CN112121222A - Paper diaper or paper napkin for preventing diaper rash and preparation method thereof - Google Patents
Paper diaper or paper napkin for preventing diaper rash and preparation method thereof Download PDFInfo
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- CN112121222A CN112121222A CN202011059697.1A CN202011059697A CN112121222A CN 112121222 A CN112121222 A CN 112121222A CN 202011059697 A CN202011059697 A CN 202011059697A CN 112121222 A CN112121222 A CN 112121222A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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Abstract
The invention discloses a paper diaper or a paper napkin for preventing diaper rash and a preparation method thereof. The inner surface layer of the paper diaper or the paper napkin of the present invention is an inner surface layer treated with a solution containing hyaluronic acid or a salt thereof and optionally ectoin. The paper diaper or the paper napkin prepared by using the inner surface layer treated by the solution containing the hyaluronic acid or the salt thereof and the optional ectoin can effectively prevent diaper rash caused by long-term use of the paper diaper or the paper napkin, and can effectively protect the skin area contacting the paper diaper for a long time, so that the contacting skin is in a weak acid environment but not in a weak alkali environment, and the occurrence of diaper rash can be effectively prevented.
Description
Technical Field
The invention relates to the technical field of paper diapers, in particular to a paper diaper or a paper diaper for preventing diaper rash and a preparation method thereof.
Background
Diaper rash is also called diaper dermatitis and is mainly caused by the fact that diapers soaked by excrement and urine are not replaced timely, urea in urine is decomposed by bacteria in excrement, ammonia is generated and stimulates the skin, enzymes in excrement such as protease and lipase also stimulate the skin, the urine, excrement and ammonia can increase the pH value of the skin surface, the healthy skin surface is weakly acidic and is generally between 5.5 and 6.5, so when the diapers soaked by urine contact the skin for a long time, the pH value of the skin is changed, the skin barrier function is more fragile, the barrier function is damaged, common symptoms are skin redness, itching and discomfort, rash, dermatitis and allergy can be seriously caused, and more serious skin diseases such as acne and the like can be caused sometimes for the old people lying in bed for a long time.
Clinically, for treating skin inflammation such as diaper rash and acne, topical skin ointment such as tannic acid ointment, antibiotic-containing ointment, or antibacterial agent is generally adopted. Although effective in drug treatment, long-term use of drugs causes certain side effects on the skin and causes discomfort and inconvenience to daily life, so that it is particularly important to prevent skin inflammation caused by frequent use of diapers. Generally, the diaper is changed in time, so that the patients with dermatitis such as diaper rash are less likely to take care of babies and bedridden old people. However, the current approaches to solving the problem of diaper dermatitis from the aspects of diaper products such as diapers and paper towels are few, and the method is also the fundamental method for preventing diaper rash.
Hyaluronic Acid (HA), also known as Hyaluronic acid, is widely present in various tissues of the body, such as the vitreous humor of the eye, synovial fluid of joints, skin, umbilical cord, it HAs many special physiological functions, such as moisturizing, repairing, lubricating, it HAs been widely used in many fields such as orthopedics, ophthalmology, cosmetics, health food, etc. Hyaluronic acid is an acidic macromolecular mucopolysaccharide, the molecular weight of the hyaluronic acid is distributed from thousands of daltons to millions of daltons, and the hyaluronic acid HAs different physiological functions aiming at HA with different molecular weight sections, such as good film forming property and good lubricity of HA with large molecular weight, and strong repairing effect and antioxidation effect of HA with small molecular weight. Hyaluronic acid includes acidic hyaluronic acid and metal salts of hyaluronic acid, generally sodium hyaluronate, which is neutral.
Ectoin (Ectoine), also known as tetrahydro-methyl pyrimidine carboxylic acid, is a natural amino acid derivative, belonging to small molecular substances, which is produced by microorganisms living under extremely severe environmental conditions, serves as a compatible solute for osmotic pressure regulation of microorganisms, and has the function of stabilizing microbial cell membranes, enzymes and nucleic acids, so that the microorganisms can survive in extreme environments of high salt, high temperature and high ultraviolet radiation. Researches find that the tetrahydro-methyl pyrimidine carboxylic acid is a cell totipotent protective agent and an anti-compression protective molecule with excellent efficacy, is a multifunctional active ingredient, has the effects of moisturizing, resisting inflammation and repairing, and is safe and nontoxic. It is currently used mainly in the skin care field.
At present, hyaluronic acid and ectoin are not used in diaper products such as paper diapers and paper towels.
Disclosure of Invention
In view of the above problems, the present invention provides a diaper or a napkin for preventing diaper rash and a method for preparing the same.
The inner surface layer of the paper diaper or the paper napkin for preventing diaper rash is made of pure cotton or PE net-shaped materials after being treated by the solution containing hyaluronic acid or salt thereof and optional ectoine, and other layers of the paper diaper or the paper napkin are the same as those of the conventional paper diaper or the paper napkin. The paper diaper or the paper napkin provided by the invention can effectively prevent diaper rash caused by long-term use of the paper diaper or the paper napkin, and can effectively protect the skin area which is in contact with the paper diaper for a long time, so that the skin in contact with the paper diaper is in a weak acid environment instead of a weak base environment, thereby effectively preventing the occurrence of diaper rash.
The specific technical scheme of the invention is as follows:
1. a paper diaper or a paper napkin, wherein the inner surface layer of the paper diaper or the paper napkin is an inner surface layer treated with a solution containing hyaluronic acid or a salt thereof and optionally ectoin.
2. The diaper or the napkin according to item 1, wherein the ectoin is 0 to 2%, preferably 0.1 to 2%, and more preferably 0.4 to 0.8% in terms of mass% in a solution containing hyaluronic acid or a salt thereof and optionally ectoin.
3. The diaper or napkin according to claim 1 or 2, wherein the hyaluronic acid or salt thereof comprises high molecular hyaluronic acid or salt thereof and low molecular hyaluronic acid or salt thereof, preferably the low molecular hyaluronic acid or salt thereof has a molecular weight of 1k-1000kDa, preferably 5k-400kDa, more preferably 5k-15 kDa;
preferably, the molecular weight of the high molecular weight hyaluronic acid or the salt thereof is 1000k-3000kDa, preferably 1800k-3000kDa, and more preferably 1800k-2200 kDa.
4. The diaper or the napkin according to item 3, wherein the polymeric hyaluronic acid or the salt thereof is 0.01% to 0.2%, preferably 0.01% to 0.1%, and more preferably 0.03% to 0.08%, in terms of mass percentage in the solution containing hyaluronic acid or the salt thereof and optionally ectoine; preferably, the low molecular weight hyaluronic acid or a salt thereof is 0.1% to 2%, preferably 0.1% to 1.5%, and more preferably 0.3% to 0.8%.
5. The paper diaper or paper napkin according to any one of claims 1 to 4, wherein the solution containing hyaluronic acid or a salt thereof and optionally ectoin further comprises one or more selected from a humectant, a bacteriostatic agent, a surfactant and a pH adjuster.
6. The paper diaper or the paper napkin according to any one of claims 1 to 5, wherein the treatment method of the inner surface layer is a solution immersion treatment or a spray treatment.
7. The disposable diaper or napkin according to claim 6, wherein when the treatment method is a solution soaking treatment, the soaking time of the inner surface layer is 5 to 30 min.
8. The diaper or the napkin according to item 6, wherein when the treatment method is a spraying treatment, the amount of spraying of the inner surface layer is 0.1 to 0.8kg/m2。
9. A pant diaper or napkin according to any of claims 1 to 8, wherein the solution comprising hyaluronic acid or a salt thereof and optionally ectoin has a pH of from 4.5 to 6.5, preferably from 4.8 to 5.5.
10. A method for preparing a paper diaper or a paper napkin, which comprises treating the inner surface layer of the paper diaper or the paper napkin with a solution containing hyaluronic acid or a salt thereof and optionally ectoine, and then drying.
11. The method according to item 10, wherein the temperature of drying is 50-85 ℃, preferably 65-80 ℃; preferably, the drying time is 6-12 h.
12. The method according to item 10 or 11, wherein the treatment method is a solution immersion treatment or a spray treatment.
13. The method according to item 12, wherein when the treatment method is a solution soaking treatment, the soaking time of the inner surface layer is 5 to 30 min.
14. The method according to item 12, wherein, when the treatment manner is a spraying treatment, the spraying amount of the inner surface layer is 0.1 to 0.8kg/m2。
15. The method of any one of items 10-14, wherein,
the ectoin is 0 to 2% by mass, preferably 0.1 to 2% by mass, and more preferably 0.4 to 0.8% by mass, based on the mass of the solution containing hyaluronic acid or a salt thereof and optionally ectoin.
16. The method according to any one of claims 10 to 15, wherein the hyaluronic acid or salt thereof comprises high molecular hyaluronic acid or salt thereof and low molecular hyaluronic acid or salt thereof, preferably the low molecular hyaluronic acid or salt thereof has a molecular weight of 1k-1000kDa, preferably 5k-400kDa, more preferably 5k-15 kDa;
preferably, the molecular weight of the high molecular weight hyaluronic acid or the salt thereof is 1000k-3000kDa, preferably 1800k-3000kDa, and more preferably 1800k-2200 kDa.
17. The method according to item 16, wherein the content of the high molecular weight hyaluronic acid or a salt thereof is 0.01 to 0.2%, preferably 0.01 to 0.1%, and more preferably 0.03 to 0.08%, in terms of mass percentage in the solution containing hyaluronic acid or a salt thereof and optionally ectoine; preferably, the content of the low molecular weight hyaluronic acid or the salt thereof is 0.1% to 2%, preferably 0.1% to 1.5%, and more preferably 0.3% to 0.8%.
18. The method of any of claims 10-17, wherein the solution comprising hyaluronic acid or salt thereof and optionally ectoin further comprises one or more selected from a humectant, a bacteriostatic agent, a surfactant, and a pH adjuster.
19. The method of any one of claims 10-18, wherein the solution comprising hyaluronic acid or salt thereof and optionally ectoin is prepared by a process comprising:
hyaluronic acid or a salt thereof and optionally ectoin are dissolved in water and then adjusted using a pH adjuster to obtain a solution containing hyaluronic acid or a salt thereof and optionally ectoin.
20. The method of item 19, wherein the solution comprising hyaluronic acid or a salt thereof and optionally ectoin has a pH of 4.5-6.5, preferably 4.8-5.5.
ADVANTAGEOUS EFFECTS OF INVENTION
The paper diaper or the paper napkin provided by the invention can effectively prevent diaper rash caused by long-term use of the paper diaper or the paper napkin, and can effectively protect the skin area which is in contact with the paper diaper for a long time, so that the skin in contact with the paper diaper is in a weak acid environment instead of a weak base environment, and the occurrence of diaper rash can be effectively prevented.
Detailed Description
The present invention will be described in detail below. While specific embodiments of the invention have been shown, it should be understood that the invention may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, however, the description is given for the purpose of illustrating the general principles of the invention and not for the purpose of limiting the scope of the invention. The scope of the present invention is defined by the appended claims.
The invention provides a paper diaper or a paper napkin for preventing diaper rash, wherein the inner surface layer of the paper diaper or the paper napkin is an inner surface layer treated by a solution containing hyaluronic acid or a salt thereof and optionally ectoin.
The material of the inner surface layer of the diaper or the napkin is not limited in the present invention, and may be, for example, an inner surface layer made of a conventional material such as pure cotton or a PE mesh material.
The optional ectoin is a solution which may or may not contain ectoin.
For the treatment, the present invention is not limited, and for example, the inner surface layer material of a diaper or a napkin may be prepared by soaking with the above-mentioned solution or sprayed with the above-mentioned solution.
The step of soaking the inner surface layer of the paper diaper or the paper napkin with the solution is to soak the inner surface layer material of the paper diaper or the paper napkin in the solution, and the soaking time is not limited, for example, the soaking time may be 5 to 30min, such as 5min, 6min, 7min, 8min, 9min, 10min, 11min, 12min, 13min, 14min, 15min, 16min, 17min, 18min, 19min, 20min, 21min, 22min, 23min, 24min, 25min, 26min, 27min, 28min, 29min, 30min, or any range therebetween.
The soaking refers to completely soaking the inner surface layer material of the paper diaper or the paper napkin.
The use of the solution for spraying the inner surface of a diaper or a napkin refers to the use of the solutionThe solution is uniformly sprayed on the inner surface of a diaper or a napkin, the spraying amount is not limited, for example, the spraying amount may be 0.2 to 0.8kg/m2For example 0.2kg/m2、0.3kg/m2、0.4kg/m2、0.5kg/m2、0.6kg/m2、0.7kg/m2、0.8kg/m2Or any range therebetween.
In a preferred embodiment of the present invention, the ectoin is 0 to 2% by mass, preferably 0.1 to 2% by mass, and more preferably 0.4 to 0.8% by mass, based on the mass of the solution containing hyaluronic acid or a salt thereof and optionally ectoin.
For example, the ectoin may be 0, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0% or any range therebetween, as a mass percentage of the ectoin solution containing hyaluronic acid or a salt thereof and optionally ectoin.
In a preferred embodiment of the present invention, wherein the hyaluronic acid or a salt thereof comprises a high molecular weight hyaluronic acid or a salt thereof and a low molecular weight hyaluronic acid or a salt thereof, preferably, the low molecular weight hyaluronic acid or a salt thereof has a molecular weight of 1k to 1000kDa, preferably 5k to 400kDa, and more preferably 5k to 15 kDa;
preferably, the molecular weight of the high molecular weight hyaluronic acid or the salt thereof is 1000k-3000kDa, preferably 1800k-3000kDa, and more preferably 1800k-2200 kDa.
For example, the low molecular hyaluronic acid or salt thereof may have a molecular weight of 1kDa, 5kDa, 10kDa, 15kDa, 20kDa, 25kDa, 30kDa, 35kDa, 40kDa, 45kDa, 50kDa, 60kDa, 70kDa, 80kDa, 90kDa, 100kDa, 200kDa, 300kDa, 400kDa, 500kDa, 600kDa, 700kDa, 800kDa, 900kDa, 1000kDa, or any range therebetween;
the molecular weight of the high molecular hyaluronic acid or the salt thereof is 1000kDa, 1100kDa, 1200kDa, 1300kDa, 1400kDa, 1500kDa, 1600kDa, 1700kDa, 1800kDa, 1900kDa, 2000kDa, 2100kDa, 2200kDa, 2300kDa, 2400kDa, 2500kDa, 2600kDa, 2700kDa, 2800kDa, 2900kDa, 3000kDa or any range therebetween.
In a preferred embodiment of the present invention, the amount of the polymeric hyaluronic acid or a salt thereof is 0.01% to 0.2%, preferably 0.01% to 0.1%, and more preferably 0.03% to 0.08%, by mass of the solution containing hyaluronic acid or a salt thereof and optionally ectoine; preferably, the low molecular weight hyaluronic acid or a salt thereof is 0.1% to 2%, preferably 0.1% to 1.5%, and more preferably 0.3% to 0.8%.
For example, the polymeric hyaluronic acid or a salt thereof may be 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2% or any range therebetween, in terms of mass percentage in a solution containing hyaluronic acid or a salt thereof and optionally ectoine;
the low molecular hyaluronic acid or salt thereof may be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, or any range therebetween.
In a preferred embodiment of the present invention, the solution containing hyaluronic acid or a salt thereof and optionally ectoin further comprises one or more selected from a humectant, a bacteriostatic agent, a surfactant and a pH adjuster.
The invention is not limited as long as the humectant, the bacteriostatic agent, the surfactant and the pH regulator can play corresponding roles, and for example, the humectant can be trehalose, tremella polysaccharide, polyglutamic acid or glycerol.
The bacteriostatic agent can be one or more of phenoxyethanol, ethylhexyl glycerol, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, sorbic acid and its salt, and benzoic acid and its salt.
The surfactant can be one or more of polyoxyethylene lauryl alcohol ether, polyoxyethylene stearate, polyoxyethylene polyoxypropylene acetyl ether, polyoxyethylene alkyl phenyl ether, butanol polyether-26, and polyethylene glycol hydrogenated castor oil, preferably butanol polyether-26/PEG-40 hydrogenated castor oil.
The pH regulator can be solution prepared from lactic acid/sodium lactate, phosphate or citric acid/sodium citrate, and hydrochloric acid/sodium hydroxide.
In a preferred embodiment of the present invention, wherein the solution comprising hyaluronic acid or a salt thereof and optionally ectoin has a pH of 4.5-6.5, preferably 4.8-5.5.
For example, the pH of the solution comprising hyaluronic acid or salt thereof and optionally ectoin may be 4.5, 4.6, 4.7, 4.8, 4.9, 5.0, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, or any range therebetween.
The invention provides a method for preparing a paper diaper or a paper napkin for preventing diaper rash, which comprises the steps of treating the inner surface layer of the paper diaper or the paper napkin with a solution containing hyaluronic acid or a salt thereof and optional ectoin, and then drying the inner surface layer.
The treatment may be, for example, a solution soaking treatment or a spraying treatment.
In a preferred embodiment of the invention, the drying temperature is 50-85 ℃, preferably 65-80 ℃; preferably, the drying time is 6-12 h.
For example, the temperature of the drying may be 50 ℃, 51 ℃, 52 ℃, 53 ℃, 54 ℃, 55 ℃, 56 ℃, 57 ℃, 58 ℃, 59 ℃, 60 ℃, 61 ℃, 62 ℃, 63 ℃, 64 ℃, 65 ℃, 66 ℃, 67 ℃, 68 ℃, 69 ℃, 70 ℃, 71 ℃, 72 ℃, 73 ℃, 74 ℃, 75 ℃, 76 ℃, 77 ℃, 78 ℃, 79 ℃, 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃ or any range therebetween;
the drying time may be 6h, 7h, 8h, 9h, 10h, 11h, 12h or any range therebetween.
In a preferred embodiment of the present invention, the ectoin is 0 to 2% by mass, preferably 0.1 to 2% by mass, and more preferably 0.4 to 0.8% by mass, based on the mass of the solution containing hyaluronic acid or a salt thereof and optionally ectoin.
In a preferred embodiment of the present invention, wherein the hyaluronic acid or a salt thereof comprises a high molecular weight hyaluronic acid or a salt thereof and a low molecular weight hyaluronic acid or a salt thereof, preferably, the low molecular weight hyaluronic acid or a salt thereof has a molecular weight of 1k to 1000kDa, preferably 5k to 400kDa, and more preferably 5k to 15 kDa;
preferably, the molecular weight of the high molecular weight hyaluronic acid or the salt thereof is 1000k-3000kDa, preferably 1800k-3000kDa, and more preferably 1800k-2200 kDa.
In a preferred embodiment of the present invention, the content of the high molecular weight hyaluronic acid or a salt thereof is 0.01% to 0.2%, preferably 0.01% to 0.1%, and more preferably 0.03% to 0.08%, in terms of mass percentage of the solution containing hyaluronic acid or a salt thereof and optionally ectoine; preferably, the content of the low molecular weight hyaluronic acid or the salt thereof is 0.1% to 2%, preferably 0.1% to 1.5%, and more preferably 0.5% to 1.0%.
In a preferred embodiment of the present invention, wherein the solution containing hyaluronic acid or a salt thereof and optionally ectoin is prepared by a method comprising the steps of:
hyaluronic acid or a salt thereof and optionally ectoin are dissolved in water and then adjusted using a pH adjuster to obtain a solution containing hyaluronic acid or a salt thereof and optionally ectoin.
Preferably, the hyaluronic acid salt is a hyaluronic acid metal salt, and examples thereof include sodium hyaluronate, zinc hyaluronate, potassium hyaluronate, and the like.
In a preferred embodiment of the present invention, the treated inner surface layer material is prepared together with other layer materials according to a conventional manufacturing process of a diaper or a paper napkin, and the other layer materials are prepared by using conventional materials for preparing the diaper or the paper napkin.
It was found that a diaper or a paper napkin obtained by treating the inner surface layer of the diaper or the paper napkin with a solution containing hyaluronic acid or a salt thereof and optionally ectoin is effective in preventing development of diaper rash due to long-term use of the diaper or the paper napkin, for analysis reasons: the diaper or napkin treated with the solution containing hyaluronic acid or a salt thereof and optionally ectoin according to the present invention may protect the skin area contacting the diaper for a long time, so that the contacted skin is in a weak acid environment rather than a weak base environment, and the mechanism for maintaining the acidic environment of the inner surface of the diaper or napkin may be related to a large amount of carboxylic acid and carboxylate groups in hyaluronic acid or a salt thereof.
Examples
The invention is described generally and/or specifically for the materials used in the tests and the test methods, in the following examples,% means wt%, i.e. percent by weight, unless otherwise specified. The reagents or instruments are not indicated by manufacturers, and are conventional reagent products commercially available, wherein sodium hyaluronate and hyaluronic acid are both available from Huaxi Biotechnology corporation, and ectoin is available from Huaxi Biotechnology corporation. The paper diapers used in the examples and comparative examples were obtained from Shandong Jingxin nonwoven products, Inc.
Example 1 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or salt thereof
Dissolving 0.2g of acidic hyaluronic acid (molecular weight of 1500kDa) and 2g of sodium hyaluronate (molecular weight of 1kDa) in 100g of purified water, stirring to completely dissolve the acidic hyaluronic acid and the sodium hyaluronate, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; then, the inner surface of the paper napkin was sprayed with the above-prepared solution in an amount of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ for drying for 10 h.
Example 2 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving hyaluronic acid (molecular weight 3000kDa)0.01g, sodium hyaluronate (molecular weight 400kDa)1.5g, and ectoin 0.1g in purified water 100g, and stirringCompletely dissolving the mixture, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ for drying for 6 h.
Example 3 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.03g of hyaluronic acid (molecular weight of 2500kDa), 1.8g of sodium hyaluronate (molecular weight of 25kDa) and 2g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and adjusting the pH value of the solution to 5.0 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ for drying for 12 h.
Example 4 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.05g of hyaluronic acid (molecular weight is 1800kDa), 0.3g of sodium hyaluronate (molecular weight is 10kDa) and 0.8g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ for drying for 10 h.
Example 5 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.03g of hyaluronic acid (molecular weight is 1800kDa), 0.8g of sodium hyaluronate (molecular weight is 5kDa) and 0.6g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ for drying for 8 h.
Example 6 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Mixing hyaluronic acid1800kDa)0.04g, sodium hyaluronate (molecular weight of 5kDa)0.8g and ectoin 0.6g are dissolved in 100g of purified water, stirred to be completely dissolved, and then lactic acid is used for adjusting the pH value of the solution to 5.0 to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ for drying for 12 h.
Example 7 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.08g of hyaluronic acid (molecular weight of 2000kDa), 0.5g of sodium hyaluronate (molecular weight of 15kDa) and 0.4g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and adjusting the pH value of the solution to 4.8 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.8kg/m2Then placing the mixture in a drying device at 60 ℃ for drying for 6 h.
Example 8 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.06g of hyaluronic acid (molecular weight of 2200kDa), 0.3g of sodium hyaluronate (molecular weight of 12kDa) and 0.5g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and adjusting the pH value of the solution to 5.0 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in drying equipment at the temperature of 55 ℃ for drying for 10 h.
Example 9 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.15g of hyaluronic acid (molecular weight of 1000kDa), 0.1g of sodium hyaluronate (molecular weight of 1000kDa) and 2g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and adjusting the pH value of the solution to 4.5 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.1kg/m2Then placing the mixture in a drying device at 50 ℃ for drying for 10 h.
Example 10 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.18g of hyaluronic acid (molecular weight is 1800kDa), 1.2g of sodium hyaluronate (molecular weight is 800kDa) and 1.8g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and adjusting the pH value of the solution to 6.5 by using lactic acid or sodium lactate to obtain a clear solution; soaking the inner surface of a paper napkin in the solution for 5min, and drying at 65 deg.C for 10 hr.
Example 11 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.04g of hyaluronic acid (molecular weight is 1800kDa), 0.8g of sodium hyaluronate (molecular weight is 5kDa) and 0.6g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in drying equipment at the temperature of 55 ℃ for drying for 10 h.
EXAMPLE 12 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.1g of hyaluronic acid (molecular weight of 2800kDa), 1.5g of sodium hyaluronate (molecular weight of 100kDa) and 1.0g of ectoin in 100g of purified water, stirring to completely dissolve the hyaluronic acid, and adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; spraying the prepared solution on the inner surface of paper napkin at a rate of 0.5kg/m2Then placing the mixture in a drying device at 85 ℃ for drying for 10 h.
Example 13 preparation of inner surface layer of paper napkin treated with solution containing hyaluronic acid or its salt and ectoin
Dissolving 0.04g of hyaluronic acid (molecular weight is 1800kDa), 0.8g of sodium hyaluronate (molecular weight is 5kDa) and 0.6g of ectoin into 100g of purified water, stirring to completely dissolve the hyaluronic acid, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; the prepared solution is used for soaking the inner surface of the paper diaper made of the hot-air non-woven fabric material for 30 minutes, and then the paper diaper is placed in a drying device at the temperature of 65 ℃ and dried for 10 hours.
Comparative example 1
Dissolving 0.6g of ectoin into 100g of purified water, stirring to completely dissolve the ectoin, and then adjusting the pH value of the solution to 5.5 by using lactic acid to obtain a clear solution; the inner surface of a commercially available paper napkin was sprayed with the above prepared solution in an amount of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ until drying.
Comparative example 2
100g of purified water was taken, the pH was adjusted to 5.5 with lactic acid, and the solution was sprayed onto the inner surface of a commercially available paper napkin in an amount of 0.5kg/m2Then placing the mixture in a drying device at 65 ℃ until drying.
Comparative example 3
The paper napkin was the same as the above examples and comparative examples without any treatment.
TABLE 1 dosage of ingredients used in examples and comparative examples
Experimental example 1 test of pH of inner surface of paper napkin
Three pieces of the paper diapers prepared in the examples 1 to 13, the comparative example 1, the comparative example 2 and the comparative example 3 were taken, 50mL of infant urine was added to each piece of paper diaper, after the paper diapers were completely soaked, a region of 5cm × 5cm was selected on the inner side of each piece of paper diaper, the pH value of the inner surface of the test region was measured with a precision pH paper at 1 hour, 2 hours and 4 hours, respectively, and the average value was taken. The test results are shown in Table 2.
TABLE 2 pH of inner surface of paper napkin after treatment in examples 1-13 and comparative examples 1-3
| Item | pH value (1h) | pH value (2h) | pH value (4h) |
| Example 1 | 6.0 | 6.8 | 6.9 |
| Example 2 | 5.8 | 6.3 | 6.6 |
| Example 3 | 5.2 | 6.4 | 6.7 |
| Example 4 | 5.5 | 5.8 | 5.9 |
| Example 5 | 5.6 | 5.7 | 5.9 |
| Example 6 | 5.0 | 5.3 | 5.8 |
| Example 7 | 5.0 | 5.3 | 5.5 |
| Example 8 | 5.2 | 5.5 | 5.6 |
| Example 9 | 5.0 | 6.2 | 6.8 |
| Example 10 | 6.4 | 6.7 | 7.0 |
| Example 11 | 5.6 | 5.7 | 6.0 |
| Example 12 | 5.8 | 6.1 | 6.6 |
| Example 13 | 5.7 | 5.8 | 6.0 |
| Comparative example 1 | 6.0 | 6.5 | 7.4 |
| Comparative example 2 | 6.0 | 6.5 | 7.4 |
| Comparative example 3 | 6.3 | 6.7 | 7.6 |
As can be seen from Table 2, the paper napkins treated in examples 1 to 13 were weakly acidic or weakly acidic within 4 hours, while the paper napkins of comparative examples 1 to 3 gradually changed from weakly acidic to weakly basic within 4 hours, indicating that after the paper napkins were treated with hyaluronic acid or a salt thereof and optionally an ionogenic solution, a weakly acidic water film was formed on the inner surface of the paper napkin, which film had the intelligent effect of maintaining the pH of the inner surface of the paper napkin acidic, thereby leaving the surrounding skin in a weakly acidic environment and preventing the occurrence of diaper rash.
Experimental example 2 sensory evaluation and skin Barrier function test after human body trial
1. 10 babies of 6-18 months are selected and divided into A, B groups, each group comprises 5 babies, the baby in the group A uses a batch of baby paper diaper prepared by the conventional method on the inner surface of the paper diaper obtained in the example 13, the baby in the group B uses the conventional paper diaper without any treatment (comparative example 3), the using time is 30 days, whether the skin of the baby in each group has erythema and eczema is observed on the 10 th day, the 20 th day and the 30 th day respectively, the evaluation indexes are that whether the skin has erythema and eczema symptoms, the severity degree records the erythema or eczema by 3 minutes, 0 minute-no erythema or eczema, 1 minute-1-5 eczema or erythema, 2 minute-6-10 eczema or erythema, and 3 minutes-11, then the average score of each group is calculated, and the experimental results are shown in the table 3.
TABLE 3 sensory evaluation score
As can be seen from the experimental results scored in table 3, the paper diaper prepared by treating the inner surface of example 13 with the solution containing hyaluronic acid or a salt thereof and ectoin is effective in preventing the skin eczema problem of infants and has a skin barrier function for protecting infants, compared to the conventional paper diaper (comparative example 3).
Experimental example 3 evaluation of skin Barrier function
The skin barrier function is damaged, the percutaneous water loss of the skin is increased, and the water content of the horny layer is reduced, so that whether the skin barrier function of the buttocks area of the infant is intact after the infant uses the paper diaper can be evaluated by evaluating the water content of the horny layer of the skin and the percutaneous water loss.
The region of the buttocks of 10 infants in Experimental example 3 was tested using a skin moisture tester Corneometer CM825(Courage + Khazaka, Germany) and a percutaneous moisture loss tester Tewameter TM300(Courage + Khazaka).
Relative water content (%) of stratum corneum of the skin x 100 as measured after the experiment/as measured before the experiment;
transdermal water dispersion (%) as post-test measurement/pre-test measurement × 100
The test results are shown in tables 4 and 5.
TABLE 4 Effect of paper diapers on the Water content of the stratum corneum
| Item | Before experiment (day 0) | Experiment day 10 | Experiment day 20 | Day 30 of experiment |
| Group A | 100.00 | 105.66 | 108.19 | 110.86 |
| Group B | 100.00 | 98.12 | 87.65 | 90.32 |
TABLE 5 Effect of paper diapers on transdermal moisture loss
| Item | Before experiment (day 0) | Experiment day 10 | Experiment day 20 | Day 30 of experiment |
| Group A | 100.00 | 95.46 | 97.15 | 98.05 |
| Group B | 100.00 | 105.62 | 110.70 | 108.53 |
As can be seen from tables 4 and 5, the paper diapers (group a) prepared using the inner surface of the paper diaper described in example 13 had a higher water content in the stratum corneum and a lower amount of water loss through the skin as compared with the conventional paper diapers (group B), indicating that the skin barrier function of group a was better than that of group B, thus indicating that the paper diapers prepared by treating the inner surface of the paper diapers with a solution containing hyaluronic acid or a salt thereof and optionally ectoin were effective in protecting the skin and were better able to care for sensitive skin of infants.
In conclusion, the inner surface of the paper diaper or the paper napkin is treated by the solution containing the hyaluronic acid or the salt thereof and the optional ectoin, so that the prepared paper diaper or paper napkin can effectively protect the skin area contacting the paper diaper for a long time, and the skin at the contact part is in a weak acid environment, thereby better caring the sensitive skin of the baby.
The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.
Claims (10)
1. A paper diaper or a paper napkin, wherein the inner surface layer of the paper diaper or the paper napkin is an inner surface layer treated with a solution containing hyaluronic acid or a salt thereof and optionally ectoin.
2. A diaper or towelette according to claim 1, wherein the ectoine is present in an amount of 0-2%, preferably 0.1-2%, more preferably 0.4-0.8% by mass of the solution containing hyaluronic acid or a salt thereof and optionally ectoine.
3. The diaper or towelette according to claim 1 or 2, wherein the hyaluronic acid or salt thereof comprises a high molecular hyaluronic acid or salt thereof and a low molecular hyaluronic acid or salt thereof, preferably the low molecular hyaluronic acid or salt thereof has a molecular weight of 1k-1000kDa, preferably 5k-400kDa, further preferably 5k-15 kDa;
preferably, the molecular weight of the high molecular weight hyaluronic acid or the salt thereof is 1000k-3000kDa, preferably 1800k-3000kDa, and more preferably 1800k-2200 kDa.
4. A paper diaper or napkin according to claim 3, wherein the amount of said polymeric hyaluronic acid or salt thereof is 0.01% to 0.2%, preferably 0.01% to 0.1%, more preferably 0.03% to 0.08%, by mass of the solution containing hyaluronic acid or salt thereof and optionally ectoine; preferably, the low molecular weight hyaluronic acid or a salt thereof is 0.1% to 2%, preferably 0.1% to 1.5%, and more preferably 0.3% to 0.8%.
5. The paper diaper or paper towel according to any one of claims 1 to 4, wherein the solution containing hyaluronic acid or a salt thereof and optionally ectoin further comprises one or more selected from a humectant, a bacteriostatic agent, a surfactant and a pH adjuster.
6. A paper diaper or napkin according to any one of claims 1 to 5, wherein the treatment of the inner surface layer is a solution soaking treatment or a spraying treatment.
7. The disposable diaper or napkin according to claim 6, wherein when the treatment method is a solution soaking treatment, the soaking time of the inner surface layer is 5 to 30 min.
8. The disposable diaper or napkin of claim 6, wherein when the treatment method is a spraying treatment, the amount of spraying of the inner surface layer is 0.1 to 0.8kg/m2。
9. A pant diaper or napkin according to any one of claims 1-8, wherein the solution comprising hyaluronic acid or a salt thereof and optionally ectoin has a pH of 4.5-6.5, preferably 4.8-5.5.
10. A method for preparing a paper diaper or a paper napkin, which comprises treating the inner surface layer of the paper diaper or the paper napkin with a solution containing hyaluronic acid or a salt thereof and optionally ectoine, and then drying.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115198558A (en) * | 2021-07-27 | 2022-10-18 | 北京华熙海御科技有限公司 | Composition containing sodium hyaluronate and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127456A1 (en) * | 2004-12-10 | 2006-06-15 | Hossain Shafi U | Novel fiber-based consumer products based on new concepts of fiber modification |
| CN101862471A (en) * | 2009-04-17 | 2010-10-20 | 陈斌 | Novel diaper skin care formula |
| CN103191461A (en) * | 2013-04-26 | 2013-07-10 | 华熙福瑞达生物医药有限公司 | Wound nursing dressing containing hyaluronic acid |
| KR101304474B1 (en) * | 2013-01-15 | 2013-09-04 | 원이세라믹 주식회사 | Diaper with improved antibiosis and durability |
| CN105796249A (en) * | 2016-05-19 | 2016-07-27 | 俞祖勋 | Manufacturing method of paper diaper using antibacterial polypeptide and antibacterial paper diaper thereof |
| CN110237054A (en) * | 2019-07-11 | 2019-09-17 | 华熙生物科技股份有限公司 | A kind of scar repair material and preparation method thereof |
| CN111228296A (en) * | 2020-03-18 | 2020-06-05 | 华熙生物科技股份有限公司 | Cross-linked hyaluronic acid ectoine isotonic wound flushing fluid |
| CN111714396A (en) * | 2020-07-22 | 2020-09-29 | 华熙生物科技股份有限公司 | Composition containing ectoin and application thereof in laser beauty treatment |
-
2020
- 2020-09-30 CN CN202011059697.1A patent/CN112121222B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060127456A1 (en) * | 2004-12-10 | 2006-06-15 | Hossain Shafi U | Novel fiber-based consumer products based on new concepts of fiber modification |
| CN101862471A (en) * | 2009-04-17 | 2010-10-20 | 陈斌 | Novel diaper skin care formula |
| KR101304474B1 (en) * | 2013-01-15 | 2013-09-04 | 원이세라믹 주식회사 | Diaper with improved antibiosis and durability |
| CN103191461A (en) * | 2013-04-26 | 2013-07-10 | 华熙福瑞达生物医药有限公司 | Wound nursing dressing containing hyaluronic acid |
| CN105796249A (en) * | 2016-05-19 | 2016-07-27 | 俞祖勋 | Manufacturing method of paper diaper using antibacterial polypeptide and antibacterial paper diaper thereof |
| CN110237054A (en) * | 2019-07-11 | 2019-09-17 | 华熙生物科技股份有限公司 | A kind of scar repair material and preparation method thereof |
| CN111228296A (en) * | 2020-03-18 | 2020-06-05 | 华熙生物科技股份有限公司 | Cross-linked hyaluronic acid ectoine isotonic wound flushing fluid |
| CN111714396A (en) * | 2020-07-22 | 2020-09-29 | 华熙生物科技股份有限公司 | Composition containing ectoin and application thereof in laser beauty treatment |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115198558A (en) * | 2021-07-27 | 2022-10-18 | 北京华熙海御科技有限公司 | Composition containing sodium hyaluronate and application thereof |
| CN115198558B (en) * | 2021-07-27 | 2024-01-23 | 北京华熙海御科技有限公司 | Composition containing sodium hyaluronate and application thereof |
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