CN1115253A - Eye drops - Google Patents

Abstract

The eye drops for curing eyeball surficial inflammation, acute inflammatory affection and refractory or infectious eyeball surficial ulcer with better curative effect is prepared from alpha 2-macroglobulin (2-15%), distilled water or deionized water, and antiseptic.

Description

A kind of eye drop

The invention belongs to medicinal preparation, particularly a kind of α that contains ₂The eye drop of-macroglobulin.

To eyeball table inflammation, the general antibiotics that adopts cooperates vitamins and micro-hormone medicine (containing medicament for the eyes) to treat, this therapeutic effect is not satisfactory, especially to the acute inflammation pathological changes, to prolonged property eyeball table ulcer (the alkali burn ulcer that do not heal, radiation ulcer and dystrophoneurosis ulcer) and infective ulcer still do not have satisfied Therapeutic Method, often cause anopia, cause the patient disabled all the life.

The object of the present invention is to provide a kind of α of containing ₂The eye drop of-macroglobulin, this eye drop can effectively be treated eyeball table inflammation and effectively be suppressed generation, the development of acute inflammation pathological changes and ulcer, and prolonged ulcer (alkali burn ulcer, radiation ulcer and dystrophoneurosis ulcer) and the infective ulcer of not healing also do not had better curative effect.

Technical solution of the present invention is: a kind of eye drop, it is mainly by α ₂-macroglobulin and distilled water or deionized water are formed, wherein α ₂-macroglobulin weight percent content is 2-15%.

α in this eye drop ₂-macroglobulin weight percent content optimum range is 5-8%.

Contain micro-antiseptic in this eye drop in addition, this antiseptic is nipalgin or thimerosal or bromo geramine.

This eye drop preparation method is: the spissated α of process ₂-macroglobulin extracting solution is transferred PH to 5.6-7.2, is diluted to α with distilled water or deionized water ₂The weight percent content of-macroglobulin is 2-15%, adds micro-antiseptic, filtration sterilization, and meat soup pipe antibacterial culturing should (one), and rabbit thermal source, toxicity test should (one), and it is no abnormal after 10 days to put sterilizing room, is distributed into eye drop.

Eye drop of the present invention is mainly used in treatment eyeball table inflammation, acute inflammation pathological changes and the prolonged property eyeball table ulcer (alkali burn ulcer, radiation ulcer and dystrophoneurosis ulcer) that do not heal are with antibiotic and with improving some serious antibacterial and treatment viral, fungal infection.

This eye drop using method is every day 4 times, each 1, or take the circumstances into consideration increase and decrease according to clinical needs.

Contained α in this eye drop ₂-macroglobulin has multiple function, as have improve the protective action be subjected to irradiation animal dis motility rate and promote hemopoietic tissue according to the back recover, regeneration function; Can remove proteolytic enzyme in the circulation; Can suppress the multiple protein enzyme that the invasion of pathogen and parasite discharges during body, and some virus is had inhibitory action; Have effect, therefore tangible promoting immunity and growth promoting function are arranged in conjunction with macrophage sex factor and nerve growth factor.Recently research shows that also it has the function of SOD content in the rising aqueous humor, the long-term prolonged eyeball table inflammation that does not heal is also had significant curative effect, so use α ₂The eye drop that-macroglobulin is made can be eliminated eyeball table inflammation effectively, suppresses the generation and the development of acute inflammation pathological changes and ulcer, shows good curative effect.

Further specify its result of use below in conjunction with clinical case.

Case 1; Appoint * *, man, 19 years old, the Puyang chlor-alkali plant potroom workman of Henan Province.Patient's the first five day work of being admitted to hospital the time is splashed into right eye with 30% sodium hydroxide accidentally, hinder back speed to clinic of factory with the flushing of boric acid water, local hospitalize is changeed in the back, the state of an illness did not have improvement in four days, the decline of carrying out property of vision.Look into after going into my institute: the vision left eye manually/20cm, the bulbar conjunctiva atropurpureus, pale, the edema of cornea is attached most importance to the below, about 1/2 quadrant of limbus of corneae is pale, top may be seen indistinctly anterior chamber and iris, intraocular pressure Tn.

Treatment: dead point cephalosporin associating every day vitamin C; Partial points vitamin C collyrium, cornea are peaceful, subconjunctival injection heparin and white serum treatment, two week back temporos top cornea recover transparent gradually, should the blood supply of quadrant angle film edge improve mutually.Cornea nasal downside position is still pale, and epithelial defect occurs.During the 3rd week, the epithelial defect district enlarges, and has the shallow-layer ulcer of middle section to occur, and add for the 3rd weekend and use eye drop of the present invention, per hour 1 time, the back ulcer reparation of 2 week of medication, the epithelial defect district diminishes gradually, healing at last, vision 0.2 when leaving hospital.

Case 2: the Shen * *, the man, 19 years old, village township, Xunxian, Henan Province Liu He people from village was chief complaint and is admitted to hospital with " overturning of driving causes eyes alkali burn companion visual deterioration three days ".Patient drove small tractor stone transporting ash before three days, overturn accidentally, was embedded under the lime pile of short duration at that time loss of consciousness, awake aftersensation eyes causalgia, blurring of vision, the huge pain of companion's right thigh, handle the shank wound in local hospital, eye is simply flushing only, changes my institute's treatment eye burn.Have an eyesight test: right eye index/30cm, left eye index/1m, the inhomogeneous white casse of cornea of both eyes, right eye is heavier, and the anterior chamber is may be seen indistinctly, and iris is looked and is loseed; The iris of left eye texture is visual to be reached, and the room dodges (+), pupil circle, and crystal is transparent, and the vitreous body optical fundus is fuzzy, eyes intraocular pressure Tn.Diagnosis: the alkali burn of right eye moderate, the slight alkali burn of left eye.

Treatment: intravenous drip lincomycin associating vitamin C, oral indometacin, partial points antibiotic collyrium, the peaceful collyrium of cornea and eye drop of the present invention, after 2 weeks of medication, cornea of left eye recovered part gradually is transparent, and the epithelium healing is good; Epithelial damage appears in right eye temporo below, does not form ulcer, adhere to 4 weeks of medication after, epithelium heals gradually with the new vessels hypertrophy, corneal healing is good.

Case 3: Cui * *, man, 28 years old, the north suburb, Zhengzhou City peasant.Sky surplus right eye is scalded 50 by hot edible oil, the patient buys Drug therapy by oneself, fails to respond to any medical treatment with chloromycetin eyedrops, erythromycin eye ointment, tetracycline cortisone collyrium etc.Come my gate to examine, per hour replace, unite eye drop of the present invention, per hour 1 time to antibiotic tarivid collyrium, rifampicin eye drop.After 2 weeks of medication, ulcer surface diminishes, and secretions reduces, and Shui Chong disappears in the district, ulcer healing gradually, residual corneal facet.Vision is by 0.06 reaching 0.4 at the beginning.

Case 4; Zhao * *, man, 46 years old, electric welder.

Right corner film wound (after the foreign body enucleation) outer court's antibiotic therapy does not see that corneal ulcer takes a turn for the better February, and ulcer surface constantly enlarges, and the back of being admitted to hospital is with eye drop 2 all ulcer surface secretions minimizings of the present invention, and ulcer heals gradually.

Embodiment 1; Spissated α learnt from else's experience ₂-macroglobulin extracting solution is transferred PH to 5.6-7.2, and distilled water is diluted to α ₂The concentration of-macroglobulin is 7% (weight percent concentration), adds 0.005% thimerosal, filtration sterilization, and meat soup pipe antibacterial culturing is answered (one), and rabbit thermal source, toxicity test are answered (one), put sterilizing room after 10 days, and be no abnormal, is distributed into eye drop.

Embodiment 2: spissated α learnt from else's experience ₂-macroglobulin extracting solution is transferred PH to 5.6-7.2, and distilled water is diluted to α ₂The concentration of-macroglobulin is 2% (weight percent concentration), adds 0.03% nipalgin, filtration sterilization, and meat soup pipe antibacterial culturing should (one), and family exempts from thermal source, toxicity test should (one), and it is no abnormal after 10 days to put sterilizing room, is distributed into eye drop.

Embodiment 3: spissated α learnt from else's experience ₂-macroglobulin extracting solution is transferred PH to 5.6-7.2, and deionized water is diluted to α ₂-macroglobulin concentration is 10% (weight percent concentration), adds 0.01% bromo geramine, filtration sterilization, and meat soup pipe antibacterial culturing should (one), and rabbit thermal source, toxicity test should (one), and it is no abnormal after 10 days to put sterilizing room, is distributed into eye drop.

Claims (3)

1, a kind of eye drop, it is mainly by α ₂-macroglobulin and distilled water or deionized water are formed, wherein α ₂-macroglobulin weight percent content is 2-15%.

2, eye drop according to claim 1, wherein α ₂-macroglobulin weight percent content optimum range is 5-8%.

3, eye drop according to claim 1 and 2 wherein contains micro-antiseptic, and this antiseptic is nipalgin or thimerosal or bromo geramine.