CN112007115A - Hypertension fast-reducing pill and preparation and application thereof - Google Patents
Hypertension fast-reducing pill and preparation and application thereof Download PDFInfo
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- CN112007115A CN112007115A CN202010774706.9A CN202010774706A CN112007115A CN 112007115 A CN112007115 A CN 112007115A CN 202010774706 A CN202010774706 A CN 202010774706A CN 112007115 A CN112007115 A CN 112007115A
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- hypertension
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- wine
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a hypertension quick-reducing pill as well as preparation and application thereof. The hypertension quickly-reducing composition provided by the invention has the effects of clearing heat and purging fire, clearing liver and improving vision, calming liver and suppressing yang, calming endogenous wind and dredging collaterals, clearing phlegm heat, inducing resuscitation and inducing resuscitation, tranquilizing and allaying excitement, promoting blood circulation and dredging collaterals, guiding blood downward, nourishing yin and blood, tonifying liver and kidney, purging fire and relaxing bowels, and promoting qi circulation and lowering adverse qi; the liquorice is used for regulating the functions of the medicines, clearing heat and calming wind, calming the liver and lowering the adverse flow of qi, the disclosed hypertension quick-lowering preparation is added with conventional auxiliary materials and prepared into a clinically acceptable preparation according to a conventional process, the preparation method has wide application, the preparation method of the hypertension quick-lowering pill is scientific, the operation method is easy to mature, the obtained hypertension quick-lowering pill is stable and controllable, and the prepared hypertension quick-lowering pill is clinically used for preparing related medicines and is applied to symptoms of dizziness, distending pain in the brain, neck rigidity, red face, restlessness, slurred speech, light head and feet, unstable walking and consciousness deterioration caused by the rise of deficient fire, and the obvious curative effect is achieved.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a hypertension quick-reducing pill as well as preparation and application thereof.
Background
Modern western medicine considers that hypertension is the most common chronic disease with overhigh blood pressure in arterial blood vessels, can be accompanied by functional and organic damages of organs such as heart, brain, kidney and the like, has no name of hypertension in the records of traditional Chinese medicine medical literature, and belongs to the category of diseases such as dizziness, headache and the like according to the clinical manifestations of headache, dizziness, nausea, vomit, tinnitus and the like, the disease is equivalent to wind dizziness in the national standards of traditional Chinese medicine disease names, and the disease is mostly related to factors such as emotional disorder, improper diet, internal injury and deficiency.
The syndrome of hyperactivity of liver-yang is the most common type of hypertension, and its pathogenesis is that liver-yang is hyperactivity of the liver-yang and kidney-yin is deficient of the kidney-yin. The pathogenesis is that the five emotions are extremely crossed for a long time, the qi movement is stagnated, the fire is transformed for a long time, the yin does not control the yang, and the liver yang is hyperactivity; or deficiency of kidney yin, loss of liver nourishment, liver yin deficiency, liver yang hyperactivity. The main symptoms of vertigo, tinnitus, headache and fullness are manifested by dizziness, headache aggravation, drunkenness, irritability, insomnia, dreaminess, soreness and weakness of waist and knees, heavy head and floating feet.
Therefore, the inventor considers that liver and kidney imbalance, kidney yin deficiency, yang hyperactivity and water retention wood are main pathogenesis of liver yang hyperactivity, heat clearing and wind calming, liver calming and adverse qi descending, yin liquid nourishing, nerve calming and collateral dredging are important treatment methods, and effective medicines for treating hypertension liver yang hyperactivity are screened.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide a hypertension quick-reducing pill and a preparation method and application thereof.
The invention discloses a hypertension quick-reducing composition which comprises the following raw material medicines in parts by weight: 15-45 parts of motherwort fruit, 3-9 parts of amber, 7.5-22.5 parts of salt-roasted tribulus terrestris, 6-18 parts of wine-roasted zaocys dhumnade, 3-9 parts of tabasheer, 9-27 parts of donkey-hide gelatin, 4.5-13.5 parts of chrysanthemum, 3-9 parts of rhizoma pinellinae praeparata, 4.5-13.5 parts of selfheal, 3-9 parts of wine-fried rhubarb, 3-9 parts of white peony root, 3-9 parts of red paeony root, 3-9 parts of cynanchum atratum bunge, 3-9 parts of angelica, 7.5-22.5 parts of achyranthes bidentata, 1.5-4.5 parts of bran-fried stiff silkworm, 3-9 parts of liquorice water-roasted polygala tenuifolia, 1.5-4.5 parts of cassia twig, 4.5-13.5 parts of figwort root, 3-9 parts of gentian, 12-36 parts of gypsum, 3-9 parts of hawksbill carapace, 6-18 parts of uncaria stem, 3-9 parts of calamus, 1.5-4.5 parts of pummelo flower, 1, 2.95-8.85 parts of dwarf lilyturf tuber, 9-27 parts of rehmannia root, 6-18 parts of baical skullcap root, 1.5-4.5 parts of wine-fried szechuan lovage rhizome, 3-9 parts of fried immature bitter orange, 3-9 parts of tall gastrodia tuber, 3-9 parts of cattail pollen, 1.5-4.5 parts of agilawood, 3-9 parts of amur corktree bark, 3-9 parts of Chinese thorowax root, 4.5-13.5 parts of weeping forsythia capsule, 4.5-13.5 parts of mulberry leaf, 4.5-13.5 parts of earthworm, 1.5-4.5 parts of aloe, 1.5-4.5 parts of scorpion, 3-9 parts of golden thread, 1.5-4.5 parts of dalbergia wood, 4.5-13.5 parts of tree peony bark, 6-18 parts of honey-fried liquoric root, 0.45-1.35 parts of antelope horn, 4.4-13.2 parts of cinn.
Optionally, the composition comprises the following raw material medicines in parts by weight: motherwort fruit 30 parts, amber 6 parts, salt-roasted tribulus terrestris 15 parts, wine-roasted zaocys dhumnade 12 parts, tabasheer 6 parts, donkey-hide gelatin 18 parts, chrysanthemum 9 parts, rhizoma pinellinae praeparata 6 parts, selfheal 9 parts, wine-fried rhubarb 6 parts, white peony root 6 parts, red peony root 6 parts, cynanchum atratum 6 parts, angelica 6 parts, achyranthes root 15 parts, bran-fried stiff silkworm 3 parts, licorice-water-roasted polygala root 6 parts, cassia twig 3 parts, figwort 9 parts, gentian 6 parts, gypsum 24 parts, hawksbill 6 parts, uncaria 12 parts, irkusnezoff monkshood 6 parts, pummelo rhizome 6 parts, pummelo peel 3 parts, saffron 3 parts, poria 11.8 parts, ophiopogon root 5.9 parts, rehmannia root 18 parts, scutellaria 12 parts, wine-roasted ligusticum wallichii 3 parts, fried immature bitter orange 6 parts, gastrodia tuber 6 parts, cattail pollen 6 parts, agilawood 3 parts, yellow-corktree bark 6 parts, bupleurum 6 parts, 9 parts, mulberry leaf 9 parts, earthworm 9 parts, aloe, 0.9 part of antelope horn, 8.8 parts of cinnabar, 44 parts of talcum and 6 parts of mung bean.
Optionally, the composition comprises the following raw material medicines in parts by weight: 15 parts of motherwort fruit, 3 parts of amber, 7.5 parts of salt-roasted tribulus terrestris, 6 parts of wine-roasted zaocys dhumnade, 3 parts of tabasheer, 9 parts of donkey-hide gelatin, 4.5 parts of chrysanthemum, 3 parts of rhizoma pinellinae praeparata, 4.5 parts of selfheal, 3 parts of wine-roasted rhubarb, 3 parts of white peony root, 3 parts of red peony root, 3 parts of cynanchum atratum bunge, 3 parts of angelica, 7.5 parts of achyranthes root, 1.5 parts of bran-roasted stiff silkworm, 3 parts of liquorice water-roasted polygala tenuifolia, 1.5 parts of cassia twig, 4.5 parts of figwort root, 3 parts of gentian, 12 parts of gypsum, 3 parts of hawksbill, 6 parts of uncaria rhynchophylla, 3 parts of irhizoma glauca calamus, 1.5 parts of pummelo peel, 1.5 parts of saffron, 5 parts of poria with hostwood, 2.95 parts of dwarf lilyturf tuber, 9 parts of rehmannia root, 6 parts of scutellaria baicalensis, 1.5 parts of wine-roasted ligusticum wallichii, 3 parts of fried immature bitter orange, 3 parts of cattail pollen, 1.5 parts of agilawood, 0.45 part of antelope horn, 4.4 parts of cinnabar, 22 parts of talcum and 3 parts of mung bean.
Optionally, the composition comprises the following raw material medicines in parts by weight: 45 parts of motherwort fruit, 9 parts of amber, 22.5 parts of salt-roasted tribulus terrestris, 18 parts of wine-roasted zaocys dhumnade, 9 parts of concretio silicea bambusae, 27 parts of donkey-hide gelatin, 13.5 parts of chrysanthemum, 9 parts of rhizoma pinellinae praeparata, 13.5 parts of selfheal, 9 parts of wine-roasted rhubarb, 9 parts of white peony root, 9 parts of red peony root, 9 parts of cynanchum atratum bunge, 9 parts of angelica, 22.5 parts of achyranthes root, 4.5 parts of bran-roasted stiff silkworm, 9 parts of liquorice water-roasted polygala tenuifolia, 4.5 parts of cassia twig, 13.5 parts of figwort root, 9 parts of gentiana scabra bunge, 36 parts of gypsum, 9 parts of hawksbill, 18 parts of uncaria rhynchophylla, 9 parts of irhizoma glaucescent sweetflag rhizome, 4.5 parts of pummelo peel, 4.5 parts of saffron, 17.7 parts of poria with hostwood, 8.85 parts of ophiopogon root, 27 parts of rehmannia root, 18 parts of scutellaria baical, 4.5 parts of wine-roasted ligusticum wallichii, 9 parts of fried immature bitter orange, 9 parts of coptis, 9 parts of pollen, 9 parts of catt, 1.35 parts of antelope horn, 13.2 parts of cinnabar, 66 parts of talcum and 9 parts of mung bean.
The invention also discloses a preparation for quickly reducing the hypertension, which comprises the composition for quickly reducing the hypertension.
Optionally, the auxiliary material also comprises at least one of conventional auxiliary materials such as 40-530 parts of water, 105-660 parts of beeswax and 10-330 parts of cooked glutinous rice flour.
Optionally, the hypertension quick-reducing preparation comprises pills, tablets, capsules, powder, mixtures, granules, oral liquids, syrups, ointments, granules, medicated wine, injections, beverages, biscuits, candies, cake foods or instant foods.
The invention also discloses a method for preparing the hypertension quick-reducing pill, which comprises the following steps:
(1) weighing motherwort fruit, amber, salt-roasted tribulus terrestris, wine-roasted zaocys dhumnade, tabasheer, donkey-hide gelatin, chrysanthemum, rhizoma pinellinae praeparata, selfheal, wine-fried rhubarb, white paeony root, red paeony root, cynanchum atratum bunge, angelica, achyranthes bidentata, bran-fried stiff silkworm, liquorice water-roasted polygala tenuifolia, cassia twig, figwort root, gentian, gypsum, hawksbill carapace, uncaria, irkutsk anemone rhizome, pummelo peel, saffron, poria with hostwood, radix ophiopogonis, rehmannia, scutellaria baicalensis, wine-roasted ligusticum wallichii, roasted immature bitter orange, gastrodia elata, cattail pollen, agilawood, phellodendron, radix bupleuri, forsythia, mulberry leaf, earthworm, aloe, scorpio; grinding cornu Saigae Tataricae into fine powder, mixing with the above fine powder, sieving, and mixing;
(2) weighing mung beans according to the selected parts, adding water, decocting for 1-3 times, each time for 1-3 hours, and filtering to obtain mung bean decoction;
(3) decocting semen Phaseoli Radiati to obtain decoction, drying at a temperature of not higher than 60 deg.C for 12-24 hr to obtain crude pill;
(4) refining Cinnabaris with water or pulverizing into fine powder; pulverizing pulvis Talci into pulvis Talci, mixing with Cinnabaris powder, grinding, sieving, mixing to obtain coating powder, coating the coarse pill, polishing, and drying to obtain the final product.
Optionally, step (1) further comprises weighing at least one of water, beeswax and conventional adjuvants of cooked glutinous rice flour according to selected parts, grinding into fine powder, mixing with the powder, sieving, and mixing well.
Optionally, in the step (2), the mung bean decoction is sieved by a sieve of 80-100 meshes.
Optionally, in the step (2), the mung beans are weighed according to the selected parts, water is added for decoction for 2 times, 15-45 times of water is added for the first time, and 5-15 times of water is added for the second time.
The invention also discloses a hypertension quick-reducing pill prepared by the method.
The invention also discloses the application of the hypertension quickly-reducing composition, the hypertension quickly-reducing preparation, the hypertension quickly-reducing pill prepared by the hypertension quickly-reducing pill preparation method, or the hypertension quickly-reducing pill in preparing medicines for preventing and treating dizziness, distending pain in brain, neck rigidity, red face, restlessness, slurred speech, heavy head and light feet, unstable walking and consciousness decline caused by deficient fire rising.
The technical scheme of the invention has the following advantages:
1. the invention provides a hypertension quick-reducing composition, which is prepared from selfheal, gentian, scutellaria, coptis, phellodendron, cynanchum atratum, forsythia and gypsum for clearing heat and purging fire; motherwort fruit, radix bupleuri, mulberry leaf and chrysanthemum flower are used for clearing liver and improving vision; rhizoma Gastrodiae, ramulus Uncariae cum uncis, cornu Saigae Tataricae, carapax Eretmochelydis, fructus Tribuli, Bombyx Batryticatus, Scorpio, and Zaocys for calming liver, suppressing yang hyperactivity, calming endogenous wind, and dredging collaterals; concretio silicea Bambusae seu Schizostachyi, rhizoma Acori Calami, cortex et radix Polygalae, rhizoma Pinelliae Preparata, exocarpium Citri Grandis, Poria, Succinum for removing phlegm heat, inducing resuscitation, tranquilizing mind; radix Paeoniae Rubra, cortex moutan, Achyranthis radix, rhizoma Ligustici Chuanxiong, stigma croci Sativi, pollen Typhae, lignum Dalbergiae Odoriferae, ramulus Cinnamomi, and Lumbricus with effects of promoting blood circulation, dredging collaterals, and drawing blood downward; rehmannia root, Chinese angelica, dwarf lilyturf tuber, figwort root, white paeony root and donkey-hide gelatin nourish yin and blood, and tonify liver and kidney; rhubarb and aloe can purge fire and relieve constipation; immature bitter orange and Chinese eaglewood are used for promoting qi circulation and lowering adverse qi; the liquorice coordinates the other medicines, so that the medicines are combined, the effects of clearing heat and calming endogenous wind are achieved, the liver is calmed, the adverse qi is lowered, and various components are matched with each other in an assistant and guide mode, so that the content of angiotensin and aldosterone in blood plasma can be remarkably reduced, and the blood pressure is lowered.
2. The hypertension quick-reducing preparation provided by the invention is added with conventional auxiliary materials, and is prepared into a clinically acceptable preparation according to a conventional process, so that the hypertension quick-reducing preparation has wide application.
3. The preparation method of the hypertension quick-reducing pill provided by the invention is easy to operate, the preparation method is mature after years of production practice accumulation, and the quality of the obtained product is stable and controllable.
4. The preparation method of the hypertension quick-reducing pill provided by the invention is scientific, is clinically used for preparing related medicines, and is applied to treating the diseases caused by the rise of deficient fire: dizziness, distending pain in brain, neck rigidity, red face, dysphoria, slurred speech, heavy head and light feet, unstable walking and hypoesthesia, and has good effect and safety.
Detailed Description
Example 1
The embodiment provides a specific implementation method of a hypertension quick-reducing pill, which comprises the following steps:
weighing the following traditional Chinese medicine components in parts by weight according to selected grams:
motherwort fruit 30 g, amber 6 g, salt-baked tribulus terrestris 15g, wine-baked zaocys dhumnade 12 g, tabasheer 6 g, donkey-hide gelatin 18 g, chrysanthemum 9 g, rhizoma pinellinae praeparata 6 g, selfheal 9 g, wine-baked rhubarb 6 g, white peony root 6 g, red peony root 6 g, cynanchum atratum 6 g, angelica 6 g, achyranthes and cyathula root 15g, bran-baked stiff silkworm 3 g, licorice water-baked polygala root 6 g, cassia twig 3 g, figwort 9 g, gentian 6 g, gypsum 24 g, hawksbill 6 g, uncaria 12 g, irkusnezoff anemone rhizome 6 g, pummelo peel 3 g, saffron 3 g, poria cocos 11.8 g, ophiopogon root 5.9 g, rehmannia root 18 g, baikal skullcap root 12 g, wine-baked ligusticum wallichii 3 g, parched immature bitter orange 6 g, gastrodia tuber 6 g, cattail pollen 6 g, agilawood 3 g, agilawood tree bark 6 g, bupleurum 6 g, 9 g, mulberry leaf 9 g, earthworm 9 g, aloe 3 g, buthus, pulverizing all the materials into fine powder; grinding cornu Saigae Tataricae 0.9 g into fine powder, mixing with above fine powder, sieving, and mixing;
weighing 6 g of mung bean, firstly adding 180g of water for decocting for 2 hours, then adding 60g of water for decocting for 1 hour, and filtering through a 80-mesh sieve to obtain mung bean decoction liquid;
decocting semen Phaseoli Radiati to obtain liquid pill, and drying at 60 deg.C for 12 hr to obtain crude pill;
and then 44 g of talcum is taken and crushed into fine powder, 8.8 g of cinnabar is refined into superfine powder by water, the fine powder is ground, sieved and mixed evenly to obtain coating powder, and the coating powder is used for coating the coarse pills, polishing and drying to obtain the finished product.
Example 2
The embodiment provides a specific implementation method of a hypertension quick-reducing pill, which comprises the following steps:
weighing the following traditional Chinese medicine components in parts by weight according to selected grams:
motherwort fruit 15g, amber 3 g, salt roasted caltrop 7.5 g, wine roasted zaocys dhumnade 6 g,
3 g of concretio silicea bambusae, 9 g of donkey-hide gelatin, 4.5 g of chrysanthemum, 3 g of rhizoma pinellinae praeparata, 4.5 g of selfheal, 3 g of wine-fried rhubarb, 3 g of white peony root, 3 g of red peony root, 3 g of cynanchum atratum, 3 g of angelica, 7.5 g of achyranthes bidentata, 1.5 g of stiff silkworm fried with bran, 3 g of polygala tenuifolia fried with liquoric water, 1.5 g of cassia twig, 4.5 g of figwort, 3 g of gentian, 12 g of gypsum, 3 g of hawksbill carapace, 6 g of uncaria, 3 g of irkutsk anemone rhizome, 1.5 g of exocarpium citri grandiflorum, 1.5 g of saffron, 5.9 g of poria with hostwood, 2.95 g of ophiopogon root, 9 g of rehmannia root, 6 g of scutellaria baicalensis, 1.5 g of wine-fried ligusticum wallichii, 3 g of fried immature bitter orange, 3 g of gastrodia elata, 3 g of yellow pollen, 1.5 g of agilawood, 1.5 g of phellodendron, 3 g of radix bupleuri, 4.5 g of forsythia, 4.; grinding cornu Saigae Tataricae 0.45 g into fine powder, mixing with above fine powder, sieving, and mixing; weighing 3 g of mung beans, firstly adding 45g of water, decocting for 1 hour, then adding 15g of water, decocting for 3 hours, then adding 15g of water, decocting for 1 hour, sieving with a 100-mesh sieve, and filtering to obtain mung bean decoction;
decocting semen Phaseoli Radiati to obtain liquid pill, and drying at 50 deg.C for 24 hr to obtain crude pill;
and then 22 g of talcum is taken and crushed into fine powder, 4.4 g of cinnabar is crushed into superfine powder, the fine powder is ground, sieved and mixed evenly to form coating powder, and the coating powder is used for coating the coarse pills, polishing and drying to obtain the finished product.
Example 3
The embodiment provides a specific implementation method of a hypertension quick-reducing pill, which comprises the following steps:
weighing the following traditional Chinese medicine components in parts by weight according to selected grams:
45g of motherwort fruit, 9 g of amber, 22.5 g of salt-roasted tribulus terrestris, 18 g of wine-roasted zaocys dhumnade, 9 g of concretio silicea bambusae, 27 g of donkey-hide gelatin, 13.5 g of chrysanthemum, 9 g of rhizoma pinellinae praeparata, 13.5 g of selfheal, 9 g of wine-fried rhubarb, 9 g of white peony root, 9 g of red peony root, 9 g of cynanchum atratum, 9 g of angelica, 22.5 g of achyranthes root, 4.5 g of bran-fried stiff silkworm, 9 g of liquorice water-roasted polygala tenuifolia, 4.5 g of cassia twig, 13.5 g of figwort root, 9 g of gentian root, 36 g of, 9 g of irkutsk anemone rhizome, 4.5 g of pummelo peel, 4.5 g of saffron, 17.7 g of poria with hostwood, 8.85 g of dwarf lilyturf tuber, 27 g of rehmannia root, 18 g of baical skullcap root, 4.5 g of wine-fried szechuan lovage rhizome, 9 g of fried immature bitter orange, 9 g of tall gastrodia tuber, 9 g of cattail pollen, 4.5 g of Chinese eaglewood, 9 g of amur corktree bark, 9 g of Chinese thorowax root, 13.5 g of weeping forsythia capsule, 13.5 g of mulberry leaf, 13.5 g of earthworm, 4.5 g of aloe, 4.5 g of scorpion, 9 g of golden thread, 4.5 g of dalbergia wood, 13; grinding cornu Saigae Tataricae 1.35 g into fine powder, mixing with above fine powder, sieving, and mixing;
weighing 9 g of mung beans, adding 405g of water, decocting for 3 hours, sieving with a 80-mesh sieve, and filtering to obtain mung bean decoction;
decocting semen Phaseoli Radiati to obtain liquid pill, and drying at 50 deg.C for 18 hr to obtain crude pill;
and then 66 g of talcum is taken and crushed into fine powder, 13.2 g of cinnabar is refined into superfine powder by water, the fine powder is ground, sieved and mixed evenly to obtain coating powder, and the coating powder is used for coating the coarse pills, polishing and drying to obtain the finished product.
Example 4
The embodiment provides a specific implementation method of a hypertension quick-reducing pill, which comprises the following steps:
weighing the following traditional Chinese medicine components in parts by weight according to selected grams:
motherwort fruit 30 g, amber 6 g, salt-baked tribulus terrestris 15g, wine-baked zaocys dhumnade 12 g, tabasheer 6 g, donkey-hide gelatin 18 g, chrysanthemum 9 g, rhizoma pinellinae praeparata 6 g, selfheal 9 g, wine-baked rhubarb 6 g, white peony root 6 g, red peony root 6 g, cynanchum atratum 6 g, angelica 6 g, achyranthes and cyathula root 15g, bran-baked stiff silkworm 3 g, licorice water-baked polygala root 6 g, cassia twig 3 g, figwort 9 g, gentian 6 g, gypsum 24 g, hawksbill 6 g, uncaria 12 g, irkusnezoff anemone rhizome 6 g, pummelo peel 3 g, saffron 3 g, poria cocos 11.8 g, ophiopogon root 5.9 g, rehmannia root 18 g, baikal skullcap root 12 g, wine-baked ligusticum wallichii 3 g, parched immature bitter orange 6 g, gastrodia tuber 6 g, cattail pollen 6 g, agilawood 3 g, agilawood tree bark 6 g, bupleurum 6 g, 9 g, mulberry leaf 9 g, earthworm 9 g, aloe 3 g, buthus, pulverizing all the materials into fine powder; 131 g of cooked glutinous rice flour, and uniformly mixing the cooked glutinous rice flour with the powder; grinding cornu Saigae Tataricae 0.9 g into fine powder, mixing with the above powder, sieving, and mixing;
weighing 6 g of mung bean, firstly adding 180g of water for decocting for 2 hours, then adding 60g of water for decocting for 1 hour, and filtering through a 80-mesh sieve to obtain mung bean decoction liquid;
decocting semen Phaseoli Radiati to obtain liquid pill, and drying at 60 deg.C for 12 hr to obtain crude pill;
and then 44 g of talcum is taken and crushed into fine powder, 8.8 g of cinnabar is refined into superfine powder by water, the fine powder is ground, sieved and mixed evenly to obtain coating powder, and the coating powder is used for coating the coarse pills, polishing and drying to obtain the finished product.
Example 5
The embodiment provides a specific implementation manner of a hypertension quick-reducing tablet, which comprises the following steps:
weighing the following traditional Chinese medicine components in parts by weight according to selected grams:
15g of motherwort fruit, 3 g of amber, 7.5 g of salt-roasted tribulus terrestris, 6 g of wine-roasted zaocys dhumnade, 3 g of tabasheer, 9 g of donkey-hide gelatin, 4.5 g of chrysanthemum, 3 g of rhizoma pinellinae praeparata, 4.5 g of selfheal, 3 g of wine-fried rhubarb, 3 g of white peony root, 3 g of red peony root, 3 g of cynanchum atratum bunge, 3 g of angelica, 7.5 g of achyranthes root, 1.5 g of bran-fried stiff silkworm, 3 g of liquorice water-roasted polygala tenuifolia, 1.5 g of cassia twig, 4.5 g of figwort, 3 g of gentian, 12 g of gypsum, 3 g of hawksbill, 6 g of uncaria rhynchophylla, 3 g of irhizoma glauca, 1.5 g of pummelo peel, 1.5 g of saffron, 5g of poria with hostwood, 2.95 g of dwarf lilyturf tuber, 9 g of rehmannia root, 6 g of scutellaria baicalensis, 1.5 g of wine-roasted ligusticum wallichii, 3 g of fried immature bitter orange, 3 g of gastrodia elata, 3 g of cattail pollen, 3 g of Chinese eaglewood, 1.5 g of agilawood, 3, pulverizing all the materials into fine powder; grinding 22 g of talcum into fine powder; 4.4 g of cinnabar is crushed into fine powder, 0.45 g of antelope horn is filed into fine powder, and the fine powder are mixed and ground, sieved and mixed evenly; weighing 3 g of mung beans, firstly adding 45g of water, decocting for 1 hour, then adding 15g of water, decocting for 3 hours, then adding 15g of water, decocting for 1 hour, sieving with a 100-mesh sieve, and filtering to obtain mung bean decoction;
decocting semen Phaseoli Radiati to obtain decoction, granulating, drying, making into tablet, and coating with film.
Experimental example 1
Research on influence of hypertension fast-decreasing pill on two-kidney one-clamp type hypertension rat
According to clinical indications of the hypertension quick-reducing pill, a rat model with two kidney-clamping type hypertension copied by an operation is selected, and related pharmacodynamic observation indexes are selected according to the hypertension effect to study the treatment effect of the hypertension rat model.
1 materials of the experiment
1.1 Experimental animals
SD rats, male, 10 weeks old, SPF grade, 83, body weight (250 + -20) g, purchased from Tokyo Wintolite laboratory animals technologies, Inc.
1.2 drugs and reagents
The hypertension-treating bolus prepared in example 1; .
Captopril tablet, shanghai schubao pharmaceutical limited, zhong mei, lot number: 1412032.
penicillin sodium for injection, Shandong Shanglu anti-medicine, Inc., batch number: B151006.
1.3 Experimental materials and instruments
0.25mm-U silver clip, Shanghai Orkets Biotech, Inc.
BP2010A rat and mouse intelligent noninvasive blood pressure measuring instrument, softron.
2 method of experiment
2.1 two-kidney one-clamp type hypertension rat model establishment
A10-week-old male SD rat is fed adaptively for 1 week, then blood pressure basic value measurement is carried out, under a quiet environment, a conscious rat is placed into a rat intelligent noninvasive blood pressure measuring instrument fixing belt to be preheated for 5-10 min, after pulse waves are stabilized, tail arterial systolic pressure (SBP) is measured continuously for 3 times, and an average value is taken as an SBP basic value. Except 10 rats were used as normal controls (blank group), other rats underwent left renal aortic stenosis surgery (two kidneys with one clip) to replicate the hypertension model.
Stopping feeding 12h before operation and freely drinking water; metal instruments, glass instruments, silk threads and the like for operation are subjected to high-pressure sterilization before operation. During operation, 40mg/kg of sodium pentobarbital is used for carrying out intraperitoneal injection and anaesthetizing rats, an operating table is fixed on the supine position, the furs of about 3cm multiplied by 4cm in the left abdominal area and the left kidney area are cut off, 1% iodine tincture and 75% ethanol are respectively used for disinfecting the skin, the skin is cut by about 3cm, the cut is parallel to the abdominal median line, the skin is fixed by a skin pulling hook, an abdominal muscle layer is separated bluntly by hemostatic forceps, the surgical forceps carefully push away the intestinal canal, pancreas and other internal organs to expose the left kidney, the renal artery is carefully separated by a glass needle, the left renal artery of the rat is clamped by a U-shaped silver clip of 0.25mm, the muscle and the skin are sequentially sutured, the normal group of rats is not treated, and the rat is continuously fed with 3d ip penicillin injection (10 ten. Blood pressure monitoring is carried out continuously for four weeks every week after operation, the blood pressure value at the 4 th week is referred, SBP is more than or equal to 160mmHg before and after model making is compared, and the model replication success is determined by the increase of 20 mmHg.
2.2 grouping and administration
The rats with successful model taking are randomly divided into 4 groups according to the SBP value, namely a model group, a positive drug captopril group, a hypertension quick-reducing pill medium dose group and a hypertension quick-reducing pill low dose group, the number of the mice is shown in table 2, the rats are continuously administrated for 4 weeks, the blood pressure value is monitored once per week, and the drug dose is adjusted according to the change condition of the SBP.
Wherein the dosage of the hypertension quick-reducing pill is equivalent to the equivalent dosage of the clinical dosage of human; the low dose of the hypertension pill is 1/2 which is equivalent to the dose of human clinical medication, and the specific administration condition is shown in Table 1.
TABLE 1 influence of hypertension-treating pill on two kidneys and one clip type hypertension rats
2.3 detection of animal index
Monitoring blood pressure once a week after administration, taking materials after four weeks, fasting for 12h before material taking, weighing fasting body mass of all animals, after 1h of last administration, injecting 40mg/kg sodium pentobarbital into abdominal cavity for anesthesia, taking blood from abdominal aorta, anticoagulating heparin, and separating plasma for measuring Aldosterone (ALD) and angiotensin (Ang II).
2.4 statistical methods
Statistical analysis was performed using a sps 17.0 and data was recorded using "± s". The data fit to a normal distribution, multiple sample mean comparisons were performed using one-way-ANOVA, with all subjects tested with LSD and all subjects tested with Dunnett's T3, and P <0.05 was statistically significant.
3 results of the experiment
3.1 Effect of hypertension-treating pill on blood pressure of hypertensive rat with two kidneys and one clip
The experimental result shows that the basal SBP of rats in each group has no significant difference (p is more than 0.05) compared with each other;
after four weeks of two-kidney one-clamp surgery, the SBP appeared significantly higher in each surgery group compared to the blank group (mean P <0.01), indicating successful model replication.
After four weeks of administration, the model group and rats in each administration group had significantly increased SBP (mean P <0.01) compared to the blank group; however, the blood pressure values of the captopril group and the hypertension pills in the middle and low dose groups were significantly decreased (P <0.01, 0.05, 0.01, respectively) compared to the model group, and the results are shown in table 2.
TABLE 2 influence of hypertension pill on the blood pressure of two-kidney and one-clamp type hypertension rat
Note: in comparison to the blank set, the data is,#P<0.05，##P<0.01; compared with model group<0.05，**P<0.01。
3.2 Effect of hypertension-lowering pill on angiotensin and aldosterone in blood plasma of hypertensive rat with two kidneys and one clip
The experimental result shows that compared with the blank group, the angiotensin in the plasma of the model group is obviously increased and has significant difference (P < 0.01). Compared with the model group, the positive medicine captopril, the high blood pressure quick-reducing pill and the low dosage can obviously reduce the content of angiotensin in blood plasma, and have obvious difference (P <0.01, P <0.01, P < 0.05).
The plasma aldosterone content of the model group tended to increase compared to the blank group; compared with a model group, the dosage group in the hypertension quick-reducing pill can reduce the content of aldosterone in blood plasma, and the trends of the dosage group have certain physiological significance, but no statistical difference occurs; as described in table 3.
TABLE 3 Effect of hypertension-lowering pill on angiotensin and aldosterone in blood plasma of two-kidney and one-clamp type hypertensive rat
| Group of | Number of examples | Angiotensin (pg/ml) | Aldosterone (ng/ml) |
| Blank group | 9 | 532.34±223.29** | 0.53±0.11 |
| Model set | 9 | 901.45±425.06## | 0.78±0.38 |
| Captopril group | 9 | 520.77±211.14** | 0.71±0.30 |
| Medium-dosage group of hypertension quick-reducing pills | 8 | 524.91±223.46** | 0.51±0.16 |
| Low-dose group of hypertension quick-reducing pills | 8 | 633.82±171.01* | 0.84±0.64 |
Note: in comparison to the blank set, the data is,#P<0.05，##P<0.01; compared with model group<0.05，**P<0.01。
4 discussion of Experimental results
The two-kidney one-clamp type hypertension animal model is a common experimental model for evaluating the antihypertensive effect of drugs, and the mechanism of the hypertension model is renal ischemia caused by renal artery constriction, renin-angiotensin-aldosterone system (RAAS) activation induced by renin-angiotensin-aldosterone system increase in kidney and secondary. The experimental result shows that stable hypertension is formed in rats 4 weeks after two-kidney one-clamp operation, and the significant increase of Ang II in plasma indicates that the model is successfully copied and accords with the literature report. The hypertensive fast-reducing pill can obviously reduce the tail arterial systolic pressure of a model rat on the basis of successful model replication after being continuously administrated for 4 weeks, reduce the obvious expression of Ang II caused by operation in plasma, and show the trend of reducing the content of the high-expression aldosterone, which indicates that the hypertensive fast-reducing pill has better antihypertensive effect on two-kidney one-clamp type hypertensive rat, and the mechanism is realized by regulating RAAS system.
It should be understood that the above examples and experimental examples are only examples for clearly illustrating the present invention, and are not intended to limit the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the spirit or scope of the invention.
Claims (13)
1. The composition for quickly reducing the hypertension is characterized by comprising the following raw material medicines in parts by weight: 15-45 parts of motherwort fruit, 3-9 parts of amber, 7.5-22.5 parts of salt-roasted tribulus terrestris, 6-18 parts of wine-roasted zaocys dhumnade, 3-9 parts of tabasheer, 9-27 parts of donkey-hide gelatin, 4.5-13.5 parts of chrysanthemum, 3-9 parts of rhizoma pinellinae praeparata, 4.5-13.5 parts of selfheal, 3-9 parts of wine-fried rhubarb, 3-9 parts of white peony root, 3-9 parts of red paeony root, 3-9 parts of cynanchum atratum bunge, 3-9 parts of angelica, 7.5-22.5 parts of achyranthes bidentata, 1.5-4.5 parts of bran-fried stiff silkworm, 3-9 parts of liquorice water-roasted polygala tenuifolia, 1.5-4.5 parts of cassia twig, 4.5-13.5 parts of figwort root, 3-9 parts of gentian, 12-36 parts of gypsum, 3-9 parts of hawksbill carapace, 6-18 parts of uncaria stem, 3-9 parts of calamus, 1.5-4.5 parts of pummelo flower, 1, 2.95-8.85 parts of dwarf lilyturf tuber, 9-27 parts of rehmannia root, 6-18 parts of baical skullcap root, 1.5-4.5 parts of wine-fried szechuan lovage rhizome, 3-9 parts of fried immature bitter orange, 3-9 parts of tall gastrodia tuber, 3-9 parts of cattail pollen, 1.5-4.5 parts of agilawood, 3-9 parts of amur corktree bark, 3-9 parts of Chinese thorowax root, 4.5-13.5 parts of weeping forsythia capsule, 4.5-13.5 parts of mulberry leaf, 4.5-13.5 parts of earthworm, 1.5-4.5 parts of aloe, 1.5-4.5 parts of scorpion, 3-9 parts of golden thread, 1.5-4.5 parts of dalbergia wood, 4.5-13.5 parts of tree peony bark, 6-18 parts of honey-fried liquoric root, 0.45-1.35 parts of antelope horn, 4.4-13.2 parts of cinn.
2. The hypertension quick-reducing composition according to claim 1, which comprises the following raw material medicines in parts by weight: motherwort fruit 30 parts, amber 6 parts, salt-roasted tribulus terrestris 15 parts, wine-roasted zaocys dhumnade 12 parts, tabasheer 6 parts, donkey-hide gelatin 18 parts, chrysanthemum 9 parts, rhizoma pinellinae praeparata 6 parts, selfheal 9 parts, wine-fried rhubarb 6 parts, white peony root 6 parts, red peony root 6 parts, cynanchum atratum 6 parts, angelica 6 parts, achyranthes root 15 parts, bran-fried stiff silkworm 3 parts, licorice-water-roasted polygala root 6 parts, cassia twig 3 parts, figwort 9 parts, gentian 6 parts, gypsum 24 parts, hawksbill 6 parts, uncaria 12 parts, irkusnezoff monkshood 6 parts, pummelo rhizome 6 parts, pummelo peel 3 parts, saffron 3 parts, poria 11.8 parts, ophiopogon root 5.9 parts, rehmannia root 18 parts, scutellaria 12 parts, wine-roasted ligusticum wallichii 3 parts, fried immature bitter orange 6 parts, gastrodia tuber 6 parts, cattail pollen 6 parts, agilawood 3 parts, yellow-corktree bark 6 parts, bupleurum 6 parts, 9 parts, mulberry leaf 9 parts, earthworm 9 parts, aloe, 0.9 part of antelope horn, 8.8 parts of cinnabar, 44 parts of talcum and 6 parts of mung bean.
3. The hypertension quick-reducing composition according to claim 1, which comprises the following raw material medicines in parts by weight: 15 parts of motherwort fruit, 3 parts of amber, 7.5 parts of salt-roasted tribulus terrestris, 6 parts of wine-roasted zaocys dhumnade, 3 parts of tabasheer, 9 parts of donkey-hide gelatin, 4.5 parts of chrysanthemum, 3 parts of rhizoma pinellinae praeparata, 4.5 parts of selfheal, 3 parts of wine-roasted rhubarb, 3 parts of white peony root, 3 parts of red peony root, 3 parts of cynanchum atratum bunge, 3 parts of angelica, 7.5 parts of achyranthes root, 1.5 parts of bran-roasted stiff silkworm, 3 parts of liquorice water-roasted polygala tenuifolia, 1.5 parts of cassia twig, 4.5 parts of figwort root, 3 parts of gentian, 12 parts of gypsum, 3 parts of hawksbill, 6 parts of uncaria rhynchophylla, 3 parts of irhizoma glauca calamus, 1.5 parts of pummelo peel, 1.5 parts of saffron, 5 parts of poria with hostwood, 2.95 parts of dwarf lilyturf tuber, 9 parts of rehmannia root, 6 parts of scutellaria baicalensis, 1.5 parts of wine-roasted ligusticum wallichii, 3 parts of fried immature bitter orange, 3 parts of cattail pollen, 1.5 parts of agilawood, 0.45 part of antelope horn, 4.4 parts of cinnabar, 22 parts of talcum and 3 parts of mung bean.
4. The hypertension quick-reducing composition according to claim 1, which comprises the following raw material medicines in parts by weight: 45 parts of motherwort fruit, 9 parts of amber, 22.5 parts of salt-roasted tribulus terrestris, 18 parts of wine-roasted zaocys dhumnade, 9 parts of concretio silicea bambusae, 27 parts of donkey-hide gelatin, 13.5 parts of chrysanthemum, 9 parts of rhizoma pinellinae praeparata, 13.5 parts of selfheal, 9 parts of wine-roasted rhubarb, 9 parts of white peony root, 9 parts of red peony root, 9 parts of cynanchum atratum bunge, 9 parts of angelica, 22.5 parts of achyranthes root, 4.5 parts of bran-roasted stiff silkworm, 9 parts of liquorice water-roasted polygala tenuifolia, 4.5 parts of cassia twig, 13.5 parts of figwort root, 9 parts of gentiana scabra bunge, 36 parts of gypsum, 9 parts of hawksbill, 18 parts of uncaria rhynchophylla, 9 parts of irhizoma glaucescent sweetflag rhizome, 4.5 parts of pummelo peel, 4.5 parts of saffron, 17.7 parts of poria with hostwood, 8.85 parts of ophiopogon root, 27 parts of rehmannia root, 18 parts of scutellaria baical, 4.5 parts of wine-roasted ligusticum wallichii, 9 parts of fried immature bitter orange, 9 parts of coptis, 9 parts of pollen, 9 parts of catt, 1.35 parts of antelope horn, 13.2 parts of cinnabar, 66 parts of talcum and 9 parts of mung bean.
5. A rapid hypotensive preparation comprising the rapid hypotensive composition according to any one of claims 1 to 4.
6. The preparation of claim 5, further comprising an adjuvant, wherein the adjuvant comprises at least one of conventional adjuvants including water 40-530 parts, beeswax 105-660 parts, cooked glutinous rice flour 10-330 parts.
7. The preparation of claim 5 or 6, wherein the preparation comprises pills, tablets, capsules, powders, mixtures, granules, oral liquids, syrups, ointments, granules, medicated liquors, injections, beverages, biscuits, candies, pastry foods or instant foods.
8. A preparation method of a hypertension quick-reducing pill is characterized by comprising the following steps:
(1) weighing motherwort fruit, amber, salt-roasted tribulus terrestris, wine-roasted zaocys dhumnade, tabasheer, donkey-hide gelatin, chrysanthemum, rhizoma pinellinae praeparata, selfheal, wine-fried rhubarb, white paeony root, red paeony root, cynanchum atratum bunge, angelica, achyranthes bidentata, bran-fried stiff silkworm, liquorice water-roasted polygala tenuifolia, cassia twig, figwort root, gentian, gypsum, hawksbill carapace, uncaria, irkutsk anemone rhizome, pummelo peel, saffron, poria with hostwood, radix ophiopogonis, rehmannia, scutellaria baicalensis, wine-roasted ligusticum wallichii, roasted immature bitter orange, gastrodia elata, cattail pollen, agilawood, phellodendron, radix bupleuri, forsythia, mulberry leaf, earthworm, aloe, scorpio; grinding cornu Saigae Tataricae into fine powder, mixing with the above fine powder, grinding, sieving, and mixing;
(2) weighing mung beans according to the selected parts, adding water, decocting for 1-3 times, each time for 1-3 hours, and filtering to obtain mung bean decoction;
(3) decocting semen Phaseoli Radiati to obtain decoction, drying at a temperature of not higher than 60 deg.C for 12-24 hr to obtain crude pill;
(4) refining Cinnabaris with water or pulverizing into fine powder; pulverizing pulvis Talci into pulvis Talci, mixing with Cinnabaris powder, grinding, sieving, mixing to obtain coating powder, coating the coarse pill, polishing, and drying to obtain the final product.
9. The method for preparing a bolus for quickly reducing blood pressure according to claim 8, wherein the step (1) further comprises weighing at least one of water, beeswax and conventional auxiliary materials of cooked glutinous rice flour according to selected parts, grinding into fine powder, mixing with other fine powder, grinding, sieving and mixing uniformly.
10. The method for preparing the hypertension rapidly-reducing pill according to claim 8 or 9, wherein in the step (2), the mung bean decoction is sieved by a sieve of 80-100 meshes.
11. The method for preparing the hypertension rapid-decreasing pill according to claim 8 or 9, wherein in the step (2), the mung beans are weighed according to the selected parts, the mung beans are added with water and decocted for 2 times, 15-45 times of water is added for the first time, and 5-15 times of water is added for the second time.
12. A hypertension-treating bolus prepared by the process of any one of claims 8 to 11.
13. The hypertension-reducing composition according to any one of claims 1 to 4, or the hypertension-reducing preparation according to any one of claims 5 to 7, or the hypertension-reducing pill prepared by the hypertension-reducing pill preparation method according to any one of claims 8 to 11, or the hypertension-reducing pill according to claim 12, for use in preparing a medicament for preventing or treating dizziness, distending pain in the brain, neck rigidity, red face, restlessness, slurred speech, light head and feet, unstable gait and reduced perception caused by the rise of deficient fire, or for use in preparing a medicament for preventing or treating hypertension.
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