CN113588602A - Rapid parathyroid hormone detection method - Google Patents
Rapid parathyroid hormone detection method Download PDFInfo
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- CN113588602A CN113588602A CN202110772347.8A CN202110772347A CN113588602A CN 113588602 A CN113588602 A CN 113588602A CN 202110772347 A CN202110772347 A CN 202110772347A CN 113588602 A CN113588602 A CN 113588602A
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- 108090000445 Parathyroid hormone Proteins 0.000 title claims abstract description 55
- 239000000199 parathyroid hormone Substances 0.000 title claims abstract description 47
- 229960001319 parathyroid hormone Drugs 0.000 title claims abstract description 47
- 238000001514 detection method Methods 0.000 title claims abstract description 33
- 102000003982 Parathyroid hormone Human genes 0.000 title claims description 46
- 239000010931 gold Substances 0.000 claims abstract description 40
- 229910052737 gold Inorganic materials 0.000 claims abstract description 40
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 38
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000002105 nanoparticle Substances 0.000 claims abstract description 6
- 239000013307 optical fiber Substances 0.000 claims abstract description 6
- 238000005259 measurement Methods 0.000 claims abstract description 4
- 239000000523 sample Substances 0.000 claims abstract description 4
- 102100036893 Parathyroid hormone Human genes 0.000 claims abstract 9
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- NOGFHTGYPKWWRX-UHFFFAOYSA-N 2,2,6,6-tetramethyloxan-4-one Chemical compound CC1(C)CC(=O)CC(C)(C)O1 NOGFHTGYPKWWRX-UHFFFAOYSA-N 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 abstract description 10
- 108090000623 proteins and genes Proteins 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 9
- 239000012535 impurity Substances 0.000 abstract description 2
- 238000006303 photolysis reaction Methods 0.000 abstract description 2
- 230000015843 photosynthesis, light reaction Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 31
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 210000003372 endocrine gland Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000001483 mobilizing effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 210000002990 parathyroid gland Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202110772347.8A CN113588602B (en) | 2021-07-08 | 2021-07-08 | Rapid parathyroid hormone detection method |
Applications Claiming Priority (1)
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CN202110772347.8A CN113588602B (en) | 2021-07-08 | 2021-07-08 | Rapid parathyroid hormone detection method |
Publications (2)
Publication Number | Publication Date |
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CN113588602A true CN113588602A (en) | 2021-11-02 |
CN113588602B CN113588602B (en) | 2024-06-04 |
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CN202110772347.8A Active CN113588602B (en) | 2021-07-08 | 2021-07-08 | Rapid parathyroid hormone detection method |
Country Status (1)
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030082179A1 (en) * | 2001-07-03 | 2003-05-01 | Hutchison James Scott | Parathyroid hormone antibodies and related methods |
US20090280575A1 (en) * | 2006-09-28 | 2009-11-12 | Cmed Technologies Ltd. | Method for quantitative measurement of thyroid hormones and related antibodies in a serum sample |
EP2221603A1 (en) * | 2009-02-18 | 2010-08-25 | Koninklijke Philips Electronics N.V. | Sensing device for detecting a target substance |
WO2013021206A2 (en) * | 2011-08-10 | 2013-02-14 | Heptares Therapeutics Limited | Stable proteins |
US20140012224A1 (en) * | 2006-04-07 | 2014-01-09 | The Regents Of The University Of California | Targeted hollow gold nanostructures and methods of use |
CN107402300A (en) * | 2017-08-02 | 2017-11-28 | 江苏省原子医学研究所 | A kind of method of quick discriminating human parathyroid |
CN111781370A (en) * | 2020-05-20 | 2020-10-16 | 量准(武汉)生命科技有限公司 | Method for measuring molecular binding capacity by utilizing enzyme-labeling instrument and nano-gold particle-enhanced SPR sensor |
-
2021
- 2021-07-08 CN CN202110772347.8A patent/CN113588602B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030082179A1 (en) * | 2001-07-03 | 2003-05-01 | Hutchison James Scott | Parathyroid hormone antibodies and related methods |
US20140012224A1 (en) * | 2006-04-07 | 2014-01-09 | The Regents Of The University Of California | Targeted hollow gold nanostructures and methods of use |
US20090280575A1 (en) * | 2006-09-28 | 2009-11-12 | Cmed Technologies Ltd. | Method for quantitative measurement of thyroid hormones and related antibodies in a serum sample |
EP2221603A1 (en) * | 2009-02-18 | 2010-08-25 | Koninklijke Philips Electronics N.V. | Sensing device for detecting a target substance |
WO2013021206A2 (en) * | 2011-08-10 | 2013-02-14 | Heptares Therapeutics Limited | Stable proteins |
CN107402300A (en) * | 2017-08-02 | 2017-11-28 | 江苏省原子医学研究所 | A kind of method of quick discriminating human parathyroid |
CN111781370A (en) * | 2020-05-20 | 2020-10-16 | 量准(武汉)生命科技有限公司 | Method for measuring molecular binding capacity by utilizing enzyme-labeling instrument and nano-gold particle-enhanced SPR sensor |
Non-Patent Citations (2)
Title |
---|
LISA KEHLER 等: "Vitamin D deficiency in children presenting to the emergency department: a growing concern. Vitamin D deficiency in Birmingham\'s children: presentation to the emergency department", EMERGENCY MEDICINE JOURNAL, vol. 30, no. 09, 30 September 2013 (2013-09-30), pages 201473 * |
甘良英;: "甲状旁腺激素及其检测方法新进展", 中国血液净化, no. 05, 12 May 2016 (2016-05-12), pages 15 - 17 * |
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CN113588602B (en) | 2024-06-04 |
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TA01 | Transfer of patent application right |
Effective date of registration: 20220505 Address after: 2 / F, building F2, phase II, innovation industrial park, Hefei hi tech Zone, Anhui 230000 Applicant after: HEFEI NOVEL GENE TECHNOLOGY SERVICE CO.,LTD. Address before: Room 402, building 2, No. 188, Fuchunjiang Road, high tech Zone, Suzhou, Jiangsu 215129 Applicant before: Suzhou nuoweer Medical Technology Co.,Ltd. |
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Country or region after: China Address after: 2 / F, building F2, phase II, innovation industrial park, Hefei hi tech Zone, Anhui 230000 Applicant after: Hefei Xinwei Gene Technology Co.,Ltd. Address before: 2 / F, building F2, phase II, innovation industrial park, Hefei hi tech Zone, Anhui 230000 Applicant before: HEFEI NOVEL GENE TECHNOLOGY SERVICE CO.,LTD. Country or region before: China |
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