组合物及其应用 |
| CN101791336A (zh) * | 2010-04-08 | 2010-08-04 | 首都医科大学 | 来自荜茇的提取物及其制备方法与应用 |
| CN106456690A (zh) * | 2014-03-21 | 2017-02-22 | 同和药品株式会社 | 包含来自荜茇的提取物的用于预防、治疗和改善排尿功能障碍的组合物 |
| US20170095520A1 (en) * | 2014-03-21 | 2017-04-06 | Dong Wha Pharm. Co., Ltd. | A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L. |
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