CN1103762C - 新的具有抗惊厥活性且4-位上含有二取代氨基的1-芳(烷)基咪唑啉-2-酮类化合物,以及它们的制备方法 - Google Patents
新的具有抗惊厥活性且4-位上含有二取代氨基的1-芳(烷)基咪唑啉-2-酮类化合物,以及它们的制备方法 Download PDFInfo
- Publication number
- CN1103762C CN1103762C CN96197801A CN96197801A CN1103762C CN 1103762 C CN1103762 C CN 1103762C CN 96197801 A CN96197801 A CN 96197801A CN 96197801 A CN96197801 A CN 96197801A CN 1103762 C CN1103762 C CN 1103762C
- Authority
- CN
- China
- Prior art keywords
- tetrahydroglyoxaline
- ketone
- compound
- phenyl
- morpholino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
实施例化合物 | log P2) | 试验3) | 剂量4) | 活性5) |
1 | 0.64 | MESPTZ | 100100 | 3030 |
2 | 1.48 | MESPTZ | 30030 | 3070 |
3 | 2.29 | MESPTZ | 100100 | 100100 |
4 | 0.48 | MESPTZ | 300300 | 3030 |
5 | 2.17 | MESPTZ | 300300 | 100100 |
6 | 1.61 | MESPTZ | 300100 | 10020 |
7 | 1.53 | MESPTZ | 300100 | 100100 |
8 | 1.45 | MESPTZ | 300100 | 30100 |
9 | 0.97 | MESPTZ | 100100 | 30100 |
10 | 1.28 | MESPTZ | 300300 | 1070 |
11 | 2.56 | MESPTZ | 300300 | 10040 |
对比物质 | 试验3) | 剂量4) | 活性5) |
氨甲酰氮 | MESPTZ | 100100 | 1000 |
丙戊酸盐 | MESPTZ | 100100 | 030 |
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19532668.7 | 1995-09-05 | ||
DE19532668A DE19532668A1 (de) | 1995-09-05 | 1995-09-05 | Neue, antikonvulsiv wirkende 1-Ar(alk)yl-imidazolin-2-one, die in 4-Stellung einen disubstituierten Amin-Rest enthalten, und Verfahren zu deren Herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1200728A CN1200728A (zh) | 1998-12-02 |
CN1103762C true CN1103762C (zh) | 2003-03-26 |
Family
ID=7771261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96197801A Expired - Lifetime CN1103762C (zh) | 1995-09-05 | 1996-07-26 | 新的具有抗惊厥活性且4-位上含有二取代氨基的1-芳(烷)基咪唑啉-2-酮类化合物,以及它们的制备方法 |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP0863880B1 (zh) |
JP (1) | JP4030578B2 (zh) |
CN (1) | CN1103762C (zh) |
AR (1) | AR003502A1 (zh) |
AT (1) | ATE254606T1 (zh) |
AU (1) | AU700602B2 (zh) |
BG (1) | BG63917B1 (zh) |
BR (1) | BR9610359A (zh) |
CA (1) | CA2184871C (zh) |
CZ (1) | CZ291839B6 (zh) |
DE (2) | DE19532668A1 (zh) |
DK (1) | DK0863880T3 (zh) |
EA (1) | EA000535B1 (zh) |
EE (1) | EE03562B1 (zh) |
ES (1) | ES2208758T3 (zh) |
FR (1) | FR13C0049I2 (zh) |
GE (1) | GEP20022652B (zh) |
HK (1) | HK1015776A1 (zh) |
HU (1) | HU225956B1 (zh) |
IL (1) | IL123333A (zh) |
LT (1) | LT4482B (zh) |
LU (1) | LU92263I2 (zh) |
NO (1) | NO313829B1 (zh) |
NZ (1) | NZ315624A (zh) |
PL (1) | PL188287B1 (zh) |
PT (1) | PT863880E (zh) |
SK (1) | SK284868B6 (zh) |
TR (1) | TR199800476T1 (zh) |
TW (1) | TW422838B (zh) |
UA (1) | UA46790C2 (zh) |
WO (1) | WO1997009314A1 (zh) |
ZA (1) | ZA967014B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19721580A1 (de) * | 1997-05-23 | 1998-11-26 | Dresden Arzneimittel | Verwendung von 1-Ar(alk)yl-imidazolin-2-one zur Behandlung von Angst- und Spannungszuständen |
US20050070537A1 (en) * | 2002-10-10 | 2005-03-31 | Chris Rundfeldt | Use of dihydroimidazolones for the treatment of dogs |
AU2004255414A1 (en) * | 2003-07-11 | 2005-01-20 | Boehringer Ingelheim Vetmedica Gmbh | Method of treating or preventing central nervous system disorders with compounds having selectivity for the alpha 3 subunit of the benzodiazepine receptor |
EP2093218A1 (en) * | 2008-02-22 | 2009-08-26 | Ruggero Fariello | Arylalkyl substituted imidazolidinones |
WO2013024036A1 (en) | 2011-08-12 | 2013-02-21 | Boehringer Ingelheim Vetmedica Gmbh | Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline |
US9820988B2 (en) | 2014-03-24 | 2017-11-21 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of epileptic disorders in feline animals |
IT202100000782A1 (it) | 2021-01-18 | 2022-07-18 | Procos Spa | Processo per la sintesi di imepitoina |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932452A (en) * | 1975-02-07 | 1976-01-13 | Morton-Norwich Products, Inc. | 1-Arylmethyl-2-imidazolidinones |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4044021A (en) * | 1971-10-21 | 1977-08-23 | American Cyanamid Company | Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism |
BE790380A (fr) | 1971-10-21 | 1973-04-20 | American Cyanamid Co | Nouvelles (p-chloro) phenyl-1 methyl-3 imidazolidines, 2,4-disubstituees utiles notamment comme agents diuretiques antialdosterone et leur procede de preparation |
-
1995
- 1995-09-05 DE DE19532668A patent/DE19532668A1/de not_active Ceased
-
1996
- 1996-07-26 EA EA199800271A patent/EA000535B1/ru not_active IP Right Cessation
- 1996-07-26 PT PT96927607T patent/PT863880E/pt unknown
- 1996-07-26 UA UA98041717A patent/UA46790C2/uk unknown
- 1996-07-26 SK SK216-98A patent/SK284868B6/sk not_active IP Right Cessation
- 1996-07-26 JP JP51080097A patent/JP4030578B2/ja not_active Expired - Lifetime
- 1996-07-26 BR BR9610359A patent/BR9610359A/pt active IP Right Grant
- 1996-07-26 AU AU67375/96A patent/AU700602B2/en not_active Expired
- 1996-07-26 DK DK96927607T patent/DK0863880T3/da active
- 1996-07-26 CZ CZ1998661A patent/CZ291839B6/cs not_active IP Right Cessation
- 1996-07-26 EE EE9800063A patent/EE03562B1/xx unknown
- 1996-07-26 DE DE59610827T patent/DE59610827D1/de not_active Expired - Lifetime
- 1996-07-26 GE GEAP19964221A patent/GEP20022652B/en unknown
- 1996-07-26 ES ES96927607T patent/ES2208758T3/es not_active Expired - Lifetime
- 1996-07-26 CN CN96197801A patent/CN1103762C/zh not_active Expired - Lifetime
- 1996-07-26 PL PL96325413A patent/PL188287B1/pl unknown
- 1996-07-26 TR TR1998/00476T patent/TR199800476T1/xx unknown
- 1996-07-26 EP EP96927607A patent/EP0863880B1/de not_active Expired - Lifetime
- 1996-07-26 HU HU9802941A patent/HU225956B1/hu unknown
- 1996-07-26 WO PCT/EP1996/003295 patent/WO1997009314A1/de active IP Right Grant
- 1996-07-26 AT AT96927607T patent/ATE254606T1/de active
- 1996-07-26 IL IL12333396A patent/IL123333A/en not_active IP Right Cessation
- 1996-07-26 NZ NZ315624A patent/NZ315624A/en not_active IP Right Cessation
- 1996-08-19 ZA ZA967014A patent/ZA967014B/xx unknown
- 1996-09-03 TW TW085110749A patent/TW422838B/zh not_active IP Right Cessation
- 1996-09-04 AR ARP960104226A patent/AR003502A1/es active IP Right Grant
- 1996-09-05 CA CA002184871A patent/CA2184871C/en not_active Expired - Lifetime
-
1998
- 1998-02-27 BG BG102287A patent/BG63917B1/bg unknown
- 1998-03-02 NO NO19980906A patent/NO313829B1/no not_active IP Right Cessation
- 1998-04-03 LT LT98-047A patent/LT4482B/lt not_active IP Right Cessation
-
1999
- 1999-03-01 HK HK99100827A patent/HK1015776A1/xx not_active IP Right Cessation
-
2013
- 2013-08-07 LU LU92263C patent/LU92263I2/fr unknown
- 2013-08-13 FR FR13C0049C patent/FR13C0049I2/fr active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932452A (en) * | 1975-02-07 | 1976-01-13 | Morton-Norwich Products, Inc. | 1-Arylmethyl-2-imidazolidinones |
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C14 | Grant of patent or utility model | ||
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ASS | Succession or assignment of patent right |
Owner name: ELBION AG Free format text: FORMER OWNER: ARZNEIMITTELWERK DRESDEN GMBH Effective date: 20040405 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20040405 Address after: Ladd Boer, Germany Patentee after: Elbion AG Address before: Radebeul, Federal Republic of Germany Patentee before: Arzneimittelwerk Dresden GMBH |
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C56 | Change in the name or address of the patentee |
Owner name: BIOTIE THERAPIES CORP. Free format text: FORMER NAME: ARZNEIMITTELWERK DRESDEN GMBH |
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CP03 | Change of name, title or address |
Address after: Radebeul, Germany Patentee after: Biological junction therapy limited liability company Address before: Ladd Boer, Germany Patentee before: Elbion AG |
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ASS | Succession or assignment of patent right |
Owner name: BIOCLAY PTY LTD. Free format text: FORMER OWNER: CRITTER CRUST TREATMENT CO., LTD. Effective date: 20110701 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110701 Address after: Radebeul, Germany Patentee after: Limited liability company Address before: Radebeul, Germany Patentee before: Biological junction therapy limited liability company |
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CX01 | Expiry of patent term |
Granted publication date: 20030326 |
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EXPY | Termination of patent right or utility model |