CN112546205A - Composition with function of improving skin aging and preparation method and application thereof - Google Patents
Composition with function of improving skin aging and preparation method and application thereof Download PDFInfo
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- CN112546205A CN112546205A CN202011449592.7A CN202011449592A CN112546205A CN 112546205 A CN112546205 A CN 112546205A CN 202011449592 A CN202011449592 A CN 202011449592A CN 112546205 A CN112546205 A CN 112546205A
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- rhizoma polygonati
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/17—Amino acids, peptides or proteins
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K36/06—Fungi, e.g. yeasts
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention provides a composition with a function of improving skin aging, a preparation method and an application thereof, wherein the composition with the function of improving skin aging is prepared from the following raw materials in parts by weight: 60-120 parts of collagen, 15-45 parts of braised rhizoma polygonati, 15-45 parts of poria cocos, 15-45 parts of wolfberry fruits and 1-2 parts of vitamin C. In the formula, the braised rhizoma polygonati and the wolfberry fruits can nourish liver and kidney and can replenish essence and blood. Poria has effects in invigorating spleen and stomach, promoting circulation of qi and blood, and nourishing skin. Meanwhile, the collagen and the vitamin C can promote the synthesis of collagen in vivo and have the effect of oxidation resistance. The medicines are combined to play a role in delaying skin aging together, and can be applied to the fields of medicines, health-care foods and the like.
Description
Technical Field
The invention relates to the technical field of medicines and foods, in particular to a composition with a function of improving skin aging and a preparation method and application thereof.
Background
The skin is the largest organ of the human body and, like other organs, has endogenous aging problems. Intrinsic aging is a slow irreversible tissue deterioration process that can occur in all parts of the skin tissue throughout the body, mainly resulting in the loss of various functions of the skin. The clinical manifestations mainly include pale skin, fine wrinkles and decreased elasticity. Histological manifestations include: the epidermis atrophy becomes thin, the junction of the epidermis and the dermis becomes flat, the dermis becomes thin, the vascular network is reduced, the fibroblasts and the collagen are reduced, the elastic fibers are degraded, the content is reduced, and the appendages are reduced and atrophy.
The traditional Chinese medicine considers that: skin aging is caused by various factors inside and outside, and liver and kidney deficiency is the main etiology and pathogenesis of skin aging. Liver and kidney deficiency can lead to essence and blood deficiency and failure to reach the skin, which leads to loss of moistening and dryness of the skin, manifested as dry, wrinkled and rough skin. Modern medicine considers that: excessive accumulation of free radicals and loss of collagen in the human body are the main causes of skin aging. Research shows that with the aging, the function of an in-vivo antioxidant system is reduced, and free radicals are excessively accumulated to trigger the accumulation of irreversible damage of nucleic acid, protein, sugar and lipid of skin cells, so that a series of aging damage is finally caused; the collagen content in the skin decreases at a rate of 1% per year after age 20, and the ability of fibroblasts to synthesize collagen also decreases with age. At the same time, uv light can activate matrix metalloproteinases, degrading collagen, eventually causing the skin to become stiff and inelastic.
At present, products for delaying skin aging on the market are various in variety, most of the products are cosmetics, which can not treat the symptoms and root causes, and cannot radically delay skin aging, so that a composition with functions of tonifying liver and kidney, benefiting essence and blood, and clearing harmful free radicals accumulated in the body is needed to be developed, and the composition can be applied to the fields of medicines, health-care foods and the like.
Disclosure of Invention
In view of the above, the present application provides a composition with skin aging improving function, and a preparation method and an application thereof, and the composition provided by the present invention has the functions of liver and kidney nourishing, essence and blood benefiting, oxidation resistance and skin aging improvement.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides a composition with a function of improving skin aging, which comprises the following raw materials in parts by weight: 60-120 parts of collagen, 15-45 parts of braised rhizoma polygonati, 15-45 parts of poria cocos, 15-45 parts of wolfberry fruits and 1-2 parts of vitamin C.
In the composition formula of the invention, collagen is a biological macromolecule and is mainly present in connective tissues of animals, wherein the protein in mammals occupies nearly 30% of the total protein of the whole body. The molecular structure of collagen is a triple helix structure (collagen domain) formed by 3 polypeptide chains, namely, the left-handed helix structure is formed by the left-handed rotation of the 3 polypeptide chains, and then the firm right-handed supercoiled structure is formed by mutual occlusion of hydrogen bonds. The collagen peptide has certain scavenging effect on nitrogen center free radical, hydroxyl free radical and superoxide anion free radical. The variety of the collagen is more, the commercially available collagen is a mixture of various types, the sources are various, and the collagen is fish, shrimp, pig, cow and the like; among them, some fish scale collagen peptides have high antioxidant activity. The collagen source in the examples of the present invention is not particularly limited, and commercially available products are used.
Vitamin C is structurally similar to glucose, and is a polyhydroxy compound in which two adjacent enol-type hydroxyl groups at the 2 nd and 3 rd positions in the molecule are easily dissociated to release H+Therefore, it has the property of acid, also called ascorbic acid. Vitamin C is a water-soluble vitamin, which cannot be synthesized by the human body itself and must be ingested through foods, medicines, and the like. Modern researches find that vitamin C is not only a high-efficiency antioxidant, but also can remove radicals such as super negative oxygen ions, hydroxyl radicals, organic radicals and organic peroxy radicals in vivo, and is an important cofactor for collagen maturation.
Braise rhizoma Polygonati is a product of rhizoma Polygonati by braising method; polygonatum kingianum Coll et al, Polygonatum sibiricum Red or dried rhizome of Polygonatum cyrtonema Hua of Liliaceae, belonging to yin tonifying medicine. Rhizoma Polygonati is sweet, neutral, and moist; it enters spleen, lung and kidney meridians. Rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney. Compared with the raw product, the cooked braised rhizoma polygonati has the advantages that the polysaccharide content is reduced, and the total amino acid content is increased. In addition, the braised rhizoma polygonati has an anti-oxidation effect. Specifically, the braised rhizoma polygonati prepared by referring to the processing standard of traditional Chinese medicine decoction pieces in Jiangxi province can be adopted.
Poria, also known as Yuling, Fu Ling, Wanling Gui, etc.; poria is dried sclerotium of Wolf of Polyporaceae fungus Poria cocos (Schw.). Poria has sweet and light taste, neutral nature, and has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. Poria cocos is often used for treating skin symptoms, is also used for spleen deficiency, dampness accumulation and other symptoms, has the effects of tonifying spleen and qi, enables spleen and stomach to be healthy, is normal in ascending and descending, does not stop dampness, is not obstructed in qi and blood circulation, and can nourish skin by circulating collaterals outside. The composition of the present invention may include 15 parts, 25 parts, 30 parts, 40 parts, 45 parts, preferably 30 parts by weight of poria cocos.
Fructus Lycii is mature fruit of Lycium barbarum L. of Solanaceae. Sweet in flavor and neutral in nature. Enter liver and kidney meridians. Has the effects of nourishing kidney, moistening lung, nourishing liver and improving eyesight. The book of drug properties describes the effects of changing color, whitening, tranquilizing and prolonging life. Modern research shows that: the lycium barbarum polysaccharide can obviously enhance the function of phagocyte, enhance the multiplication capacity of immune cells, and increase the IgG level and the complement activity, thereby achieving the effect of delaying senility. The composition of the present invention may include 30 parts, 35 parts, 20 parts, 45 parts, 15 parts by weight of wolfberry fruit.
In some embodiments of the present application, the composition for improving skin aging function is composed of the following raw materials by weight: 80-110 parts of collagen, 20-40 parts of braised rhizoma polygonati, 30-45 parts of poria cocos, 20-35 parts of wolfberry fruits and 1-2 parts of vitamin C. The composition of the present invention may include collagen in an amount of 80 parts, 90 parts, 100 parts, etc. by weight. The weight parts of the braised rhizoma polygonati can be 20 parts, 30 parts, 40 parts and the like.
Preferably, the composition with the function of improving skin aging consists of the following raw materials in parts by weight: 90 parts of collagen, 30 parts of braised rhizoma polygonati, 30 parts of poria cocos, 30 parts of wolfberry fruits and 1.67 parts of vitamin C.
Compared with the prior art, according to the theories of traditional Chinese medicine, pharmacological research and the like, the invention provides the composition with the function of delaying skin aging. Poria has effects in invigorating spleen and stomach, promoting circulation of qi and blood, and nourishing skin. Meanwhile, the collagen and the vitamin C can promote the synthesis of collagen in vivo and have the effect of oxidation resistance. The traditional Chinese medicine composition is combined with various medicines, and has the effect of delaying skin aging.
Further, embodiments of the present invention provide a method of preparing a composition as described above, comprising the steps of:
step 1: weighing the braised rhizoma polygonati, the poria cocos and the wolfberry fruit according to the weight ratio (in grams), adding 500-1500 parts (preferably 800-1000 parts, more preferably 900 parts) of water, extracting for 2-3 times (preferably 2 times), each time for 1-2 hours, preferably 1 hour, filtering, and concentrating to obtain a concentrated solution.
Step 2: weighing collagen and vitamin C according to the weight ratio, and placing the collagen and the vitamin C into the concentrated solution to be completely dissolved, so as to obtain the liquid composition product.
Wherein the extraction, filtration, etc. are technical operations well known in the art. After concentration, the embodiment of the invention can be obtained by firstly adding collagen and stirring until the collagen is dissolved, standing at room temperature, then adding vitamin C, adding water and stirring until the collagen is completely dissolved.
Furthermore, the invention also provides the application of the composition in the preparation of medicines or health-care foods for improving skin aging. Specifically, the composition according to the embodiment of the present invention has any one of the following functions:
increasing the moisture content and/or Hydroxyproline (HYP) content of the skin;
increasing superoxide dismutase (SOD) activity in the skin;
reducing the Lipofuscin (LF) content and/or the Malondialdehyde (MDA) content of the skin tissue.
In some embodiments of the present application, the health food for improving skin aging may be in a liquid or solid state; in other embodiments, the drug is in liquid or solid form. In addition, the composition can be further added with auxiliary materials acceptable in the field and prepared into health-care food and medicines with different forms according to a conventional mode.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
For further understanding of the present application, the compositions having skin aging improving function provided herein, and the preparation method and use thereof are specifically described below with reference to examples.
In the following examples, commercially available products were used as raw materials.
Example 1
Weighing 90g of collagen, 30g of braised rhizoma polygonati, 30g of poria cocos, 30g of wolfberry fruit and 1.67g of vitamin C according to the formula. Adding 900g of water into the cooked braised rhizoma polygonati, the poria cocos and the wolfberry fruit, extracting for 2 times, each time for 1 hour, filtering and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Example 2
60g of collagen, 20g of braised rhizoma polygonati, 40g of poria cocos, 35g of wolfberry fruit and 1.8g of vitamin are weighed according to the formula. Adding water 1200g into cooked rhizoma Polygonati, Poria and fructus Lycii, extracting for 2 times, each for 1.5 hr, filtering, and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Example 3
Weighing 120g of collagen, 15g of braised rhizoma polygonati, 45g of poria cocos, 20g of wolfberry fruit and 1.2g of vitamin C according to the formula. Adding 1500g of water into the cooked rhizoma Polygonati, Poria and fructus Lycii, extracting for 3 times, each for 2 hr, filtering, and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Example 4
Weighing 80g of collagen, 45g of braised rhizoma polygonati, 15g of poria cocos, 45g of wolfberry fruit and 2g of vitamin C according to the formula. Adding water of 700g into the cooked rhizoma Polygonati, Poria and fructus Lycii, extracting for 2 times, each time for 1 hr, filtering, and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Example 5
Weighing 100g of collagen, 40g of braised rhizoma polygonati, 25g of poria cocos, 15g of wolfberry fruit and vitamin C1g according to the formula. Adding water of 500g into the cooked rhizoma Polygonati, Poria and fructus Lycii, extracting for 2 times, each time for 1 hr, filtering, and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Comparative example 1
Weighing 40g of collagen, 10g of braised rhizoma polygonati, 5g of poria cocos, 60g of wolfberry fruit and 5g of vitamin C. Adding 1000g of water into the cooked braised rhizoma Polygonati, Poria and fructus Lycii, extracting for 2 times, each time for 1.5 hr, filtering, and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Comparative example 2
Weighing 150g of collagen, 60g of braised rhizoma polygonati, 70g of poria cocos, 10g of wolfberry fruit and 0.5g of vitamin C. Adding 2000g of water into the cooked braised rhizoma polygonati, poria cocos and wolfberry fruits, extracting for 3 times, each time for 2 hours, filtering and concentrating to about 900 g. Adding collagen, stirring to dissolve, standing at room temperature, adding vitamin C, adding water to 1000g, and stirring to dissolve completely.
Comparative example 3
Compared with the embodiment 1, the braised rhizoma polygonati is replaced by rhizoma polygonati, and the rest is the same.
Comparative example 4
Compared with example 1, the collagen is not contained, and the rest is the same.
Comparative example 5
Compared with example 1, the decoction does not contain the braised rhizoma Polygonati, and the rest is the same.
Comparative example 6
Compared with example 1, the composition does not contain Poria cocos and wolfberry fruit, and the rest is the same.
Comparative example 7
Compared with example 1, the composition does not contain Poria, fructus Lycii and vitamin C, and the rest is the same.
Comparative example 8
Compared with example 1, the decoction does not contain the braised rhizoma Polygonati and Poria, and the rest is the same.
Comparative example 9
Compared with example 1, the collagen and the braised rhizoma Polygonati are not contained, and the rest is the same.
Comparative example 10
Compared with the embodiment 1, the braised rhizoma polygonati is replaced by the donkey-hide gelatin, and the rest is the same.
Comparative example 11
Compared with example 1, Poria was replaced by colla Corii Asini, and the rest was the same.
Example 6
The invention provides experimental studies on the improvement of skin aging for the preparations of the above examples and comparative examples:
grouping and modeling experimental animals: 180 SPF-grade healthy Kunming-breed mice, half of each mouse, 6 weeks old, 18-22g in weight. Randomized into 18 groups: blank control group, subacute aging model group, examples 1-5 groups, comparative examples 1-11 groups. Taking the model group and the mice of the groups of examples 1-5 and the groups of comparative examples 1-11, carrying out subcutaneous injection of 0.1mL/20g of 5% D-galactose on the neck and the back, establishing a subacute aging model of the mice, and carrying out subcutaneous injection of equal volume of physiological saline on the neck and the back for 1 time/D and 42 days continuously on the normal group.
The administration method comprises the following steps: the model is made and the medicines are administrated at the same time, the blank control group and the subacute aging model group are intragastrically administrated with 6.0g/kg BW purified water every day, the example group is intragastrically administrated with 6.0g/kg BW of the corresponding example sample every day according to the number, and the comparative example group is intragastrically administrated with 6.0g/kg BW of the corresponding comparative example sample every day according to the number. Each group was administered for 42d continuously.
The determination method comprises the following steps: after the experiment, the mice are sacrificed and the back skin is shaved, about 0.5g of skin tissue block after the back depilation is taken, the skin tissue block is rinsed by precooled 0.9% sodium chloride solution, subcutaneous fat and other connective tissues are removed, filter paper is wiped and dried, weighing is carried out, the tissue block is cut into pieces and poured into a homogenate tube, precooled 0.9% sodium chloride solution with the mass 9 times that of the tissue block is added, and homogenate is carried out for 8 minutes to prepare 10% tissue homogenate (carried out in ice water), so that the tissue homogenate is completely crushed, and the cell content is completely dissociated in a liquid phase. Hydroxyproline (HYP), superoxide dismutase (SOD), Malondialdehyde (MDA), Lipofuscin (LF) values and skin moisture content (Water content) were determined.
The results of the measurements of the pharmaceutical compositions prepared in examples 1 to 5 and comparative examples 1 to 11 on the HYP, SOD, MDA, LF and skin moisture content in the skin of mice are shown in Table 1 below:
table 1 effect of examples and comparative examples on skin HYP, SOD activity, LF, MDA content and moisture content (x ± s, n ═ 10) of aging model mice
Note:acompared with a blank control group, P is less than 0.01;bcompared with a blank control group, P is less than 0.05;ccompared with the subacute aging model group, P is less than 0.01;dcompared with the subacute aging model group, P is less than 0.05.
The experimental result shows that the examples can improve the moisture content, the Hydroxyproline (HYP) content and the activity of superoxide dismutase (SOD) in the skin of the aged mice, reduce the contents of Lipofuscin (LF) and Malondialdehyde (MDA) in the skin tissues of the aged mice, and have significant difference (P is less than 0.05). Therefore, the samples of the embodiment of the invention have certain efficacy of delaying skin aging. From the viewpoint of effect, the sample of example 1 is superior; the comparative examples have no obvious effect.
In conclusion, the components of the composition provided by the invention have synergistic effect, can tonify liver and kidney, benefit essence and blood, resist oxidation and have the function of improving skin aging.
The above description is only a preferred embodiment of the present invention, and it should be noted that various modifications to these embodiments can be implemented by those skilled in the art without departing from the technical principle of the present invention, and these modifications should be construed as the scope of the present invention.
Claims (8)
1. The composition with the function of improving skin aging is characterized by comprising the following raw materials in parts by weight: 60-120 parts of collagen, 15-45 parts of braised rhizoma polygonati, 15-45 parts of poria cocos, 15-45 parts of wolfberry fruits and 1-2 parts of vitamin C.
2. The composition according to claim 1, which is prepared from the following raw materials in parts by weight: 80-110 parts of collagen, 20-40 parts of braised rhizoma polygonati, 30-45 parts of poria cocos, 20-35 parts of wolfberry fruits and 1-2 parts of vitamin C.
3. The composition according to claim 2, which is prepared from the following raw materials in parts by weight: 90 parts of collagen, 30 parts of braised rhizoma polygonati, 30 parts of poria cocos, 30 parts of wolfberry fruits and 1.67 parts of vitamin C.
4. Use of the composition according to any one of claims 1 to 3 for the preparation of a medicament or health food for improving skin aging.
5. Use according to claim 4, wherein the composition has any one of the following functions: increasing the moisture content and/or hydroxyproline content of the skin; increasing the activity of superoxide dismutase in the skin; reducing the lipofuscin content and/or the malondialdehyde content of the skin tissue.
6. The use according to claim 4, wherein the pharmaceutical or nutraceutical composition for improving skin aging is in liquid or solid form.
7. A process for the preparation of a composition as claimed in any one of claims 1 to 3, comprising the steps of:
weighing cooked rhizoma Polygonati, Poria and fructus Lycii at a certain weight ratio, extracting with water, filtering, and concentrating to obtain concentrated solution;
weighing collagen and vitamin C according to the weight ratio, and dissolving the collagen and the vitamin C in the concentrated solution to obtain the collagen vitamin C.
8. The method according to claim 7, wherein the extraction with water is in particular: adding 500-1500 parts of water to extract for 2-3 times, and each time lasts for 1-2 hours.
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